Global trends in neglected tropical disease control and elimination: impact on child health
Identifieur interne : 001158 ( Istex/Corpus ); précédent : 001157; suivant : 001159Global trends in neglected tropical disease control and elimination: impact on child health
Auteurs : Meagan A. Barry ; Gregory G. Simon ; Neeraj Mistry ; Peter J. HotezSource :
- Archives of Disease in Childhood [ 0003-9888 ] ; 2013-08.
English descriptors
- KwdEn :
- Adult worms, African infants, Albendazole, Annual deworming, Anthelminthic, Anthelminthic chemotherapy, Audacious goal, Baylor college, Bill melinda gates foundation, Blinding trachoma, Chemotherapy, Child growth, Child health, Chronic infections, Chronic schistosomiasis, Cognitive function, Common ntds, Control programmes, Corresponding authors, Deworming, Deworming drugs, Disease control, Disease transmission, Drug resistance, Fenwick, Geographical overlap, Global, Global child health, Global impact, Global network, Global support, Heavy infections, Helminth, Helminth infections, High rates, High risk, Hookworm, Hookworm infection, Hookworm vaccine, Hotez, Image courtesy, Infection, International development, Intestinal schistosomiasis, Intestinal worms, Ivermectin, London declaration, Lymphatic, Major soil, Mass drug administration, Merck kgaa, Millennium development goals, Morbidity, Ntds, Onchocerciasis, Parasitol, Parasitol hotez, Pharmaceutical companies, Plo, Plos negl, Praziquantel, Preschool, Preschool children, Preventative, Preventative chemotherapy, Preventive chemotherapy, Preventive chemotherapy databank, Programme, Public health image library, Rapid impact package, Regular deworming, Sabin, Sabin vaccine institute, Schistosoma mansoni, Schistosomiasis, Schistosomiasis control initiative, Scientist training program, Single dose, Systematic review, Texas hospital, Trachoma, Treatment strategy, Trends parasitol stothard, Trichuris trichiura, Tropical disease control, Tropical diseases, Vaccine, Wkly epidemiol, World health assembly.
- Teeft :
- Adult worms, African infants, Albendazole, Annual deworming, Anthelminthic, Anthelminthic chemotherapy, Audacious goal, Baylor college, Bill melinda gates foundation, Blinding trachoma, Chemotherapy, Child growth, Child health, Chronic infections, Chronic schistosomiasis, Cognitive function, Common ntds, Control programmes, Corresponding authors, Deworming, Deworming drugs, Disease control, Disease transmission, Drug resistance, Fenwick, Geographical overlap, Global, Global child health, Global impact, Global network, Global support, Heavy infections, Helminth, Helminth infections, High rates, High risk, Hookworm, Hookworm infection, Hookworm vaccine, Hotez, Image courtesy, Infection, International development, Intestinal schistosomiasis, Intestinal worms, Ivermectin, London declaration, Lymphatic, Major soil, Mass drug administration, Merck kgaa, Millennium development goals, Morbidity, Ntds, Onchocerciasis, Parasitol, Parasitol hotez, Pharmaceutical companies, Plo, Plos negl, Praziquantel, Preschool, Preschool children, Preventative, Preventative chemotherapy, Preventive chemotherapy, Preventive chemotherapy databank, Programme, Public health image library, Rapid impact package, Regular deworming, Sabin, Sabin vaccine institute, Schistosoma mansoni, Schistosomiasis, Schistosomiasis control initiative, Scientist training program, Single dose, Systematic review, Texas hospital, Trachoma, Treatment strategy, Trends parasitol stothard, Trichuris trichiura, Tropical disease control, Tropical diseases, Vaccine, Wkly epidemiol, World health assembly.
Abstract
The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.
