Serological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV‐1 subtype C and of markers of hepatitis B and C viruses
Identifieur interne : 001E99 ( Istex/Corpus ); précédent : 001E98; suivant : 001F00Serological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV‐1 subtype C and of markers of hepatitis B and C viruses
Auteurs : D. Candotti ; C. Mundy ; G. Kadewele ; W. Nkhoma ; I. Bates ; J. AllainSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2001-09.
English descriptors
- KwdEn :
- Assay, Blood donations, Blood donors, Blood safety, Donation, Donor, Dual infections, False positivity, General population, Glycosylation site, Grant sponsor, Gsgq motif, Hbsag, Hepatitis, High endemicity, High prevalence, Homogeneous circulation, Human virus type, International development, Malawi, Malawian, Malawian sequences, Multiplex assay, National blood service, Ntcheu, Parenteral antischistosomal therapy, Phylogenetic analyses, Positive samples, Potential glycosylation site, Pregnant women, Present study, Prevalence, Primer, Retroviral infections, Seroprevalence, Subtype, Subtypes, Transfusion medicine, Virol, Volume limitation, West africa.
- Teeft :
- Assay, Blood donations, Blood donors, Blood safety, Donation, Donor, Dual infections, False positivity, General population, Glycosylation site, Grant sponsor, Gsgq motif, Hbsag, Hepatitis, High endemicity, High prevalence, Homogeneous circulation, Human virus type, International development, Malawi, Malawian, Malawian sequences, Multiplex assay, National blood service, Ntcheu, Parenteral antischistosomal therapy, Phylogenetic analyses, Positive samples, Potential glycosylation site, Pregnant women, Present study, Prevalence, Primer, Retroviral infections, Seroprevalence, Subtype, Subtypes, Transfusion medicine, Virol, Volume limitation, West africa.
Abstract
The prevalence of antibodies to human immunodeficiency virus type 1 (HIV‐1), hepatitis C virus (HCV), human T lymphotropic virus I (HTLV‐I), and hepatitis B (HBV) surface antigen (HBsAg) was determined in blood donors from Ntcheu, Malawi. Each donation was also screened for HIV‐1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV‐1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti‐HCV, and 2.5% for anti‐HTLV‐I. HIV‐1/HTLV‐I and HIV‐1/HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV‐1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood‐borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. J. Med. Virol. 65:1–5, 2001. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.1093
Links to Exploration step
ISTEX:5ED41533C7F0B672B03C513AC6851E6700B94C08Le document en format XML
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Candotti</name><affiliations><json:string>National Blood Service, Cambridge, United Kingdom</json:string><json:string>National Blood Service, East Anglia Blood Centre, Long Road, Cambridge CB2 2PT, UK.===</json:string></affiliations></json:item><json:item><name>C. Mundy</name><affiliations><json:string>Liverpool School of Tropical Medicine, United Kingdom</json:string></affiliations></json:item><json:item><name>G. Kadewele</name><affiliations><json:string>Ministry of Health and Population, Ntcheu, Malawi</json:string></affiliations></json:item><json:item><name>W. Nkhoma</name><affiliations><json:string>Ministry of Health and Population, Ntcheu, Malawi</json:string></affiliations></json:item><json:item><name>I. Bates</name><affiliations><json:string>Liverpool School of Tropical Medicine, United Kingdom</json:string></affiliations></json:item><json:item><name>J.‐P. 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Each donation was also screened for HIV‐1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV‐1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti‐HCV, and 2.5% for anti‐HTLV‐I. HIV‐1/HTLV‐I and HIV‐1/HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV‐1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood‐borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. J. Med. 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role="corresp"><persName><forename type="first">D.</forename><surname>Candotti</surname></persName><email>dc241@cam.ac.uk</email><affiliation>National Blood Service, Cambridge, United Kingdom<address><country key="GB"></country></address></affiliation><affiliation>National Blood Service, East Anglia Blood Centre, Long Road, Cambridge CB2 2PT, UK.===</affiliation></author><author xml:id="author-0001"><persName><forename type="first">C.</forename><surname>Mundy</surname></persName><affiliation>Liverpool School of Tropical Medicine, United Kingdom<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">G.</forename><surname>Kadewele</surname></persName><affiliation>Ministry of Health and Population, Ntcheu, Malawi<address><country key="MW"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">W.</forename><surname>Nkhoma</surname></persName><affiliation>Ministry of 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type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v65:1</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">65</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="5">5</biblScope><biblScope unit="page-count">5</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The prevalence of antibodies to human immunodeficiency virus type 1 (HIV‐1), hepatitis C virus (HCV), human T lymphotropic virus I (HTLV‐I), and hepatitis B (HBV) surface antigen (HBsAg) was determined in blood donors from Ntcheu, Malawi. Each donation was also screened for HIV‐1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV‐1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti‐HCV, and 2.5% for anti‐HTLV‐I. HIV‐1/HTLV‐I and HIV‐1/HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV‐1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood‐borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. J. Med. Virol. 