Changing Patterns of Disease and Mortality at the Children's Hospital, Accra: Are Infections Rising?
Identifieur interne : 000463 ( PubMed/Curation ); précédent : 000462; suivant : 000464Changing Patterns of Disease and Mortality at the Children's Hospital, Accra: Are Infections Rising?
Auteurs : Edem M A. Tette [Ghana] ; Margaret Neizer [Ghana] ; Maame Yaa Nyarko [Ghana] ; Eric K. Sifah [Ghana] ; Edmund T. Nartey [Ghana] ; Eric S. Donkor [Ghana]Source :
- PloS one [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Anémie (mortalité), Bases de données factuelles, Déshydratation (mortalité), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Facteurs sexuels, Femelle, Gastroentérite (mortalité), Ghana, Humains, Hôpitaux pédiatriques, Infections à VIH (mortalité), Mortalité hospitalière, Mâle, Nourrisson, Nouveau-né, Paludisme (mortalité), Pneumopathie infectieuse (mortalité), Sepsie (mortalité), Troubles nutritionnels de l'enfant (mortalité), Études rétrospectives.
- MESH :
- mortalité : Anémie, Déshydratation, Gastroentérite, Infections à VIH, Paludisme, Pneumopathie infectieuse, Sepsie, Troubles nutritionnels de l'enfant.
- Adolescent, Bases de données factuelles, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Facteurs sexuels, Femelle, Ghana, Humains, Hôpitaux pédiatriques, Mortalité hospitalière, Mâle, Nourrisson, Nouveau-né, Études rétrospectives.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Age Factors, Anemia (mortality), Child, Child Nutrition Disorders (mortality), Child, Preschool, Databases, Factual, Dehydration (mortality), Female, Gastroenteritis (mortality), Ghana, HIV Infections (mortality), Hospital Mortality, Hospitals, Pediatric, Humans, Infant, Infant, Newborn, Malaria (mortality), Male, Pneumonia (mortality), Retrospective Studies, Sepsis (mortality), Sex Factors.
- MESH :
- geographic : Ghana.
- mortality : Anemia, Child Nutrition Disorders, Dehydration, Gastroenteritis, HIV Infections, Malaria, Pneumonia, Sepsis.
- Adolescent, Age Factors, Child, Child, Preschool, Databases, Factual, Female, Hospital Mortality, Hospitals, Pediatric, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Sex Factors.
Abstract
The Millennium Development Goals (MDGs) have led to reductions in child mortality world-wide. This has, invariably, led to the changes in the epidemiology of diseases associated with child mortality. Although facility based data do not capture all deaths, they provide an opportunity to confirm diagnoses and insight into these changes which are relevant for further disease control.
DOI: 10.1371/journal.pone.0150387
PubMed: 27045667
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Tette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community Health, School of Public Health, University of Ghana, Legon, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Community Health, School of Public Health, University of Ghana, Legon</wicri:regionArea></affiliation></author><author><name sortKey="Neizer, Margaret" sort="Neizer, Margaret" uniqKey="Neizer M" first="Margaret" last="Neizer">Margaret Neizer</name><affiliation wicri:level="1"><nlm:affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Princess Marie Louis Children's Hospital, Accra</wicri:regionArea></affiliation></author><author><name sortKey="Nyarko, Maame Yaa" sort="Nyarko, Maame Yaa" uniqKey="Nyarko M" first="Maame Yaa" last="Nyarko">Maame Yaa Nyarko</name><affiliation wicri:level="1"><nlm:affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Princess Marie Louis Children's Hospital, Accra</wicri:regionArea></affiliation></author><author><name sortKey="Sifah, Eric K" sort="Sifah, Eric K" uniqKey="Sifah E" first="Eric K" last="Sifah">Eric K. Sifah</name><affiliation wicri:level="1"><nlm:affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Princess Marie Louis Children's Hospital, Accra</wicri:regionArea></affiliation></author><author><name sortKey="Nartey, Edmund T" sort="Nartey, Edmund T" uniqKey="Nartey E" first="Edmund T" last="Nartey">Edmund T. Nartey</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Tropical Clinical Pharmacology and Therapeutics, School of Medicine and Dentistry, University of Ghana, Legon, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Centre for Tropical Clinical Pharmacology and Therapeutics, School of Medicine and Dentistry, University of Ghana, Legon</wicri:regionArea></affiliation></author><author><name sortKey="Donkor, Eric S" sort="Donkor, Eric S" uniqKey="Donkor E" first="Eric S" last="Donkor">Eric S. Donkor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology, College of Health Sciences, University