Higher viral load may explain the dominance of CRF02_AG in the molecular epidemiology of HIV in Ghana.
Identifieur interne : 000687 ( PubMed/Checkpoint ); précédent : 000686; suivant : 000688Higher viral load may explain the dominance of CRF02_AG in the molecular epidemiology of HIV in Ghana.
Auteurs : Lucia Fischetti [Royaume-Uni] ; Ohene Opare-Sem ; Daniel Candotti ; Helen Lee ; Jean-Pierre AllainSource :
- AIDS (London, England) [ 0269-9370 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- génétique : ARN complémentaire, ARN viral, Infections à VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- virologie : Infections à VIH.
- épidémiologie : Ghana, Infections à VIH.
- Charge virale, Humains, Prévalence.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : RNA, Complementary, RNA, Viral.
- geographic , epidemiology : Ghana.
- epidemiology : HIV Infections.
- genetics : HIV Infections, HIV-1.
- virology : HIV Infections.
- Humans, Prevalence, Viral Load.
Abstract
Phylogenetic analysis of Ghanaian plasma samples from 84 asymptomatic candidate blood donors and 150 AIDS patients revealed a 63% prevalence of HIV-1 CRF02_AG. HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02_AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02-AG is compatible with higher infectivity and prevalence.
PubMed: 15166539
Affiliations:
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pubmed:15166539Le document en format XML
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HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02_AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02-AG is compatible with higher infectivity and prevalence.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15166539</PMID><DateCreated><Year>2004</Year><Month>05</Month><Day>28</Day></DateCreated><DateCompleted><Year>2004</Year><Month>07</Month><Day>01</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0269-9370</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>8</Issue><PubDate><Year>2004</Year><Month>May</Month><Day>21</Day></PubDate></JournalIssue><Title>AIDS (London, England)</Title><ISOAbbreviation>AIDS</ISOAbbreviation></Journal><ArticleTitle>Higher viral load may explain the dominance of CRF02_AG in the molecular epidemiology of HIV in Ghana.</ArticleTitle><Pagination><MedlinePgn>1208-10</MedlinePgn></Pagination><Abstract><AbstractText>Phylogenetic analysis of Ghanaian plasma samples from 84 asymptomatic candidate blood donors and 150 AIDS patients revealed a 63% prevalence of HIV-1 CRF02_AG. HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02_AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02-AG is compatible with higher infectivity and prevalence.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fischetti</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Opare-Sem</LastName><ForeName>Ohene</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Candotti</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Allain</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>AIDS</MedlineTA><NlmUniqueID>8710219</NlmUniqueID><ISSNLinking>0269-9370</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018075">RNA, Complementary</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018075" MajorTopicYN="N">RNA, Complementary</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>5</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>7</Month><Day>2</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>5</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15166539</ArticleId><ArticleId IdType="pii">00002030-200405210-00017</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name><name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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