Effect of immunomodulating and antiviral agent of medicinal mushrooms (immune assist 24/7) on CD4+ T-lymphocyte counts of HIV-infected patients.
Identifieur interne : 000506 ( PubMed/Checkpoint ); précédent : 000505; suivant : 000507Effect of immunomodulating and antiviral agent of medicinal mushrooms (immune assist 24/7) on CD4+ T-lymphocyte counts of HIV-infected patients.
Auteurs : Gideon Adotey [Ghana] ; Abraham Quarcoo ; John C. Holliday ; Solomon Fofie ; Braimah SaakaSource :
- International journal of medicinal mushrooms [ 1521-9437 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agaricales (), Agaricales (immunologie), Agents antiVIH (administration et posologie), Agents antiVIH (usage thérapeutique), Facteurs immunologiques (usage thérapeutique), Femelle, Humains, Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD4+ (virologie), Mâle, Numération des lymphocytes CD4, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), bêta-Glucanes (usage thérapeutique).
- MESH :
- administration et posologie : Agents antiVIH.
- immunologie : Agaricales, Infections à VIH, Lymphocytes T CD4+.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH, Facteurs immunologiques, bêta-Glucanes.
- virologie : Infections à VIH, Lymphocytes T CD4+.
- Adulte, Adulte d'âge moyen, Agaricales, Femelle, Humains, Mâle, Numération des lymphocytes CD4, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- Adult, Agaricales (chemistry), Agaricales (immunology), Anti-HIV Agents (administration & dosage), Anti-HIV Agents (therapeutic use), CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (virology), Female, HIV Infections (drug therapy), HIV Infections (immunology), HIV Infections (virology), HIV-1, Humans, Immunologic Factors (therapeutic use), Male, Middle Aged, beta-Glucans (therapeutic use).
- MESH :
- chemical , administration & dosage : Anti-HIV Agents.
- chemistry : Agaricales.
- drug therapy : HIV Infections.
- immunology : Agaricales, CD4-Positive T-Lymphocytes, HIV Infections.
- chemical , therapeutic use : Anti-HIV Agents, Immunologic Factors, beta-Glucans.
- virology : CD4-Positive T-Lymphocytes, HIV Infections.
- Adult, CD4 Lymphocyte Count, Female, HIV-1, Humans, Male, Middle Aged.
Abstract
Immune enhancement through the use of natural products is a potentially valuable therapeutic modality in HIV-infected people, especially those who are not good candidates for aggressive ARV therapy. One such immune enhancement, a medicinal mushroom product from the United States, is Immune Assist 24/7. In this study the effect of Immune Assist 24/7, which is a naturally derived immune-modulating and antiviral agent, on CD4+ T-lymphocyte counts was evaluated in 8 HIV-infected patients at the Sunyani Regional Hospital (Ghana). The subjects were administered three tablets of 800 mg Immune Assist 24/7 once daily (2.4 g/day) and peripheral blood samples were drawn at baseline, day 30, and day 60, and the CD4+ count measured. The study revealed that Immune Assist 24/7, used as a sole therapeutic agent without additional ARV drugs, significantly increased CD4+ T-lymphocyte populations in all of the patients. In one patient, the CD4+ T-lymphocyte count went from 4 at the baseline, to 170 cells in 60 days, representing an increase of more than 4000%. In another patient, the CD4+ count went from 88 to 470 cells within the same period. Even in the patients with the highest CD4+ counts of around 800, there was a significant elevation in the CD4+ count noted. This study did not deal with the effect of Immune Assist 24/7 on other immune parameters such as CD3+ T-lymphocyte count, natural killer cells count, or viral load among HIV-infected patients. These initial results are promising, and indicate the potential value of further evaluating the effects of Immune Assist 24/7 on other immune parameters and viral load among HIV patients, administered either as a sole therapeutic agent, as an adjuvant with standard ARV therapy, or in comparison with standard ARV therapy alone.
