Options in human papillomavirus (HPV) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative HPV-DNA assay in Ghana.
Identifieur interne : 000224 ( PubMed/Corpus ); précédent : 000223; suivant : 000225Options in human papillomavirus (HPV) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative HPV-DNA assay in Ghana.
Auteurs : Dorcas Obiri-Yeboah ; Yaw Adu-Sarkodie ; Florencia Djigma ; Kafui Akakpo ; Ebenezer Aniakwa-Bonsu ; Daniel Amoako-Sakyi ; Simpore Jacques ; Philippe MayaudSource :
- Gynecologic oncology research and practice [ 2053-6844 ] ; 2017.
Abstract
Modern cervical cancer screening increasingly relies on the use of molecular techniques detecting high-risk oncogenic human papillomavirus (hr-HPV). A major challenge for developing countries like Ghana has been the unavailability and costs of HPV DNA-based testing. This study compares the performance of careHPV, a semi-rapid and affordable qualitative detection assay for 14 hr-HPV genotypes, with HPV genotyping, for the detection of cytological cervical squamous intraepithelial lesions (SIL).
DOI: 10.1186/s40661-017-0041-1
PubMed: 28270915
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Options in human papillomavirus (HPV) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative HPV-DNA assay in Ghana.</title><author><name sortKey="Obiri Yeboah, Dorcas" sort="Obiri Yeboah, Dorcas" uniqKey="Obiri Yeboah D" first="Dorcas" last="Obiri-Yeboah">Dorcas Obiri-Yeboah</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Adu Sarkodie, Yaw" sort="Adu Sarkodie, Yaw" uniqKey="Adu Sarkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name><affiliation><nlm:affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Djigma, Florencia" sort="Djigma, Florencia" uniqKey="Djigma F" first="Florencia" last="Djigma">Florencia Djigma</name><affiliation><nlm:affiliation>Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Ouagadougou, Burkina Faso.</nlm:affiliation></affiliation></author><author><name sortKey="Akakpo, Kafui" sort="Akakpo, Kafui" uniqKey="Akakpo K" first="Kafui" last="Akakpo">Kafui Akakpo</name><affiliation><nlm:affiliation>Department of Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Aniakwa Bonsu, Ebenezer" sort="Aniakwa Bonsu, Ebenezer" uniqKey="Aniakwa Bonsu E" first="Ebenezer" last="Aniakwa-Bonsu">Ebenezer Aniakwa-Bonsu</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Amoako Sakyi, Daniel" sort="Amoako Sakyi, Daniel" uniqKey="Amoako Sakyi D" first="Daniel" last="Amoako-Sakyi">Daniel Amoako-Sakyi</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Jacques, Simpore" sort="Jacques, Simpore" uniqKey="Jacques S" first="Simpore" last="Jacques">Simpore Jacques</name><affiliation><nlm:affiliation>Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Ouagadougou, Burkina Faso.</nlm:affiliation></affiliation></author><author><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name><affiliation><nlm:affiliation>Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28270915</idno><idno type="pmid">28270915</idno><idno type="doi">10.1186/s40661-017-0041-1</idno><idno type="wicri:Area/PubMed/Corpus">000224</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Options in human papillomavirus (HPV) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative HPV-DNA assay in Ghana.</title><author><name sortKey="Obiri Yeboah, Dorcas" sort="Obiri Yeboah, Dorcas" uniqKey="Obiri Yeboah D" first="Dorcas" last="Obiri-Yeboah">Dorcas Obiri-Yeboah</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Adu Sarkodie, Yaw" sort="Adu Sarkodie, Yaw" uniqKey="Adu Sarkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name><affiliation><nlm:affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Djigma, Florencia" sort="Djigma, Florencia" uniqKey="Djigma F" first="Florencia" last="Djigma">Florencia Djigma</name><affiliation><nlm:affiliation>Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Ouagadougou, Burkina Faso.</nlm:affiliation></affiliation></author><author><name sortKey="Akakpo, Kafui" sort="Akakpo, Kafui" uniqKey="Akakpo K" first="Kafui" last="Akakpo">Kafui Akakpo</name><affiliation><nlm:affiliation>Department of Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Aniakwa Bonsu, Ebenezer" sort="Aniakwa Bonsu, Ebenezer" uniqKey="Aniakwa Bonsu E" first="Ebenezer" last="Aniakwa-Bonsu">Ebenezer Aniakwa-Bonsu</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Amoako Sakyi, Daniel" sort="Amoako Sakyi, Daniel" uniqKey="Amoako Sakyi D" first="Daniel" last="Amoako-Sakyi">Daniel Amoako-Sakyi</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Jacques, Simpore" sort="Jacques, Simpore" uniqKey="Jacques S" first="Simpore" last="Jacques">Simpore Jacques</name><affiliation><nlm:affiliation>Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Ouagadougou, Burkina Faso.</nlm:affiliation></affiliation></author><author><name sortKey="Mayaud, Philippe" sort="Mayaud, Philippe" uniqKey="Mayaud P" first="Philippe" last="Mayaud">Philippe Mayaud</name><affiliation><nlm:affiliation>Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Gynecologic oncology research and practice</title><idno type="ISSN">2053-6844</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Modern cervical cancer screening increasingly relies on the use of molecular techniques detecting high-risk oncogenic human papillomavirus (hr-HPV). A major challenge for developing countries like Ghana has been the unavailability and costs of HPV DNA-based testing. This study compares the performance of careHPV, a semi-rapid and affordable qualitative detection assay for 14 hr-HPV genotypes, with HPV genotyping, for the detection of cytological cervical squamous intraepithelial lesions (SIL).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28270915</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>08</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>16</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2053-6844</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Gynecologic oncology research and practice</Title><ISOAbbreviation>Gynecol Oncol Res Pract</ISOAbbreviation></Journal><ArticleTitle>Options in human papillomavirus (HPV) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative HPV-DNA assay in Ghana.</ArticleTitle><Pagination><MedlinePgn>5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s40661-017-0041-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Modern cervical cancer screening increasingly relies on the use of molecular techniques detecting high-risk oncogenic human papillomavirus (hr-HPV). A major challenge for developing countries like Ghana has been the unavailability and costs of HPV DNA-based testing. This study compares the performance of careHPV, a semi-rapid and affordable qualitative detection assay for 14 hr-HPV genotypes, with HPV genotyping, for the detection of cytological cervical squamous intraepithelial lesions (SIL).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A study comparing between frequency matched HIV-1 seropositive and HIV-seronegative women was conducted in the Cape Coast Teaching Hospital, Ghana. A systematic sampling method was used to select women attending clinics in the hospital. Cervical samples were tested for HPV by careHPV and Anyplex-II HPV28 genotyping assay, and by conventional cytology.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 175 paired results (94 from HIV-1 seropositive and 81 from HIV-seronegative women) were analyzed based on the ability of both tests to detect the 14 hr-HPV types included in the careHPV assay. The inter-assay concordance was 94.3% (95%CI: 89.7-97.2%, kappa = 0.88), similar by HIV serostatus. The careHPV assay was equally sensitive among HIV-1 seropositive and seronegative women (97.3% vs. 95.7%, p = 0.50) and slightly more specific among HIV-seronegative women (85.0% vs. 93.1%, p = 0.10). careHPV had good sensitivity (87.5%) but low specificity (52.1%) for the detection of low SIL or greater lesions, but its performance was superior to genotyping (87.5 and 38.8%, respectively). Reproducibility of careHPV, tested on 97 samples by the same individual was 82.5% (95%CI: 73.4-89.4%).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The performance characteristics of careHPV compared to genotyping suggest that this simpler and cheaper HPV detection assay could offer a suitable alternative for HPV screening in Ghana.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Obiri-Yeboah</LastName><ForeName>Dorcas</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</Affiliation><Identifier Source="ISNI">0000 0001 2322 8567</Identifier><Identifier Source="GRID">grid.413081.f</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adu-Sarkodie</LastName><ForeName>Yaw</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation><Identifier Source="ISNI">0000000109466120</Identifier><Identifier Source="GRID">grid.9829.a</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djigma</LastName><ForeName>Florencia</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Ouagadougou, Burkina Faso.</Affiliation><Identifier Source="ISNI">0000 0000 8737 921X</Identifier><Identifier Source="GRID">grid.218069.4</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akakpo</LastName><ForeName>Kafui</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</Affiliation><Identifier Source="ISNI">0000 0001 2322 8567</Identifier><Identifier Source="GRID">grid.413081.f</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aniakwa-Bonsu</LastName><ForeName>Ebenezer</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</Affiliation><Identifier Source="ISNI">0000 0001 2322 8567</Identifier><Identifier Source="GRID">grid.413081.f</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amoako-Sakyi</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.</Affiliation><Identifier Source="ISNI">0000 0001 2322 8567</Identifier><Identifier Source="GRID">grid.413081.f</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacques</LastName><ForeName>Simpore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Ouagadougou, Burkina Faso.</Affiliation><Identifier Source="ISNI">0000 0000 8737 921X</Identifier><Identifier Source="GRID">grid.218069.4</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayaud</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.</Affiliation><Identifier Source="ISNI">0000 0004 0425 469X</Identifier><Identifier Source="GRID">grid.8991.9</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Gynecol Oncol Res 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Version="1">22473652</PMID></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>Gynecol Oncol Res Pract. 2017 Mar 23;4:8</RefSource><PMID Version="1">28352472</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cervical cancer</Keyword><Keyword MajorTopicYN="N">Genotyping</Keyword><Keyword MajorTopicYN="N">Ghana</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">Human papillomavirus (HPV)</Keyword><Keyword MajorTopicYN="N">Screening</Keyword><Keyword MajorTopicYN="N">careHPV</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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