The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia
Identifieur interne : 002108 ( Istex/Corpus ); précédent : 002107; suivant : 002109The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia
Auteurs : P. Kelly ; K. S. Baboo ; M. Wolff ; B. Ngwenya ; N. Luo ; M. J. G. FarthingSource :
- Acta Tropica [ 0001-706X ] ; 1996.
English descriptors
- KwdEn :
- Africa, African aids patients, Attack rate, Childhood diarrhoea, Community survey, Cryptosporidium, Cryptosporidium parvum, Diarrhoea, Diarrhoeal, Diarrhoeal disease, Diarrhoeal illness, George township, HIV, Health care facilities, Histological study, Hospital sample, Hospital study, Industrialised countries, Isospora, Lusaka, Medical college, Microsporidia, Month duration, Persistent diarrhoea, Polymerase chain reaction detection, Prevalence, Protozoa, Septata intestinalis, University teaching hospital, Urban community, Urban zambia, Weeks duration, Zambia.
- Teeft :
- African aids patients, Attack rate, Childhood diarrhoea, Community survey, Cryptosporidium parvum, Diarrhoea, Diarrhoeal, Diarrhoeal disease, Diarrhoeal illness, George township, Health care facilities, Histological study, Hospital sample, Hospital study, Industrialised countries, Lusaka, Medical college, Month duration, Persistent diarrhoea, Polymerase chain reaction detection, Prevalence, Septata intestinalis, University teaching hospital, Urban community, Urban zambia, Weeks duration, Zambia.
Abstract
Abstract: As the AIDS pandemic has spread, diarrhoea in adults has become a major burden on health care institutions in central Africa and on the families of sufferers. In order to assess the magnitude of the problem, we carried out a survey of households in a high population density township of Lusaka to determine the prevalence of persistent diarrhoea in adults. We also carried out a study of the causes of persistent diarrhoea in patients attending the University Teaching Hospital, Lusaka. The community survey assessed 460 households, representing a sample of 1440 adults. 94 adults were reported as having had diarrhoea in the 2 weeks prior to the survey, implying an attack rate of 1.74 per adult per year. Of these 94 cases, six had diarrhoea of between 2 and 4 weeks duration, and ten had diarrhoea of over 4 weeks duration. In the hospital study, 75 (97%) out of 77 patients with diarrhoea of over 1 months' duration were HIV seropositive; potentially pathogenic parasites were found in 6175 (81%) of seropositives. This information indicates that persistent diarrhoea in adults, mostly related to HIV infection, is likely to be an important and growing reservoir of enteric pathogens and represents a significant burden on hospitals and relatives. This emerging problem in sub-Saharan Africa may foreshadow developments in other continents.
Url:
DOI: 10.1016/0001-706X(95)00142-2
Links to Exploration step
ISTEX:66039BA570F15B0EE8C11000E21D1D068B40BA1DLe document en format XML
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Kelly</name><affiliation><mods:affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</mods:affiliation></affiliation></author><author><name sortKey="Baboo, K S" sort="Baboo, K S" uniqKey="Baboo K" first="K. S." last="Baboo">K. S. Baboo</name><affiliation><mods:affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</mods:affiliation></affiliation></author><author><name sortKey="Wolff, M" sort="Wolff, M" uniqKey="Wolff M" first="M." last="Wolff">M. Wolff</name><affiliation><mods:affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</mods:affiliation></affiliation></author><author><name sortKey="Ngwenya, B" sort="Ngwenya, B" uniqKey="Ngwenya B" first="B." last="Ngwenya">B. Ngwenya</name><affiliation><mods:affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. 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Farthing</name><affiliation><mods:affiliation>Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Tropica</title><title level="j" type="abbrev">ACTROP</title><idno type="ISSN">0001-706X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="190">190</biblScope></imprint><idno type="ISSN">0001-706X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-706X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa</term><term>African aids patients</term><term>Attack rate</term><term>Childhood diarrhoea</term><term>Community survey</term><term>Cryptosporidium</term><term>Cryptosporidium parvum</term><term>Diarrhoea</term><term>Diarrhoeal</term><term>Diarrhoeal disease</term><term>Diarrhoeal illness</term><term>George township</term><term>HIV</term><term>Health care facilities</term><term>Histological study</term><term>Hospital sample</term><term>Hospital study</term><term>Industrialised countries</term><term>Isospora</term><term>Lusaka</term><term>Medical college</term><term>Microsporidia</term><term>Month