Adverse drug reactions to antiretroviral therapy during the early art period at a tertiary hospital in Ghana.
Identifieur interne : 000367 ( PubMed/Checkpoint ); précédent : 000366; suivant : 000368Adverse drug reactions to antiretroviral therapy during the early art period at a tertiary hospital in Ghana.
Auteurs : Margaret Lartey [Ghana] ; Abena Asante-Quashie [Ghana] ; Ama Essel [Ghana] ; Ernest Kenu [Ghana] ; Vincent Ganu [Ghana] ; Alfred Neequaye [Ghana]Source :
- The Pan African medical journal [ 1937-8688 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Anémie (), Anémie (épidémiologie), Centres de soins tertiaires, Facteurs de risque, Facteurs sexuels, Facteurs temps, Femelle, Ghana (épidémiologie), Humains, Infections à VIH (traitement médicamenteux), Modèles logistiques, Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active (), Thérapie antirétrovirale hautement active (effets indésirables), Études rétrospectives, Études transversales.
- MESH :
- effets indésirables : Agents antiVIH, Thérapie antirétrovirale hautement active.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- épidémiologie : Anémie, Ghana.
- Adulte, Adulte d'âge moyen, Anémie, Centres de soins tertiaires, Facteurs de risque, Facteurs sexuels, Facteurs temps, Femelle, Humains, Modèles logistiques, Mâle, Numération des lymphocytes CD4, Thérapie antirétrovirale hautement active, Études rétrospectives, Études transversales.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Anemia (chemically induced), Anemia (epidemiology), Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiretroviral Therapy, Highly Active (adverse effects), Antiretroviral Therapy, Highly Active (methods), CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Ghana (epidemiology), HIV Infections (drug therapy), Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Factors, Sex Factors, Tertiary Care Centers, Time Factors.
- MESH :
- chemical , adverse effects : Anti-HIV Agents.
- geographic , epidemiology : Ghana.
- adverse effects : Antiretroviral Therapy, Highly Active.
- chemically induced : Anemia.
- drug therapy : HIV Infections.
- epidemiology : Anemia.
- methods : Antiretroviral Therapy, Highly Active.
- chemical , therapeutic use : Anti-HIV Agents.
- Adult, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Factors, Sex Factors, Tertiary Care Centers, Time Factors.
Abstract
Antiretroviral therapy (ART) has reduced HIV morbidity and mortality worldwide but has many adverse effects. These adverse drug reactions (ADRs) lead to discontinuations, disease progression or treatment failure. We explored the types and risk factors for ADRs in a cohort starting ART in a teaching hospital in Accra, Ghana where the main regimens used were a combination of nucleotide and non nucleotide reverse transcriptase inhibitors.
DOI: 10.11604/pamj.2014.18.25.3886
PubMed: 25368714
Affiliations:
Links toward previous steps (curation, corpus...)
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pubmed:25368714Le document en format XML
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These adverse drug reactions (ADRs) lead to discontinuations, disease progression or treatment failure. We explored the types and risk factors for ADRs in a cohort starting ART in a teaching hospital in Accra, Ghana where the main regimens used were a combination of nucleotide and non nucleotide reverse transcriptase inhibitors.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25368714</PMID><DateCreated><Year>2014</Year><Month>11</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1937-8688</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>The Pan African medical journal</Title><ISOAbbreviation>Pan Afr Med J</ISOAbbreviation></Journal><ArticleTitle>Adverse drug reactions to antiretroviral therapy during the early art period at a tertiary hospital in Ghana.</ArticleTitle><Pagination><MedlinePgn>25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.11604/pamj.2014.18.25.3886</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Antiretroviral therapy (ART) has reduced HIV morbidity and mortality worldwide but has many adverse effects. These adverse drug reactions (ADRs) lead to discontinuations, disease progression or treatment failure. We explored the types and risk factors for ADRs in a cohort starting ART in a teaching hospital in Accra, Ghana where the main regimens used were a combination of nucleotide and non nucleotide reverse transcriptase inhibitors.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A Cross-sectional retrospective study was conducted reviewing data of 2042 patients initiated on HAART from 2003 to 2007. Univariate analysis was done for the dependent and independent variables. Stepwise logistic regression procedures were used to model the effect of gender on the development of ADRs controlling for other variables like age, marital status, weight at baseline and CD4 at baseline.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The period prevalence of ADRs was 9.4%. The two most common adverse reactions were anaemia and diarrhoea. Female sex was a statistically significant independent predictor of an adverse drug reaction (AOR: 1.66, p=0.01, CI: 1.16-2.36). CD4 counts 250 cells/mm3 or more was significantly associated with the occurrence of an ADR. The occurrence of anaemia in females was statistically significant compared to males.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Adverse drug reactions were less common than expected, anaemia was the commonest ADR. Female sex and high CD4 counts>250 mm3 were predictors of ADRs whereas females were significantly more likely to develop anaemia than males. Recommendations were made for interventions to prevent and also mitigate the high levels of anaemia especially among women in the ART scale up.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lartey</LastName><ForeName>Margaret</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana ; Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asante-Quashie</LastName><ForeName>Abena</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>International Organization of Migration, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Essel</LastName><ForeName>Ama</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kenu</LastName><ForeName>Ernest</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ganu</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neequaye</LastName><ForeName>Alfred</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana ; Fevers Unit, Korle Bu Teaching Hospital, Korle Bu, Accra, Ghana.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Uganda</Country><MedlineTA>Pan Afr Med J</MedlineTA><NlmUniqueID>101517926</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>HIV Med. 2002 Jul;3(3):195-9</RefSource><PMID Version="1">12139658</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS Patient Care STDS. 2008 Apr;22(4):337-44</RefSource><PMID Version="1">18422462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(6):e10490</RefSource><PMID Version="1">20531956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Acquir 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Source="NLM">PMC4214560</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adverse Drug reaction</Keyword><Keyword MajorTopicYN="N">Anaemia</Keyword><Keyword MajorTopicYN="N">CD4 cells</Keyword><Keyword MajorTopicYN="N">Female sex</Keyword><Keyword MajorTopicYN="N">HAART</Keyword><Keyword MajorTopicYN="N">HIV</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>01</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25368714</ArticleId><ArticleId IdType="doi">10.11604/pamj.2014.18.25.3886</ArticleId><ArticleId IdType="pii">PAMJ-18-25</ArticleId><ArticleId IdType="pmc">PMC4214560</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Ghana</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name></region><name sortKey="Asante Quashie, Abena" sort="Asante Quashie, Abena" uniqKey="Asante Quashie A" first="Abena" last="Asante-Quashie">Abena Asante-Quashie</name><name sortKey="Essel, Ama" sort="Essel, Ama" uniqKey="Essel A" first="Ama" last="Essel">Ama Essel</name><name sortKey="Ganu, Vincent" sort="Ganu, Vincent" uniqKey="Ganu V" first="Vincent" last="Ganu">Vincent Ganu</name><name sortKey="Kenu, Ernest" sort="Kenu, Ernest" uniqKey="Kenu E" first="Ernest" last="Kenu">Ernest Kenu</name><name sortKey="Neequaye, Alfred" sort="Neequaye, Alfred" uniqKey="Neequaye A" first="Alfred" last="Neequaye">Alfred Neequaye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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