S4.1 Challenges in global estimates of syphilis in pregnancy
Identifieur interne : 002734 ( Istex/Corpus ); précédent : 002733; suivant : 002735S4.1 Challenges in global estimates of syphilis in pregnancy
Auteurs : L. Newman ; S. Hawkes ; M. Kamb ; I. Toskin ; L. Say ; N. BroutetSource :
- Sexually Transmitted Infections [ 1368-4973 ] ; 2011-07.
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Abstract
Background Estimates of the current number of pregnant women infected with syphilis (maternal syphilis) are necessary for the global Elimination of Congenital Syphilis initiative such that advocacy, program implementation, and monitoring are based on a clear understanding of the current situation. In addition to understanding morbidity in pregnant women, an accurate estimate of maternal syphilis is also the cornerstone of calculations of the burden of adverse outcomes associated with syphilis in pregnancy. Methods A MEDLINE search from January 2003 to September 2010 was conducted to identify studies of syphilis prevalence in women attending antenatal care with the following inclusion criteria: sample size of at least 100, use of both reaginic and non-reaginic tests, English language, and no apparent selection bias. Methods are similar to those used by Schmid et al in 2007 to estimate maternal syphilis, except that current estimates include Europe and North America, and will be compared with syphilis seropositivity data reported by countries through the WHO HIV Universal Access reporting system for 2008 through 2010 (reported data may or may not use both reaginic and non-reaginic tests). Global and regional estimates will be based on country data where available, and where not available, a regional pregnancy-weighted mean based on live births (per United Nations Population Division) and known country seropositivity will be used. Country and regional estimates will be validated by WHO regional advisors to assess if estimates are reasonable. Results Studies on approximately 35 of 193 countries (18%) met the inclusion criteria for the MEDLINE search, and 96 countries (50%) reported seropositivity in either 2008 or 2009; additional reported data for 2010 will be available in May 2011, at which time estimates will be completed. Conclusions Data on maternal syphilis are available in recent published literature for only a small proportion of countries. Therefore, global and regional estimates of maternal syphilis must rely on alternative data sources such as the WHO HIV Universal Access reporting system. Increased efforts are required globally to highlight the importance of having sufficient high-quality data to guide implementation of congenital syphilis elimination efforts.
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DOI: 10.1136/sextrans-2011-050102.14
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>S4.1 Challenges in global estimates of syphilis in pregnancy</title><author><name sortKey="Newman, L" sort="Newman, L" uniqKey="Newman L" first="L" last="Newman">L. Newman</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Hawkes, S" sort="Hawkes, S" uniqKey="Hawkes S" first="S" last="Hawkes">S. Hawkes</name><affiliation><mods:affiliation>University College, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Kamb, M" sort="Kamb, M" uniqKey="Kamb M" first="M" last="Kamb">M. Kamb</name><affiliation><mods:affiliation>Centre for Disease Control and Prevention (CDC), Atlanta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Toskin, I" sort="Toskin, I" uniqKey="Toskin I" first="I" last="Toskin">I. Toskin</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Say, L" sort="Say, L" uniqKey="Say L" first="L" last="Say">L. Say</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Broutet, N" sort="Broutet, N" uniqKey="Broutet N" first="N" last="Broutet">N. Broutet</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:78873D9E86BB5D9FA428D7579660AA4A9A188345</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1136/sextrans-2011-050102.14</idno><idno type="url">https://api.istex.fr/document/78873D9E86BB5D9FA428D7579660AA4A9A188345/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002734</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002734</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">S4.1 Challenges in global estimates of syphilis in pregnancy</title><author><name sortKey="Newman, L" sort="Newman, L" uniqKey="Newman L" first="L" last="Newman">L. Newman</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Hawkes, S" sort="Hawkes, S" uniqKey="Hawkes S" first="S" last="Hawkes">S. Hawkes</name><affiliation><mods:affiliation>University College, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Kamb, M" sort="Kamb, M" uniqKey="Kamb M" first="M" last="Kamb">M. Kamb</name><affiliation><mods:affiliation>Centre for Disease Control and Prevention (CDC), Atlanta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Toskin, I" sort="Toskin, I" uniqKey="Toskin