Url:
DOI: 10.1136/archdischild-2012-302338
Links to Exploration step
ISTEX:36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFALe document en format XML
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type="ISSN">0003-9888</idno><idno type="eISSN">1468-2044</idno><imprint><publisher>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><date type="published" when="2013-08">2013-08</date><biblScope unit="volume">98</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="635">635</biblScope></imprint><idno type="ISSN">0003-9888</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-9888</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult worms</term><term>African infants</term><term>Albendazole</term><term>Annual deworming</term><term>Anthelminthic</term><term>Anthelminthic chemotherapy</term><term>Audacious goal</term><term>Baylor college</term><term>Bill melinda gates foundation</term><term>Blinding trachoma</term><term>Chemotherapy</term><term>Child growth</term><term>Child health</term><term>Chronic infections</term><term>Chronic schistosomiasis</term><term>Cognitive function</term><term>Common ntds</term><term>Control programmes</term><term>Corresponding authors</term><term>Deworming</term><term>Deworming drugs</term><term>Disease control</term><term>Disease transmission</term><term>Drug resistance</term><term>Fenwick</term><term>Geographical overlap</term><term>Global</term><term>Global child health</term><term>Global impact</term><term>Global network</term><term>Global support</term><term>Heavy infections</term><term>Helminth</term><term>Helminth infections</term><term>High rates</term><term>High risk</term><term>Hookworm</term><term>Hookworm infection</term><term>Hookworm vaccine</term><term>Hotez</term><term>Image courtesy</term><term>Infection</term><term>International development</term><term>Intestinal schistosomiasis</term><term>Intestinal worms</term><term>Ivermectin</term><term>London declaration</term><term>Lymphatic</term><term>Major soil</term><term>Mass drug administration</term><term>Merck kgaa</term><term>Millennium development goals</term><term>Morbidity</term><term>Ntds</term><term>Onchocerciasis</term><term>Parasitol</term><term>Parasitol hotez</term><term>Pharmaceutical companies</term><term>Plo</term><term>Plos negl</term><term>Praziquantel</term><term>Preschool</term><term>Preschool children</term><term>Preventative</term><term>Preventative chemotherapy</term><term>Preventive chemotherapy</term><term>Preventive chemotherapy databank</term><term>Programme</term><term>Public health image library</term><term>Rapid impact package</term><term>Regular deworming</term><term>Sabin</term><term>Sabin vaccine institute</term><term>Schistosoma mansoni</term><term>Schistosomiasis</term><term>Schistosomiasis control initiative</term><term>Scientist training program</term><term>Single dose</term><term>Systematic review</term><term>Texas hospital</term><term>Trachoma</term><term>Treatment strategy</term><term>Trends parasitol stothard</term><term>Trichuris trichiura</term><term>Tropical disease control</term><term>Tropical diseases</term><term>Vaccine</term><term>Wkly epidemiol</term><term>World health assembly</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult worms</term><term>African infants</term><term>Albendazole</term><term>Annual deworming</term><term>Anthelminthic</term><term>Anthelminthic chemotherapy</term><term>Audacious goal</term><term>Baylor college</term><term>Bill melinda gates foundation</term><term>Blinding trachoma</term><term>Chemotherapy</term><term>Child growth</term><term>Child health</term><term>Chronic infections</term><term>Chronic schistosomiasis</term><term>Cognitive function</term><term>Common ntds</term><term>Control programmes</term><term>Corresponding authors</term><term>Deworming</term><term>Deworming drugs</term><term>Disease control</term><term>Disease transmission</term><term>Drug resistance</term><term>Fenwick</term><term>Geographical overlap</term><term>Global</term><term>Global child health</term><term>Global impact</term><term>Global network</term><term>Global support</term><term>Heavy infections</term><term>Helminth</term><term>Helminth infections</term><term>High rates</term><term>High risk</term><term>Hookworm</term><term>Hookworm infection</term><term>Hookworm vaccine</term><term>Hotez</term><term>Image courtesy</term><term>Infection</term><term>International development</term><term>Intestinal schistosomiasis</term><term>Intestinal worms</term><term>Ivermectin</term><term>London declaration</term><term>Lymphatic</term><term>Major soil</term><term>Mass drug administration</term><term>Merck kgaa</term><term>Millennium development goals</term><term>Morbidity</term><term>Ntds</term><term>Onchocerciasis</term><term>Parasitol</term><term>Parasitol hotez</term><term>Pharmaceutical companies</term><term>Plo</term><term>Plos negl</term><term>Praziquantel</term><term>Preschool</term><term>Preschool children</term><term>Preventative</term><term>Preventative chemotherapy</term><term>Preventive chemotherapy</term><term>Preventive chemotherapy databank</term><term>Programme</term><term>Public health image library</term><term>Rapid impact package</term><term>Regular deworming</term><term>Sabin</term><term>Sabin vaccine institute</term><term>Schistosoma mansoni</term><term>Schistosomiasis</term><term>Schistosomiasis control initiative</term><term>Scientist training program</term><term>Single dose</term><term>Systematic review</term><term>Texas hospital</term><term>Trachoma</term><term>Treatment strategy</term><term>Trends parasitol stothard</term><term>Trichuris trichiura</term><term>Tropical disease control</term><term>Tropical diseases</term><term>Vaccine</term><term>Wkly epidemiol</term><term>World health assembly</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>ntds</json:string><json:string>schistosomiasis</json:string><json:string>programme</json:string><json:string>tropical diseases</json:string><json:string>chemotherapy</json:string><json:string>trachoma</json:string><json:string>helminth</json:string><json:string>hotez</json:string><json:string>deworming</json:string><json:string>vaccine</json:string><json:string>hookworm</json:string><json:string>global