GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.
Identifieur interne : 000341 ( PubMed/Corpus ); précédent : 000340; suivant : 000342GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.
Auteurs : Chengyao Li ; Paul Collini ; Kwabena Danso ; Shirley Owusu-Ofori ; Albert Dompreh ; Daniel Candotti ; Ohene Opare-Sem ; Jean-Pierre AllainSource :
- AIDS (London, England) [ 0269-9370 ] ; 2006.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Flaviviridae Infections (complications), Flaviviridae Infections (epidemiology), GB virus C, Ghana (epidemiology), HIV Infections (complications), HIV Infections (epidemiology), HIV-1, Hepatitis, Viral, Human (complications), Hepatitis, Viral, Human (epidemiology), Humans, Infant, Infant, Newborn, Middle Aged, Pregnancy, Pregnancy Complications, Infectious (epidemiology), Pregnancy Complications, Infectious (virology), Prevalence, RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction, Viral Load.
- MESH :
- chemical , analysis : RNA, Viral.
- geographic , epidemiology : Ghana.
- complications : Flaviviridae Infections, HIV Infections, Hepatitis, Viral, Human.
- epidemiology : Flaviviridae Infections, HIV Infections, Hepatitis, Viral, Human, Pregnancy Complications, Infectious.
- virology : Pregnancy Complications, Infectious.
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, GB virus C, HIV-1, Humans, Infant, Infant, Newborn, Middle Aged, Pregnancy, Prevalence, Reverse Transcriptase Polymerase Chain Reaction, Viral Load.
Abstract
Investigations on the impact of GB virus C (GBV-C) co-infection on HIV disease progression relied essentially on clinical follow-up but not on virologic parameters.
DOI: 10.1097/01.aids.0000200536.79360.03
PubMed: 16439871
Links to Exploration step
pubmed:16439871Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.</title>
<author><name sortKey="Li, Chengyao" sort="Li, Chengyao" uniqKey="Li C" first="Chengyao" last="Li">Chengyao Li</name>
<affiliation><nlm:affiliation>National Blood Service, UK.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Collini, Paul" sort="Collini, Paul" uniqKey="Collini P" first="Paul" last="Collini">Paul Collini</name>
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<author><name sortKey="Danso, Kwabena" sort="Danso, Kwabena" uniqKey="Danso K" first="Kwabena" last="Danso">Kwabena Danso</name>
</author>
<author><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name>
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<author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name>
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<author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name>
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<author><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name>
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<author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.</title>
<author><name sortKey="Li, Chengyao" sort="Li, Chengyao" uniqKey="Li C" first="Chengyao" last="Li">Chengyao Li</name>
<affiliation><nlm:affiliation>National Blood Service, UK.</nlm:affiliation>
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<author><name sortKey="Collini, Paul" sort="Collini, Paul" uniqKey="Collini P" first="Paul" last="Collini">Paul Collini</name>
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<author><name sortKey="Danso, Kwabena" sort="Danso, Kwabena" uniqKey="Danso K" first="Kwabena" last="Danso">Kwabena Danso</name>
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<author><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name>
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<author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name>
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<author><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name>
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<author><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name>
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<author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
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<series><title level="j">AIDS (London, England)</title>
<idno type="ISSN">0269-9370</idno>
<imprint><date when="2006" type="published">2006</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Flaviviridae Infections (complications)</term>
<term>Flaviviridae Infections (epidemiology)</term>
<term>GB virus C</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (complications)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV-1</term>
<term>Hepatitis, Viral, Human (complications)</term>
<term>Hepatitis, Viral, Human (epidemiology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Middle Aged</term>
<term>Pregnancy</term>
<term>Pregnancy Complications, Infectious (epidemiology)</term>
<term>Pregnancy Complications, Infectious (virology)</term>
<term>Prevalence</term>
<term>RNA, Viral (analysis)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Flaviviridae Infections</term>
<term>HIV Infections</term>
<term>Hepatitis, Viral, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Flaviviridae Infections</term>
<term>HIV Infections</term>
<term>Hepatitis, Viral, Human</term>
<term>Pregnancy Complications, Infectious</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pregnancy Complications, Infectious</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>GB virus C</term>
<term>HIV-1</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Middle Aged</term>
<term>Pregnancy</term>
<term>Prevalence</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Viral Load</term>
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<front><div type="abstract" xml:lang="en">Investigations on the impact of GB virus C (GBV-C) co-infection on HIV disease progression relied essentially on clinical follow-up but not on virologic parameters.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16439871</PMID>
<DateCreated><Year>2006</Year>
<Month>01</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2006</Year>
<Month>10</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0269-9370</ISSN>
<JournalIssue CitedMedium="Print"><Volume>20</Volume>
<Issue>3</Issue>
<PubDate><Year>2006</Year>
<Month>Feb</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>AIDS (London, England)</Title>
<ISOAbbreviation>AIDS</ISOAbbreviation>
</Journal>
<ArticleTitle>GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals.</ArticleTitle>
<Pagination><MedlinePgn>379-86</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Investigations on the impact of GB virus C (GBV-C) co-infection on HIV disease progression relied essentially on clinical follow-up but not on virologic parameters.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To detect and quantify GBV-C RNA in West African populations co-infected or not with HIV-1 and to correlate the RNA load of HIV-1 and GBV-C in co-replicating patients with different clinical conditions.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Three Ghanaian populations (blood donors, pregnant women and HIV-infected patients) were subdivided into six groups according to HIV-1 and clinical status and GBV-C and HIV-1 RNA load was tested by quantitative real time reverse transcriptase-polymerase chain reaction. In one population with HIV-1 disease, CD4+ cell count was also measured.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Prevalence of GBV-C markers in HIV-1-infected groups and HIV-1 non-infected pregnant women were significantly higher than in healthy blood donors. Similar levels and distribution of GBV-C RNA load were found in each population irrespective of HIV-1 status except for a lower GBV-C RNA load in AIDS patients. There was a significant shift of HIV-1 load towards lower value when GBV-C RNA was present and a trend towards an inverse correlation between HIV-1 and GBV-C RNA load. A positive correlation between CD4+ cell count and GBV-C RNA load in symptomatic HIV-1-infected patients was observed.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The moderate impact of GBV-C on HIV-1 viremia is unlikely to entirely account for a favourable clinical outcome of replicating co-infections.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Chengyao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>National Blood Service, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Collini</LastName>
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<Initials>P</Initials>
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<Author ValidYN="Y"><LastName>Danso</LastName>
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<Author ValidYN="Y"><LastName>Owusu-Ofori</LastName>
<ForeName>Shirley</ForeName>
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<Author ValidYN="Y"><LastName>Dompreh</LastName>
<ForeName>Albert</ForeName>
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<Author ValidYN="Y"><LastName>Candotti</LastName>
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<Author ValidYN="Y"><LastName>Opare-Sem</LastName>
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<Author ValidYN="Y"><LastName>Allain</LastName>
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<Language>eng</Language>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
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<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D018178" MajorTopicYN="N">Flaviviridae Infections</DescriptorName>
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<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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<MeshHeading><DescriptorName UI="D029407" MajorTopicYN="Y">GB virus C</DescriptorName>
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<MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
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<MeshHeading><DescriptorName UI="D015497" MajorTopicYN="Y">HIV-1</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName>
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<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
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<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
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<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
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