Cost-effectiveness of HIV screening of blood donations in Accra (Ghana).
Identifieur interne : 000907 ( PubMed/Checkpoint ); précédent : 000906; suivant : 000908Cost-effectiveness of HIV screening of blood donations in Accra (Ghana).
Auteurs : Marinus Van Hulst [Pays-Bas] ; Kwamena W C. Sagoe ; Jacobien E. Vermande ; Ido P. Van Der Schaaf ; Willem P A. Van Der Tuuk Adriani ; Kwasi Torpey ; Justina Ansah ; Julius A A. Mingle ; Cees Th Smit Sibinga ; Maarten J. PostmaSource :
- Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research [ 1524-4733 ]
Descripteurs français
- KwdFr :
- Anticorps anti-VIH (sang), Anticorps anti-VIH (économie), Coûts des soins de santé, Donneurs de sang, Dépenses de santé, Dépistage systématique (économie), Ghana (épidémiologie), Humains, Infections à VIH (), Infections à VIH (transmission), Infections à VIH (économie), Infections à VIH (épidémiologie), Pays en voie de développement, Protéine de capside p24 du VIH (analyse), Protéine de capside p24 du VIH (économie), Prévalence, Transfusion sanguine (normes).
- MESH :
- analyse : Protéine de capside p24 du VIH.
- normes : Transfusion sanguine.
- sang : Anticorps anti-VIH.
- économie : Anticorps anti-VIH, Dépistage systématique, Infections à VIH, Protéine de capside p24 du VIH.
- épidémiologie : Ghana, Infections à VIH.
- Coûts des soins de santé, Donneurs de sang, Dépenses de santé, Humains, Infections à VIH, Pays en voie de développement, Prévalence.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Blood Donors, Blood Transfusion (standards), Developing Countries, Ghana (epidemiology), HIV Antibodies (blood), HIV Antibodies (economics), HIV Core Protein p24 (analysis), HIV Core Protein p24 (economics), HIV Infections (economics), HIV Infections (epidemiology), HIV Infections (prevention & control), HIV Infections (transmission), Health Care Costs, Health Expenditures, Humans, Mass Screening (economics), Prevalence.
- MESH :
- chemical , analysis : HIV Core Protein p24.
- chemical , blood : HIV Antibodies.
- chemical , economics : HIV Antibodies, HIV Core Protein p24.
- geographic , epidemiology : Ghana.
- economics : HIV Infections, Mass Screening.
- epidemiology : HIV Infections.
- prevention & control : HIV Infections.
- standards : Blood Transfusion.
- transmission : HIV Infections.
- Blood Donors, Developing Countries, Health Care Costs, Health Expenditures, Humans, Prevalence.
Abstract
Areas with high HIV-incidence rates compared to the developed world may benefit from additional testing in blood banks and may show more favorable cost-effectiveness ratios. We evaluated the cost-effectiveness of adding p24 antigen, mini pool nucleic acid amplification testing (MP-NAT), or individual donation NAT (ID-NAT) to the HIV-antibody screening at the Korle Bu Teaching Hospital (Accra, Ghana), where currently only HIV-antibody screening is undertaken.
DOI: 10.1111/j.1524-4733.2008.00337.x
PubMed: 18489518
Affiliations:
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pubmed:18489518Le document en format XML
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Sagoe</name></author><author><name sortKey="Vermande, Jacobien E" sort="Vermande, Jacobien E" uniqKey="Vermande J" first="Jacobien E" last="Vermande">Jacobien E. Vermande</name></author><author><name sortKey="Van Der Schaaf, Ido P" sort="Van Der Schaaf, Ido P" uniqKey="Van Der Schaaf I" first="Ido P" last="Van Der Schaaf">Ido P. Van Der Schaaf</name></author><author><name sortKey="Van Der Tuuk Adriani, Willem P A" sort="Van Der Tuuk Adriani, Willem P A" uniqKey="Van Der Tuuk Adriani W" first="Willem P A" last="Van Der Tuuk Adriani">Willem P A. Van Der Tuuk Adriani</name></author><author><name sortKey="Torpey, Kwasi" sort="Torpey, Kwasi" uniqKey="Torpey K" first="Kwasi" last="Torpey">Kwasi Torpey</name></author><author><name sortKey="Ansah, Justina" sort="Ansah, Justina" uniqKey="Ansah J" first="Justina" last="Ansah">Justina Ansah</name></author><author><name sortKey="Mingle, Julius A A" sort="Mingle, Julius A A" uniqKey="Mingle J" first="Julius A A" last="Mingle">Julius A A. Mingle</name></author><author><name sortKey="Smit Sibinga, Cees Th" sort="Smit Sibinga, Cees Th" uniqKey="Smit Sibinga C" first="Cees Th" last="Smit Sibinga">Cees Th Smit Sibinga</name></author><author><name sortKey="Postma, Maarten J" sort="Postma, Maarten J" uniqKey="Postma M" first="Maarten J" last="Postma">Maarten J. Postma</name></author></analytic><series><title level="j">Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research</title><idno type="eISSN">1524-4733</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Donors</term><term>Blood Transfusion (standards)</term><term>Developing Countries</term><term>Ghana (epidemiology)</term><term>HIV Antibodies (blood)</term><term>HIV Antibodies (economics)</term><term>HIV Core Protein p24 (analysis)</term><term>HIV Core Protein p24 (economics)</term><term>HIV Infections (economics)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (prevention & control)</term><term>HIV Infections (transmission)</term><term>Health Care Costs</term><term>Health Expenditures</term><term>Humans</term><term>Mass Screening (economics)</term><term>Prevalence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps anti-VIH (sang)</term><term>Anticorps anti-VIH (économie)</term><term>Coûts des soins de santé</term><term>Donneurs de sang</term><term>Dépenses de santé</term><term>Dépistage systématique (économie)</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (transmission)</term><term>Infections à VIH (économie)</term><term>Infections à VIH (épidémiologie)</term><term>Pays en voie de développement</term><term>Protéine de capside p24 du VIH (analyse)</term><term>Protéine de capside p24 du VIH (économie)</term><term>Prévalence</term><term>Transfusion sanguine (normes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>HIV Core Protein p24</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>HIV Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="economics" xml:lang="en"><term>HIV Antibodies</term><term>HIV Core Protein p24</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéine de capside p24 du VIH</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>HIV Infections</term><term>Mass Screening</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Transfusion sanguine</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps anti-VIH</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Blood Transfusion</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="économie" xml:lang="fr"><term>Anticorps anti-VIH</term><term>Dépistage systématique</term><term>Infections à VIH</term><term>Protéine de capside p24 du VIH</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blood Donors</term><term>Developing Countries</term><term>Health Care Costs</term><term>Health Expenditures</term><term>Humans</term><term>Prevalence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coûts des soins de santé</term><term>Donneurs de sang</term><term>Dépenses de santé</term><term>Humains</term><term>Infections à VIH</term><term>Pays en voie de développement</term><term>Prévalence</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Areas with high HIV-incidence rates compared to the developed world may benefit from additional testing in blood banks and may show more favorable cost-effectiveness ratios. We evaluated the cost-effectiveness of adding p24 antigen, mini pool nucleic acid amplification testing (MP-NAT), or individual donation NAT (ID-NAT) to the HIV-antibody screening at the Korle Bu Teaching Hospital (Accra, Ghana), where currently only HIV-antibody screening is undertaken.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18489518</PMID><DateCreated><Year>2009</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>2009</Year><Month>07</Month><Day>15</Day></DateCompleted><DateRevised><Year>2009</Year><Month>06</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4733</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>5</Issue><PubDate><MedlineDate>2008 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research</Title><ISOAbbreviation>Value Health</ISOAbbreviation></Journal><ArticleTitle>Cost-effectiveness of HIV screening of blood donations in Accra (Ghana).</ArticleTitle><Pagination><MedlinePgn>809-19</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1524-4733.2008.00337.x</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Areas with high HIV-incidence rates compared to the developed world may benefit from additional testing in blood banks and may show more favorable cost-effectiveness ratios. We evaluated the cost-effectiveness of adding p24 antigen, mini pool nucleic acid amplification testing (MP-NAT), or individual donation NAT (ID-NAT) to the HIV-antibody screening at the Korle Bu Teaching Hospital (Accra, Ghana), where currently only HIV-antibody screening is undertaken.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The residual risk of HIV transmission was derived from blood donations to the blood bank of the Korle Bu Teaching Hospital in 2004. Remaining life expectancies of patients receiving blood transfusion were estimated using the World Health Organization life expectancies. Cost-effectiveness ratios for adding the tests to HIV-antibody screening only were determined using a decision tree model and a Markov model for HIV.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The prevalence of HIV was estimated at 1.51% in 18,714 donations during 2004. The incremental cost per disability-adjusted life-year (DALY) averted was US$1237 for p24 antigen, US$3142 for MP-NAT and US$7695 compared to the next least expensive strategy. HIV-antibody screening itself was cost-saving compared to no screening at all, gaining US$73.85 and averting 0.86 DALY per transfused patient. Up to a willingness-to-pay of US$2736 per DALY averted, HIV-antibody screening without additional testing was the most cost-effective strategy. Over a willingness-to-pay of US$11,828 per DALY averted, ID-NAT was significantly more cost-effective than the other strategies.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Adding p24 antigen, MP-NAT, or ID-NAT to the current antibody screening cannot be regarded as a cost-effective health-care intervention for Ghana.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Hulst</LastName><ForeName>Marinus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands. m.van.hulst@rug.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sagoe</LastName><ForeName>Kwamena W C</ForeName><Initials>KW</Initials></Author><Author ValidYN="Y"><LastName>Vermande</LastName><ForeName>Jacobien E</ForeName><Initials>JE</Initials></Author><Author ValidYN="Y"><LastName>van der Schaaf</LastName><ForeName>Ido P</ForeName><Initials>IP</Initials></Author><Author ValidYN="Y"><LastName>van der Tuuk Adriani</LastName><ForeName>Willem P A</ForeName><Initials>WP</Initials></Author><Author ValidYN="Y"><LastName>Torpey</LastName><ForeName>Kwasi</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Ansah</LastName><ForeName>Justina</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Mingle</LastName><ForeName>Julius A A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Smit Sibinga</LastName><ForeName>Cees Th</ForeName><Initials>CT</Initials></Author><Author ValidYN="Y"><LastName>Postma</LastName><ForeName>Maarten J</ForeName><Initials>MJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>05</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Value Health</MedlineTA><NlmUniqueID>100883818</NlmUniqueID><ISSNLinking>1098-3015</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015483">HIV Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016655">HIV Core Protein p24</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001782" MajorTopicYN="Y">Blood Donors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001803" MajorTopicYN="N">Blood Transfusion</DescriptorName><QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003906" MajorTopicYN="N">Developing Countries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015483" MajorTopicYN="N">HIV Antibodies</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016655" MajorTopicYN="N">HIV Core Protein p24</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017048" MajorTopicYN="N">Health Care Costs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005102" MajorTopicYN="N">Health Expenditures</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008403" MajorTopicYN="N">Mass Screening</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>5</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Mingle</name><name sortKey="Postma, Maarten J" sort="Postma, Maarten J" uniqKey="Postma M" first="Maarten J" last="Postma">Maarten J. Postma</name><name sortKey="Sagoe, Kwamena W C" sort="Sagoe, Kwamena W C" uniqKey="Sagoe K" first="Kwamena W C" last="Sagoe">Kwamena W C. Sagoe</name><name sortKey="Smit Sibinga, Cees Th" sort="Smit Sibinga, Cees Th" uniqKey="Smit Sibinga C" first="Cees Th" last="Smit Sibinga">Cees Th Smit Sibinga</name><name sortKey="Torpey, Kwasi" sort="Torpey, Kwasi" uniqKey="Torpey K" first="Kwasi" last="Torpey">Kwasi Torpey</name><name sortKey="Van Der Schaaf, Ido P" sort="Van Der Schaaf, Ido P" uniqKey="Van Der Schaaf I" first="Ido P" last="Van Der Schaaf">Ido P. Van Der Schaaf</name><name sortKey="Van Der Tuuk Adriani, Willem P A" sort="Van Der Tuuk Adriani, Willem P A" uniqKey="Van Der Tuuk Adriani W" first="Willem P A" last="Van Der Tuuk Adriani">Willem P A. Van Der Tuuk Adriani</name><name sortKey="Vermande, Jacobien E" sort="Vermande, Jacobien E" uniqKey="Vermande J" first="Jacobien E" last="Vermande">Jacobien E. Vermande</name></noCountry><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Van Hulst, Marinus" sort="Van Hulst, Marinus" uniqKey="Van Hulst M" first="Marinus" last="Van Hulst">Marinus Van Hulst</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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