Le SIDA au Ghana (serveur d'exploration)

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Absence of novel human parvovirus (PARV4) in Danish mothers and children.

Identifieur interne : 000830 ( PubMed/Curation ); précédent : 000829; suivant : 000831

Absence of novel human parvovirus (PARV4) in Danish mothers and children.

Auteurs : Marie-Louise Von Linstow [Danemark] ; Vibeke Rosenfeldt [Danemark] ; Ellinor Lindberg [Danemark] ; Lise Jensen [Danemark] ; Lea Hedman [Finlande] ; Xuemeng Li [Finlande] ; Elina V Is Nen [Finlande] ; Klaus Hedman [Finlande] ; P Ivi Norja [Finlande]

Source :

RBID : pubmed:25766982

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English descriptors

Abstract

The recently discovered human parvovirus 4 (PARV4) is found most frequently in injection drug users, HIV-positive patients, and in haemophiliacs. Studies from Ghana report the finding of PARV4 in plasma from 2 to 12% of children without acute infection, and in nasal secretions and faecal samples. Studies of PARV4 in children from industrialized countries are few.

DOI: 10.1016/j.jcv.2015.01.021
PubMed: 25766982

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pubmed:25766982

Le document en format XML

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<term>Humans</term>
<term>Infant</term>
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<term>Mothers</term>
<term>Polymerase Chain Reaction</term>
<term>Population Surveillance</term>
<term>Real-Time Polymerase Chain Reaction</term>
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<div type="abstract" xml:lang="en">The recently discovered human parvovirus 4 (PARV4) is found most frequently in injection drug users, HIV-positive patients, and in haemophiliacs. Studies from Ghana report the finding of PARV4 in plasma from 2 to 12% of children without acute infection, and in nasal secretions and faecal samples. Studies of PARV4 in children from industrialized countries are few.</div>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The recently discovered human parvovirus 4 (PARV4) is found most frequently in injection drug users, HIV-positive patients, and in haemophiliacs. Studies from Ghana report the finding of PARV4 in plasma from 2 to 12% of children without acute infection, and in nasal secretions and faecal samples. Studies of PARV4 in children from industrialized countries are few.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We aimed to describe the occurrence of PARV4 in a population-based birth cohort of 228 Danish mothers and their healthy children who previously participated in a study of respiratory tract infections in infancy.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Children were included over a whole calendar year and were monitored through monthly home visits through the first year of life. Plasma samples for the present study were available from 228 mothers, 176 newborns, and 202 12-months-old children. All samples were analysed for the presence of PARV4 antibodies by enzyme immunoassay, and samples with detectable antibodies were in addition studied by real-time PCR.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">One (0.4%) of 228 mothers had PARV4 IgG exceeding the cut-off absorbance level and another had borderline IgG reactivity. No mother among these two had an acute infection, as they were IgM and PARV4 DNA negative. All blood samples from newborns and one-year-old children had IgG and IgM reactivity below cut-off.</AbstractText>
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<Affiliation>Department of Virology, University of Helsinki, Helsinki, Finland. Electronic address: norjap@gmail.com.</Affiliation>
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<MeshHeading>
<DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
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<Keyword MajorTopicYN="N">Children</Keyword>
<Keyword MajorTopicYN="N">Denmark</Keyword>
<Keyword MajorTopicYN="N">Infants</Keyword>
<Keyword MajorTopicYN="N">PARV4 antibodies</Keyword>
<Keyword MajorTopicYN="N">Parvovirus</Keyword>
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<Year>2014</Year>
<Month>11</Month>
<Day>27</Day>
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<PubMedPubDate PubStatus="revised">
<Year>2015</Year>
<Month>01</Month>
<Day>20</Day>
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<PubMedPubDate PubStatus="accepted">
<Year>2015</Year>
<Month>01</Month>
<Day>28</Day>
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<Month>3</Month>
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<Year>2015</Year>
<Month>12</Month>
<Day>19</Day>
<Hour>6</Hour>
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<PublicationStatus>ppublish</PublicationStatus>
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<ArticleId IdType="pubmed">25766982</ArticleId>
<ArticleId IdType="pii">S1386-6532(15)00035-9</ArticleId>
<ArticleId IdType="doi">10.1016/j.jcv.2015.01.021</ArticleId>
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