duration</term><term>Persistent diarrhoea</term><term>Polymerase chain reaction detection</term><term>Prevalence</term><term>Protozoa</term><term>Septata intestinalis</term><term>University teaching hospital</term><term>Urban community</term><term>Urban zambia</term><term>Weeks duration</term><term>Zambia</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>African aids patients</term><term>Attack rate</term><term>Childhood diarrhoea</term><term>Community survey</term><term>Cryptosporidium parvum</term><term>Diarrhoea</term><term>Diarrhoeal</term><term>Diarrhoeal disease</term><term>Diarrhoeal illness</term><term>George township</term><term>Health care facilities</term><term>Histological study</term><term>Hospital sample</term><term>Hospital study</term><term>Industrialised countries</term><term>Lusaka</term><term>Medical college</term><term>Month duration</term><term>Persistent diarrhoea</term><term>Polymerase chain reaction detection</term><term>Prevalence</term><term>Septata intestinalis</term><term>University teaching hospital</term><term>Urban community</term><term>Urban zambia</term><term>Weeks duration</term><term>Zambia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: As the AIDS pandemic has spread, diarrhoea in adults has become a major burden on health care institutions in central Africa and on the families of sufferers. In order to assess the magnitude of the problem, we carried out a survey of households in a high population density township of Lusaka to determine the prevalence of persistent diarrhoea in adults. We also carried out a study of the causes of persistent diarrhoea in patients attending the University Teaching Hospital, Lusaka. The community survey assessed 460 households, representing a sample of 1440 adults. 94 adults were reported as having had diarrhoea in the 2 weeks prior to the survey, implying an attack rate of 1.74 per adult per year. Of these 94 cases, six had diarrhoea of between 2 and 4 weeks duration, and ten had diarrhoea of over 4 weeks duration. In the hospital study, 75 (97%) out of 77 patients with diarrhoea of over 1 months' duration were HIV seropositive; potentially pathogenic parasites were found in 6175 (81%) of seropositives. This information indicates that persistent diarrhoea in adults, mostly related to HIV infection, is likely to be an important and growing reservoir of enteric pathogens and represents a significant burden on hospitals and relatives. This emerging problem in sub-Saharan Africa may foreshadow developments in other continents.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>lusaka</json:string><json:string>persistent diarrhoea</json:string><json:string>zambia</json:string><json:string>diarrhoeal</json:string><json:string>diarrhoea</json:string><json:string>university teaching hospital</json:string><json:string>community survey</json:string><json:string>diarrhoeal disease</json:string><json:string>hospital study</json:string><json:string>attack rate</json:string><json:string>cryptosporidium parvum</json:string><json:string>weeks duration</json:string><json:string>hospital sample</json:string><json:string>urban zambia</json:string><json:string>medical college</json:string><json:string>urban community</json:string><json:string>george township</json:string><json:string>diarrhoeal illness</json:string><json:string>month duration</json:string><json:string>african aids patients</json:string><json:string>polymerase chain reaction detection</json:string><json:string>septata intestinalis</json:string><json:string>industrialised countries</json:string><json:string>childhood diarrhoea</json:string><json:string>health care facilities</json:string><json:string>histological study</json:string><json:string>prevalence</json:string></teeft></keywords><author><json:item><name>P. Kelly</name><affiliations><json:string>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</json:string></affiliations></json:item><json:item><name>K.S. Baboo</name><affiliations><json:string>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</json:string></affiliations></json:item><json:item><name>M. Wolff</name><affiliations><json:string>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</json:string></affiliations></json:item><json:item><name>B. Ngwenya</name><affiliations><json:string>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</json:string></affiliations></json:item><json:item><name>N. Luo</name><affiliations><json:string>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</json:string></affiliations></json:item><json:item><name>M.J.G. Farthing</name><affiliations><json:string>Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>HIV</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Diarrhoea</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Prevalence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Zambia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Africa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Protozoa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cryptosporidium</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Microsporidia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Isospora</value></json:item></subject><articleId><json:string>95001422</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>As