65:1–5, 2001. © 2001 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">blood‐borne viruses</term><term xml:id="kwd2">viral infection</term><term xml:id="kwd3">blood donors</term><term xml:id="kwd4">HIV‐1 prevalence</term><term xml:id="kwd5">hepatitis viruses</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/5ED41533C7F0B672B03C513AC6851E6700B94C08/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/jmv.v65:1</doi><numberingGroup><numbering type="journalVolume" number="65">65</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2001-09">September 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="1" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jmv.1093</doi><idGroup><id type="unit" value="JMV1093"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><copyright ownership="publisher">Copyright © 2001 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2001-01-08"></event><event type="firstOnline" date="2001-07-31"></event><event type="publishedOnlineFinalForm" date="2001-07-31"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">1</numbering><numbering type="pageLast">5</numbering></numberingGroup><correspondenceTo>National Blood Service, East Anglia Blood Centre, Long Road, Cambridge CB2 2PT, UK.===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV1093.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="23"></count><count type="wordTotal" number="912"></count></countGroup><titleGroup><title type="main" xml:lang="en">Serological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV‐1 subtype C and of markers of hepatitis B and C viruses</title><title type="short" xml:lang="en">Screening for Viruses in Blood Donors in Malawi</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>D.</givenNames><familyName>Candotti</familyName></personName><contactDetails><email>dc241@cam.ac.uk</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>C.</givenNames><familyName>Mundy</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>G.</givenNames><familyName>Kadewele</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>W.</givenNames><familyName>Nkhoma</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>I.</givenNames><familyName>Bates</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>J.‐P.</givenNames><familyName>Allain</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>National Blood Service, Cambridge, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Liverpool School of Tropical Medicine, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="MW" type="organization"><unparsedAffiliation>Ministry of Health and Population, Ntcheu, Malawi</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">blood‐borne viruses</keyword><keyword xml:id="kwd2">viral infection</keyword><keyword xml:id="kwd3">blood donors</keyword><keyword xml:id="kwd4">HIV‐1 prevalence</keyword><keyword xml:id="kwd5">hepatitis viruses</keyword></keywordGroup><fundingInfo><fundingAgency>National Blood Service NAT committee</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Chiron corporation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Department for International Development, UK</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ministry of Health and Population, Malawi</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The prevalence of antibodies to human immunodeficiency virus type 1 (HIV‐1), hepatitis C virus (HCV), human T lymphotropic virus I (HTLV‐I), and hepatitis B (HBV) surface antigen (HBsAg) was determined in blood donors from Ntcheu, Malawi. Each donation was also screened for HIV‐1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV‐1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti‐HCV, and 2.5% for anti‐HTLV‐I. HIV‐1/HTLV‐I and HIV‐1/HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV‐1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood‐borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. J. Med. Virol. 65:1–5, 2001. © 2001 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Serological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV‐1 subtype C and of markers of hepatitis B and C viruses</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Screening for Viruses in Blood Donors in Malawi</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Serological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV‐1 subtype C and of markers of hepatitis B and C viruses</title></titleInfo><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Candotti</namePart><affiliation>National Blood Service, Cambridge, United Kingdom</affiliation><affiliation>E-mail: dc241@cam.ac.uk</affiliation><affiliation>Correspondence address: National Blood Service, East Anglia Blood Centre, Long Road, Cambridge CB2 2PT, UK.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Mundy</namePart><affiliation>Liverpool School of Tropical Medicine, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Kadewele</namePart><affiliation>Ministry of Health and Population, Ntcheu, Malawi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Nkhoma</namePart><affiliation>Ministry of Health and Population, Ntcheu, Malawi</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Bates</namePart><affiliation>Liverpool School of Tropical Medicine, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐P.</namePart><namePart type="family">Allain</namePart><affiliation>Department of Haematology, Division of Transfusion Medicine, University of Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-09</dateIssued><dateValid encoding="w3cdtf">2001-01-08</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="references">23</extent><extent unit="words">912</extent></physicalDescription><abstract lang="en">The prevalence of antibodies to human immunodeficiency virus type 1 (HIV‐1), hepatitis C virus (HCV), human T lymphotropic virus I (HTLV‐I), and hepatitis B (HBV) surface antigen (HBsAg) was determined in blood donors from Ntcheu, Malawi. Each donation was also screened for HIV‐1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV‐1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti‐HCV, and 2.5% for anti‐HTLV‐I. HIV‐1/HTLV‐I and HIV‐1/HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV‐1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood‐borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. J. Med. Virol. 65:1–5, 2001. © 2001 Wiley‐Liss, Inc.</abstract><note type="funding">National Blood Service NAT committee</note><note type="funding">Chiron corporation</note><note type="funding">Department for International Development, UK</note><note type="funding">Ministry of Health and Population, Malawi</note><subject lang="en"><genre>keywords</genre><topic>blood‐borne viruses</topic><topic>viral infection</topic><topic>blood donors</topic><topic>HIV‐1 prevalence</topic><topic>hepatitis viruses</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. 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