Predonation screening of blood donors with rapid tests: implementation and efficacy of a novel approach to blood safety in resource‐poor settings
Identifieur interne : 001C64 ( Istex/Corpus ); précédent : 001C63; suivant : 001C65Predonation screening of blood donors with rapid tests: implementation and efficacy of a novel approach to blood safety in resource‐poor settings
Auteurs : Shirley Owusu-Ofori ; Jillian Temple ; Francis Sarkodie ; Margaret Anokwa ; Daniel Candotti ; Jean-Pierre AllainSource :
- Transfusion [ 0041-1132 ] ; 2005-02.
English descriptors
- KwdEn :
- Aids clinic, Allain, Assay, Blood bags, Blood bank, Blood center, Blood donors, Blood pressure, Blood ranges, Blood safety, Blood transfusion, Blood unit, Blood units, Cambridge blood center, Candidate blood donors, Candidate donors, Clinical examination, Core antigen, Deferral, Disposable tips, Donation, Donor, Donor care program, Donor screening, February, Hbsag, Hbsag reactivity, Hepatitis, Individual donations, Individual samples, Komfo anokye teaching hospital blood bank, Kumasi, Mobile sessions, National blood service, Novel approach, Nucleic acid testing, Operational characteristics, Percent sensitivity, Plasma pools, Plasma samples, Positive pools, Positive samples, Postdonation triplex, Predonation, Predonation screening, Public health, Rapid test, Rapid testing, Rapid tests, Reactive, Replacement donors, Replacement unit, Residual risk, Safe blood, Screening, Screening assays, Screening tests, Sera samples, Surface antigen, Test failures, Testing errors, Total number, Transfusion, Transfusion medicine, Transfusion volume, Triplex, Viral, Viral infections, Viral load, Viral markers, Viral screening, Virol methods, Virus infection, Volunteer candidate donors, Volunteer donors, West africa.
- Teeft :
- Aids clinic, Allain, Assay, Blood bags, Blood bank, Blood center, Blood donors, Blood pressure, Blood ranges, Blood safety, Blood transfusion, Blood unit, Blood units, Cambridge blood center, Candidate blood donors, Candidate donors, Clinical examination, Core antigen, Deferral, Disposable tips, Donation, Donor, Donor care program, Donor screening, February, Hbsag, Hbsag reactivity, Hepatitis, Individual donations, Individual samples, Komfo anokye teaching hospital blood bank, Kumasi, Mobile sessions, National blood service, Novel approach, Nucleic acid testing, Operational characteristics, Percent sensitivity, Plasma pools, Plasma samples, Positive pools, Positive samples, Postdonation triplex, Predonation, Predonation screening, Public health, Rapid test, Rapid testing, Rapid tests, Reactive, Replacement donors, Replacement unit, Residual risk, Safe blood, Screening, Screening assays, Screening tests, Sera samples, Surface antigen, Test failures, Testing errors, Total number, Transfusion, Transfusion medicine, Transfusion volume, Triplex, Viral, Viral infections, Viral load, Viral markers, Viral screening, Virol methods, Virus infection, Volunteer candidate donors, Volunteer donors, West africa.
Abstract
BACKGROUND: In sub‐Saharan Africa, the percentage of screened blood is limited to approximately 75 percent for human immunodeficiency virus antibodies (anti‐HIV), 50 percent for hepatitis B surface antigen, and 19 percent for hepatitis C virus antibodies (anti‐HCV), mainly because of costs.
