Evaluation of a commercial immunodiagnostic kit incorporating lipoarabinomannan in the serodiagnosis of pulmonary tuberculosis in Ghana.
Identifieur interne : 000589 ( PubMed/Corpus ); précédent : 000588; suivant : 000590Evaluation of a commercial immunodiagnostic kit incorporating lipoarabinomannan in the serodiagnosis of pulmonary tuberculosis in Ghana.
Auteurs : S D Lawn ; E H Frimpong ; E. NyarkoSource :
- Tropical medicine & international health : TM & IH [ 1360-2276 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
- chemical : Antigens, Bacterial, Lipopolysaccharides, Reagent Kits, Diagnostic.
- geographic : Ghana.
- complications : HIV Seropositivity, Tuberculosis, Pulmonary.
- diagnosis : Tuberculosis, Pulmonary.
- immunology : Mycobacterium.
- Adult, Humans, Male, Sensitivity and Specificity.
Abstract
We evaluated 'Mycodot', a commercially marketed immunodiagnostic test for tuberculosis which detects antibodies to lipoarabinomannan antigen. Serum was tested from 52 patients with newly diagnosed smear-positive pulmonary tuberculosis, of whom 20 were HIV-positive and 32 HIV-negative. Control sera were taken from 40 patients of whom 20 had acute non-tuberculous lobar pneumonia and 20 patients had no respiratory disease. The test was found to have a very high specificity of 97.5% (95% CI:92.5-100%). However, the sensitivity in HIV-negative patients was 56% (95% CI:39-73%), and was substantially lower at 25% (95% CI:6-44%) in HIV-positive patients.
PubMed: 9357487
Links to Exploration step
pubmed:9357487Le document en format XML
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<author><name sortKey="Lawn, S D" sort="Lawn, S D" uniqKey="Lawn S" first="S D" last="Lawn">S D Lawn</name>
<affiliation><nlm:affiliation>Department of Medicine, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana.</nlm:affiliation>
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<author><name sortKey="Frimpong, E H" sort="Frimpong, E H" uniqKey="Frimpong E" first="E H" last="Frimpong">E H Frimpong</name>
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<author><name sortKey="Nyarko, E" sort="Nyarko, E" uniqKey="Nyarko E" first="E" last="Nyarko">E. Nyarko</name>
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<author><name sortKey="Frimpong, E H" sort="Frimpong, E H" uniqKey="Frimpong E" first="E H" last="Frimpong">E H Frimpong</name>
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<author><name sortKey="Nyarko, E" sort="Nyarko, E" uniqKey="Nyarko E" first="E" last="Nyarko">E. Nyarko</name>
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<series><title level="j">Tropical medicine & international health : TM & IH</title>
<idno type="ISSN">1360-2276</idno>
<imprint><date when="1997" type="published">1997</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antigens, Bacterial</term>
<term>Ghana</term>
<term>HIV Seropositivity (complications)</term>
<term>Humans</term>
<term>Lipopolysaccharides</term>
<term>Male</term>
<term>Mycobacterium (immunology)</term>
<term>Reagent Kits, Diagnostic</term>
<term>Sensitivity and Specificity</term>
<term>Tuberculosis, Pulmonary (complications)</term>
<term>Tuberculosis, Pulmonary (diagnosis)</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antigens, Bacterial</term>
<term>Lipopolysaccharides</term>
<term>Reagent Kits, Diagnostic</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Seropositivity</term>
<term>Tuberculosis, Pulmonary</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Tuberculosis, Pulmonary</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Mycobacterium</term>
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<front><div type="abstract" xml:lang="en">We evaluated 'Mycodot', a commercially marketed immunodiagnostic test for tuberculosis which detects antibodies to lipoarabinomannan antigen. Serum was tested from 52 patients with newly diagnosed smear-positive pulmonary tuberculosis, of whom 20 were HIV-positive and 32 HIV-negative. Control sera were taken from 40 patients of whom 20 had acute non-tuberculous lobar pneumonia and 20 patients had no respiratory disease. The test was found to have a very high specificity of 97.5% (95% CI:92.5-100%). However, the sensitivity in HIV-negative patients was 56% (95% CI:39-73%), and was substantially lower at 25% (95% CI:6-44%) in HIV-positive patients.</div>
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<DateCreated><Year>1997</Year>
<Month>12</Month>
<Day>02</Day>
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<DateCompleted><Year>1997</Year>
<Month>12</Month>
<Day>02</Day>
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<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">1360-2276</ISSN>
<JournalIssue CitedMedium="Print"><Volume>2</Volume>
<Issue>10</Issue>
<PubDate><Year>1997</Year>
<Month>Oct</Month>
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<Title>Tropical medicine & international health : TM & IH</Title>
<ISOAbbreviation>Trop. Med. Int. Health</ISOAbbreviation>
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<ArticleTitle>Evaluation of a commercial immunodiagnostic kit incorporating lipoarabinomannan in the serodiagnosis of pulmonary tuberculosis in Ghana.</ArticleTitle>
<Pagination><MedlinePgn>978-81</MedlinePgn>
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<Abstract><AbstractText Label="UNLABELLED">We evaluated 'Mycodot', a commercially marketed immunodiagnostic test for tuberculosis which detects antibodies to lipoarabinomannan antigen. Serum was tested from 52 patients with newly diagnosed smear-positive pulmonary tuberculosis, of whom 20 were HIV-positive and 32 HIV-negative. Control sera were taken from 40 patients of whom 20 had acute non-tuberculous lobar pneumonia and 20 patients had no respiratory disease. The test was found to have a very high specificity of 97.5% (95% CI:92.5-100%). However, the sensitivity in HIV-negative patients was 56% (95% CI:39-73%), and was substantially lower at 25% (95% CI:6-44%) in HIV-positive patients.</AbstractText>
<AbstractText Label="IN CONCLUSION" NlmCategory="CONCLUSIONS">'Mycodot' was found to be a highly specific and easily performed assay. However, the poor sensitivity, especially in HIV-infected patients, renders it unlikely to be useful either as a primary or adjunctive diagnostic test for tuberculosis, particularly in countries with a high prevalence of HIV. A larger trial of this assay in Ghana was not deemed necessary.</AbstractText>
</Abstract>
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<AffiliationInfo><Affiliation>Department of Medicine, School of Medical Sciences, University of Science and Technology, Kumasi, Ghana.</Affiliation>
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<Author ValidYN="Y"><LastName>Frimpong</LastName>
<ForeName>E H</ForeName>
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<Author ValidYN="Y"><LastName>Nyarko</LastName>
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<NameOfSubstance UI="C050016">lipoarabinomannan</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D000942" MajorTopicYN="Y">Antigens, Bacterial</DescriptorName>
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<MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D009161" MajorTopicYN="N">Mycobacterium</DescriptorName>
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<MeshHeading><DescriptorName UI="D011933" MajorTopicYN="Y">Reagent Kits, Diagnostic</DescriptorName>
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<MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
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<MeshHeading><DescriptorName UI="D014397" MajorTopicYN="N">Tuberculosis, Pulmonary</DescriptorName>
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<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
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