The immunological response of HIV-positive patients initiating HAART at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Identifieur interne : 000063 ( PubMed/Corpus ); précédent : 000062; suivant : 000064The immunological response of HIV-positive patients initiating HAART at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Auteurs : L. Annison ; A. Dompreh ; Y. Adu-SarkodieSource :
- Ghana medical journal [ 0016-9560 ] ; 2013.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antiretroviral Therapy, Highly Active (methods), CD4 Lymphocyte Count (methods), CD4-Positive T-Lymphocytes (drug effects), CD4-Positive T-Lymphocytes (immunology), Developing Countries, Female, Ghana, HIV Seropositivity (blood), HIV Seropositivity (drug therapy), HIV Seropositivity (immunology), HIV Seropositivity (virology), HIV-1 (drug effects), HIV-1 (immunology), Hospitals, Teaching, Humans, Male, Medication Adherence (statistics & numerical data), Middle Aged, Surveys and Questionnaires, Treatment Outcome, Viral Load (drug effects).
- MESH :
- geographic : Ghana.
- blood : HIV Seropositivity.
- drug effects : CD4-Positive T-Lymphocytes, HIV-1, Viral Load.
- drug therapy : HIV Seropositivity.
- immunology : CD4-Positive T-Lymphocytes, HIV Seropositivity, HIV-1.
- methods : Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count.
- statistics & numerical data : Medication Adherence.
- virology : HIV Seropositivity.
- Adolescent, Adult, Aged, Developing Countries, Female, Hospitals, Teaching, Humans, Male, Middle Aged, Surveys and Questionnaires, Treatment Outcome.
Abstract
The study sought to document the experience of immunological improvement among Ghanaian PLHIV on HAART comparing different categories of patients.
PubMed: 24669021
Links to Exploration step
pubmed:24669021Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The immunological response of HIV-positive patients initiating HAART at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.</title><author><name sortKey="Annison, L" sort="Annison, L" uniqKey="Annison L" first="L" last="Annison">L. Annison</name><affiliation><nlm:affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Dompreh, A" sort="Dompreh, A" uniqKey="Dompreh A" first="A" last="Dompreh">A. Dompreh</name><affiliation><nlm:affiliation>Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Adu Sarkodie, Y" sort="Adu Sarkodie, Y" uniqKey="Adu Sarkodie Y" first="Y" last="Adu-Sarkodie">Y. Adu-Sarkodie</name><affiliation><nlm:affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24669021</idno><idno type="pmid">24669021</idno><idno type="wicri:Area/PubMed/Corpus">000063</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The immunological response of HIV-positive patients initiating HAART at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.</title><author><name sortKey="Annison, L" sort="Annison, L" uniqKey="Annison L" first="L" last="Annison">L. Annison</name><affiliation><nlm:affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Dompreh, A" sort="Dompreh, A" uniqKey="Dompreh A" first="A" last="Dompreh">A. Dompreh</name><affiliation><nlm:affiliation>Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation></affiliation></author><author><name sortKey="Adu Sarkodie, Y" sort="Adu Sarkodie, Y" uniqKey="Adu Sarkodie Y" first="Y" last="Adu-Sarkodie">Y. Adu-Sarkodie</name><affiliation><nlm:affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Ghana medical journal</title><idno type="ISSN">0016-9560</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antiretroviral Therapy, Highly Active (methods)</term><term>CD4 Lymphocyte Count (methods)</term><term>CD4-Positive T-Lymphocytes (drug effects)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Developing Countries</term><term>Female</term><term>Ghana</term><term>HIV Seropositivity (blood)</term><term>HIV Seropositivity (drug therapy)</term><term>HIV Seropositivity (immunology)</term><term>HIV Seropositivity (virology)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (immunology)</term><term>Hospitals, Teaching</term><term>Humans</term><term>Male</term><term>Medication Adherence (statistics & numerical data)</term><term>Middle Aged</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term><term>Viral Load (drug effects)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>HIV-1</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>HIV Seropositivity</term><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Medication Adherence</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Developing Countries</term><term>Female</term><term>Hospitals, Teaching</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The study sought to document the experience of immunological improvement among Ghanaian PLHIV on HAART comparing different categories of patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24669021</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0016-9560</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Ghana medical journal</Title><ISOAbbreviation>Ghana Med J</ISOAbbreviation></Journal><ArticleTitle>The immunological response of HIV-positive patients initiating HAART at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.</ArticleTitle><Pagination><MedlinePgn>164-70</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The study sought to document the experience of immunological improvement among Ghanaian PLHIV on HAART comparing different categories of patients.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Serology Unit, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">The study comprised a convenient sample of 303 treatment naïve HIV patients due to start HAART.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Questionnaires were used to collect patient demographic and clinical data. Four CD4 counts were measured at six-monthly intervals to determine rates of CD4 change. These were pre-therapy, 1(st) post-therapy, 2(nd) post-therapy, and 3(rd) post-therapy counts. The rates of CD4 change among the different categories of patients were also compared.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At baseline, women had higher CD4 count (mean of 77.4 cells/μl), and mean age of participants was 40 years. The CD4 count increased from a mean baseline of 70.2 cells/μl to 229.2, 270.0, and 297.6 cells/μl at 6, 12, and 18 months of treatment respectively (P < 0.0001 at each time point). There were no gender (P=0.46) and age (P=0.96) differences in treatment response. There was no difference (P=0.18) in treatment response comparing those with CD4 <250 cells/μl and those whose CD4 count was between 250 and 350 cells/μl at baseline although patients with baseline CD4 count <250 cells/μl showed larger increases after 12 months of treatment. Out of 282 patients with pre-therapy CD4 count ≤250 cells/μl, 241 (85.5%) and 41 (14.5%) were adherents and nonadherents respectively. Mean rate of increase was 15.2 and 8.4 cells/μl/month in adherent and non-adherent patients respectively (p=0.2).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The study suggests that a sustained CD4 increase could be achieved in adherent patients commencing therapy with baseline CD4 count ≤250 cells/μl, and that these patients have greater ability for immunological recovery during 12 months of treatment The study, therefore, concludes that significant immunological improvement is possible among Ghanaian PLHIV on HAART as long as a high level of treatment adherence is observed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Annison</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dompreh</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Serology Unit, Department of Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adu-Sarkodie</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Ghana</Country><MedlineTA>Ghana Med J</MedlineTA><NlmUniqueID>0073210</NlmUniqueID><ISSNLinking>0016-9560</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nature. 1998 Dec 17;396(6712):690-5</RefSource><PMID Version="1">9872319</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS Res Ther. 2009 Oct 12;6:21</RefSource><PMID Version="1">19821997</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>SAHARA J. 2006 Aug;3(2):457-65</RefSource><PMID Version="1">17605205</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Antimicrob Chemother. 2004 Aug;54(2):503-7</RefSource><PMID Version="1">15201230</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Acquir Immune Defic Syndr. 2006 Sep;43(1):27-34</RefSource><PMID Version="1">16878047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Acquir Immune Defic 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UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003906" MajorTopicYN="Y">Developing Countries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006679" MajorTopicYN="N">HIV Seropositivity</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" 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Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3961850</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ghana</Keyword><Keyword MajorTopicYN="N">HAART</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">Immunological</Keyword><Keyword MajorTopicYN="N">Response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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