the AIDS pandemic has spread, diarrhoea in adults has become a major burden on health care institutions in central Africa and on the families of sufferers. In order to assess the magnitude of the problem, we carried out a survey of households in a high population density township of Lusaka to determine the prevalence of persistent diarrhoea in adults. We also carried out a study of the causes of persistent diarrhoea in patients attending the University Teaching Hospital, Lusaka. The community survey assessed 460 households, representing a sample of 1440 adults. 94 adults were reported as having had diarrhoea in the 2 weeks prior to the survey, implying an attack rate of 1.74 per adult per year. Of these 94 cases, six had diarrhoea of between 2 and 4 weeks duration, and ten had diarrhoea of over 4 weeks duration. In the hospital study, 75 (97%) out of 77 patients with diarrhoea of over 1 months' duration were HIV seropositive; potentially pathogenic parasites were found in 6175 (81%) of seropositives. This information indicates that persistent diarrhoea in adults, mostly related to HIV infection, is likely to be an important and growing reservoir of enteric pathogens and represents a significant burden on hospitals and relatives. This emerging problem in sub-Saharan Africa may foreshadow developments in other continents.</abstract><qualityIndicators><score>5.842</score><pdfVersion>1.2</pdfVersion><pdfPageSize>540 x 749 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>9</keywordCount><abstractCharCount>1344</abstractCharCount><pdfWordCount>3238</pdfWordCount><pdfCharCount>19381</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>217</abstractWordCount></qualityIndicators><title>The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia</title><pii><json:string>0001-706X(95)00142-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Acta Tropica</title><language><json:string>unknown</json:string></language><publicationDate>1996</publicationDate><issn><json:string>0001-706X</json:string></issn><pii><json:string>S0001-706X(00)X0001-0</json:string></pii><volume>61</volume><issue>3</issue><pages><first>183</first><last>190</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>tropical medicine</json:string><json:string>parasitology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>tropical medicine</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>cardiologie. appareil circulatoire</json:string></inist></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1016/0001-706X(95)00142-2</json:string></doi><id>66039BA570F15B0EE8C11000E21D1D068B40BA1D</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/66039BA570F15B0EE8C11000E21D1D068B40BA1D/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/66039BA570F15B0EE8C11000E21D1D068B40BA1D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/66039BA570F15B0EE8C11000E21D1D068B40BA1D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1996</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia</title><author xml:id="author-0000"><persName><forename type="first">P.</forename><surname>Kelly</surname></persName><note type="correspondence"><p>Corresponding author: Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK. Tel: 0044 171 382 6123, fax: 0044 171 982 6121.</p></note><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation></author><author xml:id="author-0001"><persName><forename type="first">K.S.</forename><surname>Baboo</surname></persName><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M.</forename><surname>Wolff</surname></persName><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation></author><author xml:id="author-0003"><persName><forename type="first">B.</forename><surname>Ngwenya</surname></persName><note type="biography">Deceased.</note><affiliation>Deceased.</affiliation><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation></author><author xml:id="author-0004"><persName><forename type="first">N.</forename><surname>Luo</surname></persName><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation></author><author xml:id="author-0005"><persName><forename type="first">M.J.G.