Url:
DOI: 10.1111/j.1537-2995.2004.04279.x
Links to Exploration step
ISTEX:57FDF1C85823C46BA34F16A9ECEDD737762B7C07Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predonation screening of blood donors with rapid tests: implementation and efficacy of a novel approach to blood safety in resource‐poor settings</title><author><name sortKey="Owusu Fori, Shirley" sort="Owusu Fori, Shirley" uniqKey="Owusu Fori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Temple, Jillian" sort="Temple, Jillian" uniqKey="Temple J" first="Jillian" last="Temple">Jillian Temple</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of 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last="Owusu-Ofori">Shirley Owusu-Ofori</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Temple, Jillian" sort="Temple, Jillian" uniqKey="Temple J" first="Jillian" last="Temple">Jillian Temple</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Anokwa, Margaret" sort="Anokwa, Margaret" uniqKey="Anokwa M" first="Margaret" last="Anokwa">Margaret Anokwa</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation></author><author><name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation><mods:affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jpa1000@cam.ac.uk</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="ISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><imprint><biblScope unit="vol">45</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="133">133</biblScope><biblScope unit="page" to="140">140</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK and Malden, USA</pubPlace><date type="published" when="2005-02">2005-02</date></imprint><idno type="ISSN">0041-1132</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aids clinic</term><term>Allain</term><term>Assay</term><term>Blood bags</term><term>Blood bank</term><term>Blood center</term><term>Blood donors</term><term>Blood pressure</term><term>Blood ranges</term><term>Blood safety</term><term>Blood transfusion</term><term>Blood unit</term><term>Blood units</term><term>Cambridge blood center</term><term>Candidate blood donors</term><term>Candidate 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transfusion</term><term>Blood unit</term><term>Blood units</term><term>Cambridge blood center</term><term>Candidate blood donors</term><term>Candidate donors</term><term>Clinical examination</term><term>Core antigen</term><term>Deferral</term><term>Disposable tips</term><term>Donation</term><term>Donor</term><term>Donor care program</term><term>Donor screening</term><term>February</term><term>Hbsag</term><term>Hbsag reactivity</term><term>Hepatitis</term><term>Individual donations</term><term>Individual samples</term><term>Komfo anokye teaching hospital blood bank</term><term>Kumasi</term><term>Mobile sessions</term><term>National blood service</term><term>Novel approach</term><term>Nucleic acid testing</term><term>Operational characteristics</term><term>Percent sensitivity</term><term>Plasma pools</term><term>Plasma samples</term><term>Positive pools</term><term>Positive samples</term><term>Postdonation triplex</term><term>Predonation</term><term>Predonation screening</term><term>Public health</term><term>Rapid test</term><term>Rapid testing</term><term>Rapid tests</term><term>Reactive</term><term>Replacement donors</term><term>Replacement unit</term><term>Residual risk</term><term>Safe blood</term><term>Screening</term><term>Screening assays</term><term>Screening tests</term><term>Sera samples</term><term>Surface antigen</term><term>Test failures</term><term>Testing errors</term><term>Total number</term><term>Transfusion</term><term>Transfusion medicine</term><term>Transfusion volume</term><term>Triplex</term><term>Viral</term><term>Viral infections</term><term>Viral load</term><term>Viral markers</term><term>Viral screening</term><term>Virol methods</term><term>Virus infection</term><term>Volunteer candidate donors</term><term>Volunteer donors</term><term>West africa</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">BACKGROUND: In sub‐Saharan Africa, the percentage of screened blood is limited to 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Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Francis Sarkodie</name><affiliations><json:string>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Margaret Anokwa</name><affiliations><json:string>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Daniel Candotti</name><affiliations><json:string>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</json:string></affiliations></json:item><json:item><name>Jean‐Pierre Allain</name><affiliations><json:string>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</json:string><json:string>E-mail: jpa1000@cam.ac.uk</json:string></affiliations></json:item></author><articleId><json:string>TRF04279</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>5.375</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 783 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Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.<address><country key="GH"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Jillian</forename><surname>Temple</surname></persName><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.<address><country key="GH"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Francis</forename><surname>Sarkodie</surname></persName><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.<address><country key="GH"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Margaret</forename><surname>Anokwa</surname></persName><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.<address><country key="GH"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Daniel</forename><surname>Candotti</surname></persName><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.<address><country key="GH"></country></address></affiliation></author><author xml:id="author-0005" role="corresp"><persName><forename type="first">Jean‐Pierre</forename><surname>Allain</surname></persName><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.<address><country key="GH"></country></address></affiliation><affiliation>Address reprint requests to: Jean‐Pierre Allain, MD, PhD, Division of Transfusion Medicine, Department of Haematology, Cambridge Blood Center, Long Road, Cambridge CB2 2PT, UK; e‐mail: jpa1000@cam.ac.uk.