HIV-1 drug-resistance surveillance among treatment-experienced and -naïve patients after the implementation of antiretroviral therapy in Ghana.
Identifieur interne : 000057 ( PubMed/Corpus ); précédent : 000056; suivant : 000058HIV-1 drug-resistance surveillance among treatment-experienced and -naïve patients after the implementation of antiretroviral therapy in Ghana.
Auteurs : Nicholas I. Nii-Trebi ; Shiro Ibe ; Jacob S. Barnor ; Koichi Ishikawa ; James A M. Brandful ; Sampson B. Ofori ; Shoji Yamaoka ; William K. Ampofo ; Wataru SugiuraSource :
- PloS one [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Anti-HIV Agents (pharmacology), Anti-HIV Agents (therapeutic use), Benzoxazines (pharmacology), Benzoxazines (therapeutic use), Child, Child, Preschool, Drug Resistance, Viral, Epidemiological Monitoring, Female, Ghana (epidemiology), HIV Infections (drug therapy), HIV Infections (epidemiology), HIV Infections (transmission), HIV Protease (genetics), HIV-1 (drug effects), HIV-1 (genetics), Humans, Infant, Lamivudine (pharmacology), Lamivudine (therapeutic use), Male, Middle Aged, Molecular Epidemiology, Molecular Typing, Mutation, Missense, Nevirapine (pharmacology), Nevirapine (therapeutic use), Prevalence, Sequence Analysis, DNA, Stavudine (pharmacology), Stavudine (therapeutic use), Zidovudine (pharmacology), Zidovudine (therapeutic use).
- MESH :
- chemical , genetics : HIV Protease.
- chemical , pharmacology : Anti-HIV Agents, Benzoxazines, Lamivudine, Nevirapine, Stavudine, Zidovudine.
- chemical , therapeutic use : Anti-HIV Agents, Benzoxazines, Lamivudine, Nevirapine, Stavudine, Zidovudine.
- geographic , epidemiology : Ghana.
- drug effects : HIV-1.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections.
- genetics : HIV-1.
- transmission : HIV Infections.
- Adult, Child, Child, Preschool, Drug Resistance, Viral, Epidemiological Monitoring, Female, Humans, Infant, Male, Middle Aged, Molecular Epidemiology, Molecular Typing, Mutation, Missense, Prevalence, Sequence Analysis, DNA.
Abstract
Limited HIV-1 drug-resistance surveillance has been carried out in Ghana since the implementation of antiretroviral therapy (ART). This study sought to provide data on the profile of HIV-1 drug resistance in ART-experienced and newly diagnosed individuals in Ghana.
DOI: 10.1371/journal.pone.0071972
PubMed: 23977189
Links to Exploration step
pubmed:23977189Le document en format XML
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<front><div type="abstract" xml:lang="en">Limited HIV-1 drug-resistance surveillance has been carried out in Ghana since the implementation of antiretroviral therapy (ART). This study sought to provide data on the profile of HIV-1 drug resistance in ART-experienced and newly diagnosed individuals in Ghana.</div>
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<Month>08</Month>
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<Day>20</Day>
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<Title>PloS one</Title>
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<ArticleTitle>HIV-1 drug-resistance surveillance among treatment-experienced and -naïve patients after the implementation of antiretroviral therapy in Ghana.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Limited HIV-1 drug-resistance surveillance has been carried out in Ghana since the implementation of antiretroviral therapy (ART). This study sought to provide data on the profile of HIV-1 drug resistance in ART-experienced and newly diagnosed individuals in Ghana.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Samples were collected from 101 HIV-1-infected patients (32 ART-experienced cases with virological failure and 69 newly diagnosed ART-naïve cases, including 11 children), in Koforidua, Eastern region of Ghana, from February 2009 to January 2010. The pol gene sequences were analyzed by in-house HIV-1 drug-resistance testing.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The most prevalent HIV-1 subtype was CRF02_AG (66.3%, 67/101) followed by unique recombinant forms (25.7%, 26/101). Among 31 ART-experienced adults, 22 (71.0%) possessed at least one drug-resistance mutation, and 14 (45.2%) had two-class-resistance to nucleoside and non-nucleoside reverse-transcriptase inhibitors used in their first ART regimen. Importantly, the number of accumulated mutations clearly correlated with the duration of ART. The most prevalent mutation was lamivudine-resistance M184V (n = 12, 38.7%) followed by efavirenz/nevirapine-resistance K103N (n = 9, 29.0%), and zidovudine/stavudine-resistance T215Y/F (n = 6, 19.4%). Within the viral protease, the major nelfinavir-resistance mutation L90M was found in one case. No transmitted HIV-1 drug-resistance mutation was found in 59 ART-naïve adults, but K103N and G190S mutations were observed in one ART-naïve child.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite expanding accessibility to ART in Eastern Ghana, the prevalence of transmitted HIV-1 drug resistance presently appears to be low. As ART provision with limited options is scaled up nationwide in Ghana, careful monitoring of transmitted HIV-1 drug resistance is necessary.</AbstractText>
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<ArticleId IdType="doi">10.1371/journal.pone.0071972</ArticleId>
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