Childhood cancers in Zambia before and after the HIV epidemic.
Identifieur interne : 001695 ( Istex/Corpus ); précédent : 001694; suivant : 001696Childhood cancers in Zambia before and after the HIV epidemic.
Auteurs : C. Chintu ; U H Athale ; P S PatilSource :
- Archives of Disease in Childhood [ 0003-9888 ] ; 1995-08.
English descriptors
- KwdEn :
- Aggressive sarcoma, Bilateral disease, Carcinoma, Child health, Childhood cancers, Childhood malignancies, Comparative prevalence, Different childhood cancers, Different malignancies, Disease control, Epidemic period, Epidemiological, Epidemiological features, Epidemiological study, Epidemiology, Extranodal sites, Female predominance, Female ratio, General population, High grade lymphoma, Histopathological, Histopathological records, Human immunodeficiency virus, Human services, Immunodeficiency, Immunodeficiency syndrome, Incidence, Luapula province, Lymphoma, Lymphomas lymphoma lymphoma lymphoma retinoblastoma sarcoma wilms, Male predominance, Malignancy, Nasopharyngeal, Nasopharyngeal carcinoma, Other cancers, Ovarian lymphoma, Paediatric, Paediatric sarcoma, Peak incidence, Percentage prevalence, Retinoblastoma, Retrospective study, Rhabdomyosarcoma, Same lymph node mass, Sarcoma, Short periods, Significant increase, Significant reduction, Total childhood cancers, Tumour, University teaching hospital, Unknown relation, Vaginal rhabdomyosarcoma, Various childhood cancers, Zambia.
- Teeft :
- Aggressive sarcoma, Bilateral disease, Carcinoma, Child health, Childhood cancers, Childhood malignancies, Comparative prevalence, Different childhood cancers, Different malignancies, Disease control, Epidemic period, Epidemiological, Epidemiological features, Epidemiological study, Epidemiology, Extranodal sites, Female predominance, Female ratio, General population, High grade lymphoma, Histopathological, Histopathological records, Human immunodeficiency virus, Human services, Immunodeficiency, Immunodeficiency syndrome, Incidence, Luapula province, Lymphoma, Lymphomas lymphoma lymphoma lymphoma retinoblastoma sarcoma wilms, Male predominance, Malignancy, Nasopharyngeal, Nasopharyngeal carcinoma, Other cancers, Ovarian lymphoma, Paediatric, Paediatric sarcoma, Peak incidence, Percentage prevalence, Retinoblastoma, Retrospective study, Rhabdomyosarcoma, Same lymph node mass, Sarcoma, Short periods, Significant increase, Significant reduction, Total childhood cancers, Tumour, University teaching hospital, Unknown relation, Vaginal rhabdomyosarcoma, Various childhood cancers, Zambia.
Abstract
Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. A prospective in depth epidemiological study of HIV related childhood cancers in Africa is urgently needed.
Url:
DOI: 10.1136/adc.73.2.100
Links to Exploration step
ISTEX:45EFAC8B832EEFB49FDCB98A4F61892311409957Le document en format XML
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An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. 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An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. 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An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. A prospective in depth epidemiological study of HIV related childhood cancers in Africa is urgently needed.</p></abstract></profileDesc><revisionDesc><change when="1995-08-01">Created</change><change when="1995-08">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-10-17">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/45EFAC8B832EEFB49FDCB98A4F61892311409957/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">archdischild</journal-id><journal-id journal-id-type="nlm-ta">Arch Dis Child</journal-id><journal-title>Archives of Disease in Childhood</journal-title><abbrev-journal-title abbrev-type="publisher">Arch Dis Child</abbrev-journal-title><issn pub-type="ppub">0003-9888</issn><issn pub-type="epub">1468-2044</issn><publisher><publisher-name>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">7574850</article-id><article-id pub-id-type="other">archdischild;73/2/100</article-id><article-id pub-id-type="doi">10.1136/adc.73.2.100</article-id><article-id pub-id-type="other">100</article-id><article-id pub-id-type="other">adc.73.2.100</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Childhood cancers in Zambia before and after the HIV epidemic.</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Chintu</surname><given-names>C</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Athale</surname><given-names>U H</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Patil</surname><given-names>P S</given-names></name></contrib></contrib-group><aff>School of Medicine, University of Zambia, Department of Paediatrics and Child Health, Lusaka.</aff><pub-date pub-type="ppub"><month>8</month><year>1995</year></pub-date><pub-date pub-type="epub"><day>1</day><month>8</month><year>1995</year></pub-date><volume>73</volume><volume-id pub-id-type="other">73</volume-id><volume-id pub-id-type="other">73</volume-id><issue>2</issue><issue-id pub-id-type="other">archdischild;73/2</issue-id><issue-id pub-id-type="other">2</issue-id><issue-id pub-id-type="other">73/2</issue-id><fpage>100</fpage><self-uri content-type="pdf" xlink:role="full-text" xlink:href="archdischild-73-100.pdf"></self-uri><abstract><p>Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. A prospective in depth epidemiological study of HIV related childhood cancers in Africa is urgently needed.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Childhood cancers in Zambia before and after the HIV epidemic.</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Childhood cancers in Zambia before and after the HIV epidemic.</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Chintu</namePart><affiliation>School of Medicine, University of Zambia, Department of Paediatrics and Child Health, Lusaka.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U H</namePart><namePart type="family">Athale</namePart><affiliation>School of Medicine, University of Zambia, Department of Paediatrics and Child Health, Lusaka.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P S</namePart><namePart type="family">Patil</namePart><affiliation>School of Medicine, University of Zambia, Department of Paediatrics and Child Health, Lusaka.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><dateIssued encoding="w3cdtf">1995-08</dateIssued><dateCreated encoding="w3cdtf">1995-08-01</dateCreated><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. A prospective in depth epidemiological study of HIV related childhood cancers in Africa is urgently needed.</abstract><relatedItem type="host"><titleInfo><title>Archives of Disease in Childhood</title></titleInfo><titleInfo type="abbreviated"><title>Arch Dis Child</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0003-9888</identifier><identifier type="eISSN">1468-2044</identifier><identifier type="PublisherID-hwp">archdischild</identifier><identifier type="PublisherID-nlm-ta">Arch Dis Child</identifier><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>100</start></extent></part></relatedItem><identifier type="istex">45EFAC8B832EEFB49FDCB98A4F61892311409957</identifier><identifier type="ark">ark:/67375/NVC-VJ33CH8R-6</identifier><identifier type="DOI">10.1136/adc.73.2.100</identifier><identifier type="href">archdischild-73-100.pdf</identifier><identifier type="PMID">7574850</identifier><identifier type="local">archdischild;73/2/100</identifier><accessCondition type="use and reproduction" contentType="copyright">© British Medical Journal Publishing Group</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>© British Medical Journal Publishing Group</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/45EFAC8B832EEFB49FDCB98A4F61892311409957/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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