I" first="I" last="Toskin">I. Toskin</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Say, L" sort="Say, L" uniqKey="Say L" first="L" last="Say">L. Say</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Broutet, N" sort="Broutet, N" uniqKey="Broutet N" first="N" last="Broutet">N. Broutet</name><affiliation><mods:affiliation>World Health Organization (WHO), Geneva, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Sexually Transmitted Infections</title><title level="j" type="abbrev">Sex Transm Infect</title><idno type="ISSN">1368-4973</idno><idno type="eISSN">1472-3263</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-07">2011-07</date><biblScope unit="volume">87</biblScope><biblScope unit="issue">Suppl 1</biblScope><biblScope unit="page" from="A4">A4</biblScope></imprint><idno type="ISSN">1368-4973</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1368-4973</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antenatal care</term><term>Imperial college</term><term>Inclusion criteria</term><term>Maternal syphilis</term><term>Medline search</term><term>Pmtct</term><term>Pmtct services</term><term>Pregnant women</term><term>Prevention programmes</term><term>Prevention strategies</term><term>Programme</term><term>Rapid syphilis testing</term><term>Regional estimates</term><term>Syphilis</term><term>Transmission dynamics models</term><term>Universal access</term><term>Zambia</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antenatal care</term><term>Imperial college</term><term>Inclusion criteria</term><term>Maternal syphilis</term><term>Medline search</term><term>Pmtct</term><term>Pmtct services</term><term>Pregnant women</term><term>Prevention programmes</term><term>Prevention strategies</term><term>Programme</term><term>Rapid syphilis testing</term><term>Regional estimates</term><term>Syphilis</term><term>Transmission dynamics models</term><term>Universal access</term><term>Zambia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Estimates of the current number of pregnant women infected with syphilis (maternal syphilis) are necessary for the global Elimination of Congenital Syphilis initiative such that advocacy, program implementation, and monitoring are based on a clear understanding of the current situation. In addition to understanding morbidity in pregnant women, an accurate estimate of maternal syphilis is also the cornerstone of calculations of the burden of adverse outcomes associated with syphilis in pregnancy. Methods A MEDLINE search from January 2003 to September 2010 was conducted to identify studies of syphilis prevalence in women attending antenatal care with the following inclusion criteria: sample size of at least 100, use of both reaginic and non-reaginic tests, English language, and no apparent selection bias. Methods are similar to those used by Schmid et al in 2007 to estimate maternal syphilis, except that current estimates include Europe and North America, and will be compared with syphilis seropositivity data reported by countries through the WHO HIV Universal Access reporting system for 2008 through 2010 (reported data may or may not use both reaginic and non-reaginic tests). Global and regional estimates will be based on country data where available, and where not available, a regional pregnancy-weighted mean based on live births (per United Nations Population Division) and known country seropositivity will be used. Country and regional estimates will be validated by WHO regional advisors to assess if estimates are reasonable. Results Studies on approximately 35 of 193 countries (18%) met the inclusion criteria for the MEDLINE search, and 96 countries (50%) reported seropositivity in either 2008 or 2009; additional reported data for 2010 will be available in May 2011, at which time estimates will be completed. Conclusions Data on maternal syphilis are available in recent published literature for only a small proportion of countries. Therefore, global and regional estimates of maternal syphilis must rely on alternative data sources such as the WHO HIV Universal Access reporting system. Increased efforts are required globally to highlight the importance of having sufficient high-quality data to guide implementation of congenital syphilis elimination efforts.