Low level of transmitted HIV Drug resistance at two HIV care centres in Ghana: a threshold survey.
Identifieur interne : 000398 ( PubMed/Checkpoint ); précédent : 000397; suivant : 000399Low level of transmitted HIV Drug resistance at two HIV care centres in Ghana: a threshold survey.
Auteurs : E Y Bonney [Ghana] ; N A Addo ; N A A. Ntim ; F. Addo-Yobo ; P. Bondzie ; K-E Aryee ; J. Barnor ; J. Brandful ; V. Bekoe ; S-A Ohene ; W. AmpofoSource :
- Ghana medical journal [ 0016-9560 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Analyse de mutations d'ADN, Antirétroviraux (usage thérapeutique), Femelle, Ghana (épidémiologie), Grossesse, Génotype, Humains, Jeune adulte, Mutation, Programmes nationaux de santé, Protéase du VIH (génétique), Prévalence, Résistance virale aux médicaments (génétique), Surveillance sentinelle, Séropositivité VIH (traitement médicamenteux), Séropositivité VIH (transmission), Séropositivité VIH (virologie), Séropositivité VIH (épidémiologie), Transcriptase inverse du VIH (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique).
- MESH :
- génétique : Protéase du VIH, Résistance virale aux médicaments, Transcriptase inverse du VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- traitement médicamenteux : Séropositivité VIH.
- usage thérapeutique : Antirétroviraux, Séropositivité VIH.
- virologie : Séropositivité VIH.
- épidémiologie : Ghana, Séropositivité VIH.
- Adolescent, Adulte, Analyse de mutations d'ADN, Femelle, Grossesse, Génotype, Humains, Jeune adulte, Mutation, Programmes nationaux de santé, Prévalence, Surveillance sentinelle.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-Retroviral Agents (therapeutic use), DNA Mutational Analysis, Drug Resistance, Viral (genetics), Female, Genotype, Ghana (epidemiology), HIV Protease (genetics), HIV Reverse Transcriptase (genetics), HIV Seropositivity (drug therapy), HIV Seropositivity (epidemiology), HIV Seropositivity (transmission), HIV Seropositivity (virology), HIV-1 (genetics), Humans, Mutation, National Health Programs, Pregnancy, Prevalence, Sentinel Surveillance, Young Adult.
- MESH :
- chemical , genetics : HIV Protease, HIV Reverse Transcriptase.
- chemical , therapeutic use : Anti-Retroviral Agents.
- geographic , epidemiology : Ghana.
- drug therapy : HIV Seropositivity.
- epidemiology : HIV Seropositivity.
- genetics : Drug Resistance, Viral, HIV-1.
- transmission : HIV Seropositivity.
- virology : HIV Seropositivity.
- Adolescent, Adult, DNA Mutational Analysis, Female, Genotype, Humans, Mutation, National Health Programs, Pregnancy, Prevalence, Sentinel Surveillance, Young Adult.
Abstract
As access to antiretroviral therapy (ART) increases, the emergence and transmission of HIV drug resistant strains becomes a major problem. The World Health Organization (WHO) therefore recommends an initial minimum-resource method to signal when transmitted HIV drug resistance (HIVDR) requires action.
