HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Identifieur interne : 000465 ( PubMed/Corpus ); précédent : 000464; suivant : 000466HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Auteurs : Timothy Na Archampong ; Ceejay L. Boyce ; Margaret Lartey ; Kwamena W. Sagoe ; Adjoa Obo-Akwa ; Ernest Kenu ; Jason T. Blackard ; Awewura KwaraSource :
- Antiviral therapy [ 2040-2058 ] ; 2017.
Abstract
The presence of HBV resistance mutations upon initiation or during antiretroviral therapy (ART) in HIV-coinfected patients is an important determinant of treatment response. The main objective of the study was to determine the prevalence of HBV resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected Ghanaian patients with detectable HBV viraemia.
DOI: 10.3851/IMP3055
PubMed: 27167598
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.</title><author><name sortKey="Archampong, Timothy Na" sort="Archampong, Timothy Na" uniqKey="Archampong T" first="Timothy Na" last="Archampong">Timothy Na Archampong</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Boyce, Ceejay L" sort="Boyce, Ceejay L" uniqKey="Boyce C" first="Ceejay L" last="Boyce">Ceejay L. Boyce</name><affiliation><nlm:affiliation>Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Sagoe, Kwamena W" sort="Sagoe, Kwamena W" uniqKey="Sagoe K" first="Kwamena W" last="Sagoe">Kwamena W. Sagoe</name><affiliation><nlm:affiliation>Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Obo Akwa, Adjoa" sort="Obo Akwa, Adjoa" uniqKey="Obo Akwa A" first="Adjoa" last="Obo-Akwa">Adjoa Obo-Akwa</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Kenu, Ernest" sort="Kenu, Ernest" uniqKey="Kenu E" first="Ernest" last="Kenu">Ernest Kenu</name><affiliation><nlm:affiliation>Korle-Bu Teaching Hospital, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Blackard, Jason T" sort="Blackard, Jason T" uniqKey="Blackard J" first="Jason T" last="Blackard">Jason T. Blackard</name><affiliation><nlm:affiliation>Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kwara, Awewura" sort="Kwara, Awewura" uniqKey="Kwara A" first="Awewura" last="Kwara">Awewura Kwara</name><affiliation><nlm:affiliation>Warren Alpert Medical School of Brown University, Providence, RI, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27167598</idno><idno type="pmid">27167598</idno><idno type="doi">10.3851/IMP3055</idno><idno type="wicri:Area/PubMed/Corpus">000465</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000465</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.</title><author><name sortKey="Archampong, Timothy Na" sort="Archampong, Timothy Na" uniqKey="Archampong T" first="Timothy Na" last="Archampong">Timothy Na Archampong</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Boyce, Ceejay L" sort="Boyce, Ceejay L" uniqKey="Boyce C" first="Ceejay L" last="Boyce">Ceejay L. Boyce</name><affiliation><nlm:affiliation>Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Sagoe, Kwamena W" sort="Sagoe, Kwamena W" uniqKey="Sagoe K" first="Kwamena W" last="Sagoe">Kwamena W. Sagoe</name><affiliation><nlm:affiliation>Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Obo Akwa, Adjoa" sort="Obo Akwa, Adjoa" uniqKey="Obo Akwa A" first="Adjoa" last="Obo-Akwa">Adjoa Obo-Akwa</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Kenu, Ernest" sort="Kenu, Ernest" uniqKey="Kenu E" first="Ernest" last="Kenu">Ernest Kenu</name><affiliation><nlm:affiliation>Korle-Bu Teaching Hospital, Accra, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Blackard, Jason T" sort="Blackard, Jason T" uniqKey="Blackard J" first="Jason T" last="Blackard">Jason T. Blackard</name><affiliation><nlm:affiliation>Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kwara, Awewura" sort="Kwara, Awewura" uniqKey="Kwara A" first="Awewura" last="Kwara">Awewura Kwara</name><affiliation><nlm:affiliation>Warren Alpert Medical School of Brown University, Providence, RI, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Antiviral therapy</title><idno type="eISSN">2040-2058</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The presence of HBV resistance mutations upon initiation or during antiretroviral therapy (ART) in HIV-coinfected patients is an important determinant of treatment response. The main objective of the study was to determine the prevalence of HBV resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected Ghanaian patients with detectable HBV viraemia.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27167598</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>03</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>1</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Antiviral therapy</Title><ISOAbbreviation>Antivir. Ther. (Lond.)</ISOAbbreviation></Journal><ArticleTitle>HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.</ArticleTitle><Pagination><MedlinePgn>13-20</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3851/IMP3055</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The presence of HBV resistance mutations upon initiation or during antiretroviral therapy (ART) in HIV-coinfected patients is an important determinant of treatment response. The main objective of the study was to determine the prevalence of HBV resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected Ghanaian patients with detectable HBV viraemia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">HBV-HIV-coinfected patients who were ART-naive or had received at least 9 months of lamivudine (3TC)-containing ART were enrolled in a cross-sectional study. Demographic and clinical data were collected and HBV DNA quantified. Partial HBV sequences were amplified by PCR and sequenced bi-directionally to obtain a 2.1-2.2 kb fragment for phylogenetic analysis of HBV genotypes and evaluation of drug resistance mutations.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 100 HBV-HIV-coinfected study patients, 75 were successfully PCR-amplified, and 63 were successfully sequenced. Of these 63 patients, 27 (42.9%) were ART-experienced and 58 (92.1%) had HBV genotype E. No resistance mutations were observed in the 36 ART-naive patients, while 21 (77.8%) of 27 treatment-experienced patients had resistance mutations. All patients with resistance mutations had no tenofovir in their regimens, and 80% of them had HIV RNA <40 copies/ml. The 3TC resistance mutations rtL180M and rtM204V were observed in 10 (47.6%) of the 21 patients, while 5 patients (23.8%) had rtV173L, rtL180M and rtM204V mutations.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A high proportion of HBV-HIV-coinfected patients with detectable viraemia on 3TC-containing ART had resistance mutations despite good ART adherence as determined by HIV RNA suppression. This study emphasizes the need for dual therapy as part of a fully suppressive ART in all HBV-HIV-coinfected patients in Ghana.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Archampong</LastName><ForeName>Timothy Na</ForeName><Initials>TN</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Korle-Bu Teaching Hospital, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyce</LastName><ForeName>Ceejay L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lartey</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Korle-Bu Teaching Hospital, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sagoe</LastName><ForeName>Kwamena W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obo-Akwa</LastName><ForeName>Adjoa</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kenu</LastName><ForeName>Ernest</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Korle-Bu Teaching Hospital, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blackard</LastName><ForeName>Jason T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwara</LastName><ForeName>Awewura</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Warren Alpert Medical School of Brown University, Providence, RI, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Miriam Hospital, Providence, RI, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>D43 TW000237</GrantID><Acronym>TW</Acronym><Agency>FIC NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>D43 TW010055</GrantID><Acronym>TW</Acronym><Agency>FIC NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AI042853</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Antivir Ther</MedlineTA><NlmUniqueID>9815705</NlmUniqueID><ISSNLinking>1359-6535</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Viral Hepat. 2007 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