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>syphilis</json:string><json:string>rapid syphilis testing</json:string><json:string>zambia</json:string><json:string>programme</json:string><json:string>maternal syphilis</json:string><json:string>pmtct</json:string><json:string>prevention programmes</json:string><json:string>regional estimates</json:string><json:string>imperial college</json:string><json:string>antenatal care</json:string><json:string>inclusion criteria</json:string><json:string>universal access</json:string><json:string>pregnant women</json:string><json:string>transmission dynamics models</json:string><json:string>prevention strategies</json:string><json:string>pmtct services</json:string><json:string>medline search</json:string></teeft></keywords><author><json:item><name>L Newman</name><affiliations><json:string>World Health Organization (WHO), Geneva, Switzerland</json:string></affiliations></json:item><json:item><name>S Hawkes</name><affiliations><json:string>University College, London, UK</json:string></affiliations></json:item><json:item><name>M Kamb</name><affiliations><json:string>Centre for Disease Control and Prevention (CDC), Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>I Toskin</name><affiliations><json:string>World Health Organization (WHO), Geneva, Switzerland</json:string></affiliations></json:item><json:item><name>L Say</name><affiliations><json:string>World Health Organization (WHO), Geneva, Switzerland</json:string></affiliations></json:item><json:item><name>N Broutet</name><affiliations><json:string>World Health Organization (WHO), Geneva, Switzerland</json:string></affiliations></json:item></author><articleId><json:string>sextrans-2011-050102.14</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>Background Estimates of the current number of pregnant women infected with syphilis (maternal syphilis) are necessary for the global Elimination of Congenital Syphilis initiative such that advocacy, program implementation, and monitoring are based on a clear understanding of the current situation. In addition to understanding morbidity in pregnant women, an accurate estimate of maternal syphilis is also the cornerstone of calculations of the burden of adverse outcomes associated with syphilis in pregnancy. Methods A MEDLINE search from January 2003 to September 2010 was conducted to identify studies of syphilis prevalence in women attending antenatal care with the following inclusion criteria: sample size of at least 100, use of both reaginic and non-reaginic tests, English language, and no apparent selection bias. Methods are similar to those used by Schmid et al in 2007 to estimate maternal syphilis, except that current estimates include Europe and North America, and will be compared with syphilis seropositivity data reported by countries through the WHO HIV Universal Access reporting system for 2008 through 2010 (reported data may or may not use both reaginic and non-reaginic tests). Global and regional estimates will be based on country data where available, and where not available, a regional pregnancy-weighted mean based on live births (per United Nations Population Division) and known country seropositivity will be used. Country and regional estimates will be validated by WHO regional advisors to assess if estimates are reasonable. Results Studies on approximately 35 of 193 countries (18%) met the inclusion criteria for the MEDLINE search, and 96 countries (50%) reported seropositivity in either 2008 or 2009; additional reported data for 2010 will be available in May 2011, at which time estimates will be completed. Conclusions Data on maternal syphilis are available in recent published literature for only a small proportion of countries. Therefore, global and regional estimates of maternal syphilis must rely on alternative data sources such as the WHO HIV Universal Access reporting system. Increased efforts are required globally to highlight the importance of having sufficient high-quality data to guide implementation of congenital syphilis elimination efforts.</abstract><qualityIndicators><score>5.387</score><pdfVersion>1.6</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>2308</abstractCharCount><pdfWordCount>887</pdfWordCount><pdfCharCount>6108</pdfCharCount><pdfPageCount>1</pdfPageCount><abstractWordCount>342</abstractWordCount></qualityIndicators><title>S4.1 Challenges in global estimates of syphilis in pregnancy</title><genre><json:string>abstract</json:string></genre><host><title>Sexually Transmitted Infections</title><language><json:string>unknown</json:string></language><issn><json:string>1368-4973</json:string></issn><eissn><json:string>1472-3263</json:string></eissn><publisherId><json:string>sti</json:string></publisherId><volume>87</volume><issue>Suppl 1</issue><pages><first>A4</first></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>infectious diseases</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>public health & health services</json:string><json:string>public health</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1136/sextrans-2011-050102.14</json:string></doi><id>78873D9E86BB5D9FA428D7579660AA4A9A188345</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/78873D9E86BB5D9FA428D7579660AA4A9A188345/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/78873D9E86BB5D9FA428D7579660AA4A9A188345/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/78873D9E86BB5D9FA428D7579660AA4A9A188345/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">S4.1 Challenges in global estimates of syphilis in pregnancy</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">BMJ Publishing Group