Genomic divergence of an HIV-2 from a German AIDS patient probably infected in Mali.
Identifieur interne : 000535 ( PubMed/Corpus ); précédent : 000534; suivant : 000536Genomic divergence of an HIV-2 from a German AIDS patient probably infected in Mali.
Auteurs : F. Kirchhoff ; K D Jentsch ; A. Stuke ; J. Mous ; G. HunsmannSource :
- AIDS (London, England) [ 0269-9370 ] ; 1990.
English descriptors
- KwdEn :
- Acquired Immunodeficiency Syndrome (microbiology), Amino Acid Sequence, Base Sequence, Gene Products, env (chemistry), Gene Products, env (genetics), Gene Products, gag (chemistry), Gene Products, gag (genetics), Gene Products, nef (chemistry), Gene Products, nef (genetics), Gene Products, pol (chemistry), Gene Products, pol (genetics), Genetic Variation, HIV-2 (classification), HIV-2 (genetics), Humans, Mali, Molecular Sequence Data, Phylogeny, Repetitive Sequences, Nucleic Acid, Sequence Alignment, Sequence Homology, Nucleic Acid, Simian Immunodeficiency Virus (genetics), Viral Regulatory and Accessory Proteins (chemistry), Viral Regulatory and Accessory Proteins (genetics), nef Gene Products, Human Immunodeficiency Virus.
- MESH :
- chemical , chemistry : Gene Products, env, Gene Products, gag, Gene Products, nef, Gene Products, pol, Viral Regulatory and Accessory Proteins.
- chemical , genetics : Gene Products, env, Gene Products, gag, Gene Products, nef, Gene Products, pol, Viral Regulatory and Accessory Proteins.
- geographic : Mali, nef Gene Products, Human Immunodeficiency Virus.
- classification : HIV-2.
- genetics : HIV-2, Simian Immunodeficiency Virus.
- microbiology : Acquired Immunodeficiency Syndrome.
- Amino Acid Sequence, Base Sequence, Genetic Variation, Humans, Molecular Sequence Data, Phylogeny, Repetitive Sequences, Nucleic Acid, Sequence Alignment, Sequence Homology, Nucleic Acid.
Abstract
The complete nucleotide sequence of an HIV-2 isolate derived from a German AIDS patient with predominantly neurological symptoms is reported. The HIV-2BEN sequence is highly divergent from those of previously described HIV-2 and SIV strains. Evolutionary tree analysis of eight HIV-2 sequences reveals the existence of three HIV-2 groups. HIV-2BEN belongs to a group with two isolates from Ghana and The Gambia. Based on a comparison of HIV-2BEN with six HIV-2 isolates, SIVsmm and SIVmac, the variability of the structural env and gag proteins is similar within the HIV-2/SIVsmm/mac and HIV-1 groups. In contrast, the regulatory HIV-1 proteins are more highly conserved than those from HIV-2 strains. Multiple sequence alignments reveal that some domains of the envelope and regulatory proteins are well conserved among HIV-1, HIV-2/SIVsmm/mac, SIVagm and SIVmnd. The identification of conserved domains within the external glycoprotein could help to develop broadly active vaccines.
PubMed: 2252559
Links to Exploration step
pubmed:2252559Le document en format XML
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<affiliation><nlm:affiliation>German Primate Center, Department of Virology and Immunology, Göttingen.</nlm:affiliation>
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<author><name sortKey="Jentsch, K D" sort="Jentsch, K D" uniqKey="Jentsch K" first="K D" last="Jentsch">K D Jentsch</name>
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<author><name sortKey="Stuke, A" sort="Stuke, A" uniqKey="Stuke A" first="A" last="Stuke">A. Stuke</name>
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<author><name sortKey="Mous, J" sort="Mous, J" uniqKey="Mous J" first="J" last="Mous">J. Mous</name>
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<author><name sortKey="Hunsmann, G" sort="Hunsmann, G" uniqKey="Hunsmann G" first="G" last="Hunsmann">G. Hunsmann</name>
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<term>Gene Products, env (genetics)</term>
<term>Gene Products, gag (chemistry)</term>
<term>Gene Products, gag (genetics)</term>
<term>Gene Products, nef (chemistry)</term>
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<term>HIV-2 (classification)</term>
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<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Repetitive Sequences, Nucleic Acid</term>
<term>Sequence Alignment</term>
<term>Sequence Homology, Nucleic Acid</term>
<term>Simian Immunodeficiency Virus (genetics)</term>
<term>Viral Regulatory and Accessory Proteins (chemistry)</term>
<term>Viral Regulatory and Accessory Proteins (genetics)</term>
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<term>Gene Products, pol</term>
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<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
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<front><div type="abstract" xml:lang="en">The complete nucleotide sequence of an HIV-2 isolate derived from a German AIDS patient with predominantly neurological symptoms is reported. The HIV-2BEN sequence is highly divergent from those of previously described HIV-2 and SIV strains. Evolutionary tree analysis of eight HIV-2 sequences reveals the existence of three HIV-2 groups. HIV-2BEN belongs to a group with two isolates from Ghana and The Gambia. Based on a comparison of HIV-2BEN with six HIV-2 isolates, SIVsmm and SIVmac, the variability of the structural env and gag proteins is similar within the HIV-2/SIVsmm/mac and HIV-1 groups. In contrast, the regulatory HIV-1 proteins are more highly conserved than those from HIV-2 strains. Multiple sequence alignments reveal that some domains of the envelope and regulatory proteins are well conserved among HIV-1, HIV-2/SIVsmm/mac, SIVagm and SIVmnd. The identification of conserved domains within the external glycoprotein could help to develop broadly active vaccines.</div>
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<Abstract><AbstractText>The complete nucleotide sequence of an HIV-2 isolate derived from a German AIDS patient with predominantly neurological symptoms is reported. The HIV-2BEN sequence is highly divergent from those of previously described HIV-2 and SIV strains. Evolutionary tree analysis of eight HIV-2 sequences reveals the existence of three HIV-2 groups. HIV-2BEN belongs to a group with two isolates from Ghana and The Gambia. Based on a comparison of HIV-2BEN with six HIV-2 isolates, SIVsmm and SIVmac, the variability of the structural env and gag proteins is similar within the HIV-2/SIVsmm/mac and HIV-1 groups. In contrast, the regulatory HIV-1 proteins are more highly conserved than those from HIV-2 strains. Multiple sequence alignments reveal that some domains of the envelope and regulatory proteins are well conserved among HIV-1, HIV-2/SIVsmm/mac, SIVagm and SIVmnd. The identification of conserved domains within the external glycoprotein could help to develop broadly active vaccines.</AbstractText>
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