</forename><surname>Farthing</surname></persName><affiliation>Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK</affiliation></author><idno type="istex">66039BA570F15B0EE8C11000E21D1D068B40BA1D</idno><idno type="DOI">10.1016/0001-706X(95)00142-2</idno><idno type="PII">0001-706X(95)00142-2</idno><idno type="ArticleID">95001422</idno></analytic><monogr><title level="j">Acta Tropica</title><title level="j" type="abbrev">ACTROP</title><idno type="pISSN">0001-706X</idno><idno type="PII">S0001-706X(00)X0001-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">61</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="190">190</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>As the AIDS pandemic has spread, diarrhoea in adults has become a major burden on health care institutions in central Africa and on the families of sufferers. In order to assess the magnitude of the problem, we carried out a survey of households in a high population density township of Lusaka to determine the prevalence of persistent diarrhoea in adults. We also carried out a study of the causes of persistent diarrhoea in patients attending the University Teaching Hospital, Lusaka. The community survey assessed 460 households, representing a sample of 1440 adults. 94 adults were reported as having had diarrhoea in the 2 weeks prior to the survey, implying an attack rate of 1.74 per adult per year. Of these 94 cases, six had diarrhoea of between 2 and 4 weeks duration, and ten had diarrhoea of over 4 weeks duration. In the hospital study, 75 (97%) out of 77 patients with diarrhoea of over 1 months' duration were HIV seropositive; potentially pathogenic parasites were found in 6175 (81%) of seropositives. This information indicates that persistent diarrhoea in adults, mostly related to HIV infection, is likely to be an important and growing reservoir of enteric pathogens and represents a significant burden on hospitals and relatives. This emerging problem in sub-Saharan Africa may foreshadow developments in other continents.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>HIV</term></item><item><term>Diarrhoea</term></item><item><term>Prevalence</term></item><item><term>Zambia</term></item><item><term>Africa</term></item><item><term>Protozoa</term></item><item><term>Cryptosporidium</term></item><item><term>Microsporidia</term></item><item><term>Isospora</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995-10-27">Modified</change><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/66039BA570F15B0EE8C11000E21D1D068B40BA1D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>ACTROP</jid><aid>95001422</aid><ce:pii>0001-706X(95)00142-2</ce:pii><ce:doi>10.1016/0001-706X(95)00142-2</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright></item-info><head><ce:title>The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia</ce:title><ce:author-group><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Kelly</ce:surname><ce:cross-ref refid="COR1"><ce:sup loc="post">∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.S.</ce:given-name><ce:surname>Baboo</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Wolff</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>B.</ce:given-name><ce:surname>Ngwenya</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>N.</ce:given-name><ce:surname>Luo</ce:surname><ce:cross-ref refid="AFF1"><ce:sup loc="post">a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.J.G.</ce:given-name><ce:surname>Farthing</ce:surname><ce:cross-ref refid="AFF2"><ce:sup loc="post">b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author: Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK. Tel: 0044 171 382 6123, fax: 0044 171 982 6121.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Deceased.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="22" month="6" year="1995"></ce:date-received><ce:date-revised day="27" month="10" year="1995"></ce:date-revised><ce:date-accepted day="6" month="11" year="1995"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">As the AIDS pandemic has spread, diarrhoea in adults has become a major burden on health care institutions in central Africa and on the families of sufferers. In order to assess the magnitude of the problem, we carried out a survey of households in a high population density township of Lusaka to determine the prevalence of persistent diarrhoea in adults. We also carried out a study of the causes of persistent diarrhoea in patients attending the University Teaching Hospital, Lusaka. The community survey assessed 460 households, representing a sample of 1440 adults. 94 adults were reported as having had diarrhoea in the 2 weeks prior to the survey, implying an attack rate of 1.74 per adult per year. Of these 94 cases, six had diarrhoea of between 2 and 4 weeks duration, and ten had diarrhoea of over 4 weeks duration. In the hospital study, 75 (97%) out of 77 patients with diarrhoea of over 1 months' duration were HIV seropositive; potentially pathogenic parasites were found in <math altimg="si1.gif"><fr shape="case" align="c" style="s"><nu>61</nu><de>75</de></fr></math> (81%) of seropositives. This information indicates that persistent diarrhoea in adults, mostly related to HIV infection, is likely to be an important and growing reservoir of enteric pathogens and represents a significant burden on hospitals and relatives. This emerging problem in sub-Saharan Africa may foreshadow developments in other continents.