PubMed: 23966745
Affiliations:
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pubmed:23966745Le document en format XML
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Ampofo</name></author></analytic><series><title level="j">Ghana medical journal</title><idno type="ISSN">0016-9560</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Retroviral Agents (therapeutic use)</term><term>DNA Mutational Analysis</term><term>Drug Resistance, Viral (genetics)</term><term>Female</term><term>Genotype</term><term>Ghana (epidemiology)</term><term>HIV Protease (genetics)</term><term>HIV Reverse Transcriptase (genetics)</term><term>HIV Seropositivity (drug therapy)</term><term>HIV Seropositivity (epidemiology)</term><term>HIV Seropositivity (transmission)</term><term>HIV Seropositivity (virology)</term><term>HIV-1 (genetics)</term><term>Humans</term><term>Mutation</term><term>National Health Programs</term><term>Pregnancy</term><term>Prevalence</term><term>Sentinel Surveillance</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Analyse de mutations d'ADN</term><term>Antirétroviraux (usage thérapeutique)</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Grossesse</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Mutation</term><term>Programmes nationaux de santé</term><term>Protéase du VIH (génétique)</term><term>Prévalence</term><term>Résistance virale aux médicaments (génétique)</term><term>Surveillance sentinelle</term><term>Séropositivité VIH (traitement médicamenteux)</term><term>Séropositivité VIH (transmission)</term><term>Séropositivité VIH (virologie)</term><term>Séropositivité VIH (épidémiologie)</term><term>Transcriptase inverse du VIH (génétique)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HIV Protease</term><term>HIV Reverse Transcriptase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Viral</term><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéase du VIH</term><term>Résistance virale aux médicaments</term><term>Transcriptase inverse du VIH</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Seropositivity</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Séropositivité VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>DNA Mutational Analysis</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Mutation</term><term>National Health Programs</term><term>Pregnancy</term><term>Prevalence</term><term>Sentinel Surveillance</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Analyse de mutations d'ADN</term><term>Femelle</term><term>Grossesse</term><term>Génotype</term><term>Humains</term><term>Jeune adulte</term><term>Mutation</term><term>Programmes nationaux de santé</term><term>Prévalence</term><term>Surveillance sentinelle</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As access to antiretroviral therapy (ART) increases, the emergence and transmission of HIV drug resistant strains becomes a major problem. The World Health Organization (WHO) therefore recommends an initial minimum-resource method to signal when transmitted HIV drug resistance (HIVDR) requires action.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23966745</PMID><DateCreated><Year>2013</Year><Month>08</Month><Day>22</Day></DateCreated><DateCompleted><Year>2014</Year><Month>04</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0016-9560</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Ghana medical journal</Title><ISOAbbreviation>Ghana Med J</ISOAbbreviation></Journal><ArticleTitle>Low level of transmitted HIV Drug resistance at two HIV care centres in Ghana: a threshold survey.</ArticleTitle><Pagination><MedlinePgn>82-6</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">As access to antiretroviral therapy (ART) increases, the emergence and transmission of HIV drug resistant strains becomes a major problem. The World Health Organization (WHO) therefore recommends an initial minimum-resource method to signal when transmitted HIV drug resistance (HIVDR) requires action.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This survey sought to generate information on the presence of HIV drug-resistant strains in the locality where Ghana's ART for HIV was first introduced.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The Ghana HIVDR threshold survey (TS) was conducted and analyzed according to WHO strategy for surveillance of HIVDR in the Eastern Region of Ghana. Sixty (60) plasma specimens were collected from 2007 to 2009 by an unlinked anonymous method from HIV seropositive pregnant women, aged between 15 to24 years, who were with their first pregnancy and ART naive. Genotyping was done as follows; Ribonucleic acid (RNA) was extracted from the samples and the protease (PR) and reverse transcriptase (RT) genes amplified and sequenced. The sequences were then analyzed for HIV drug resistance mutations using Stanford University HIV Drug Resistance Database.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Only two individuals were found with major HIVDR mutations: one each in the PR and RT genes. Thus the level of HIVDR in the study population in 2009 was classified as low (< 5%).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">As at February 2009, transmitted drug resistance was not a serious problem in the Eastern Region of Ghana. However, it is important to continue monitoring tHIVDR in order to understand the dynamics of the evolution of HIV drug resistance in the country.