network</json:string><json:string>albendazole</json:string><json:string>onchocerciasis</json:string><json:string>praziquantel</json:string><json:string>lymphatic</json:string><json:string>baylor 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parasitol stothard</json:string><json:string>scientist training program</json:string><json:string>tropical disease control</json:string><json:string>parasitol hotez</json:string><json:string>hookworm vaccine</json:string></teeft></keywords><author><json:item><name>Meagan A Barry</name><affiliations><json:string>Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA</json:string><json:string>Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Gregory G Simon</name><affiliations><json:string>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</json:string></affiliations></json:item><json:item><name>Neeraj Mistry</name><affiliations><json:string>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</json:string></affiliations></json:item><json:item><name>Peter J Hotez</name><affiliations><json:string>Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA</json:string><json:string>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</json:string><json:string>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA</json:string><json:string>Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA</json:string><json:string>National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ADC Global child health</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Tropical Inf Dis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Tropical Paediatrics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parasitology</value></json:item></subject><articleId><json:string>archdischild-2012-302338</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.</abstract><qualityIndicators><score>7.808</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1631</abstractCharCount><pdfWordCount>5499</pdfWordCount><pdfCharCount>38054</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>234</abstractWordCount></qualityIndicators><title>Global trends in neglected tropical disease control and elimination: impact on child health</title><pmid><json:string>23793132</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Archives of Disease in Childhood</title><language><json:string>unknown</json:string></language><issn><json:string>0003-9888</json:string></issn><eissn><json:string>1468-2044</json:string></eissn><publisherId><json:string>adc</json:string></publisherId><volume>98</volume><issue>8</issue><pages><first>635</first></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pediatrics</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>pediatrics</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1136/archdischild-2012-302338</json:string></doi><id>36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Global trends in neglected tropical disease control and elimination: impact on child health</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><availability><licence><p>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</p></availability><date>2013-06-22</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Global trends in neglected tropical disease control and elimination: impact on child health</title><author xml:id="author-0000"><persName><forename type="first">Meagan A</forename><surname>Barry</surname></persName><affiliation>Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Gregory G</forename><surname>Simon</surname></persName><affiliation>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Neeraj</forename><surname>Mistry</surname></persName><affiliation>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Peter J</forename><surname>Hotez</surname></persName><affiliation>Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</affiliation><affiliation>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><idno type="istex">36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA</idno><idno type="ark">ark:/67375/NVC-X3D8SL65-6</idno><idno type="DOI">10.1136/archdischild-2012-302338</idno><idno type="href">archdischild-98-635.pdf</idno><idno type="article-id">archdischild-2012-302338</idno><idno type="PMID">23793132</idno><idno type="local">archdischild;98/8/635</idno></analytic><monogr><title level="j">Archives of Disease in Childhood</title><title level="j" type="abbrev">Arch Dis Child</title><idno type="pISSN">0003-9888</idno><idno type="eISSN">1468-2044</idno><idno type="publisher-id">adc</idno><idno type="PublisherID-hwp">archdischild</idno><idno type="PublisherID-nlm-ta">Arch Dis Child</idno><imprint><publisher>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><date type="published" when="2013-08"></date><biblScope unit="volume">98</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="635">635</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013-06-22</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>Tropical Inf Dis</term></item><item><term>Tropical Paediatrics</term></item><item><term>Parasitology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>hwp-journal-coll</head><item><term>ADC Global child health</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2013-06-22">Created</change><change when="2013-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">archdischild</journal-id><journal-id journal-id-type="nlm-ta">Arch Dis Child</journal-id><journal-id journal-id-type="publisher-id">adc</journal-id><journal-title>Archives of Disease in Childhood</journal-title><abbrev-journal-title abbrev-type="publisher">Arch Dis Child</abbrev-journal-title><abbrev-journal-title>Arch Dis Child</abbrev-journal-title><issn pub-type="ppub">0003-9888</issn><issn pub-type="epub">1468-2044</issn><publisher><publisher-name>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">archdischild-2012-302338</article-id><article-id pub-id-type="doi">10.1136/archdischild-2012-302338</article-id><article-id pub-id-type="other">archdischild;98/8/635</article-id><article-id pub-id-type="other">archdischild;archdischild-2012-302338</article-id><article-id pub-id-type="pmid">23793132</article-id><article-id pub-id-type="other">635</article-id><article-id pub-id-type="other">archdischild-2012-302338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Global