Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression.
Identifieur interne : 000510 ( PubMed/Curation ); précédent : 000509; suivant : 000511Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression.
Auteurs : Edward K. Maina [Kenya] ; C Z Abana [Ghana] ; E A Bukusi [Kenya] ; M. Sedegah [États-Unis] ; M. Lartey [Ghana] ; W K Ampofo [Ghana]Source :
- Cytokine [ 1096-0023 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral (génétique), ARN viral (sang), Adulte, Adulte d'âge moyen, Antirétroviraux (usage thérapeutique), Cytokines (sang), Facteur de croissance transformant bêta-1 (sang), Femelle, Humains, Infections à VIH (sang), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Jeune adulte, Lymphocytes T CD4+ (métabolisme), Lymphocytes T CD8+ (métabolisme), Lymphocytes auxiliaires Th1 (métabolisme), Lymphocytes auxiliaires Th2 (métabolisme), Mâle, Numération des lymphocytes, Rapport CD4-CD8, Sujet âgé, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie), Études transversales, Évolution de la maladie.
- MESH :
- génétique : ARN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- métabolisme : Lymphocytes T CD4+, Lymphocytes T CD8+, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- physiologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- sang : ARN viral, Cytokines, Facteur de croissance transformant bêta-1, Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- virologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Numération des lymphocytes, Rapport CD4-CD8, Sujet âgé, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études transversales, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Anti-Retroviral Agents (therapeutic use), CD4-CD8 Ratio, CD4-Positive T-Lymphocytes (metabolism), CD8-Positive T-Lymphocytes (metabolism), Cross-Sectional Studies, Cytokines (blood), Disease Progression, Female, HIV Infections (blood), HIV Infections (drug therapy), HIV Infections (virology), HIV-1 (drug effects), HIV-1 (genetics), HIV-1 (physiology), Humans, Lymphocyte Count, Male, Middle Aged, RNA, Viral (blood), RNA, Viral (genetics), Th1 Cells (metabolism), Th2 Cells (metabolism), Transforming Growth Factor beta1 (blood), Young Adult.
- MESH :
- chemical , blood : Cytokines, RNA, Viral, Transforming Growth Factor beta1.
- chemical , genetics : RNA, Viral.
- chemical , therapeutic use : Anti-Retroviral Agents.
- blood : HIV Infections.
- drug effects : HIV-1.
- drug therapy : HIV Infections.
- genetics : HIV-1.
- metabolism : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Th1 Cells, Th2 Cells.
- physiology : HIV-1.
- virology : HIV Infections.
- Adult, Aged, CD4-CD8 Ratio, Cross-Sectional Studies, Disease Progression, Female, Humans, Lymphocyte Count, Male, Middle Aged, Young Adult.
Abstract
The human immunodeficiency virus (HIV) infection shows variable rate of disease progression. The underlying biological and molecular mechanisms involved in determining progression of HIV infection are not fully understood. The aims of this study were to determine plasma concentrations of active TGF β 1, Th1 and Th2 cytokines in patients with non-progressive and those with progressive HIV-1 infection, as well as to determine if there is an association of these cytokines to disease progression. In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12). Plasma concentration of these cytokines was measured using a highly sensitive luminex200 XMAP assay. Pearson correlation test was used to assess the correlation of cytokines with CD4+ and CD8+ T cells, CD4:CD8 ratio and plasma HIV-1 RNA in the different study groups. Plasma concentrations of TGF β 1 and IL-10 were significantly decreased while IL-1β, IL-12p70 and TNF-α were increased in patients with non-progressive HIV-1 infection compared to patients with progressive infection. Plasma levels of TGF β 1 and IL-10 showed an inverse correlation with CD8+ T cell counts and CD4:CD8 ratios in patients with non-progressive HIV-1 infection, while plasma HIV-1 RNA positively correlated with CD4+ T cell counts. Plasma levels of TNF-α, IL-1β, IL-12p70 and IL-13 positively correlated with CD4+ T cell counts and inversely correlated with plasma HIV-1 RNA, CD8+ T cell count and CD4:CD8 ratio in patients with non-progressive infection. The correlation of cytokines to the state of T-lymphocyte and plasma HIV-1 RNA found in this study may provide insight into the role of cytokines in both progressive and non-progressive HIV-1 infection. Additionally, these findings may have implications for systemic cytokine-based therapies in HIV-1 infection.
