Genomic divergence of HIV-2 from Ghana.
Identifieur interne : 000872 ( PubMed/Checkpoint ); précédent : 000871; suivant : 000873Genomic divergence of HIV-2 from Ghana.
Auteurs : A. Hasegawa [Japon] ; H. Tsujimoto ; N. Maki ; K. Ishikawa ; T. Miura ; M. Fukasawa ; K. Miki ; M. HayamiSource :
- AIDS research and human retroviruses [ 0889-2229 ] ; 1989.
Descripteurs français
- KwdFr :
- ADN viral (génétique), Cartographie de restriction, Données de séquences moléculaires, Ghana, Gènes viraux, Humains, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (génétique), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (isolement et purification), Variation génétique, Virus de l'immunodéficience simienne (génétique).
- MESH :
- génétique : ADN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2), Virus de l'immunodéficience simienne.
- isolement et purification : VIH-2 (Virus de l'Immunodéficience Humaine de type 2).
- Cartographie de restriction, Données de séquences moléculaires, Ghana, Gènes viraux, Humains, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, Variation génétique.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Viral.
- geographic : Ghana.
- genetics : HIV-1, HIV-2, Simian Immunodeficiency Virus.
- isolation & purification : HIV-2.
- Amino Acid Sequence, Base Sequence, Genes, Viral, Genetic Variation, Humans, Molecular Sequence Data, Restriction Mapping, Sequence Homology, Nucleic Acid.
Abstract
Genetic variability in human immunodeficiency virus type 1 (HIV-1) has been studied extensively, but the total nucleotide sequence of the HIV-2 genome has been reported only in two strains. For phylogenetic analyses of HIV, the genetic variability of HIV-2 should be investigated. This paper reports the complete nucleotide sequence of an HIV-2 isolate from Ghana, HIV-2[GH-1]. This virus showed approximately 85% homology in overall nucleotide sequence with HIV-2ROD. The amino acid sequence of the gag and pol proteins of HIV-2[GH-1] showed 90% homology with those of HIV-2ROD, but its env gene and central regions were highly variable (more than 20% divergence in amino acids), indicating the presence of extensive genetic heterogeneity in HIV-2. However, the sequences with specific functions were relatively well conserved in these HIV-2 isolates.
DOI: 10.1089/aid.1989.5.593
PubMed: 2611042
Affiliations:
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However, the sequences with specific functions were relatively well conserved in these HIV-2 isolates.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2611042</PMID><DateCreated><Year>1990</Year><Month>03</Month><Day>06</Day></DateCreated><DateCompleted><Year>1990</Year><Month>03</Month><Day>06</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0889-2229</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>6</Issue><PubDate><Year>1989</Year><Month>Dec</Month></PubDate></JournalIssue><Title>AIDS research and human retroviruses</Title><ISOAbbreviation>AIDS Res. Hum. Retroviruses</ISOAbbreviation></Journal><ArticleTitle>Genomic divergence of HIV-2 from Ghana.</ArticleTitle><Pagination><MedlinePgn>593-604</MedlinePgn></Pagination><Abstract><AbstractText>Genetic variability in human immunodeficiency virus type 1 (HIV-1) has been studied extensively, but the total nucleotide sequence of the HIV-2 genome has been reported only in two strains. For phylogenetic analyses of HIV, the genetic variability of HIV-2 should be investigated. This paper reports the complete nucleotide sequence of an HIV-2 isolate from Ghana, HIV-2[GH-1]. This virus showed approximately 85% homology in overall nucleotide sequence with HIV-2ROD. The amino acid sequence of the gag and pol proteins of HIV-2[GH-1] showed 90% homology with those of HIV-2ROD, but its env gene and central regions were highly variable (more than 20% divergence in amino acids), indicating the presence of extensive genetic heterogeneity in HIV-2. However, the sequences with specific functions were relatively well conserved in these HIV-2 isolates.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hasegawa</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fundamental Research Laboratory, Saitama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsujimoto</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Maki</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Ishikawa</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Miura</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Fukasawa</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Miki</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Hayami</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>AIDS Res Hum Retroviruses</MedlineTA><NlmUniqueID>8709376</NlmUniqueID><ISSNLinking>0889-2229</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005814" MajorTopicYN="N">Genes, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015498" MajorTopicYN="N">HIV-2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015183" MajorTopicYN="N">Restriction Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012689" MajorTopicYN="N">Sequence Homology, Nucleic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015302" MajorTopicYN="N">Simian Immunodeficiency Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1989</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2611042</ArticleId><ArticleId IdType="doi">10.1089/aid.1989.5.593</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Fukasawa, M" sort="Fukasawa, M" uniqKey="Fukasawa M" first="M" last="Fukasawa">M. Fukasawa</name><name sortKey="Hayami, M" sort="Hayami, M" uniqKey="Hayami M" first="M" last="Hayami">M. Hayami</name><name sortKey="Ishikawa, K" sort="Ishikawa, K" uniqKey="Ishikawa K" first="K" last="Ishikawa">K. Ishikawa</name><name sortKey="Maki, N" sort="Maki, N" uniqKey="Maki N" first="N" last="Maki">N. Maki</name><name sortKey="Miki, K" sort="Miki, K" uniqKey="Miki K" first="K" last="Miki">K. Miki</name><name sortKey="Miura, T" sort="Miura, T" uniqKey="Miura T" first="T" last="Miura">T. Miura</name><name sortKey="Tsujimoto, H" sort="Tsujimoto, H" uniqKey="Tsujimoto H" first="H" last="Tsujimoto">H. Tsujimoto</name></noCountry><country name="Japon"><noRegion><name sortKey="Hasegawa, A" sort="Hasegawa, A" uniqKey="Hasegawa A" first="A" last="Hasegawa">A. Hasegawa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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