child health</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>ADC Global child health</subject></subj-group></article-categories><title-group><article-title>Global trends in neglected tropical disease control and elimination: impact on child health</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Barry</surname><given-names>Meagan A</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Simon</surname><given-names>Gregory G</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mistry</surname><given-names>Neeraj</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hotez</surname><given-names>Peter J</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref><xref ref-type="aff" rid="af6">6</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Interdepartmental Program in Translational Biology and Molecular Medicine</addr-line>, <institution>Baylor College of Medicine</institution>, <addr-line>Houston, Texas</addr-line>, <country>USA</country></aff><aff id="af2"><label>2</label><addr-line>Baylor College of Medicine Medical Scientist Training Program</addr-line>, <institution>Baylor College of Medicine</institution>, <addr-line>Houston, Texas</addr-line>, <country>USA</country></aff><aff id="af3"><label>3</label><addr-line>Global Network for Neglected Tropical Diseases</addr-line>, <institution>Sabin Vaccine Institute</institution>, <addr-line>Washington, District of Columbia</addr-line>, <country>USA</country></aff><aff id="af4"><label>4</label><addr-line>Department of Pediatrics</addr-line>, <institution>Baylor College of Medicine</institution>, <addr-line>Houston, Texas</addr-line>, <country>USA</country></aff><aff id="af5"><label>5</label><addr-line>Department of Molecular Virology and Microbiology</addr-line>, <institution>Baylor College of Medicine</institution>, <addr-line>Houston, Texas</addr-line>, <country>USA</country></aff><aff id="af6"><label>6</label><institution>National School of Tropical Medicine, Baylor College of Medicine</institution>, <addr-line>Houston, Texas</addr-line>, <country>USA</country></aff><author-notes><corresp><label>Correspondence to</label> Meagan A Barry, Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, Feigin Center, 1102 Bates St, Suite FC550, Houston, TX 77030, USA; <email>mabarry@bcm.edu</email> and Dr Gregory G Simon, Global Network for Neglected Tropical Disease Control, Sabin Vaccine Institute, 2000 Pennsylvania Avenue, Washington, DC 20006, USA; <email>Gregory.simon@sabin.org</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><pub-date pub-type="epub-original"><day>22</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>6</month><year>2013</year></pub-date><volume>98</volume><volume-id pub-id-type="other">98</volume-id><volume-id pub-id-type="other">98</volume-id><issue>8</issue><issue-id pub-id-type="other">archdischild;98/8</issue-id><issue-id pub-id-type="other">8</issue-id><issue-id pub-id-type="other">98/8</issue-id><fpage>635</fpage><history><date date-type="received"><day>10</day><month>4</month><year>2013</year></date><date date-type="rev-recd"><day>26</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>28</day><month>5</month><year>2013</year></date></history><permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="archdischild-98-635.pdf"></self-uri><abstract><p>The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.</p></abstract><kwd-group><kwd>Tropical Inf Dis</kwd><kwd>Tropical Paediatrics</kwd><kwd>Parasitology</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Global trends in neglected tropical disease control and elimination: impact on child health</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Global trends in neglected tropical disease control and elimination: impact on child health</title></titleInfo><name type="personal"><namePart type="given">Meagan A</namePart><namePart type="family">Barry</namePart><affiliation>Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>Baylor College of Medicine Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregory G</namePart><namePart type="family">Simon</namePart><affiliation>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neeraj</namePart><namePart type="family">Mistry</namePart><affiliation>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter J</namePart><namePart type="family">Hotez</namePart><affiliation>Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>Global Network for Neglected Tropical Diseases, Sabin Vaccine Institute, Washington, District of Columbia, USA</affiliation><affiliation>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA</affiliation><affiliation>National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><dateIssued encoding="w3cdtf">2013-08</dateIssued><dateCreated encoding="w3cdtf">2013-06-22</dateCreated><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.</abstract><subject><genre>keywords</genre><topic>Tropical Inf Dis</topic><topic>Tropical Paediatrics</topic><topic>Parasitology</topic></subject><relatedItem type="host"><titleInfo><title>Archives of Disease in Childhood</title></titleInfo><titleInfo type="abbreviated"><title>Arch Dis Child</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>hwp-journal-coll</genre><topic>ADC Global child health</topic></subject><identifier type="ISSN">0003-9888</identifier><identifier type="eISSN">1468-2044</identifier><identifier type="PublisherID">adc</identifier><identifier type="PublisherID-hwp">archdischild</identifier><identifier type="PublisherID-nlm-ta">Arch Dis Child</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>98</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>635</start></extent></part></relatedItem><identifier type="istex">36ACA0D7C0725D9A61EFFF12DCB073ACD97E5EFA</identifier><identifier type="ark">ark:/67375/NVC-X3D8SL65-6</identifier><identifier type="DOI">10.1136/archdischild-2012-302338</identifier><identifier type="href">archdischild-98-635.pdf</identifier><identifier type="ArticleID">archdischild-2012-302338</identifier><identifier type="PMID">23793132</identifier><identifier type="local">archdischild;98/8/635</identifier><accessCondition type="use and reproduction" contentType="copyright">Published by the BMJ Publishing Group Limited. 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