SidaGhanaV1, PubMed, Curation, bibRecord, 000175

Tenofovir is associated with increased tubular proteinuria and asymptomatic renal tubular dysfunction in Ghana.

Identifieur interne : 000175 ( PubMed/Curation ); précédent : 000174; suivant : 000176

Tenofovir is associated with increased tubular proteinuria and asymptomatic renal tubular dysfunction in Ghana.

Auteurs : David R. Chadwick [Royaume-Uni] ; Fred S. Sarfo [Ghana] ; Elaine S M. Kirk [Royaume-Uni] ; Dorcas Owusu [Ghana] ; George Bedu-Addo [Ghana] ; Victoria Parris [Royaume-Uni] ; Ann Lorraine Owusu [Royaume-Uni] ; Richard Phillips [Ghana]

Source :

BMC nephrology [ 1471-2369 ] ; 2015.

RBID : pubmed:26627687

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Antiviraux, Causalité, Comorbidité, Effets secondaires indésirables des médicaments (épidémiologie), Effets secondaires indésirables des médicaments (étiologie), Femelle, Ghana (épidémiologie), Humains, Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Maladies du rein (), Maladies du rein (épidémiologie), Mâle, Protéinurie (), Protéinurie (épidémiologie), Prévalence, Ténofovir (effets indésirables), Ténofovir (usage thérapeutique), Évaluation des risques.
MESH :
- effets indésirables : Agents antiVIH, Ténofovir.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH, Ténofovir.
- épidémiologie : Effets secondaires indésirables des médicaments, Ghana, Infections à VIH, Maladies du rein, Protéinurie.
- étiologie : Effets secondaires indésirables des médicaments.
- Adulte, Adulte d'âge moyen, Antiviraux, Causalité, Comorbidité, Femelle, Humains, Maladies du rein, Mâle, Protéinurie, Prévalence, Évaluation des risques.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Adult, Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiviral Agents, Causality, Comorbidity, Drug-Related Side Effects and Adverse Reactions (epidemiology), Drug-Related Side Effects and Adverse Reactions (etiology), Female, Ghana (epidemiology), HIV Infections (drug therapy), HIV Infections (epidemiology), Humans, Kidney Diseases (chemically induced), Kidney Diseases (epidemiology), Male, Middle Aged, Prevalence, Proteinuria (chemically induced), Proteinuria (epidemiology), Risk Assessment, Tenofovir (adverse effects), Tenofovir (therapeutic use).
MESH :
- chemical , adverse effects : Anti-HIV Agents, Tenofovir.
- chemical , therapeutic use : Anti-HIV Agents, Tenofovir.
- geographic , epidemiology : Ghana.
- chemically induced : Kidney Diseases, Proteinuria.
- drug therapy : HIV Infections.
- epidemiology : Drug-Related Side Effects and Adverse Reactions, HIV Infections, Kidney Diseases, Proteinuria.
- etiology : Drug-Related Side Effects and Adverse Reactions.
- Adult, Antiviral Agents, Causality, Comorbidity, Female, Humans, Male, Middle Aged, Prevalence, Risk Assessment.

Abstract

HIV infection is associated with increased risk of renal dysfunction, including tubular dysfunction (TD) related to antiretroviral therapy (ART). Tenofovir disoproxil fumarate (TDF) is becoming available for ART in sub-Saharan Africa, although data on its long-term safety there is limited. We aimed to study the prevalence of HIV-associated renal dysfunction in Ghana and explore associations between proteinuria or TD and potential risk factors, including TDF use.