PubMed: 22135886
Affiliations:
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pubmed:22135886Le document en format XML
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One such immune enhancement, a medicinal mushroom product from the United States, is Immune Assist 24/7. In this study the effect of Immune Assist 24/7, which is a naturally derived immune-modulating and antiviral agent, on CD4+ T-lymphocyte counts was evaluated in 8 HIV-infected patients at the Sunyani Regional Hospital (Ghana). The subjects were administered three tablets of 800 mg Immune Assist 24/7 once daily (2.4 g/day) and peripheral blood samples were drawn at baseline, day 30, and day 60, and the CD4+ count measured. The study revealed that Immune Assist 24/7, used as a sole therapeutic agent without additional ARV drugs, significantly increased CD4+ T-lymphocyte populations in all of the patients. In one patient, the CD4+ T-lymphocyte count went from 4 at the baseline, to 170 cells in 60 days, representing an increase of more than 4000%. In another patient, the CD4+ count went from 88 to 470 cells within the same period. Even in the patients with the highest CD4+ counts of around 800, there was a significant elevation in the CD4+ count noted. This study did not deal with the effect of Immune Assist 24/7 on other immune parameters such as CD3+ T-lymphocyte count, natural killer cells count, or viral load among HIV-infected patients. These initial results are promising, and indicate the potential value of further evaluating the effects of Immune Assist 24/7 on other immune parameters and viral load among HIV patients, administered either as a sole therapeutic agent, as an adjuvant with standard ARV therapy, or in comparison with standard ARV therapy alone.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22135886</PMID><DateCreated><Year>2011</Year><Month>12</Month><Day>05</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>14</Day></DateCompleted><DateRevised><Year>2011</Year><Month>12</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1521-9437</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>2</Issue><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>International journal of medicinal mushrooms</Title><ISOAbbreviation>Int J Med Mushrooms</ISOAbbreviation></Journal><ArticleTitle>Effect of immunomodulating and antiviral agent of medicinal mushrooms (immune assist 24/7) on CD4+ T-lymphocyte counts of HIV-infected patients.</ArticleTitle><Pagination><MedlinePgn>109-13</MedlinePgn></Pagination><Abstract><AbstractText>Immune enhancement through the use of natural products is a potentially valuable therapeutic modality in HIV-infected people, especially those who are not good candidates for aggressive ARV therapy. One such immune enhancement, a medicinal mushroom product from the United States, is Immune Assist 24/7. In this study the effect of Immune Assist 24/7, which is a naturally derived immune-modulating and antiviral agent, on CD4+ T-lymphocyte counts was evaluated in 8 HIV-infected patients at the Sunyani Regional Hospital (Ghana). The subjects were administered three tablets of 800 mg Immune Assist 24/7 once daily (2.4 g/day) and peripheral blood samples were drawn at baseline, day 30, and day 60, and the CD4+ count measured. The study revealed that Immune Assist 24/7, used as a sole therapeutic agent without additional ARV drugs, significantly increased CD4+ T-lymphocyte populations in all of the patients. In one patient, the CD4+ T-lymphocyte count went from 4 at the baseline, to 170 cells in 60 days, representing an increase of more than 4000%. In another patient, the CD4+ count went from 88 to 470 cells within the same period. Even in the patients with the highest CD4+ counts of around 800, there was a significant elevation in the CD4+ count noted. This study did not deal with the effect of Immune Assist 24/7 on other immune parameters such as CD3+ T-lymphocyte count, natural killer cells count, or viral load among HIV-infected patients. These initial results are promising, and indicate the potential value of further evaluating the effects of Immune Assist 24/7 on other immune parameters and viral load among HIV patients, administered either as a sole therapeutic agent, as an adjuvant with standard ARV therapy, or in comparison with standard ARV therapy alone.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adotey</LastName><ForeName>Gideon</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Science Laboratory Department, Accra Polytechnic, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quarcoo</LastName><ForeName>Abraham</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Holliday</LastName><ForeName>John C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Fofie</LastName><ForeName>Solomon</ForeName><Initials>S</Initials></Author><Author 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MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000363" MajorTopicYN="N">Agaricales</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018791" MajorTopicYN="Y">CD4 Lymphocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="Y">HIV-1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007155" MajorTopicYN="N">Immunologic Factors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047071" MajorTopicYN="N">beta-Glucans</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>12</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>12</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22135886</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li></settlement></list><tree><noCountry><name sortKey="Fofie, Solomon" sort="Fofie, Solomon" uniqKey="Fofie S" first="Solomon" last="Fofie">Solomon Fofie</name><name sortKey="Holliday, John C" sort="Holliday, John C" uniqKey="Holliday J" first="John C" last="Holliday">John C. Holliday</name><name sortKey="Quarcoo, Abraham" sort="Quarcoo, Abraham" uniqKey="Quarcoo A" first="Abraham" last="Quarcoo">Abraham Quarcoo</name><name sortKey="Saaka, Braimah" sort="Saaka, Braimah" uniqKey="Saaka B" first="Braimah" last="Saaka">Braimah Saaka</name></noCountry><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Adotey, Gideon" sort="Adotey, Gideon" uniqKey="Adotey G" first="Gideon" last="Adotey">Gideon Adotey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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