of Ghana, Legon, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Medical Microbiology, College of Health Sciences, University of Ghana, Legon</wicri:regionArea></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Age Factors</term><term>Anemia (mortality)</term><term>Child</term><term>Child Nutrition Disorders (mortality)</term><term>Child, Preschool</term><term>Databases, Factual</term><term>Dehydration (mortality)</term><term>Female</term><term>Gastroenteritis (mortality)</term><term>Ghana</term><term>HIV Infections (mortality)</term><term>Hospital Mortality</term><term>Hospitals, Pediatric</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Malaria (mortality)</term><term>Male</term><term>Pneumonia (mortality)</term><term>Retrospective Studies</term><term>Sepsis (mortality)</term><term>Sex Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Anémie (mortalité)</term><term>Bases de données factuelles</term><term>Déshydratation (mortalité)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de l'âge</term><term>Facteurs sexuels</term><term>Femelle</term><term>Gastroentérite (mortalité)</term><term>Ghana</term><term>Humains</term><term>Hôpitaux pédiatriques</term><term>Infections à VIH (mortalité)</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Paludisme (mortalité)</term><term>Pneumopathie infectieuse (mortalité)</term><term>Sepsie (mortalité)</term><term>Troubles nutritionnels de l'enfant (mortalité)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Anemia</term><term>Child Nutrition Disorders</term><term>Dehydration</term><term>Gastroenteritis</term><term>HIV Infections</term><term>Malaria</term><term>Pneumonia</term><term>Sepsis</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Anémie</term><term>Déshydratation</term><term>Gastroentérite</term><term>Infections à VIH</term><term>Paludisme</term><term>Pneumopathie infectieuse</term><term>Sepsie</term><term>Troubles nutritionnels de l'enfant</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Age Factors</term><term>Child</term><term>Child, Preschool</term><term>Databases, Factual</term><term>Female</term><term>Hospital Mortality</term><term>Hospitals, Pediatric</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Retrospective Studies</term><term>Sex Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Bases de données factuelles</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de l'âge</term><term>Facteurs sexuels</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Hôpitaux pédiatriques</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Millennium Development Goals (MDGs) have led to reductions in child mortality world-wide. This has, invariably, led to the changes in the epidemiology of diseases associated with child mortality. Although facility based data do not capture all deaths, they provide an opportunity to confirm diagnoses and insight into these changes which are relevant for further disease control.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27045667</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>06</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>4</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Changing Patterns of Disease and Mortality at the Children's Hospital, Accra: Are Infections Rising?</ArticleTitle><Pagination><MedlinePgn>e0150387</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0150387</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The Millennium Development Goals (MDGs) have led to reductions in child mortality world-wide. This has, invariably, led to the changes in the epidemiology of diseases associated with child mortality. Although facility based data do not capture all deaths, they provide an opportunity to confirm diagnoses and insight into these changes which are relevant for further disease control.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To identify changes in the disease pattern of children who died at the Princess Marie Louise Children's Hospital (PML) in Ghana from 2003-2013.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A cross sectional review of mortality data was carried out at PML. The age, sex, duration of admission and diagnosis of consecutive patients who died at the hospital between 2003 and 2013 were reviewed. This information was entered into an Access database and analysed using Stata 11.0 software.