Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.
Identifieur interne : 000784 ( PubMed/Corpus ); précédent : 000783; suivant : 000785Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.
Auteurs : Alexander J. Stockdale ; Mas Chaponda ; Apostolos Beloukas ; Richard Odame Phillips ; Philippa C. Matthews ; Athanasios Papadimitropoulos ; Simon King ; Laura Bonnett ; Anna Maria GerettiSource :
- The Lancet. Global health [ 2214-109X ] ; 2017.
Abstract
Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infection in people with chronic hepatitis B, leading to accelerated progression of liver disease. In sub-Saharan Africa, where HBsAg prevalence is higher than 8%, hepatitis D virus might represent an important additive cause of chronic liver disease. We aimed to establish the prevalence of hepatitis D virus among HBsAg-positive populations in sub-Saharan Africa.
DOI: 10.1016/S2214-109X(17)30298-X
PubMed: 28911765
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.</title><author><name sortKey="Stockdale, Alexander J" sort="Stockdale, Alexander J" uniqKey="Stockdale A" first="Alexander J" last="Stockdale">Alexander J. Stockdale</name><affiliation><nlm:affiliation>Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chaponda, Mas" sort="Chaponda, Mas" uniqKey="Chaponda M" first="Mas" last="Chaponda">Mas Chaponda</name><affiliation><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Beloukas, Apostolos" sort="Beloukas, Apostolos" uniqKey="Beloukas A" first="Apostolos" last="Beloukas">Apostolos Beloukas</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name><affiliation><nlm:affiliation>Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Matthews, Philippa C" sort="Matthews, Philippa C" uniqKey="Matthews P" first="Philippa C" last="Matthews">Philippa C. Matthews</name><affiliation><nlm:affiliation>University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Papadimitropoulos, Athanasios" sort="Papadimitropoulos, Athanasios" uniqKey="Papadimitropoulos A" first="Athanasios" last="Papadimitropoulos">Athanasios Papadimitropoulos</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="King, Simon" sort="King, Simon" uniqKey="King S" first="Simon" last="King">Simon King</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnett, Laura" sort="Bonnett, Laura" uniqKey="Bonnett L" first="Laura" last="Bonnett">Laura Bonnett</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Geretti, Anna Maria" sort="Geretti, Anna Maria" uniqKey="Geretti A" first="Anna Maria" last="Geretti">Anna Maria Geretti</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK. Electronic address: geretti@liverpool.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28911765</idno><idno type="pmid">28911765</idno><idno type="doi">10.1016/S2214-109X(17)30298-X</idno><idno type="wicri:Area/PubMed/Corpus">000784</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000784</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.</title><author><name sortKey="Stockdale, Alexander J" sort="Stockdale, Alexander J" uniqKey="Stockdale A" first="Alexander J" last="Stockdale">Alexander J. Stockdale</name><affiliation><nlm:affiliation>Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chaponda, Mas" sort="Chaponda, Mas" uniqKey="Chaponda M" first="Mas" last="Chaponda">Mas Chaponda</name><affiliation><nlm:affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Beloukas, Apostolos" sort="Beloukas, Apostolos" uniqKey="Beloukas A" first="Apostolos" last="Beloukas">Apostolos Beloukas</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name><affiliation><nlm:affiliation>Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Matthews, Philippa C" sort="Matthews, Philippa C" uniqKey="Matthews P" first="Philippa C" last="Matthews">Philippa C. Matthews</name><affiliation><nlm:affiliation>University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Papadimitropoulos, Athanasios" sort="Papadimitropoulos, Athanasios" uniqKey="Papadimitropoulos A" first="Athanasios" last="Papadimitropoulos">Athanasios Papadimitropoulos</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="King, Simon" sort="King, Simon" uniqKey="King S" first="Simon" last="King">Simon King</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnett, Laura" sort="Bonnett, Laura" uniqKey="Bonnett L" first="Laura" last="Bonnett">Laura Bonnett</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Liverpool, Liverpool, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Geretti, Anna Maria" sort="Geretti, Anna Maria" uniqKey="Geretti A" first="Anna Maria" last="Geretti">Anna Maria Geretti</name><affiliation><nlm:affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK. Electronic address: geretti@liverpool.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Lancet. Global health</title><idno type="eISSN">2214-109X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infection in people with chronic hepatitis B, leading to accelerated progression of liver disease. In sub-Saharan Africa, where HBsAg prevalence is higher than 8%, hepatitis D virus might represent an important additive cause of chronic liver disease. We aimed to establish the prevalence of hepatitis D virus among HBsAg-positive populations in sub-Saharan Africa.