Ltd</publisher><availability><licence><p>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</p></availability><date>2011-07-10</date></publicationStmt><notesStmt><note type="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">S4.1 Challenges in global estimates of syphilis in pregnancy</title><author xml:id="author-0000"><persName><forename type="first">L</forename><surname>Newman</surname></persName><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S</forename><surname>Hawkes</surname></persName><affiliation>University College, London, UK</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M</forename><surname>Kamb</surname></persName><affiliation>Centre for Disease Control and Prevention (CDC), Atlanta, Georgia, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">I</forename><surname>Toskin</surname></persName><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation></author><author xml:id="author-0004"><persName><forename type="first">L</forename><surname>Say</surname></persName><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation></author><author xml:id="author-0005"><persName><forename type="first">N</forename><surname>Broutet</surname></persName><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation></author><idno type="istex">78873D9E86BB5D9FA428D7579660AA4A9A188345</idno><idno type="ark">ark:/67375/NVC-8TLBNXZ4-F</idno><idno type="DOI">10.1136/sextrans-2011-050102.14</idno><idno type="href">sextrans-87-A4-4.pdf</idno><idno type="article-id">sextrans-2011-050102.14</idno><idno type="local">sextrans;87/Suppl_1/A4-d</idno></analytic><monogr><title level="j">Sexually Transmitted Infections</title><title level="j" type="abbrev">Sex Transm Infect</title><idno type="pISSN">1368-4973</idno><idno type="eISSN">1472-3263</idno><idno type="publisher-id">sti</idno><idno type="PublisherID-hwp">sextrans</idno><idno type="PublisherID-nlm-ta">Sex Transm Infect</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-07"></date><biblScope unit="volume">87</biblScope><biblScope unit="issue">Suppl 1</biblScope><biblScope unit="page" from="A4">A4</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011-07-10</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background Estimates of the current number of pregnant women infected with syphilis (maternal syphilis) are necessary for the global Elimination of Congenital Syphilis initiative such that advocacy, program implementation, and monitoring are based on a clear understanding of the current situation. In addition to understanding morbidity in pregnant women, an accurate estimate of maternal syphilis is also the cornerstone of calculations of the burden of adverse outcomes associated with syphilis in pregnancy. Methods A MEDLINE search from January 2003 to September 2010 was conducted to identify studies of syphilis prevalence in women attending antenatal care with the following inclusion criteria: sample size of at least 100, use of both reaginic and non-reaginic tests, English language, and no apparent selection bias. Methods are similar to those used by Schmid et al in 2007 to estimate maternal syphilis, except that current estimates include Europe and North America, and will be compared with syphilis seropositivity data reported by countries through the WHO HIV Universal Access reporting system for 2008 through 2010 (reported data may or may not use both reaginic and non-reaginic tests). Global and regional estimates will be based on country data where available, and where not available, a regional pregnancy-weighted mean based on live births (per United Nations Population Division) and known country seropositivity will be used. Country and regional estimates will be validated by WHO regional advisors to assess if estimates are reasonable. Results Studies on approximately 35 of 193 countries (18%) met the inclusion criteria for the MEDLINE search, and 96 countries (50%) reported seropositivity in either 2008 or 2009; additional reported data for 2010 will be available in May 2011, at which time estimates will be completed. Conclusions Data on maternal syphilis are available in recent published literature for only a small proportion of countries. Therefore, global and regional estimates of maternal syphilis must rely on alternative data sources such as the WHO HIV Universal Access reporting system. Increased efforts are required globally to highlight the importance of having sufficient high-quality data to guide implementation of congenital syphilis elimination efforts.