Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil.
Identifieur interne : 000408 ( PubMed/Corpus ); précédent : 000407; suivant : 000409Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil.
Auteurs : Edson Delatorre ; Carlos A. Velasco-De-Castro ; José H. Pilotto ; José Carlos Couto-Fernandez ; Gonzalo Bello ; Mariza G. MorgadoSource :
- AIDS research and human retroviruses [ 1931-8405 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Africa (epidemiology), Brazil (epidemiology), Cluster Analysis, Computational Biology, Female, Genotype, HIV Infections (epidemiology), HIV Infections (transmission), HIV Infections (virology), HIV-1 (classification), HIV-1 (genetics), HIV-1 (isolation & purification), Humans, Male, Molecular Epidemiology, Phylogeography, Pregnancy.
- MESH :
- geographic , epidemiology : Africa, Brazil.
- classification : HIV-1.
- epidemiology : HIV Infections.
- genetics : HIV-1.
- isolation & purification : HIV-1.
- transmission : HIV Infections.
- virology : HIV Infections.
- Adult, Cluster Analysis, Computational Biology, Female, Genotype, Humans, Male, Molecular Epidemiology, Phylogeography, Pregnancy.
Abstract
HIV-1 CRF02_AG is responsible for at least 8% of the HIV-1 infections worldwide and is distributed mainly in West Africa. CRF02_AG has recently been reported in countries where it is not native, including Brazil. In a previous study including 10 CRF02_AG Brazilian samples, we found at least four independent introductions and two autochthonous transmission networks of this clade in Brazil. As more CRF02_AG samples have been identified in Brazil, we performed a new phylogeographic analysis using a larger dataset than before. A total of 20 Brazilian (18 from Rio de Janeiro and two from São Paulo) and 1,485 African HIV-1 CRF02_AG pol sequences were analyzed using maximum likelihood (ML). The ML tree showed that the Brazilian sequences were distributed in five different lineages. The Bayesian phylogeographic analysis of the Brazilian and their most closely related African sequences (n = 212) placed the origin of all Brazilian lineages in West Africa, probably Ghana, Senegal, and Nigeria. Two monophyletic clades were identified, comprising only sequences from Rio de Janeiro, and their date of origin was estimated at around 1985 (95% highest posterior density: 1979-1992). These results support the existence of at least five independent introductions of the CRF02_AG lineage from West Africa into Brazil and further indicate that at least two of these lineages have been locally disseminated in the Rio de Janeiro state over the past 30 years.
DOI: 10.1089/aid.2015.0183
PubMed: 26353079
Links to Exploration step
pubmed:26353079Le document en format XML
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Velasco-De-Castro</name><affiliation><nlm:affiliation>2 Laboratório de Virologia, Departamento de Patologia Clínica, Instituto Nacional de Saúde da Mulher , da Criança e do Adolescente Fernandes Figueira-FIOCRUZ, Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Pilotto, Jose H" sort="Pilotto, Jose H" uniqKey="Pilotto J" first="José H" last="Pilotto">José H. Pilotto</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Bello, Gonzalo" sort="Bello, Gonzalo" uniqKey="Bello G" first="Gonzalo" last="Bello">Gonzalo Bello</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Morgado, Mariza G" sort="Morgado, Mariza G" uniqKey="Morgado M" first="Mariza G" last="Morgado">Mariza G. 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Velasco-De-Castro</name><affiliation><nlm:affiliation>2 Laboratório de Virologia, Departamento de Patologia Clínica, Instituto Nacional de Saúde da Mulher , da Criança e do Adolescente Fernandes Figueira-FIOCRUZ, Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Pilotto, Jose H" sort="Pilotto, Jose H" uniqKey="Pilotto J" first="José H" last="Pilotto">José H. Pilotto</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Couto Fernandez, Jose Carlos" sort="Couto Fernandez, Jose Carlos" uniqKey="Couto Fernandez J" first="José Carlos" last="Couto-Fernandez">José Carlos Couto-Fernandez</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Bello, Gonzalo" sort="Bello, Gonzalo" uniqKey="Bello G" first="Gonzalo" last="Bello">Gonzalo Bello</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author><author><name sortKey="Morgado, Mariza G" sort="Morgado, Mariza G" uniqKey="Morgado M" first="Mariza G" last="Morgado">Mariza G. Morgado</name><affiliation><nlm:affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</nlm:affiliation></affiliation></author></analytic><series><title level="j">AIDS research and human retroviruses</title><idno type="eISSN">1931-8405</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Africa (epidemiology)</term><term>Brazil (epidemiology)</term><term>Cluster Analysis</term><term>Computational Biology</term><term>Female</term><term>Genotype</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (transmission)</term><term>HIV Infections (virology)</term><term>HIV-1 (classification)</term><term>HIV-1 (genetics)</term><term>HIV-1 (isolation & purification)</term><term>Humans</term><term>Male</term><term>Molecular