DOI: 10.1186/s12882-015-0192-4
PubMed: 26627687

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<term>Anti-HIV Agents (adverse effects)</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>Antiviral Agents</term>
<term>Causality</term>
<term>Comorbidity</term>
<term>Drug-Related Side Effects and Adverse Reactions (epidemiology)</term>
<term>Drug-Related Side Effects and Adverse Reactions (etiology)</term>
<term>Female</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (epidemiology)</term>
<term>Humans</term>
<term>Kidney Diseases (chemically induced)</term>
<term>Kidney Diseases (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Proteinuria (chemically induced)</term>
<term>Proteinuria (epidemiology)</term>
<term>Risk Assessment</term>
<term>Tenofovir (adverse effects)</term>
<term>Tenofovir (therapeutic use)</term>
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<term>Adulte d'âge moyen</term>
<term>Agents antiVIH (effets indésirables)</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Antiviraux</term>
<term>Causalité</term>
<term>Comorbidité</term>
<term>Effets secondaires indésirables des médicaments (épidémiologie)</term>
<term>Effets secondaires indésirables des médicaments (étiologie)</term>
<term>Femelle</term>
<term>Ghana (épidémiologie)</term>
<term>Humains</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Maladies du rein ()</term>
<term>Maladies du rein (épidémiologie)</term>
<term>Mâle</term>
<term>Protéinurie ()</term>
<term>Protéinurie (épidémiologie)</term>
<term>Prévalence</term>
<term>Ténofovir (effets indésirables)</term>
<term>Ténofovir (usage thérapeutique)</term>
<term>Évaluation des risques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Tenofovir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Tenofovir</term>
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<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Kidney Diseases</term>
<term>Proteinuria</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents antiVIH</term>
<term>Ténofovir</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term>
<term>HIV Infections</term>
<term>Kidney Diseases</term>
<term>Proteinuria</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
<term>Ténofovir</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term>
<term>Ghana</term>
<term>Infections à VIH</term>
<term>Maladies du rein</term>
<term>Protéinurie</term>
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<term>Risk Assessment</term>
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<term>Maladies du rein</term>
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<front><div type="abstract" xml:lang="en">HIV infection is associated with increased risk of renal dysfunction, including tubular dysfunction (TD) related to antiretroviral therapy (ART). Tenofovir disoproxil fumarate (TDF) is becoming available for ART in sub-Saharan Africa, although data on its long-term safety there is limited. We aimed to study the prevalence of HIV-associated renal dysfunction in Ghana and explore associations between proteinuria or TD and potential risk factors, including TDF use.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26627687</PMID>
<DateCreated><Year>2015</Year>
<Month>12</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>06</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2369</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<PubDate><Year>2015</Year>
<Month>Dec</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>BMC nephrology</Title>
<ISOAbbreviation>BMC Nephrol</ISOAbbreviation>
</Journal>
<ArticleTitle>Tenofovir is associated with increased tubular proteinuria and asymptomatic renal tubular dysfunction in Ghana.</ArticleTitle>
<Pagination><MedlinePgn>195</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12882-015-0192-4</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">HIV infection is associated with increased risk of renal dysfunction, including tubular dysfunction (TD) related to antiretroviral therapy (ART). Tenofovir disoproxil fumarate (TDF) is becoming available for ART in sub-Saharan Africa, although data on its long-term safety there is limited. We aimed to study the prevalence of HIV-associated renal dysfunction in Ghana and explore associations between proteinuria or TD and potential risk factors, including TDF use.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A single-centre cross-sectional observational study of patients taking ART was undertaken. Creatinine clearance (CrCl) was calculated and proteinuria detected with dipsticks. Spot urinary albumin and protein:creatinine ratios (uACR/uPCR) were measured and further evidence of TD (defined as having two or more characteristic features) sought. Logistic regression analysis identified factors associated with proteinuria or TD.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In 330 patients, of whom 101 were taking TDF (median 20 months), the prevalence of CrCl < 60 ml/min/1.73 m(2), dipstick proteinuria and TD was 7 %, 37 % and 15 %. Factors associated with proteinuria were baseline CD4-count [aOR 0.86/100 cell increment (95 % CI, 0.74-0.99)] and TDF use [aOR 2.74 (95 % CI, 1.38-5.43)]. The only factor associated with TD was TDF use [aOR 3.43 (95 % CI, 1.10-10.69)]. In a subset with uPCR measurements, uPCRs were significantly higher in patients taking TDF than those on other drugs (10.8 vs. 5.7 mg/mmol, p < 0.001), and urinary albuin:protein ratios significantly lower (0.24 vs. 0.58, p < 0.001).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Both proteinuria and TD are common and associated with TDF use in Ghana. Further longitudinal studies to determine whether proteinuria, TD or TDF use are linked to progressive decline in renal function or other adverse outcomes are needed in Africa.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chadwick</LastName>
<ForeName>David R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo><Affiliation>Centre for Clinical Infection, James Cook University Hospital, Middlesbrough, TS4 3BW, UK. davidr.chadwick@stees.nhs.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sarfo</LastName>
<ForeName>Fred S</ForeName>
<Initials>FS</Initials>
<AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana. stephensarfo78@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana. stephensarfo78@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kirk</LastName>
<ForeName>Elaine S M</ForeName>
<Initials>ES</Initials>
<AffiliationInfo><Affiliation>Centre for Clinical Infection, James Cook University Hospital, Middlesbrough, TS4 3BW, UK. esmkirk@msn.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Owusu</LastName>
<ForeName>Dorcas</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana. dokidinks@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bedu-Addo</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana. gbeduaddo@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana. gbeduaddo@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Parris</LastName>
<ForeName>Victoria</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Centre for Clinical Infection, James Cook University Hospital, Middlesbrough, TS4 3BW, UK. victoria.parris@stees.nhs.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Owusu</LastName>
<ForeName>Ann Lorraine</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>University of Leicester, Leicester, UK. l_owusu44@hotmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Phillips</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana. rodamephillips@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana. rodamephillips@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MRC_MR/J01477X/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
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<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>12</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Nephrol</MedlineTA>
<NlmUniqueID>100967793</NlmUniqueID>
<ISSNLinking>1471-2369</ISSNLinking>
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<NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance>
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<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
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	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

Tenofovir is associated with increased tubular proteinuria and asymptomatic renal tubular dysfunction in Ghana.

Tenofovir is associated with increased tubular proteinuria and asymptomatic renal tubular dysfunction in Ghana.

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