</p></abstract></profileDesc><revisionDesc><change when="2011-07-10">Created</change><change when="2011-07">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-10-17">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/78873D9E86BB5D9FA428D7579660AA4A9A188345/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="abstract"><front><journal-meta><journal-id journal-id-type="hwp">sextrans</journal-id><journal-id journal-id-type="nlm-ta">Sex Transm Infect</journal-id><journal-id journal-id-type="publisher-id">sti</journal-id><journal-title>Sexually Transmitted Infections</journal-title><abbrev-journal-title abbrev-type="publisher">Sex Transm Infect</abbrev-journal-title><abbrev-journal-title>Sex Transm Infect</abbrev-journal-title><issn pub-type="ppub">1368-4973</issn><issn pub-type="epub">1472-3263</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">sextrans-2011-050102.14</article-id><article-id pub-id-type="doi">10.1136/sextrans-2011-050102.14</article-id><article-id pub-id-type="other">sextrans;87/Suppl_1/A4-d</article-id><article-id pub-id-type="other">sextrans;sextrans-2011-050102.14</article-id><article-id pub-id-type="other">A4.4</article-id><article-id pub-id-type="other">sextrans-2011-050102.14</article-id><article-categories><subj-group subj-group-type="heading"><subject>Symposia</subject></subj-group><series-title>Symposium 4: Speeding up elimination of congenital syphilis with rapid syphilis testing: progress and challenges (sponsored by WHO)</series-title></article-categories><title-group><article-title>S4.1 Challenges in global estimates of syphilis in pregnancy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Newman</surname><given-names>L</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hawkes</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kamb</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Toskin</surname><given-names>I</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Say</surname><given-names>L</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Broutet</surname><given-names>N</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>World Health Organization (WHO), Geneva, Switzerland</aff><aff id="aff2"><label>2</label>University College, London, UK</aff><aff id="aff3"><label>3</label>Centre for Disease Control and Prevention (CDC), Atlanta, Georgia, USA</aff><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>10</day><month>7</month><year>2011</year></pub-date><volume>87</volume><volume-id pub-id-type="other">87</volume-id><volume-id pub-id-type="other">87</volume-id><issue>Suppl 1</issue><issue-id pub-id-type="other">sextrans;87/Suppl_1</issue-id><issue-id pub-id-type="other" content-type="supplement">Suppl_1</issue-id><issue-id pub-id-type="other">87/Suppl_1</issue-id><issue-title>19th Biennial Conference Of The International Society For Sexually Transmitted Diseases Research</issue-title><fpage seq="4">A4</fpage><permissions><copyright-statement>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="sextrans-87-A4-4.pdf"></self-uri><abstract><sec><title>Background</title><p>Estimates of the current number of pregnant women infected with syphilis (maternal syphilis) are necessary for the global Elimination of Congenital Syphilis initiative such that advocacy, program implementation, and monitoring are based on a clear understanding of the current situation. In addition to understanding morbidity in pregnant women, an accurate estimate of maternal syphilis is also the cornerstone of calculations of the burden of adverse outcomes associated with syphilis in pregnancy.</p></sec><sec><title>Methods</title><p>A MEDLINE search from January 2003 to September 2010 was conducted to identify studies of syphilis prevalence in women attending antenatal care with the following inclusion criteria: sample size of at least 100, use of both reaginic and non-reaginic tests, English language, and no apparent selection bias. Methods are similar to those used by Schmid <italic>et al</italic> in 2007 to estimate maternal syphilis, except that current estimates include Europe and North America, and will be compared with syphilis seropositivity data reported by countries through the WHO HIV Universal Access reporting system for 2008 through 2010 (reported data may or may not use both reaginic and non-reaginic tests). Global and regional estimates will be based on country data where available, and where not available, a regional pregnancy-weighted mean based on live births (per United Nations Population Division) and known country seropositivity will be used. Country and regional estimates will be validated by WHO regional advisors to assess if estimates are reasonable.</p></sec><sec><title>Results</title><p>Studies on approximately 35 of 193 countries (18%) met the inclusion criteria for the MEDLINE search, and 96 countries (50%) reported seropositivity in either 2008 or 2009; additional reported data for 2010 will be available in May 2011, at which time estimates will be completed.</p></sec><sec><title>Conclusions</title><p>Data on maternal syphilis are available in recent published literature for only a small proportion of countries. Therefore, global and regional estimates of maternal syphilis must rely on alternative data sources such as the WHO HIV Universal Access reporting system. Increased efforts are required globally to highlight the importance of having sufficient high-quality data to guide implementation of congenital syphilis elimination efforts.