DOI: 10.1016/j.cyto.2016.02.009
PubMed: 26986868
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1)</term><term>Études transversales</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The human immunodeficiency virus (HIV) infection shows variable rate of disease progression. The underlying biological and molecular mechanisms involved in determining progression of HIV infection are not fully understood. The aims of this study were to determine plasma concentrations of active TGF β 1, Th1 and Th2 cytokines in patients with non-progressive and those with progressive HIV-1 infection, as well as to determine if there is an association of these cytokines to disease progression. In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12). Plasma concentration of these cytokines was measured using a highly sensitive luminex200 XMAP assay. Pearson correlation test was used to assess the correlation of cytokines with CD4+ and CD8+ T cells, CD4:CD8 ratio and plasma HIV-1 RNA in the different study groups. Plasma concentrations of TGF β 1 and IL-10 were significantly decreased while IL-1β, IL-12p70 and TNF-α were increased in patients with non-progressive HIV-1 infection compared to patients with progressive infection. Plasma levels of TGF β 1 and IL-10 showed an inverse correlation with CD8+ T cell counts and CD4:CD8 ratios in patients with non-progressive HIV-1 infection, while plasma HIV-1 RNA positively correlated with CD4+ T cell counts. Plasma levels of TNF-α, IL-1β, IL-12p70 and IL-13 positively correlated with CD4+ T cell counts and inversely correlated with plasma HIV-1 RNA, CD8+ T cell count and CD4:CD8 ratio in patients with non-progressive infection. The correlation of cytokines to the state of T-lymphocyte and plasma HIV-1 RNA found in this study may provide insight into the role of cytokines in both progressive and non-progressive HIV-1 infection. Additionally, these findings may have implications for systemic cytokine-based therapies in HIV-1 infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26986868</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>23</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0023</ISSN><JournalIssue CitedMedium="Internet"><Volume>81</Volume><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>Cytokine</Title><ISOAbbreviation>Cytokine</ISOAbbreviation></Journal><ArticleTitle>Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression.</ArticleTitle><Pagination><MedlinePgn>109-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cyto.2016.02.009</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1043-4666(16)30033-3</ELocationID><Abstract><AbstractText>The human immunodeficiency virus (HIV) infection shows variable rate of disease progression. The underlying biological and molecular mechanisms involved in determining progression of HIV infection are not fully understood. The aims of this study were to determine plasma concentrations of active TGF β 1, Th1 and Th2 cytokines in patients with non-progressive and those with progressive HIV-1 infection, as well as to determine if there is an association of these cytokines to disease progression. In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12). Plasma concentration of these cytokines was measured using a highly sensitive luminex200 XMAP assay. Pearson correlation test was used to assess the correlation of cytokines with CD4+ and CD8+ T cells, CD4:CD8 ratio and plasma HIV-1 RNA in the different study groups. Plasma concentrations of TGF β 1 and IL-10 were significantly decreased while IL-1β, IL-12p70 and TNF-α were increased in patients with non-progressive HIV-1 infection compared to patients with progressive infection. Plasma levels of TGF β 1 and IL-10 showed an inverse correlation with CD8+ T cell counts and CD4:CD8 ratios in patients with non-progressive HIV-1 infection, while plasma HIV-1 RNA positively correlated with CD4+ T cell counts. Plasma levels of TNF-α, IL-1β, IL-12p70 and IL-13 positively correlated with CD4+ T cell counts and inversely correlated with plasma HIV-1 RNA, CD8+ T cell count and CD4:CD8 ratio in patients with non-progressive infection. The correlation of cytokines to the state of T-lymphocyte and plasma HIV-1 RNA found in this study may provide insight into the role of cytokines in both progressive and non-progressive HIV-1 infection. Additionally, these findings may have implications for systemic cytokine-based therapies in HIV-1 infection.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maina</LastName><ForeName>Edward K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences (CHS), University of Ghana, Ghana; Centre for Microbiology Research, Kenya Medical Research Institute, Kenya. Electronic address: emaina02@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abana</LastName><ForeName>C Z</ForeName><Initials>CZ</Initials><AffiliationInfo><Affiliation>Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences (CHS), University of Ghana, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bukusi</LastName><ForeName>E A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Centre for Microbiology Research, Kenya Medical Research Institute, Kenya.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sedegah</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Malaria Program, Naval Medical Research Centre, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lartey</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, School of Medicine & Dentistry, CHS, University of Ghana, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ampofo</LastName><ForeName>W K</ForeName><Initials>WK</Initials><AffiliationInfo><Affiliation>Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences (CHS), University of Ghana, Ghana.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cytokine</MedlineTA><NlmUniqueID>9005353</NlmUniqueID><ISSNLinking>1043-4666</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053773">Transforming Growth Factor beta1</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044966" MajorTopicYN="N">Anti-Retroviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016516" MajorTopicYN="N">CD4-CD8 Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000188" 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infection</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26986868</ArticleId><ArticleId IdType="pii">S1043-4666(16)30033-3</ArticleId><ArticleId 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