EBV-associated perianal Hodgkin's disease in an HIV-positive individual.
Identifieur interne : 000633 ( PubMed/Corpus ); précédent : 000632; suivant : 000634EBV-associated perianal Hodgkin's disease in an HIV-positive individual.
Auteurs : M. Sapp ; B. Perez-Ordonez ; F. Brenneman ; K. Imrie ; I. Morava-Protzner ; M S LimSource :
- American journal of hematology [ 0361-8609 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Anus Neoplasms (etiology), Anus Neoplasms (virology), Epstein-Barr Virus Infections (complications), Epstein-Barr Virus Infections (virology), Fatal Outcome, Ghana (ethnology), Hodgkin Disease (etiology), Hodgkin Disease (virology), Humans, Immunophenotyping, Lymphoma, AIDS-Related (complications), Lymphoma, AIDS-Related (virology), Male, Ontario, Rectal Neoplasms (etiology), Rectal Neoplasms (virology), Reed-Sternberg Cells (chemistry), Reed-Sternberg Cells (virology).
- MESH :
- geographic , ethnology : Ghana.
- chemistry : Reed-Sternberg Cells.
- complications : Epstein-Barr Virus Infections, Lymphoma, AIDS-Related.
- etiology : Anus Neoplasms, Hodgkin Disease, Rectal Neoplasms.
- virology : Anus Neoplasms, Epstein-Barr Virus Infections, Hodgkin Disease, Lymphoma, AIDS-Related, Rectal Neoplasms, Reed-Sternberg Cells.
- Adult, Fatal Outcome, Humans, Immunophenotyping, Male, Ontario.
Abstract
Hodgkin's disease (HD) has a higher incidence in HIV-positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable histological type with large numbers of neoplastic cells, and almost invariably harbors Epstein-Barr Virus (EBV). We describe a case of a 33-year-old HIV-positive man who presented with anal pain from a 4-cm mass in the anorectal canal. He had no B symptoms or peripheral lymphadenopathy. A chest X-ray was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed-Sternberg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positive for EBV RNA using the EBER-1 probe. This highly unusual presentation of HD may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV-positive population.
DOI: 10.1002/1096-8652(200101)66:1<42::AID-AJH1006>3.0.CO;2-V
PubMed: 11426491
Links to Exploration step
pubmed:11426491Le document en format XML
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<author><name sortKey="Sapp, M" sort="Sapp, M" uniqKey="Sapp M" first="M" last="Sapp">M. Sapp</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada.</nlm:affiliation>
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<author><name sortKey="Perez Ordonez, B" sort="Perez Ordonez, B" uniqKey="Perez Ordonez B" first="B" last="Perez-Ordonez">B. Perez-Ordonez</name>
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<author><name sortKey="Brenneman, F" sort="Brenneman, F" uniqKey="Brenneman F" first="F" last="Brenneman">F. Brenneman</name>
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<author><name sortKey="Imrie, K" sort="Imrie, K" uniqKey="Imrie K" first="K" last="Imrie">K. Imrie</name>
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<author><name sortKey="Morava Protzner, I" sort="Morava Protzner, I" uniqKey="Morava Protzner I" first="I" last="Morava-Protzner">I. Morava-Protzner</name>
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<author><name sortKey="Lim, M S" sort="Lim, M S" uniqKey="Lim M" first="M S" last="Lim">M S Lim</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">EBV-associated perianal Hodgkin's disease in an HIV-positive individual.</title>
<author><name sortKey="Sapp, M" sort="Sapp, M" uniqKey="Sapp M" first="M" last="Sapp">M. Sapp</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada.</nlm:affiliation>
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<author><name sortKey="Perez Ordonez, B" sort="Perez Ordonez, B" uniqKey="Perez Ordonez B" first="B" last="Perez-Ordonez">B. Perez-Ordonez</name>
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<author><name sortKey="Imrie, K" sort="Imrie, K" uniqKey="Imrie K" first="K" last="Imrie">K. Imrie</name>
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<author><name sortKey="Morava Protzner, I" sort="Morava Protzner, I" uniqKey="Morava Protzner I" first="I" last="Morava-Protzner">I. Morava-Protzner</name>
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<author><name sortKey="Lim, M S" sort="Lim, M S" uniqKey="Lim M" first="M S" last="Lim">M S Lim</name>
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<series><title level="j">American journal of hematology</title>
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<term>Epstein-Barr Virus Infections (complications)</term>
<term>Epstein-Barr Virus Infections (virology)</term>
<term>Fatal Outcome</term>
<term>Ghana (ethnology)</term>
<term>Hodgkin Disease (etiology)</term>
<term>Hodgkin Disease (virology)</term>
<term>Humans</term>
<term>Immunophenotyping</term>
<term>Lymphoma, AIDS-Related (complications)</term>
<term>Lymphoma, AIDS-Related (virology)</term>
<term>Male</term>
<term>Ontario</term>
<term>Rectal Neoplasms (etiology)</term>
<term>Rectal Neoplasms (virology)</term>
<term>Reed-Sternberg Cells (chemistry)</term>
<term>Reed-Sternberg Cells (virology)</term>
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<keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Ghana</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Reed-Sternberg Cells</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Epstein-Barr Virus Infections</term>
<term>Lymphoma, AIDS-Related</term>
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<term>Hodgkin Disease</term>
<term>Rectal Neoplasms</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Anus Neoplasms</term>
<term>Epstein-Barr Virus Infections</term>
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<term>Lymphoma, AIDS-Related</term>
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<term>Fatal Outcome</term>
<term>Humans</term>
<term>Immunophenotyping</term>
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<front><div type="abstract" xml:lang="en">Hodgkin's disease (HD) has a higher incidence in HIV-positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable histological type with large numbers of neoplastic cells, and almost invariably harbors Epstein-Barr Virus (EBV). We describe a case of a 33-year-old HIV-positive man who presented with anal pain from a 4-cm mass in the anorectal canal. He had no B symptoms or peripheral lymphadenopathy. A chest X-ray was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed-Sternberg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positive for EBV RNA using the EBER-1 probe. This highly unusual presentation of HD may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV-positive population.</div>
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<DateCompleted><Year>2001</Year>
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<Title>American journal of hematology</Title>
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<ArticleTitle>EBV-associated perianal Hodgkin's disease in an HIV-positive individual.</ArticleTitle>
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<Abstract><AbstractText>Hodgkin's disease (HD) has a higher incidence in HIV-positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable histological type with large numbers of neoplastic cells, and almost invariably harbors Epstein-Barr Virus (EBV). We describe a case of a 33-year-old HIV-positive man who presented with anal pain from a 4-cm mass in the anorectal canal. He had no B symptoms or peripheral lymphadenopathy. A chest X-ray was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed-Sternberg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positive for EBV RNA using the EBER-1 probe. This highly unusual presentation of HD may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV-positive population.</AbstractText>
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