Epidemiology</term><term>Phylogeography</term><term>Pregnancy</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa</term><term>Brazil</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cluster Analysis</term><term>Computational Biology</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Molecular Epidemiology</term><term>Phylogeography</term><term>Pregnancy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV-1 CRF02_AG is responsible for at least 8% of the HIV-1 infections worldwide and is distributed mainly in West Africa. CRF02_AG has recently been reported in countries where it is not native, including Brazil. In a previous study including 10 CRF02_AG Brazilian samples, we found at least four independent introductions and two autochthonous transmission networks of this clade in Brazil. As more CRF02_AG samples have been identified in Brazil, we performed a new phylogeographic analysis using a larger dataset than before. A total of 20 Brazilian (18 from Rio de Janeiro and two from São Paulo) and 1,485 African HIV-1 CRF02_AG pol sequences were analyzed using maximum likelihood (ML). The ML tree showed that the Brazilian sequences were distributed in five different lineages. The Bayesian phylogeographic analysis of the Brazilian and their most closely related African sequences (n = 212) placed the origin of all Brazilian lineages in West Africa, probably Ghana, Senegal, and Nigeria. Two monophyletic clades were identified, comprising only sequences from Rio de Janeiro, and their date of origin was estimated at around 1985 (95% highest posterior density: 1979-1992). These results support the existence of at least five independent introductions of the CRF02_AG lineage from West Africa into Brazil and further indicate that at least two of these lineages have been locally disseminated in the Rio de Janeiro state over the past 30 years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26353079</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>25</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>29</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1931-8405</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>AIDS research and human retroviruses</Title><ISOAbbreviation>AIDS Res. Hum. Retroviruses</ISOAbbreviation></Journal><ArticleTitle>Short Communication: Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil.</ArticleTitle><Pagination><MedlinePgn>1230-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/aid.2015.0183</ELocationID><Abstract><AbstractText>HIV-1 CRF02_AG is responsible for at least 8% of the HIV-1 infections worldwide and is distributed mainly in West Africa. CRF02_AG has recently been reported in countries where it is not native, including Brazil. In a previous study including 10 CRF02_AG Brazilian samples, we found at least four independent introductions and two autochthonous transmission networks of this clade in Brazil. As more CRF02_AG samples have been identified in Brazil, we performed a new phylogeographic analysis using a larger dataset than before. A total of 20 Brazilian (18 from Rio de Janeiro and two from São Paulo) and 1,485 African HIV-1 CRF02_AG pol sequences were analyzed using maximum likelihood (ML). The ML tree showed that the Brazilian sequences were distributed in five different lineages. The Bayesian phylogeographic analysis of the Brazilian and their most closely related African sequences (n = 212) placed the origin of all Brazilian lineages in West Africa, probably Ghana, Senegal, and Nigeria. Two monophyletic clades were identified, comprising only sequences from Rio de Janeiro, and their date of origin was estimated at around 1985 (95% highest posterior density: 1979-1992). These results support the existence of at least five independent introductions of the CRF02_AG lineage from West Africa into Brazil and further indicate that at least two of these lineages have been locally disseminated in the Rio de Janeiro state over the past 30 years.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Delatorre</LastName><ForeName>Edson</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Velasco-De-Castro</LastName><ForeName>Carlos A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>2 Laboratório de Virologia, Departamento de Patologia Clínica, Instituto Nacional de Saúde da Mulher , da Criança e do Adolescente Fernandes Figueira-FIOCRUZ, Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pilotto</LastName><ForeName>José H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>3 Hospital Geral de Nova Iguaçu , Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couto-Fernandez</LastName><ForeName>José Carlos</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bello</LastName><ForeName>Gonzalo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morgado</LastName><ForeName>Mariza G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>1 Laboratório de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz-FIOCRUZ , Rio de Janeiro, Brazil .</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>AIDS Res Hum Retroviruses</MedlineTA><NlmUniqueID>8709376</NlmUniqueID><ISSNLinking>0889-2229</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26353079</ArticleId><ArticleId IdType="doi">10.1089/aid.2015.0183</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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