SidaGhanaV1, PubMed, Corpus, bibRecord, 000348

High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians.

Identifieur interne : 000348 ( PubMed/Corpus ); précédent : 000347; suivant : 000349

High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians.

Auteurs : Fred S. Sarfo ; Rosie Keegan ; Lambert Appiah ; Shaid Shakoor ; Richard Phillips ; Betty Norman ; Yasmin Hardy ; George Bedu-Addo ; Lydia Longstaff ; David R. Chadwick

Source :

The Journal of infection [ 1532-2742 ] ; 2013.

RBID : pubmed:23542785

English descriptors

KwdEn :
- Adult, Female, Ghana (epidemiology), Glomerular Filtration Rate, HIV Infections (complications), HIV Infections (mortality), Humans, Male, Metabolic Clearance Rate, Middle Aged, Prevalence, Renal Insufficiency (epidemiology), Renal Insufficiency (mortality), Risk Assessment, Survival Analysis.
MESH :
- geographic , epidemiology : Ghana.
- complications : HIV Infections.
- epidemiology : Renal Insufficiency.
- mortality : HIV Infections, Renal Insufficiency.
- Adult, Female, Glomerular Filtration Rate, Humans, Male, Metabolic Clearance Rate, Middle Aged, Prevalence, Risk Assessment, Survival Analysis.

Abstract

To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana.

