Recent patterns and predictors of neurological mortality among hospitalized patients in Central Ghana.
Identifieur interne : 000194 ( PubMed/Corpus ); précédent : 000193; suivant : 000195Recent patterns and predictors of neurological mortality among hospitalized patients in Central Ghana.
Auteurs : Fred Stephen Sarfo ; Dominic Otto Awuah ; Clara Nkyi ; John Akassi ; Ohene K. Opare-Sem ; Bruce OvbiageleSource :
- Journal of the neurological sciences [ 1878-5883 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Nervous System Diseases.
- epidemiology : Ghana.
- mortality : Nervous System Diseases.
- trends : Hospital Mortality, Hospitalization, Patient Admission.
- Adult, Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies.
Abstract
Although neurological disorders are projected to escalate globally in the coming decades, there is a paucity of enumerated data on the burden, spectrum and determinants of outcomes of adult neurological admissions in resource-limited settings, especially within sub-Saharan Africa.
DOI: 10.1016/j.jns.2016.02.041
PubMed: 27000253
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent patterns and predictors of neurological mortality among hospitalized patients in Central Ghana.</title><author><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name><affiliation><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana. Electronic address: Stephensarfo78@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Awuah, Dominic Otto" sort="Awuah, Dominic Otto" uniqKey="Awuah D" first="Dominic Otto" last="Awuah">Dominic Otto Awuah</name><affiliation><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Nkyi, Clara" sort="Nkyi, Clara" uniqKey="Nkyi C" first="Clara" last="Nkyi">Clara Nkyi</name><affiliation><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Akassi, John" sort="Akassi, John" uniqKey="Akassi J" first="John" last="Akassi">John Akassi</name><affiliation><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Opare Sem, Ohene K" sort="Opare Sem, Ohene K" uniqKey="Opare Sem O" first="Ohene K" last="Opare-Sem">Ohene K. Opare-Sem</name><affiliation><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Ovbiagele, Bruce" sort="Ovbiagele, Bruce" uniqKey="Ovbiagele B" first="Bruce" last="Ovbiagele">Bruce Ovbiagele</name><affiliation><nlm:affiliation>Medical University of South Carolina, SC, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27000253</idno><idno type="pmid">27000253</idno><idno type="doi">10.1016/j.jns.2016.02.041</idno><idno type="wicri:Area/PubMed/Corpus">000194</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000194</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Recent patterns and predictors of neurological mortality among hospitalized patients in Central Ghana.</title><author><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name><affiliation><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana. Electronic address: Stephensarfo78@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Awuah, Dominic Otto" sort="Awuah, Dominic Otto" uniqKey="Awuah D" first="Dominic Otto" last="Awuah">Dominic Otto Awuah</name><affiliation><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Nkyi, Clara" sort="Nkyi, Clara" uniqKey="Nkyi C" first="Clara" last="Nkyi">Clara Nkyi</name><affiliation><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Akassi, John" sort="Akassi, John" uniqKey="Akassi J" first="John" last="Akassi">John Akassi</name><affiliation><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Opare Sem, Ohene K" sort="Opare Sem, Ohene K" uniqKey="Opare Sem O" first="Ohene K" last="Opare-Sem">Ohene K. Opare-Sem</name><affiliation><nlm:affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Ovbiagele, Bruce" sort="Ovbiagele, Bruce" uniqKey="Ovbiagele B" first="Bruce" last="Ovbiagele">Bruce Ovbiagele</name><affiliation><nlm:affiliation>Medical University of South Carolina, SC, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="eISSN">1878-5883</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Ghana (epidemiology)</term><term>Hospital Mortality (trends)</term><term>Hospitalization (trends)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous System Diseases (diagnosis)</term><term>Nervous System Diseases (mortality)</term><term>Patient Admission (trends)</term><term>Predictive Value of Tests</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Hospital Mortality</term><term>Hospitalization</term><term>Patient Admission</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although neurological disorders are projected to escalate globally in the coming decades, there is a paucity of enumerated data on the burden, spectrum and determinants of outcomes of adult neurological admissions in resource-limited settings, especially within sub-Saharan Africa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27000253</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>22</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5883</ISSN><JournalIssue CitedMedium="Internet"><Volume>363</Volume><PubDate><Year>2016</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of the neurological sciences</Title><ISOAbbreviation>J. Neurol. Sci.</ISOAbbreviation></Journal><ArticleTitle>Recent patterns and predictors of neurological mortality among hospitalized patients in Central Ghana.</ArticleTitle><Pagination><MedlinePgn>217-24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jns.2016.02.041</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0022-510X(16)30106-X</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although neurological disorders are projected to escalate globally in the coming decades, there is a paucity of enumerated data on the burden, spectrum and determinants of outcomes of adult neurological admissions in resource-limited settings, especially within sub-Saharan Africa.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the diversity, demography, and determinants of mortality among adult patients presenting with neurological disorders over a 6-year period in a tertiary medical referral institution in the Central belt of Ghana.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective analysis of data on neurological admissions and in-patient outcomes between 2008 and 2013 was undertaken. Data collected for analyses included age, gender, neurological diagnosis, documented comorbidities, duration of admission and vital status at discharge. Predictors of in-patient mortality were evaluated using Kaplan-Meier survival curves and Cox Proportional Hazards regression models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The 6494 admissions with neurological disorders represented 15.0% of all adult medical admissions over the study period. Male-to-female ratio of admissions was 1.6:1.0 with a mean±SD age of 52.9±20 years. The commonest neurological disorders were Cerebrovascular, Infectious, Seizures/epilepsy, Alcohol-use and Spinal cord disorders representing 54.0%, 26.7%, 10.3%, 4.0% and 2.3% of admissions respectively. Despite the low national HIV prevalence of 2.0%, the frequency of HIV infection among patients with infectious disorders of the nervous system was 40.9%. Overall crude mortality rate for neurologic admissions was 30.6% being 39.1% and 33.9% for Infectious affectations of the nervous system and stroke respectively and 7.4% for seizure disorders. Probability of death was higher for females than males aHR (95% CI) of 1.53 (1.40-1.68) and increasing age aHR (95% CI) of 1.11 (1.06-1.17) for each 20-year increase in age.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Almost one in three patients admitted with neurological disease to a tertiary care center in Ghana died in the hospital, and the majority of these deaths were due to non-communicable conditions. Enhanced multi-dimensional public health disease prevention strategies and neurological inpatient care processes are warranted.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sarfo</LastName><ForeName>Fred Stephen</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana. Electronic address: Stephensarfo78@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Awuah</LastName><ForeName>Dominic Otto</ForeName><Initials>DO</Initials><AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nkyi</LastName><ForeName>Clara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akassi</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Opare-Sem</LastName><ForeName>Ohene K</ForeName><Initials>OK</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science & Technology, Kumasi, Ghana; Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ovbiagele</LastName><ForeName>Bruce</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Medical University of South Carolina, SC, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21 NS094033</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 HG007479</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Neurol Sci</MedlineTA><NlmUniqueID>0375403</NlmUniqueID><ISSNLinking>0022-510X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010343" MajorTopicYN="N">Patient Admission</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ghana</Keyword><Keyword MajorTopicYN="N">Neurology admissions</Keyword><Keyword MajorTopicYN="N">Outcomes</Keyword><Keyword MajorTopicYN="N">West Africa</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>01</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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