High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study.
Identifieur interne : 000189 ( PubMed/Corpus ); précédent : 000188; suivant : 000190High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study.
Auteurs : Elena Delgado ; William Kwabena Ampofo ; María Sierra ; Kwasi Torpey ; Lucía Pérez-Alvarez ; Evelyn Yayra Bonney ; Ya Diul Mukadi ; Margaret Lartey ; Charles Nyarko ; Richard Noamesi Amenyah ; Michael Thomson ; Rafael NájeraSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2008.
English descriptors
- KwdEn :
- Anti-HIV Agents (pharmacology), Drug Resistance, Viral (genetics), Genes, pol, Ghana (epidemiology), HIV Infections (epidemiology), HIV Infections (virology), HIV Protease Inhibitors (pharmacology), HIV-1 (classification), HIV-1 (drug effects), HIV-1 (genetics), HIV-1 (isolation & purification), Humans, Molecular Epidemiology, Molecular Sequence Data, Mutation, Phylogeny, Polymorphism, Genetic, Prevalence, Recombination, Genetic, Reverse Transcriptase Inhibitors (pharmacology).
- MESH :
- chemical , pharmacology : Anti-HIV Agents, HIV Protease Inhibitors, Reverse Transcriptase Inhibitors.
- geographic , epidemiology : Ghana.
- classification : HIV-1.
- drug effects : HIV-1.
- epidemiology : HIV Infections.
- genetics : Drug Resistance, Viral, HIV-1.
- isolation & purification : HIV-1.
- virology : HIV Infections.
- Genes, pol, Humans, Molecular Epidemiology, Molecular Sequence Data, Mutation, Phylogeny, Polymorphism, Genetic, Prevalence, Recombination, Genetic.
Abstract
In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate.
DOI: 10.1097/QAI.0b013e3181806c0e
PubMed: 18645511
Links to Exploration step
pubmed:18645511Le document en format XML
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sortKey="Perez Alvarez, Lucia" sort="Perez Alvarez, Lucia" uniqKey="Perez Alvarez L" first="Lucía" last="Pérez-Alvarez">Lucía Pérez-Alvarez</name></author><author><name sortKey="Bonney, Evelyn Yayra" sort="Bonney, Evelyn Yayra" uniqKey="Bonney E" first="Evelyn Yayra" last="Bonney">Evelyn Yayra Bonney</name></author><author><name sortKey="Mukadi, Ya Diul" sort="Mukadi, Ya Diul" uniqKey="Mukadi Y" first="Ya Diul" last="Mukadi">Ya Diul Mukadi</name></author><author><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name></author><author><name sortKey="Nyarko, Charles" sort="Nyarko, Charles" uniqKey="Nyarko C" first="Charles" last="Nyarko">Charles Nyarko</name></author><author><name sortKey="Amenyah, Richard Noamesi" sort="Amenyah, Richard Noamesi" uniqKey="Amenyah R" first="Richard Noamesi" last="Amenyah">Richard Noamesi Amenyah</name></author><author><name sortKey="Thomson, Michael" sort="Thomson, Michael" uniqKey="Thomson M" first="Michael" last="Thomson">Michael Thomson</name></author><author><name sortKey="Najera, Rafael" sort="Najera, Rafael" uniqKey="Najera R" first="Rafael" last="Nájera">Rafael Nájera</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18645511</idno><idno type="pmid">18645511</idno><idno type="doi">10.1097/QAI.0b013e3181806c0e</idno><idno type="wicri:Area/PubMed/Corpus">000189</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000189</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study.</title><author><name sortKey="Delgado, Elena" sort="Delgado, Elena" uniqKey="Delgado E" first="Elena" last="Delgado">Elena Delgado</name><affiliation><nlm:affiliation>Viral Pathogenesis Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. delgade@isciii.es</nlm:affiliation></affiliation></author><author><name sortKey="Ampofo, William Kwabena" sort="Ampofo, William Kwabena" uniqKey="Ampofo W" first="William Kwabena" last="Ampofo">William Kwabena Ampofo</name></author><author><name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="María" last="Sierra">María Sierra</name></author><author><name sortKey="Torpey, Kwasi" sort="Torpey, Kwasi" uniqKey="Torpey K" first="Kwasi" last="Torpey">Kwasi Torpey</name></author><author><name sortKey="Perez Alvarez, Lucia" sort="Perez Alvarez, Lucia" uniqKey="Perez Alvarez L" first="Lucía" last="Pérez-Alvarez">Lucía Pérez-Alvarez</name></author><author><name sortKey="Bonney, Evelyn Yayra" sort="Bonney, Evelyn Yayra" uniqKey="Bonney E" first="Evelyn Yayra" last="Bonney">Evelyn Yayra Bonney</name></author><author><name sortKey="Mukadi, Ya Diul" sort="Mukadi, Ya Diul" uniqKey="Mukadi Y" first="Ya Diul" last="Mukadi">Ya Diul Mukadi</name></author><author><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name></author><author><name sortKey="Nyarko, Charles" sort="Nyarko, Charles" uniqKey="Nyarko C" first="Charles" last="Nyarko">Charles Nyarko</name></author><author><name sortKey="Amenyah, Richard Noamesi" sort="Amenyah, Richard Noamesi" uniqKey="Amenyah R" first="Richard Noamesi" last="Amenyah">Richard Noamesi Amenyah</name></author><author><name sortKey="Thomson, Michael" sort="Thomson, Michael" uniqKey="Thomson M" first="Michael" last="Thomson">Michael Thomson</name></author><author><name sortKey="Najera, Rafael" sort="Najera, Rafael" uniqKey="Najera R" first="Rafael" last="Nájera">Rafael Nájera</name></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-HIV Agents (pharmacology)</term><term>Drug Resistance, Viral (genetics)</term><term>Genes, pol</term><term>Ghana (epidemiology)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (virology)</term><term>HIV Protease Inhibitors (pharmacology)</term><term>HIV-1 (classification)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (genetics)</term><term>HIV-1 (isolation & purification)</term><term>Humans</term><term>Molecular Epidemiology</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Phylogeny</term><term>Polymorphism, Genetic</term><term>Prevalence</term><term>Recombination, Genetic</term><term>Reverse Transcriptase Inhibitors (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term><term>HIV Protease Inhibitors</term><term>Reverse Transcriptase Inhibitors</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Viral</term><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genes, pol</term><term>Humans</term><term>Molecular Epidemiology</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Phylogeny</term><term>Polymorphism, Genetic</term><term>Prevalence</term><term>Recombination, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18645511</PMID><DateCreated><Year>2008</Year><Month>08</Month><Day>19</Day></DateCreated><DateCompleted><Year>2008</Year><Month>09</Month><Day>04</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1525-4135</ISSN><JournalIssue CitedMedium="Print"><Volume>48</Volume><Issue>5</Issue><PubDate><Year>2008</Year><Month>Aug</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of acquired immune deficiency syndromes (1999)</Title><ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation></Journal><ArticleTitle>High prevalence of unique recombinant forms of HIV-1 in Ghana: molecular epidemiology from an antiretroviral resistance study.</ArticleTitle><Pagination><MedlinePgn>599-606</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAI.0b013e3181806c0e</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In Ghana, programs to expand antiretroviral access are being implemented. In this context, the dynamic genetic evolution of HIV-1 requires continuous surveillance, particularly when diverse genetic forms co-circulate.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Phylogenetic and antiretroviral resistance analyses of HIV-1 partial pol sequences from plasma RNA samples from 207 Ghanaian individuals were performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">66% of infections were CRF02_AG, whereas 25% were unique recombinant forms (URFs). All 52 URFs were characterized by bootscanning. CRF02_AG was parental strain in 87% of URFs, forming recombinants with genetic forms circulating in minor proportions: CRF06_cpx, sub-subtype A3, CRF09_cpx and subtypes G and D. Two triple recombinants (CRF02_AG/A3/CRF06_cpx and CRF02_AG/A3/CRF09_cpx) were identified. Antiretroviral resistance analyses revealed that six individuals, five of which were antiretroviral drug-experienced, harbored mutations conferring high level of resistance to reverse transcriptase inhibitors. No major resistance mutations were identified in the protease, although insertions of one and three amino acids were detected.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The high frequency of URFs detected probably reflects a significant incidence of coinfections or superinfections with diverse viral strains, which increases the genetic complexity of the HIV-1 epidemic in West Africa. Monitoring of HIV-1 drug resistance might provide data on the implications of intersubtype recombination in response to antiretrovirals.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Viral Pathogenesis Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. delgade@isciii.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ampofo</LastName><ForeName>William Kwabena</ForeName><Initials>WK</Initials></Author><Author ValidYN="Y"><LastName>Sierra</LastName><ForeName>María</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Torpey</LastName><ForeName>Kwasi</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Pérez-Alvarez</LastName><ForeName>Lucía</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Bonney</LastName><ForeName>Evelyn Yayra</ForeName><Initials>EY</Initials></Author><Author ValidYN="Y"><LastName>Mukadi</LastName><ForeName>Ya Diul</ForeName><Initials>YD</Initials></Author><Author ValidYN="Y"><LastName>Lartey</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nyarko</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Amenyah</LastName><ForeName>Richard Noamesi</ForeName><Initials>RN</Initials></Author><Author ValidYN="Y"><LastName>Thomson</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nájera</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><DataBankList 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UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017320">HIV Protease Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018894">Reverse Transcriptase Inhibitors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015751" MajorTopicYN="N">Genes, pol</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017320" MajorTopicYN="N">HIV Protease Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017720" MajorTopicYN="N">Molecular Epidemiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011995" MajorTopicYN="Y">Recombination, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018894" MajorTopicYN="N">Reverse Transcriptase Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>7</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>9</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>7</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18645511</ArticleId><ArticleId IdType="doi">10.1097/QAI.0b013e3181806c0e</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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