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonney</LastName><ForeName>E Y</ForeName><Initials>EY</Initials><AffiliationInfo><Affiliation>Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Addo</LastName><ForeName>N A</ForeName><Initials>NA</Initials></Author><Author ValidYN="Y"><LastName>Ntim</LastName><ForeName>N A A</ForeName><Initials>NA</Initials></Author><Author ValidYN="Y"><LastName>Addo-Yobo</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Bondzie</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Aryee</LastName><ForeName>K-E</ForeName><Initials>KE</Initials></Author><Author ValidYN="Y"><LastName>Barnor</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Brandful</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bekoe</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ohene</LastName><ForeName>S-A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Ampofo</LastName><ForeName>W</ForeName><Initials>W</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Ghana</Country><MedlineTA>Ghana Med J</MedlineTA><NlmUniqueID>0073210</NlmUniqueID><ISSNLinking>0016-9560</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.49</RegistryNumber><NameOfSubstance UI="D054303">HIV Reverse Transcriptase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.23.-</RegistryNumber><NameOfSubstance UI="D016333">HIV Protease</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2002 Jul 10;288(2):181-8</RefSource><PMID Version="1">12095382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2002 Aug 8;347(6):385-94</RefSource><PMID Version="1">12167680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2005 Mar 19-25;365(9464):1031-8</RefSource><PMID Version="1">15781098</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2005 May;21(5):343-57</RefSource><PMID Version="1">15929696</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2007 Jan 11;21(2):215-23</RefSource><PMID Version="1">17197813</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Jpn J Infect Dis. 2007 May;60(2-3):113-7</RefSource><PMID Version="1">17515643</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2011 Jan;27(1):5-12</RefSource><PMID Version="1">21091377</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antivir Ther. 2008;13 Suppl 2:25-36</RefSource><PMID Version="1">18575189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antivir Ther. 2008;13 Suppl 2:37-48</RefSource><PMID Version="1">18575190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antivir Ther. 2008;13 Suppl 2:83-7</RefSource><PMID Version="1">18575195</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antivir Ther. 2008;13 Suppl 2:89-94</RefSource><PMID Version="1">18575196</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009;4(3):e4724</RefSource><PMID Version="1">19266092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antivir Ther. 2009;14(3):401-11</RefSource><PMID Version="1">19474474</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Virol. 2007 Oct;40(2):163-7</RefSource><PMID Version="1">17827059</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044966" MajorTopicYN="N">Anti-Retroviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004252" MajorTopicYN="N">DNA Mutational Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016333" MajorTopicYN="N">HIV Protease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054303" MajorTopicYN="N">HIV Reverse Transcriptase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006679" MajorTopicYN="N">HIV Seropositivity</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009313" MajorTopicYN="N">National Health Programs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018571" MajorTopicYN="N">Sentinel Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3743108</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23966745</ArticleId><ArticleId 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Addo-Yobo</name><name sortKey="Addo, N A" sort="Addo, N A" uniqKey="Addo N" first="N A" last="Addo">N A Addo</name><name sortKey="Ampofo, W" sort="Ampofo, W" uniqKey="Ampofo W" first="W" last="Ampofo">W. Ampofo</name><name sortKey="Aryee, K E" sort="Aryee, K E" uniqKey="Aryee K" first="K-E" last="Aryee">K-E Aryee</name><name sortKey="Barnor, J" sort="Barnor, J" uniqKey="Barnor J" first="J" last="Barnor">J. Barnor</name><name sortKey="Bekoe, V" sort="Bekoe, V" uniqKey="Bekoe V" first="V" last="Bekoe">V. Bekoe</name><name sortKey="Bondzie, P" sort="Bondzie, P" uniqKey="Bondzie P" first="P" last="Bondzie">P. Bondzie</name><name sortKey="Brandful, J" sort="Brandful, J" uniqKey="Brandful J" first="J" last="Brandful">J. Brandful</name><name sortKey="Ntim, N A A" sort="Ntim, N A A" uniqKey="Ntim N" first="N A A" last="Ntim">N A A. Ntim</name><name sortKey="Ohene, S A" sort="Ohene, S A" uniqKey="Ohene S" first="S-A" last="Ohene">S-A Ohene</name></noCountry><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Bonney, E Y" sort="Bonney, E Y" uniqKey="Bonney E" first="E Y" last="Bonney">E Y Bonney</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SidaGhanaV1
| This area was generated with Dilib version V0.6.31. |  |