</affiliation></author><idno type="istex">57FDF1C85823C46BA34F16A9ECEDD737762B7C07</idno><idno type="ark">ark:/67375/WNG-MSVKG6W6-4</idno><idno type="DOI">10.1111/j.1537-2995.2004.04279.x</idno><idno type="unit">TRF04279</idno><idno type="toTypesetVersion">file:TRF.TRF04279.pdf</idno></analytic><monogr><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="pISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><idno type="book-DOI">10.1111/(ISSN)1537-2995</idno><idno type="book-part-DOI">10.1111/trf.2005.45.issue-2</idno><idno type="product">TRF</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">45</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="133">133</biblScope><biblScope unit="page" to="140">140</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK and Malden, USA</pubPlace><date type="published" when="2005-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">BACKGROUND: </hi> In sub‐Saharan Africa, the percentage of screened blood is limited to approximately 75 percent for human immunodeficiency virus antibodies (anti‐HIV), 50 percent for hepatitis B surface antigen, and 19 percent for hepatitis C virus antibodies (anti‐HCV), mainly because of costs.</p><p><hi rend="bold">STUDY DESIGN AND METHODS: </hi> In 2002 to 2003, candidate blood donors were screened before donation for HIV, HCV, and hepatitis B virus (HBV) serologic markers with rapid tests. The efficacy of this screening was assessed by nucleic acid testing (NAT) applied to pools of 10 plasma samples from donated units with a virus specific triplex assay. NAT‐reactive pools were resolved by viral genome identification in individual plasma sample. Deferred candidate donors were referred to a donor‐care program.</p><p><hi rend="bold">RESULTS: </hi> A total of 9372 people were screened and 1534 (16.4%) were deferred. No HIV or HCV RNA–containing samples remained undetected by rapid tests unless a human testing error was involved. In contrast, 1.3 and 3.0 percent of HBV DNA–containing blood units were negative with rapid tests but were detected in individual donations with enzyme immunoassay and genomic amplification, respectively. Only half of these units were detectable in pools of 10 samples. One‐third of deferred candidate donors attended the donor‐care program and were informed and counseled.</p><p><hi rend="bold">CONCLUSIONS: </hi> Predonation viral screening of blood donors is effective in high endemic areas, and the savings it generates may improve the safety and limit the cost of blood. Communication with deferred donors may contribute to public health. A new screening strategy associating serologic rapid test before donation and NAT on pools of 10 plasma samples after donation is proposed.</p></abstract><textClass><keywords rend="tocHeading1"><term>BLOOD DONORS AND BLOOD COLLECTION</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/57FDF1C85823C46BA34F16A9ECEDD737762B7C07/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Inc</publisherName><publisherLoc>Oxford, UK and Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1537-2995</doi><issn type="print">0041-1132</issn><issn type="electronic">1537-2995</issn><idGroup><id type="product" value="TRF"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="TRANSFUSION">Transfusion</title></titleGroup></publicationMeta><publicationMeta level="part" position="02002"><doi origin="wiley">10.1111/trf.2005.45.issue-2</doi><numberingGroup><numbering type="journalVolume" number="45">45</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2005-02">February 2005</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1537-2995.2004.04279.x</doi><idGroup><id type="unit" value="TRF04279"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">BLOOD DONORS AND BLOOD COLLECTION</title></titleGroup><eventGroup><event type="firstOnline" date="2005-01-19"></event><event type="publishedOnlineFinalForm" date="2005-01-19"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-03"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="133">133</numbering><numbering type="pageLast" number="140">140</numbering></numberingGroup><correspondenceTo><i>Address reprint requests to:</i> Jean‐Pierre Allain, MD, PhD, Division of Transfusion Medicine, Department of Haematology, Cambridge Blood Center, Long Road, Cambridge CB2 2PT, UK; e‐mail: <email>jpa1000@cam.ac.uk</email>.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:TRF.TRF04279.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received for publication July 5, 2004; revision received July 22, 2004, and accepted August 2, 2004.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="24"></count><count type="wordTotal" number="4475"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Predonation screening of blood donors with rapid tests: implementation and efficacy of a novel approach to blood safety in resource‐poor settings</title><title type="shortAuthors">OWUSU‐OFORI ET AL.</title><title type="short">RAPID TESTING OF BLOOD DONORS IN RESOURCE‐POOR SETTING</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Shirley</givenNames><familyName>Owusu‐Ofori</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Jillian</givenNames><familyName>Temple</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Francis</givenNames><familyName>Sarkodie</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Margaret</givenNames><familyName>Anokwa</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Daniel</givenNames><familyName>Candotti</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Jean‐Pierre</givenNames><familyName>Allain</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GH"><unparsedAffiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>BACKGROUND: </b> In sub‐Saharan Africa, the percentage of screened blood is limited to approximately 75 percent for human immunodeficiency virus antibodies (anti‐HIV), 50 percent for hepatitis B surface antigen, and 19 percent for hepatitis C virus antibodies (anti‐HCV), mainly because of costs.