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>S4.1 Challenges in global estimates of syphilis in pregnancy</title><partName>Symposium 4: Speeding up elimination of congenital syphilis with rapid syphilis testing: progress and challenges (sponsored by WHO)</partName></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>S4.1 Challenges in global estimates of syphilis in pregnancy</title><partName>Symposium 4: Speeding up elimination of congenital syphilis with rapid syphilis testing: progress and challenges (sponsored by WHO)</partName></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Newman</namePart><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Hawkes</namePart><affiliation>University College, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kamb</namePart><affiliation>Centre for Disease Control and Prevention (CDC), Atlanta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Toskin</namePart><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Say</namePart><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Broutet</namePart><affiliation>World Health Organization (WHO), Geneva, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2011-07</dateIssued><dateCreated encoding="w3cdtf">2011-07-10</dateCreated><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>Background Estimates of the current number of pregnant women infected with syphilis (maternal syphilis) are necessary for the global Elimination of Congenital Syphilis initiative such that advocacy, program implementation, and monitoring are based on a clear understanding of the current situation. In addition to understanding morbidity in pregnant women, an accurate estimate of maternal syphilis is also the cornerstone of calculations of the burden of adverse outcomes associated with syphilis in pregnancy. Methods A MEDLINE search from January 2003 to September 2010 was conducted to identify studies of syphilis prevalence in women attending antenatal care with the following inclusion criteria: sample size of at least 100, use of both reaginic and non-reaginic tests, English language, and no apparent selection bias. Methods are similar to those used by Schmid et al in 2007 to estimate maternal syphilis, except that current estimates include Europe and North America, and will be compared with syphilis seropositivity data reported by countries through the WHO HIV Universal Access reporting system for 2008 through 2010 (reported data may or may not use both reaginic and non-reaginic tests). Global and regional estimates will be based on country data where available, and where not available, a regional pregnancy-weighted mean based on live births (per United Nations Population Division) and known country seropositivity will be used. Country and regional estimates will be validated by WHO regional advisors to assess if estimates are reasonable. Results Studies on approximately 35 of 193 countries (18%) met the inclusion criteria for the MEDLINE search, and 96 countries (50%) reported seropositivity in either 2008 or 2009; additional reported data for 2010 will be available in May 2011, at which time estimates will be completed. Conclusions Data on maternal syphilis are available in recent published literature for only a small proportion of countries. Therefore, global and regional estimates of maternal syphilis must rely on alternative data sources such as the WHO HIV Universal Access reporting system. Increased efforts are required globally to highlight the importance of having sufficient high-quality data to guide implementation of congenital syphilis elimination efforts.</abstract><relatedItem type="host"><titleInfo><title>Sexually Transmitted Infections</title></titleInfo><titleInfo type="abbreviated"><title>Sex Transm Infect</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1368-4973</identifier><identifier type="eISSN">1472-3263</identifier><identifier type="PublisherID">sti</identifier><identifier type="PublisherID-hwp">sextrans</identifier><identifier type="PublisherID-nlm-ta">Sex Transm Infect</identifier><part><date>2011</date><detail type="title"><title>19th Biennial Conference Of The International Society For Sexually Transmitted Diseases Research</title></detail><detail type="volume"><caption>vol.</caption><number>87</number></detail><detail type="issue"><caption>no.</caption><number>Suppl 1</number></detail><extent unit="pages"><start>A4</start></extent></part></relatedItem><identifier type="istex">78873D9E86BB5D9FA428D7579660AA4A9A188345</identifier><identifier type="ark">ark:/67375/NVC-8TLBNXZ4-F</identifier><identifier type="DOI">10.1136/sextrans-2011-050102.14</identifier><identifier type="href">sextrans-87-A4-4.pdf</identifier><identifier type="ArticleID">sextrans-2011-050102.14</identifier><identifier type="local">sextrans;87/Suppl_1/A4-d</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/78873D9E86BB5D9FA428D7579660AA4A9A188345/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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