SidaGhanaV1, PubMed, Curation, bibRecord, 000077

Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.

Identifieur interne : 000077 ( PubMed/Curation ); précédent : 000076; suivant : 000078

Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.

Auteurs : Omobolawa Kukoyi [États-Unis] ; Lorna Renner [Ghana] ; Jonathan Powell [États-Unis] ; Oliver Barry [États-Unis] ; Meghan Prin [États-Unis] ; Jonas Kusah [Ghana] ; Xiangyu Cong [États-Unis] ; Elijah Paintsil [États-Unis]

Source :

BMC infectious diseases [ 1471-2334 ] ; 2016.

RBID : pubmed:26843068

Descripteurs français

KwdFr :
- Adolescent, Antirétroviraux (usage thérapeutique), Charge virale (), Enfant, Enfant d'âge préscolaire, Femelle, Ghana (épidémiologie), Hospitalisation, Humains, Infections opportunistes, Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Morbidité, Mâle, Pédiatrie, Résultat thérapeutique, Virémie, Études longitudinales, Études prospectives.
MESH :
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- épidémiologie : Ghana, Infections à VIH.
- Adolescent, Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Hospitalisation, Humains, Infections opportunistes, Morbidité, Mâle, Pédiatrie, Résultat thérapeutique, Virémie, Études longitudinales, Études prospectives.

English descriptors

KwdEn :
- Adolescent, Anti-Retroviral Agents (therapeutic use), Child, Child, Preschool, Female, Ghana (epidemiology), HIV Infections (drug therapy), HIV Infections (epidemiology), Hospitalization, Humans, Longitudinal Studies, Male, Morbidity, Opportunistic Infections, Pediatrics, Prospective Studies, Treatment Outcome, Viral Load (drug effects), Viremia.
MESH :
- chemical , therapeutic use : Anti-Retroviral Agents.
- drug effects : Viral Load.
- drug therapy : HIV Infections.
- epidemiology : Ghana, HIV Infections.
- Adolescent, Child, Child, Preschool, Female, Hospitalization, Humans, Longitudinal Studies, Male, Morbidity, Opportunistic Infections, Pediatrics, Prospective Studies, Treatment Outcome, Viremia.

Abstract

HIV-infected children in sub-Saharan Africa may be at a high risk of staying on a failing first-line regimen and developing drug-resistance HIV variants due to lack of routine viral load monitoring. We investigated whether cumulative viral load, measured as viremia copy-years (VCY) could predict morbidity in a setting where viral load is not routinely monitored.

DOI: 10.1186/s12879-016-1402-9
PubMed: 26843068

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<term>Anti-Retroviral Agents (therapeutic use)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (epidemiology)</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Morbidity</term>
<term>Opportunistic Infections</term>
<term>Pediatrics</term>
<term>Prospective Studies</term>
<term>Treatment Outcome</term>
<term>Viral Load (drug effects)</term>
<term>Viremia</term>
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<term>Antirétroviraux (usage thérapeutique)</term>
<term>Charge virale ()</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Ghana (épidémiologie)</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Infections opportunistes</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Morbidité</term>
<term>Mâle</term>
<term>Pédiatrie</term>
<term>Résultat thérapeutique</term>
<term>Virémie</term>
<term>Études longitudinales</term>
<term>Études prospectives</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
<term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
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<term>Infections à VIH</term>
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<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Morbidity</term>
<term>Opportunistic Infections</term>
<term>Pediatrics</term>
<term>Prospective Studies</term>
<term>Treatment Outcome</term>
<term>Viremia</term>
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<term>Charge virale</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Infections opportunistes</term>
<term>Morbidité</term>
<term>Mâle</term>
<term>Pédiatrie</term>
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<front><div type="abstract" xml:lang="en">HIV-infected children in sub-Saharan Africa may be at a high risk of staying on a failing first-line regimen and developing drug-resistance HIV variants due to lack of routine viral load monitoring. We investigated whether cumulative viral load, measured as viremia copy-years (VCY) could predict morbidity in a setting where viral load is not routinely monitored.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26843068</PMID>
<DateCreated><Year>2016</Year>
<Month>02</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2334</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
<Day>03</Day>
</PubDate>
</JournalIssue>
<Title>BMC infectious diseases</Title>
<ISOAbbreviation>BMC Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.</ArticleTitle>
<Pagination><MedlinePgn>58</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12879-016-1402-9</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">HIV-infected children in sub-Saharan Africa may be at a high risk of staying on a failing first-line regimen and developing drug-resistance HIV variants due to lack of routine viral load monitoring. We investigated whether cumulative viral load, measured as viremia copy-years (VCY) could predict morbidity in a setting where viral load is not routinely monitored.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This was a single-center prospective observational longitudinal study of HIV-infected children initiating antiretroviral therapy (ART) at the Pediatric HIV/AIDS Care program at Korle-Bu Teaching Hospital in Accra, Ghana. The main outcome was morbidity measured as frequency of hospitalizations, opportunistic infections, and outpatient sick visits. The main explanatory variable was viral load measured as VCY.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The study included 140 children who initiated ART between September 2009 and May 2013 and had at least 2 viral load measurements. There were 184 hospitalizations, with pneumonia being the most common cause (22.8 %). A total of 102 opportunistic infections was documented, with tuberculosis being the most common opportunistic infection (68 %). A total of 823 outpatient sick visits was documented, with upper respiratory infections (14.2 %) being the most common cause. Forty-four percent of our study participants had >4 log10 VCY. Children in this sub-cohort had a higher frequency of sick visits compared with those with <4 log10 VCY (p = 0.03). Only 6.5 % of children with >4 log10 VCY had been identified as treatment failure using WHO clinical and immunological treatment failure criteria.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">High level of cumulative viral load may translate to virological failure and subsequent increased all-cause morbidity. Our finding of potential utility of VCY in pediatrics warrants further investigations. VCY may be a good alternate to routine viral load measurement as its determination may be less frequent and could be personalized to save cost.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kukoyi</LastName>
<ForeName>Omobolawa</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>From Duke University School of Medicine, Durham, NC, USA. mkukoyi1@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Renner</LastName>
<ForeName>Lorna</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>University of Ghana School of Medicine and Dentistry, Accra, Ghana. lorna.renner@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Powell</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Weill Cornell Medical College, New York, NY, USA. powell.jonathan@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barry</LastName>
<ForeName>Oliver</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. oliver.m.barry@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prin</LastName>
<ForeName>Meghan</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Columbia University, New York, NY, USA. Meghan.prin@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kusah</LastName>
<ForeName>Jonas</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>University of Ghana School of Medicine and Dentistry, Accra, Ghana. jonaskusah@yahoo.co.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cong</LastName>
<ForeName>Xiangyu</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Yale Center for Analytical Sciences, Yale School of Medicine, New Haven, CT, USA. tcgggg@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paintsil</LastName>
<ForeName>Elijah</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Departments of Pediatrics, Pharmacology & Public Health, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT, 06520, USA. elijah.paintsil@yale.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 HD074253</GrantID>
<Acronym>HD</Acronym>
<Agency>NICHD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<Acronym>HD</Acronym>
<Agency>NICHD NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>02</Month>
<Day>03</Day>
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</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Infect Dis</MedlineTA>
<NlmUniqueID>100968551</NlmUniqueID>
<ISSNLinking>1471-2334</ISSNLinking>
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<NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance>
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<MeshHeading><DescriptorName UI="D009017" MajorTopicYN="N">Morbidity</DescriptorName>
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<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
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<MeshHeading><DescriptorName UI="D014766" MajorTopicYN="N">Viremia</DescriptorName>
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	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.

Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.

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