</p><p><b>STUDY DESIGN AND METHODS: </b> In 2002 to 2003, candidate blood donors were screened before donation for HIV, HCV, and hepatitis B virus (HBV) serologic markers with rapid tests. The efficacy of this screening was assessed by nucleic acid testing (NAT) applied to pools of 10 plasma samples from donated units with a virus specific triplex assay. NAT‐reactive pools were resolved by viral genome identification in individual plasma sample. Deferred candidate donors were referred to a donor‐care program.</p><p><b>RESULTS: </b> A total of 9372 people were screened and 1534 (16.4%) were deferred. No HIV or HCV RNA–containing samples remained undetected by rapid tests unless a human testing error was involved. In contrast, 1.3 and 3.0 percent of HBV DNA–containing blood units were negative with rapid tests but were detected in individual donations with enzyme immunoassay and genomic amplification, respectively. Only half of these units were detectable in pools of 10 samples. One‐third of deferred candidate donors attended the donor‐care program and were informed and counseled.</p><p><b>CONCLUSIONS: </b> Predonation viral screening of blood donors is effective in high endemic areas, and the savings it generates may improve the safety and limit the cost of blood. Communication with deferred donors may contribute to public health. A new screening strategy associating serologic rapid test before donation and NAT on pools of 10 plasma samples after donation is proposed.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p>This project was supported in part by Grant BS01/03 from the National Blood Service, England.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Predonation screening of blood donors with rapid tests: implementation and efficacy of a novel approach to blood safety in resource‐poor settings</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>RAPID TESTING OF BLOOD DONORS IN RESOURCE‐POOR SETTING</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Predonation screening of blood donors with rapid tests: implementation and efficacy of a novel approach to blood safety in resource‐poor settings</title></titleInfo><name type="personal"><namePart type="given">Shirley</namePart><namePart type="family">Owusu‐Ofori</namePart><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jillian</namePart><namePart type="family">Temple</namePart><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francis</namePart><namePart type="family">Sarkodie</namePart><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margaret</namePart><namePart type="family">Anokwa</namePart><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel</namePart><namePart type="family">Candotti</namePart><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Pierre</namePart><namePart type="family">Allain</namePart><affiliation>From the Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana; Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, UK; and the National Blood Service, Cambridge Blood Center, Cambridge, UK.</affiliation><affiliation>E-mail: jpa1000@cam.ac.uk</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Science Inc</publisher><place><placeTerm type="text">Oxford, UK and Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2005-02</dateIssued><edition>Received for publication July 5, 2004; revision received July 22, 2004, and accepted August 2, 2004.</edition><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="formulas">0</extent><extent unit="references">24</extent><extent unit="linksCrossRef">0</extent><extent unit="words">4475</extent></physicalDescription><abstract>BACKGROUND: In sub‐Saharan Africa, the percentage of screened blood is limited to approximately 75 percent for human immunodeficiency virus antibodies (anti‐HIV), 50 percent for hepatitis B surface antigen, and 19 percent for hepatitis C virus antibodies (anti‐HCV), mainly because of costs.</abstract><abstract>STUDY DESIGN AND METHODS: In 2002 to 2003, candidate blood donors were screened before donation for HIV, HCV, and hepatitis B virus (HBV) serologic markers with rapid tests. The efficacy of this screening was assessed by nucleic acid testing (NAT) applied to pools of 10 plasma samples from donated units with a virus specific triplex assay. NAT‐reactive pools were resolved by viral genome identification in individual plasma sample. Deferred candidate donors were referred to a donor‐care program.</abstract><abstract>RESULTS: A total of 9372 people were screened and 1534 (16.4%) were deferred. No HIV or HCV RNA–containing samples remained undetected by rapid tests unless a human testing error was involved. In contrast, 1.3 and 3.0 percent of HBV DNA–containing blood units were negative with rapid tests but were detected in individual donations with enzyme immunoassay and genomic amplification, respectively. Only half of these units were detectable in pools of 10 samples. One‐third of deferred candidate donors attended the donor‐care program and were informed and counseled.</abstract><abstract>CONCLUSIONS: Predonation viral screening of blood donors is effective in high endemic areas, and the savings it generates may improve the safety and limit the cost of blood. Communication with deferred donors may contribute to public health. A new screening strategy associating serologic rapid test before donation and NAT on pools of 10 plasma samples after donation is proposed.</abstract><relatedItem type="host"><titleInfo><title>Transfusion</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0041-1132</identifier><identifier type="eISSN">1537-2995</identifier><identifier type="DOI">10.1111/(ISSN)1537-2995</identifier><identifier type="PublisherID">TRF</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>133</start><end>140</end><total>8</total></extent></part></relatedItem><identifier type="istex">57FDF1C85823C46BA34F16A9ECEDD737762B7C07</identifier><identifier type="ark">ark:/67375/WNG-MSVKG6W6-4</identifier><identifier type="DOI">10.1111/j.1537-2995.2004.04279.x</identifier><identifier type="ArticleID">TRF04279</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Science Inc</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/57FDF1C85823C46BA34F16A9ECEDD737762B7C07/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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