Resolution of the acute-phase response in West African patients receiving treatment for pulmonary tuberculosis.
Identifieur interne : 000776 ( PubMed/Curation ); précédent : 000775; suivant : 000777Resolution of the acute-phase response in West African patients receiving treatment for pulmonary tuberculosis.
Auteurs : S D Lawn [Royaume-Uni] ; J. Obeng ; J W Acheampong ; G E GriffinSource :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [ 1027-3719 ] ; 2000.
Descripteurs français
- KwdFr :
- Adulte, Antituberculeux (usage thérapeutique), Expectoration (microbiologie), Facteurs temps, Femelle, Ghana, Humains, Hémoglobines (analyse), Marqueurs biologiques (sang), Mâle, Poids du corps, Protéine C-réactive (), Protéine C-réactive (métabolisme), Reproductibilité des résultats, Réaction inflammatoire aigüe (immunologie), Réaction inflammatoire aigüe (sang), Réaction inflammatoire aigüe (étiologie), Récepteurs à l'interleukine-2 (sang), Surveillance pharmacologique, Sédimentation du sang, Tuberculose pulmonaire (), Tuberculose pulmonaire (immunologie), Tuberculose pulmonaire (microbiologie), Tuberculose pulmonaire (traitement médicamenteux), Études cas-témoins.
- MESH :
- analyse : Hémoglobines.
- immunologie : Réaction inflammatoire aigüe, Tuberculose pulmonaire.
- microbiologie : Expectoration, Tuberculose pulmonaire.
- métabolisme : Protéine C-réactive.
- sang : Marqueurs biologiques, Réaction inflammatoire aigüe, Récepteurs à l'interleukine-2.
- traitement médicamenteux : Tuberculose pulmonaire.
- usage thérapeutique : Antituberculeux.
- étiologie : Réaction inflammatoire aigüe.
- Adulte, Facteurs temps, Femelle, Ghana, Humains, Mâle, Poids du corps, Protéine C-réactive, Reproductibilité des résultats, Surveillance pharmacologique, Sédimentation du sang, Tuberculose pulmonaire, Études cas-témoins.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Acute-Phase Reaction (blood), Acute-Phase Reaction (etiology), Acute-Phase Reaction (immunology), Adult, Antitubercular Agents (therapeutic use), Biomarkers (blood), Blood Sedimentation, Body Weight, C-Reactive Protein (drug effects), C-Reactive Protein (metabolism), Case-Control Studies, Drug Monitoring, Female, Ghana, Hemoglobins (analysis), Humans, Male, Receptors, Interleukin-2 (blood), Reproducibility of Results, Sputum (microbiology), Time Factors, Tuberculosis, Pulmonary (complications), Tuberculosis, Pulmonary (drug therapy), Tuberculosis, Pulmonary (immunology), Tuberculosis, Pulmonary (microbiology).
- MESH :
- chemical , analysis : Hemoglobins.
- chemical , blood : Biomarkers, Receptors, Interleukin-2.
- chemical , drug effects : C-Reactive Protein.
- chemical , metabolism : C-Reactive Protein.
- chemical , therapeutic use : Antitubercular Agents.
- geographic : Ghana.
- blood : Acute-Phase Reaction.
- complications : Tuberculosis, Pulmonary.
- drug therapy : Tuberculosis, Pulmonary.
- etiology : Acute-Phase Reaction.
- immunology : Acute-Phase Reaction, Tuberculosis, Pulmonary.
- microbiology : Sputum, Tuberculosis, Pulmonary.
- Adult, Blood Sedimentation, Body Weight, Case-Control Studies, Drug Monitoring, Female, Humans, Male, Reproducibility of Results, Time Factors.
Abstract
The Komfo Anokye Teaching Hospital, Kumasi, Ghana, West Africa.
PubMed: 10777083
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xml:lang="fr"><term>Réaction inflammatoire aigüe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Blood Sedimentation</term><term>Body Weight</term><term>Case-Control Studies</term><term>Drug Monitoring</term><term>Female</term><term>Humans</term><term>Male</term><term>Reproducibility of Results</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Facteurs temps</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Mâle</term><term>Poids du corps</term><term>Protéine C-réactive</term><term>Reproductibilité des résultats</term><term>Surveillance pharmacologique</term><term>Sédimentation du sang</term><term>Tuberculose pulmonaire</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Komfo Anokye Teaching Hospital, Kumasi, Ghana, West Africa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10777083</PMID><DateCreated><Year>2000</Year><Month>05</Month><Day>25</Day></DateCreated><DateCompleted><Year>2000</Year><Month>05</Month><Day>25</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1027-3719</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>4</Issue><PubDate><Year>2000</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease</Title><ISOAbbreviation>Int. J. Tuberc. Lung Dis.</ISOAbbreviation></Journal><ArticleTitle>Resolution of the acute-phase response in West African patients receiving treatment for pulmonary tuberculosis.</ArticleTitle><Pagination><MedlinePgn>340-4</MedlinePgn></Pagination><Abstract><AbstractText Label="SETTING" NlmCategory="METHODS">The Komfo Anokye Teaching Hospital, Kumasi, Ghana, West Africa.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate simple and commonly used parameters of the acute-phase response as correlates of successful resolution of smear-positive pulmonary tuberculosis (PTB) during drug treatment.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Serum C-reactive protein (CRP) concentration, erythrocyte sedimentation rate (ESR), body weight, and blood haemoglobin were measured in human immunodeficiency virus (HIV) negative Ghanaian patients with PTB (n = 15) and in age- and sex-matched healthy controls (n = 15). These parameters were subsequently measured in patients after 1, 2 and 3 months of antituberculosis treatment. Serum concentrations of soluble interleukin-2-receptor-alpha (sCD25) were also measured as a comparative index of resolution of the systemic inflammatory process.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Anti-tuberculosis treatment resulted in sputum smear conversion in all 15 patients. After one month of treatment, reductions in serum CRP concentration (>20%) and increases in haemoglobin concentration (>0.4 g/dl) occurred in the majority of patients and correlated with steep reductions in serum levels of sCD25. In contrast, weight loss and elevated ESR were slower to resolve, and were insensitive early markers of response to treatment.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">A fall in serum CRP and a rise in blood haemoglobin are correlates of the initial response to drug treatment of PTB. These parameters may assist in the evaluation of empiric trials of treatment in microbiologically unconfirmed cases of suspected PTB.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lawn</LastName><ForeName>S D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, St. George's Hospital Medical School, London, UK. sil3@cdc.gov</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obeng</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Acheampong</LastName><ForeName>J W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>G E</ForeName><Initials>GE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Int J Tuberc Lung Dis</MedlineTA><NlmUniqueID>9706389</NlmUniqueID><ISSNLinking>1027-3719</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000995">Antitubercular Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006454">Hemoglobins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015375">Receptors, Interleukin-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000210" MajorTopicYN="N">Acute-Phase Reaction</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000995" MajorTopicYN="N">Antitubercular Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001799" MajorTopicYN="Y">Blood Sedimentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="Y">Body Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016903" MajorTopicYN="N">Drug Monitoring</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006454" MajorTopicYN="N">Hemoglobins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015375" MajorTopicYN="N">Receptors, Interleukin-2</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013183" MajorTopicYN="N">Sputum</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014397" MajorTopicYN="N">Tuberculosis, Pulmonary</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>4</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>6</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>4</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10777083</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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