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Altogether, 1314 deaths (3.6%) occurred out of a total of 37,012 admissions. The majority of the deaths, 1187 (90.3%), occurred in children under the age of 5 years. While deaths caused by malaria, malnutrition, HIV infection and diarrhoea decreased, deaths caused by pneumonia were rising. Suspected septicaemia and meningitis showed a fluctuating trend with only a modest decrease between 2012 and 2013. The ten leading causes of mortality among under-fives were malnutrition, 363 (30.6%); septicaemia, 301 (25.4%); pneumonia, 218 (18.4%); HIV infection, 183 (15.4%); malaria, 155 (13.1%); anaemia, 135 (11.4%); gastroenteritis/dehydration, 110 (9.3%); meningitis, 58 (4.9%); tuberculosis, 34 (2.9%) and hypoglycaemia, 27 (2.3%). For children aged 5-9 years, the leading causes of mortality were malaria, 42 (42.9%); HIV infection, 27 (27.6%); anaemia, 14 (14.3%); septicaemia, 12 (12.2%); meningitis, 10 (10.2%); malnutrition, 9 (9.2%); tuberculosis, 5 (5.1%); pneumonia, 4 (4.1%); encephalopathy, 3 (3.1%); typhoid fever, 3 (3.1%) and lymphoma, 3 (3.1%). In the adolescent age group, malaria, 8 (27.6%); anaemia, 6 (20.7%); HIV infection, 5 (17.2%); sickle cell disease, 3 (10.3%) and meningitis, 3 (10.3%) were most common.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">There has been a decline in the under-five mortality at PML over the years; however, deaths caused by pneumonia appear to be rising. This highlights the need for better diagnostic services, wider HIV screening and clinical audits to improve outcomes in order to achieve further reductions in child mortality and maintain the gains.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tette</LastName><ForeName>Edem M A</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Department of Community Health, School of Public Health, University of Ghana, Legon, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neizer</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nyarko</LastName><ForeName>Maame Yaa</ForeName><Initials>MY</Initials><AffiliationInfo><Affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sifah</LastName><ForeName>Eric K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Princess Marie Louis Children's Hospital, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nartey</LastName><ForeName>Edmund T</ForeName><Initials>ET</Initials><AffiliationInfo><Affiliation>Centre for Tropical Clinical Pharmacology and Therapeutics, School of Medicine and Dentistry, University of Ghana, Legon, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Disease Control, School of Public Health, University of Ghana, Legon, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donkor</LastName><ForeName>Eric S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, College of Health Sciences, University of Ghana, Legon, Ghana.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2001 Jan 13;357(9250):106-10</RefSource><PMID Version="1">11197397</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>S Afr Med J. 2006 Sep;96(9 Pt 2):964-8</RefSource><PMID Version="1">17077926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2013 Apr 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Version="1">15251404</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>S Afr Med J. 2004 Mar;94(3):198-202</RefSource><PMID Version="1">15098280</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Dis Child. 2006 Aug;91(8):706-10</RefSource><PMID Version="1">16861489</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2012 Feb 25;379(9817):699-700</RefSource><PMID Version="1">22371964</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2003 Jun 28;361(9376):2226-34</RefSource><PMID Version="1">12842379</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000740" MajorTopicYN="N">Anemia</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015362" MajorTopicYN="N">Child Nutrition Disorders</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016208" MajorTopicYN="Y">Databases, Factual</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003681" MajorTopicYN="N">Dehydration</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005759" MajorTopicYN="N">Gastroenteritis</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="Y">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006776" MajorTopicYN="Y">Hospitals, Pediatric</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011014" MajorTopicYN="N">Pneumonia</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018805" MajorTopicYN="N">Sepsis</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4821618</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>09</Day></PubMedPubDate><PubMedPubDate 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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SidaGhanaV1
| This area was generated with Dilib version V0.6.31. |  |