DOI: 10.1016/j.jinf.2013.03.008
PubMed: 23542785

Links to Exploration step

pubmed:23542785

Le document en format XML

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<author><name sortKey="Sarfo, Fred S" sort="Sarfo, Fred S" uniqKey="Sarfo F" first="Fred S" last="Sarfo">Fred S. Sarfo</name>
<affiliation><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Keegan, Rosie" sort="Keegan, Rosie" uniqKey="Keegan R" first="Rosie" last="Keegan">Rosie Keegan</name>
</author>
<author><name sortKey="Appiah, Lambert" sort="Appiah, Lambert" uniqKey="Appiah L" first="Lambert" last="Appiah">Lambert Appiah</name>
</author>
<author><name sortKey="Shakoor, Shaid" sort="Shakoor, Shaid" uniqKey="Shakoor S" first="Shaid" last="Shakoor">Shaid Shakoor</name>
</author>
<author><name sortKey="Phillips, Richard" sort="Phillips, Richard" uniqKey="Phillips R" first="Richard" last="Phillips">Richard Phillips</name>
</author>
<author><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name>
</author>
<author><name sortKey="Hardy, Yasmin" sort="Hardy, Yasmin" uniqKey="Hardy Y" first="Yasmin" last="Hardy">Yasmin Hardy</name>
</author>
<author><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name>
</author>
<author><name sortKey="Longstaff, Lydia" sort="Longstaff, Lydia" uniqKey="Longstaff L" first="Lydia" last="Longstaff">Lydia Longstaff</name>
</author>
<author><name sortKey="Chadwick, David R" sort="Chadwick, David R" uniqKey="Chadwick D" first="David R" last="Chadwick">David R. Chadwick</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians.</title>
<author><name sortKey="Sarfo, Fred S" sort="Sarfo, Fred S" uniqKey="Sarfo F" first="Fred S" last="Sarfo">Fred S. Sarfo</name>
<affiliation><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Keegan, Rosie" sort="Keegan, Rosie" uniqKey="Keegan R" first="Rosie" last="Keegan">Rosie Keegan</name>
</author>
<author><name sortKey="Appiah, Lambert" sort="Appiah, Lambert" uniqKey="Appiah L" first="Lambert" last="Appiah">Lambert Appiah</name>
</author>
<author><name sortKey="Shakoor, Shaid" sort="Shakoor, Shaid" uniqKey="Shakoor S" first="Shaid" last="Shakoor">Shaid Shakoor</name>
</author>
<author><name sortKey="Phillips, Richard" sort="Phillips, Richard" uniqKey="Phillips R" first="Richard" last="Phillips">Richard Phillips</name>
</author>
<author><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name>
</author>
<author><name sortKey="Hardy, Yasmin" sort="Hardy, Yasmin" uniqKey="Hardy Y" first="Yasmin" last="Hardy">Yasmin Hardy</name>
</author>
<author><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name>
</author>
<author><name sortKey="Longstaff, Lydia" sort="Longstaff, Lydia" uniqKey="Longstaff L" first="Lydia" last="Longstaff">Lydia Longstaff</name>
</author>
<author><name sortKey="Chadwick, David R" sort="Chadwick, David R" uniqKey="Chadwick D" first="David R" last="Chadwick">David R. Chadwick</name>
</author>
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<series><title level="j">The Journal of infection</title>
<idno type="eISSN">1532-2742</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Ghana (epidemiology)</term>
<term>Glomerular Filtration Rate</term>
<term>HIV Infections (complications)</term>
<term>HIV Infections (mortality)</term>
<term>Humans</term>
<term>Male</term>
<term>Metabolic Clearance Rate</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Renal Insufficiency (epidemiology)</term>
<term>Renal Insufficiency (mortality)</term>
<term>Risk Assessment</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Renal Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>HIV Infections</term>
<term>Renal Insufficiency</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Glomerular Filtration Rate</term>
<term>Humans</term>
<term>Male</term>
<term>Metabolic Clearance Rate</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Risk Assessment</term>
<term>Survival Analysis</term>
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<front><div type="abstract" xml:lang="en">To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23542785</PMID>
<DateCreated><Year>2013</Year>
<Month>06</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>12</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2742</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>67</Volume>
<Issue>1</Issue>
<PubDate><Year>2013</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of infection</Title>
<ISOAbbreviation>J. Infect.</ISOAbbreviation>
</Journal>
<ArticleTitle>High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians.</ArticleTitle>
<Pagination><MedlinePgn>43-50</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jinf.2013.03.008</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0163-4453(13)00064-9</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine the prevalence of HIV-associated renal dysfunction (RD), identify risk factors for RD and explore the association between baseline renal function and mortality in an HIV-infected population in Ghana.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) was calculated in patients attending an HIV clinic between 2004 and 2011 using Cockcroft-Gault, MDRD and CKD-EPI formulae. Logistic regression analysis was used to identify risk factors associated with RD and Kaplan-Meier/Cox proportional regression analyses to explore associations between baseline CrCl/eGFR and subsequent mortality.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In 3137 patients starting antiretroviral therapy (ART) the frequency (95%-CI) of RD, defined by CrCl <60 ml/min/1.73 m(2) using Cockroft-Gault formula was 38.8% (37.1-40.5%). RD prevalence in a sub-population of 238 patients, including proteinuria in the definition, was 15.3% (10.3-22.1%) in ART-treated and 43.6% (34.0-53.7%) in ART-naïve patients. RD at baseline was associated with increasing age, low CD4 counts, advanced WHO stage and female gender. Cox proportional hazard analysis identified an increased hazard of death with decreasing CrCl, HR 1.46 (1.31-1.63) for each tertile lower than CrCl of 90 ml/min/1.73 m(2).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">RD is very common in HIV-infected ART-naïve Ghanaians, and associated with increased risk of mortality. Screening and monitoring of RD is important in this setting, particularly as tenofovir use increases.</AbstractText>
<CopyrightInformation>Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sarfo</LastName>
<ForeName>Fred S</ForeName>
<Initials>FS</Initials>
<AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Keegan</LastName>
<ForeName>Rosie</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Appiah</LastName>
<ForeName>Lambert</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shakoor</LastName>
<ForeName>Shaid</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Phillips</LastName>
<ForeName>Richard</ForeName>
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<Author ValidYN="Y"><LastName>Norman</LastName>
<ForeName>Betty</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hardy</LastName>
<ForeName>Yasmin</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bedu-Addo</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Longstaff</LastName>
<ForeName>Lydia</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chadwick</LastName>
<ForeName>David R</ForeName>
<Initials>DR</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MRC_MR/J01477X/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>03</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Infect</MedlineTA>
<NlmUniqueID>7908424</NlmUniqueID>
<ISSNLinking>0163-4453</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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<MeshHeading><DescriptorName UI="D005919" MajorTopicYN="N">Glomerular Filtration Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008657" MajorTopicYN="N">Metabolic Clearance Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051437" MajorTopicYN="N">Renal Insufficiency</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
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</MedlineCitation>
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<Month>10</Month>
<Day>29</Day>
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<PubMedPubDate PubStatus="revised"><Year>2013</Year>
<Month>03</Month>
<Day>08</Day>
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High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians.

High prevalence of renal dysfunction and association with risk of death amongst HIV-infected Ghanaians.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki