Clinical epidemiology, not seroepidemiology, is the answer to Africa's AIDS problem.
Identifieur interne : 000882 ( PubMed/Checkpoint ); précédent : 000881; suivant : 000883Clinical epidemiology, not seroepidemiology, is the answer to Africa's AIDS problem.
Auteurs : F I Konotey-AhuluSource :
- British medical journal (Clinical research ed.) [ 0267-0623 ] ; 1987.
Descripteurs français
- KwdFr :
- MESH :
- économie : Médecine tropicale.
- épidémiologie : Syndrome d'immunodéficience acquise.
- Afrique, Humains, Méthodes épidémiologiques, Sérologie.
English descriptors
- KwdEn :
- MESH :
- geographic : Africa.
- economics : Tropical Medicine.
- epidemiology : Acquired Immunodeficiency Syndrome.
- Epidemiologic Methods, Humans, Serology.
PubMed: 3113544
Affiliations:
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pubmed:3113544Le document en format XML
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Version="1">3113544</PMID><DateCreated><Year>1987</Year><Month>09</Month><Day>29</Day></DateCreated><DateCompleted><Year>1987</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0267-0623</ISSN><JournalIssue CitedMedium="Print"><Volume>294</Volume><Issue>6587</Issue><PubDate><Year>1987</Year><Month>Jun</Month><Day>20</Day></PubDate></JournalIssue><Title>British medical journal (Clinical research ed.)</Title><ISOAbbreviation>Br Med J (Clin Res Ed)</ISOAbbreviation></Journal><ArticleTitle>Clinical epidemiology, not seroepidemiology, is the answer to Africa's AIDS problem.</ArticleTitle><Pagination><MedlinePgn>1593-4</MedlinePgn></Pagination><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Konotey-Ahulu</LastName><ForeName>F I</ForeName><Initials>FI</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br Med J (Clin Res Ed)</MedlineTA><NlmUniqueID>8302911</NlmUniqueID><ISSNLinking>0267-0623</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CitationSubset>J</CitationSubset><CitationSubset>X</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Br Med J. 1966 Mar 5;1(5487):569-73</RefSource><PMID Version="1">5907314</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br Med J (Clin Res Ed). 1982 Jan 9;284(6309):112</RefSource><PMID Version="1">6797647</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1986 Apr 3;314(14):921-2</RefSource><PMID Version="1">3513019</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1985 Oct 26;2(8461):952-3</RefSource><PMID Version="1">2865454</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Surg. 1958 Nov;46(197):218-23</RefSource><PMID Version="1">13628987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1986 Mar 6;314(10):647-8</RefSource><PMID Version="1">3511375</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br Med J (Clin Res Ed). 1985 Mar 16;290(6471):808-10</RefSource><PMID Version="1">2983820</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>East Afr Med J. 1986 Oct;63(10):683-4</RefSource><PMID Version="1">3643841</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1986 Jan 11;1(8472):79-83</RefSource><PMID Version="1">2867324</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000163" MajorTopicYN="N">Acquired Immunodeficiency Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000349" MajorTopicYN="N" Type="Geographic">Africa</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004812" MajorTopicYN="Y">Epidemiologic Methods</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012699" MajorTopicYN="N">Serology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014330" MajorTopicYN="Y">Tropical Medicine</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1246735</OtherID><OtherID Source="PIP">043485</OtherID><OtherID Source="POP">00167022</OtherID><OtherAbstract Type="PIP" Language="eng"><AbstractText>The shortcomings of the "seroepidemiology" approach as opposed to the traditional "clinical epidemiology" approach in answer to Africa's acquired immunodeficiency syndrome (AIDS) problem, are discussed. Investigators with a knowledge of tropical medicine have observe that recurrent malaria and other infectious diseases are associated with excessively high rates of false-positivity with H9/HTV-III, enzyme linked immunoabsorbent assay (ELISA), leading to a dichotomy between seroepidemiology and clinical epidemiology in tropical Africa. In addition, patients with alcoholic liver disease have a high incidence of false positive results on tests for HTLV-III antibodies, while acute malaria infections have produced false positivity even with the Western blot. When the conclusions of clinical epidemiology differ from those of seroepidemiology, clinicians should always believe the former. Serological work should be limited to assessing the specificity and sensitivity of the various kits under African conditions, screening all blood before transfusion, and serving as a back up procedure when clinical features are not clear cut. In his Krobo tribe, in southeastern Ghana, Dr. Konotey-Ahulu suggests that the bulk of any available funds should be resourcefully utilized in answering the questions: how, when, who, which, why and where?</AbstractText></OtherAbstract><KeywordList Owner="PIP"><Keyword MajorTopicYN="Y">Acquired Immunodeficiency Syndrome</Keyword><Keyword MajorTopicYN="N">Africa</Keyword><Keyword MajorTopicYN="Y">Africa South Of The Sahara</Keyword><Keyword MajorTopicYN="Y">Critique</Keyword><Keyword MajorTopicYN="N">Developing Countries</Keyword><Keyword MajorTopicYN="Y">Diseases</Keyword><Keyword MajorTopicYN="N">English Speaking Africa</Keyword><Keyword MajorTopicYN="Y">Examinations And Diagnoses</Keyword><Keyword MajorTopicYN="N">Ghana</Keyword><Keyword MajorTopicYN="N">Hiv Infections</Keyword><Keyword MajorTopicYN="Y">Laboratory Examinations And Diagnoses</Keyword><Keyword MajorTopicYN="Y">Physical Examinations And Diagnoses</Keyword><Keyword MajorTopicYN="Y">Recommendations</Keyword><Keyword MajorTopicYN="Y">Viral Diseases</Keyword><Keyword MajorTopicYN="Y">Western Africa</Keyword></KeywordList><GeneralNote Owner="PIP">TJ: BRITISH MEDICAL JOURNAL.</GeneralNote></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>6</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>6</Month><Day>20</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>6</Month><Day>20</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3113544</ArticleId><ArticleId IdType="pmc">PMC1246735</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Konotey Ahulu, F I" sort="Konotey Ahulu, F I" uniqKey="Konotey Ahulu F" first="F I" last="Konotey-Ahulu">F I Konotey-Ahulu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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