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Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African women.

Identifieur interne : 000645 ( PubMed/Checkpoint ); précédent : 000644; suivant : 000646

Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African women.

Auteurs : Jacques Pépin [Canada] ; Guy D. Fink ; Nzambi Khonde ; Francois Sobela ; Sylvie Deslandes ; Soumaila Diakité ; Annie-Claude Labbé ; Mohamed Sylla ; Eric Frost

Source :

RBID : pubmed:16773025

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English descriptors

Abstract

Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them.

DOI: 10.1097/01.qai.0000222286.52084.9c
PubMed: 16773025


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pubmed:16773025

Le document en format XML

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<title xml:lang="en">Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African women.</title>
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<name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pépin">Jacques Pépin</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada. jacques.pepin@usherbrooke.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
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<name sortKey="Fink, Guy D" sort="Fink, Guy D" uniqKey="Fink G" first="Guy D" last="Fink">Guy D. Fink</name>
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<name sortKey="Khonde, Nzambi" sort="Khonde, Nzambi" uniqKey="Khonde N" first="Nzambi" last="Khonde">Nzambi Khonde</name>
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<name sortKey="Sobela, Francois" sort="Sobela, Francois" uniqKey="Sobela F" first="Francois" last="Sobela">Francois Sobela</name>
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<name sortKey="Deslandes, Sylvie" sort="Deslandes, Sylvie" uniqKey="Deslandes S" first="Sylvie" last="Deslandes">Sylvie Deslandes</name>
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<name sortKey="Diakite, Soumaila" sort="Diakite, Soumaila" uniqKey="Diakite S" first="Soumaila" last="Diakité">Soumaila Diakité</name>
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<name sortKey="Labbe, Annie Claude" sort="Labbe, Annie Claude" uniqKey="Labbe A" first="Annie-Claude" last="Labbé">Annie-Claude Labbé</name>
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<name sortKey="Sylla, Mohamed" sort="Sylla, Mohamed" uniqKey="Sylla M" first="Mohamed" last="Sylla">Mohamed Sylla</name>
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<name sortKey="Frost, Eric" sort="Frost, Eric" uniqKey="Frost E" first="Eric" last="Frost">Eric Frost</name>
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<title xml:lang="en">Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African women.</title>
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<name sortKey="Pepin, Jacques" sort="Pepin, Jacques" uniqKey="Pepin J" first="Jacques" last="Pépin">Jacques Pépin</name>
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<nlm:affiliation>Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada. jacques.pepin@usherbrooke.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
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<name sortKey="Fink, Guy D" sort="Fink, Guy D" uniqKey="Fink G" first="Guy D" last="Fink">Guy D. Fink</name>
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<name sortKey="Khonde, Nzambi" sort="Khonde, Nzambi" uniqKey="Khonde N" first="Nzambi" last="Khonde">Nzambi Khonde</name>
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<name sortKey="Sobela, Francois" sort="Sobela, Francois" uniqKey="Sobela F" first="Francois" last="Sobela">Francois Sobela</name>
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<name sortKey="Deslandes, Sylvie" sort="Deslandes, Sylvie" uniqKey="Deslandes S" first="Sylvie" last="Deslandes">Sylvie Deslandes</name>
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<name sortKey="Diakite, Soumaila" sort="Diakite, Soumaila" uniqKey="Diakite S" first="Soumaila" last="Diakité">Soumaila Diakité</name>
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<name sortKey="Labbe, Annie Claude" sort="Labbe, Annie Claude" uniqKey="Labbe A" first="Annie-Claude" last="Labbé">Annie-Claude Labbé</name>
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<name sortKey="Sylla, Mohamed" sort="Sylla, Mohamed" uniqKey="Sylla M" first="Mohamed" last="Sylla">Mohamed Sylla</name>
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<name sortKey="Frost, Eric" sort="Frost, Eric" uniqKey="Frost E" first="Eric" last="Frost">Eric Frost</name>
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<title level="j">Journal of acquired immune deficiency syndromes (1999)</title>
<idno type="ISSN">1525-4135</idno>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Africa, Western</term>
<term>Female</term>
<term>Humans</term>
<term>Prostate-Specific Antigen (analysis)</term>
<term>Prostate-Specific Antigen (secretion)</term>
<term>Unsafe Sex</term>
<term>Vagina (secretion)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Afrique de l'Ouest</term>
<term>Antigène spécifique de la prostate (analyse)</term>
<term>Antigène spécifique de la prostate (sécrétion)</term>
<term>Comportement sexuel à risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Vagin (sécrétion)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en">
<term>Prostate-Specific Antigen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en">
<term>Prostate-Specific Antigen</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en">
<term>Africa, Western</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr">
<term>Antigène spécifique de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="secretion" xml:lang="en">
<term>Vagina</term>
</keywords>
<keywords scheme="MESH" qualifier="sécrétion" xml:lang="fr">
<term>Antigène spécifique de la prostate</term>
<term>Vagin</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Female</term>
<term>Humans</term>
<term>Unsafe Sex</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Afrique de l'Ouest</term>
<term>Comportement sexuel à risque</term>
<term>Femelle</term>
<term>Humains</term>
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<div type="abstract" xml:lang="en">Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them.</div>
</front>
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<DateCreated>
<Year>2006</Year>
<Month>07</Month>
<Day>13</Day>
</DateCreated>
<DateCompleted>
<Year>2006</Year>
<Month>08</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised>
<Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
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<ISSN IssnType="Print">1525-4135</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>42</Volume>
<Issue>4</Issue>
<PubDate>
<Year>2006</Year>
<Month>Aug</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Journal of acquired immune deficiency syndromes (1999)</Title>
<ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation>
</Journal>
<ArticleTitle>Improving second-generation surveillance: the biological measure of unprotected intercourse using prostate-specific antigen in vaginal secretions of West African women.</ArticleTitle>
<Pagination>
<MedlinePgn>490-3</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Determine whether the prostate-specific antigen (PSA) could be used as a biological marker of unprotected intercourse.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We measured the presence of PSA in vaginal secretions of women who were (n = 508) or were not (n = 658) SW presenting with vaginal discharge in health facilities of Ghana, Togo, Guinea, and Mali. The cutoff for a positive assay was determined as > or =0.4 microg/L based on a subsample of 95 non-SW claiming abstinence for 3 months.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A positive PSA assay was correlated with infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium. Among non-SW, a positive PSA was more common among those with HIV, but less frequent in those better educated. Among SW and non-SW, women from Ghana were less likely to have a positive PSA and had a lower prevalence of sexually transmitted infections than those from elsewhere.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">PSA can be used as a biological marker of unprotected intercourse, allowing interventions to target efforts on those at highest risk.</AbstractText>
</Abstract>
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<Author ValidYN="Y">
<LastName>Pépin</LastName>
<ForeName>Jacques</ForeName>
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<Affiliation>Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada. jacques.pepin@usherbrooke.ca</Affiliation>
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<RegistryNumber>EC 3.4.21.77</RegistryNumber>
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<DescriptorName UI="D017430" MajorTopicYN="N">Prostate-Specific Antigen</DescriptorName>
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<QualifierName UI="Q000557" MajorTopicYN="N">secretion</QualifierName>
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<MeshHeading>
<DescriptorName UI="D047568" MajorTopicYN="Y">Unsafe Sex</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D014621" MajorTopicYN="N">Vagina</DescriptorName>
<QualifierName UI="Q000557" MajorTopicYN="Y">secretion</QualifierName>
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<Hour>9</Hour>
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<li>Canada</li>
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