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28911765</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>15</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2214-109X</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>10</Issue><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Lancet. Global health</Title><ISOAbbreviation>Lancet Glob Health</ISOAbbreviation></Journal><ArticleTitle>Prevalence of hepatitis D virus infection in sub-Saharan Africa: a systematic review and meta-analysis.</ArticleTitle><Pagination><MedlinePgn>e992-e1003</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2214-109X(17)30298-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2214-109X(17)30298-X</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infection in people with chronic hepatitis B, leading to accelerated progression of liver disease. In sub-Saharan Africa, where HBsAg prevalence is higher than 8%, hepatitis D virus might represent an important additive cause of chronic liver disease. We aimed to establish the prevalence of hepatitis D virus among HBsAg-positive populations in sub-Saharan Africa.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We systematically reviewed studies of hepatitis D virus prevalence among HBsAg-positive populations in sub-Saharan Africa. We searched PubMed, Embase, and Scopus for papers published between Jan 1, 1995, and Aug 30, 2016, in which patient selection criteria and geographical setting were described. Search strings included sub-Saharan Africa, the countries therein, and permutations of hepatitis D virus. Cohort data were also added from HIV-positive populations in Malawi and Ghana. Populations undergoing assessment in liver disease clinics and those sampled from other populations (defined as general populations) were analysed. We did a meta-analysis with a DerSimonian-Laird random-effects model to calculate a pooled estimate of hepatitis D virus seroprevalence.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Of 374 studies identified by our search, 30 were included in our study, only eight of which included detection of hepatitis D virus RNA among anti-hepatitis D virus seropositive participants. In west Africa, the pooled seroprevalence of hepatitis D virus was 7·33% (95% CI 3·55-12·20) in general populations and 9·57% (2·31-20·43) in liver-disease populations. In central Africa, seroprevalence was 25·64% (12·09-42·00) in general populations and 37·77% (12·13-67·54) in liver-disease populations. In east and southern Africa, seroprevalence was 0·05% (0·00-1·78) in general populations. The odds ratio for anti-hepatitis D virus detection among HBsAg-positive patients with liver fibrosis or hepatocellular carcinoma was 5·24 (95% CI 2·74-10·01; p<0·0001) relative to asymptomatic controls.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Findings suggest localised clusters of hepatitis D virus endemicity across sub-Saharan Africa. Epidemiological data are needed from southern and east Africa, and from patients with established liver disease. Further studies should aim to define the reliability of hepatitis D virus testing methods, identify risk factors for transmission, and characterise the natural history of the infection in the region.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Wellcome Trust, Royal Society.</AbstractText><CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stockdale</LastName><ForeName>Alexander J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaponda</LastName><ForeName>Mas</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Translational Medicine, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beloukas</LastName><ForeName>Apostolos</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Richard Odame</ForeName><Initials>RO</Initials><AffiliationInfo><Affiliation>Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matthews</LastName><ForeName>Philippa C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>University of Oxford and Oxford University Hospitals NHS Foundation Trust, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papadimitropoulos</LastName><ForeName>Athanasios</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnett</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Liverpool, Liverpool, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geretti</LastName><ForeName>Anna Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Institute of Infection and Global Health, University of Liverpool, Liverpool, UK. Electronic address: geretti@liverpool.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Glob Health</MedlineTA><NlmUniqueID>101613665</NlmUniqueID><ISSNLinking>2214-109X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>04</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>07</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28911765</ArticleId><ArticleId IdType="pii">S2214-109X(17)30298-X</ArticleId><ArticleId IdType="doi">10.1016/S2214-109X(17)30298-X</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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