SidaGhanaV1, PubMed, Corpus, bibRecord, 000264

Virological Characterization of Dual HIV-1/HIV-2 Seropositivity and Infections in Southern Ghana.

Identifieur interne : 000264 ( PubMed/Corpus ); précédent : 000263; suivant : 000265

Virological Characterization of Dual HIV-1/HIV-2 Seropositivity and Infections in Southern Ghana.

Auteurs : Kwc Sagoe ; Jaa Mingle ; Rk Affram ; S. Britton ; A. Dzokoto ; A. Sonnerborg

Source :

Ghana medical journal [ 0016-9560 ] ; 2008.

RBID : pubmed:18560550

Abstract

Dual HIV-1/HIV-2 seropositivity (dual seropositivity) is common in West African countries including Ghana. The diagnosis of dual HIV-1/HIV-2 infections is however complicated as HIV-2 DNA is more often not detected in dual seropositive individuals.

PubMed: 18560550

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<author><name sortKey="Sagoe, Kwc" sort="Sagoe, Kwc" uniqKey="Sagoe K" first="Kwc" last="Sagoe">Kwc Sagoe</name>
<affiliation><nlm:affiliation>Department of Microbiology University of Ghana Medical School, Accra, Ghana.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mingle, Jaa" sort="Mingle, Jaa" uniqKey="Mingle J" first="Jaa" last="Mingle">Jaa Mingle</name>
</author>
<author><name sortKey="Affram, Rk" sort="Affram, Rk" uniqKey="Affram R" first="Rk" last="Affram">Rk Affram</name>
</author>
<author><name sortKey="Britton, S" sort="Britton, S" uniqKey="Britton S" first="S" last="Britton">S. Britton</name>
</author>
<author><name sortKey="Dzokoto, A" sort="Dzokoto, A" uniqKey="Dzokoto A" first="A" last="Dzokoto">A. Dzokoto</name>
</author>
<author><name sortKey="Sonnerborg, A" sort="Sonnerborg, A" uniqKey="Sonnerborg A" first="A" last="Sonnerborg">A. Sonnerborg</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Virological Characterization of Dual HIV-1/HIV-2 Seropositivity and Infections in Southern Ghana.</title>
<author><name sortKey="Sagoe, Kwc" sort="Sagoe, Kwc" uniqKey="Sagoe K" first="Kwc" last="Sagoe">Kwc Sagoe</name>
<affiliation><nlm:affiliation>Department of Microbiology University of Ghana Medical School, Accra, Ghana.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mingle, Jaa" sort="Mingle, Jaa" uniqKey="Mingle J" first="Jaa" last="Mingle">Jaa Mingle</name>
</author>
<author><name sortKey="Affram, Rk" sort="Affram, Rk" uniqKey="Affram R" first="Rk" last="Affram">Rk Affram</name>
</author>
<author><name sortKey="Britton, S" sort="Britton, S" uniqKey="Britton S" first="S" last="Britton">S. Britton</name>
</author>
<author><name sortKey="Dzokoto, A" sort="Dzokoto, A" uniqKey="Dzokoto A" first="A" last="Dzokoto">A. Dzokoto</name>
</author>
<author><name sortKey="Sonnerborg, A" sort="Sonnerborg, A" uniqKey="Sonnerborg A" first="A" last="Sonnerborg">A. Sonnerborg</name>
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<series><title level="j">Ghana medical journal</title>
<idno type="ISSN">0016-9560</idno>
<imprint><date when="2008" type="published">2008</date>
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<front><div type="abstract" xml:lang="en">Dual HIV-1/HIV-2 seropositivity (dual seropositivity) is common in West African countries including Ghana. The diagnosis of dual HIV-1/HIV-2 infections is however complicated as HIV-2 DNA is more often not detected in dual seropositive individuals.</div>
</front>
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<DateCreated><Year>2008</Year>
<Month>06</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>07</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>07</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0016-9560</ISSN>
<JournalIssue CitedMedium="Print"><Volume>42</Volume>
<Issue>1</Issue>
<PubDate><Year>2008</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Ghana medical journal</Title>
<ISOAbbreviation>Ghana Med J</ISOAbbreviation>
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<ArticleTitle>Virological Characterization of Dual HIV-1/HIV-2 Seropositivity and Infections in Southern Ghana.</ArticleTitle>
<Pagination><MedlinePgn>16-21</MedlinePgn>
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<Abstract><AbstractText Label="SUMMARY BACKGROUND" NlmCategory="BACKGROUND">Dual HIV-1/HIV-2 seropositivity (dual seropositivity) is common in West African countries including Ghana. The diagnosis of dual HIV-1/HIV-2 infections is however complicated as HIV-2 DNA is more often not detected in dual seropositive individuals.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To detect the presence of HIV-1 and HIV-2 pro-viral DNA in dual seropositives and to determine the correlation between HIV-2 antibody titers and presence of HIV-2 DNA. The growth kinetics of HIV-1 and HIV-2 in vitro were also determined using plasma and lymphocyte cultures.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Cross-sectional study</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">Urban and semi-rural HIV/AIDS clinics</AbstractText>
<AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">13 dual HIV-1/HIV-2 seropositives from Agomanya and Accra</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">HIV-1 DNA was detected in uncultured peripheral blood mononuclear cells of all 13 patients but HIV-2 DNA in 4 (30.8%). HIV-2 antibody titres were not useful in determining the presence or absence of HIV-2 DNA (P=0.28, Mann-Whitney U test). HIV-2 specific antibody was detected in 12 of the 13 dual seropositives by peptide-inhibition, the only patient with an Innolia gp36 band rating of 1+ was shown not to be reactive. HIV-2 grew efficiently in the presence or HIV-1 in vitro.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">HIV-2 DNA may not be detected in all dual seropositives thus not all of such patients may need drugs effective against HIV-2. Peptide based assays will be useful for correctly diagnosing dual seropositivity. Since HIV-2 may grow efficiently in the presence of HIV-1 and no commercial HIV-2 HIV RNA tests are available, dual seropositives on HAART need to be monitored to determine if a lack of immune restoration may correspond to an efficient suppression of HIV-1 RNA levels.</AbstractText>
</Abstract>
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<ForeName>Kwc</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology University of Ghana Medical School, Accra, Ghana.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Mingle</LastName>
<ForeName>Jaa</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Affram</LastName>
<ForeName>Rk</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Britton</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dzokoto</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sonnerborg</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<MedlineJournalInfo><Country>Ghana</Country>
<MedlineTA>Ghana Med J</MedlineTA>
<NlmUniqueID>0073210</NlmUniqueID>
<ISSNLinking>0016-9560</ISSNLinking>
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<OtherID Source="NLM">PMC2423332</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ghana</Keyword>
<Keyword MajorTopicYN="N">HIV-1</Keyword>
<Keyword MajorTopicYN="N">HIV-2</Keyword>
<Keyword MajorTopicYN="N">dual</Keyword>
<Keyword MajorTopicYN="N">infection</Keyword>
<Keyword MajorTopicYN="N">seropositivity</Keyword>
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Virological Characterization of Dual HIV-1/HIV-2 Seropositivity and Infections in Southern Ghana.

Virological Characterization of Dual HIV-1/HIV-2 Seropositivity and Infections in Southern Ghana.

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