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>HIV</ce:text></ce:keyword><ce:keyword><ce:text>Diarrhoea</ce:text></ce:keyword><ce:keyword><ce:text>Prevalence</ce:text></ce:keyword><ce:keyword><ce:text>Zambia</ce:text></ce:keyword><ce:keyword><ce:text>Africa</ce:text></ce:keyword><ce:keyword><ce:text>Protozoa</ce:text></ce:keyword><ce:keyword><ce:text>Cryptosporidium</ce:text></ce:keyword><ce:keyword><ce:text>Microsporidia</ce:text></ce:keyword><ce:keyword><ce:text>Isospora</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>The prevalence and aetiology of persistent diarrhoea in adults in urban Zambia</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Kelly</namePart><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation><description>Corresponding author: Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK. Tel: 0044 171 382 6123, fax: 0044 171 982 6121.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.S.</namePart><namePart type="family">Baboo</namePart><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Wolff</namePart><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ngwenya</namePart><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation><description>Deceased.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Luo</namePart><affiliation>University of Zambia School of Medicine, University of Teaching Hospital, P.O. Box 50110, Lusaka, Zambia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.J.G.</namePart><namePart type="family">Farthing</namePart><affiliation>Digestive Diseases Research Centre, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London EC1 M 6BQ, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><dateModified encoding="w3cdtf">1995-10-27</dateModified><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: As the AIDS pandemic has spread, diarrhoea in adults has become a major burden on health care institutions in central Africa and on the families of sufferers. In order to assess the magnitude of the problem, we carried out a survey of households in a high population density township of Lusaka to determine the prevalence of persistent diarrhoea in adults. We also carried out a study of the causes of persistent diarrhoea in patients attending the University Teaching Hospital, Lusaka. The community survey assessed 460 households, representing a sample of 1440 adults. 94 adults were reported as having had diarrhoea in the 2 weeks prior to the survey, implying an attack rate of 1.74 per adult per year. Of these 94 cases, six had diarrhoea of between 2 and 4 weeks duration, and ten had diarrhoea of over 4 weeks duration. In the hospital study, 75 (97%) out of 77 patients with diarrhoea of over 1 months' duration were HIV seropositive; potentially pathogenic parasites were found in 6175 (81%) of seropositives. This information indicates that persistent diarrhoea in adults, mostly related to HIV infection, is likely to be an important and growing reservoir of enteric pathogens and represents a significant burden on hospitals and relatives. This emerging problem in sub-Saharan Africa may foreshadow developments in other continents.</abstract><subject lang="en"><genre>Keywords</genre><topic>HIV</topic><topic>Diarrhoea</topic><topic>Prevalence</topic><topic>Zambia</topic><topic>Africa</topic><topic>Protozoa</topic><topic>Cryptosporidium</topic><topic>Microsporidia</topic><topic>Isospora</topic></subject><relatedItem type="host"><titleInfo><title>Acta Tropica</title></titleInfo><titleInfo type="abbreviated"><title>ACTROP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">199605</dateIssued></originInfo><identifier type="ISSN">0001-706X</identifier><identifier type="PII">S0001-706X(00)X0001-0</identifier><part><date>199605</date><detail type="volume"><number>61</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>183</start><end>276</end></extent><extent unit="pages"><start>183</start><end>190</end></extent></part></relatedItem><identifier type="istex">66039BA570F15B0EE8C11000E21D1D068B40BA1D</identifier><identifier type="ark">ark:/67375/6H6-KTTQLXNG-R</identifier><identifier type="DOI">10.1016/0001-706X(95)00142-2</identifier><identifier type="PII">0001-706X(95)00142-2</identifier><identifier type="ArticleID">95001422</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/66039BA570F15B0EE8C11000E21D1D068B40BA1D/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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