SidaGhanaV1, PubMed, Checkpoint, bibRecord, 000276

A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy.

Identifieur interne : 000276 ( PubMed/Checkpoint ); précédent : 000275; suivant : 000277

A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy.

Auteurs : Harry Tagbor [Ghana] ; Matthew Cairns [Royaume-Uni] ; Kalifa Bojang [Gambie] ; Sheick Oumar Coulibaly [Burkina Faso] ; Kassoum Kayentao [Mali] ; John Williams [Ghana] ; Ismaela Abubakar [Gambie] ; Francis Akor [Gambie] ; Khalifa Mohammed [Gambie] ; Richard Bationo [Burkina Faso] ; Edgar Dabira [Burkina Faso] ; Alamissa Soulama [Burkina Faso] ; Moussa Djimdé [Mali] ; Etienne Guirou [Mali] ; Timothy Awine [Ghana] ; Stephen Quaye [Ghana] ; Fanta Njie [Gambie] ; Jaume Ordi [Espagne] ; Ogobara Doumbo [Mali] ; Abraham Hodgson [Ghana] ; Abraham Oduro [Ghana] ; Steven Meshnick [États-Unis] ; Steve Taylor [États-Unis] ; Pascal Magnussen [Danemark] ; Feiko Ter Kuile [Royaume-Uni] ; Arouna Woukeu [Royaume-Uni] ; Paul Milligan [Royaume-Uni] ; Daniel Chandramohan [Royaume-Uni] ; Brian Greenwood [Royaume-Uni]

Source :

PloS one [ 1932-6203 ] ; 2015.

RBID : pubmed:26258474

Descripteurs français

KwdFr :
- Adolescent, Adulte, Afrique, Antipaludiques (usage thérapeutique), Association médicamenteuse, Burkina, Complications parasitaires de la grossesse (diagnostic), Complications parasitaires de la grossesse (traitement médicamenteux), Dépistage systématique, Femelle, Gambie, Ghana, Grossesse, Humains, Hémoglobines (analyse), Issue de la grossesse, Jeune adulte, Mali, Paludisme (traitement médicamenteux), Placenta (parasitologie), Poids de naissance, Pyriméthamine (usage thérapeutique), Résultat thérapeutique, Sulfadoxine (usage thérapeutique).
MESH :
- analyse : Hémoglobines.
- diagnostic : Complications parasitaires de la grossesse.
- parasitologie : Placenta.
- traitement médicamenteux : Complications parasitaires de la grossesse, Paludisme.
- usage thérapeutique : Antipaludiques, Pyriméthamine, Sulfadoxine.
- Adolescent, Adulte, Afrique, Association médicamenteuse, Burkina, Dépistage systématique, Femelle, Gambie, Ghana, Grossesse, Humains, Issue de la grossesse, Jeune adulte, Mali, Poids de naissance, Résultat thérapeutique.
Wicri :
- geographic : Burkina Faso, Gambie, Ghana, Mali.

English descriptors

KwdEn :
- Adolescent, Adult, Africa, Antimalarials (therapeutic use), Birth Weight, Burkina Faso, Drug Combinations, Female, Gambia, Ghana, Hemoglobins (analysis), Humans, Malaria (drug therapy), Mali, Mass Screening, Placenta (parasitology), Pregnancy, Pregnancy Complications, Parasitic (diagnosis), Pregnancy Complications, Parasitic (drug therapy), Pregnancy Outcome, Pyrimethamine (therapeutic use), Sulfadoxine (therapeutic use), Treatment Outcome, Young Adult.
MESH :
- chemical , analysis : Hemoglobins.
- chemical , therapeutic use : Antimalarials, Pyrimethamine, Sulfadoxine.
- geographic : Africa, Burkina Faso, Drug Combinations, Gambia, Ghana, Mali.
- diagnosis : Pregnancy Complications, Parasitic.
- drug therapy : Malaria, Pregnancy Complications, Parasitic.
- parasitology : Placenta.
- Adolescent, Adult, Birth Weight, Female, Humans, Mass Screening, Pregnancy, Pregnancy Outcome, Treatment Outcome, Young Adult.

Abstract

The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive women (ISTp) is an alternative approach.

DOI: 10.1371/journal.pone.0132247
PubMed: 26258474

Affiliations:

Burkina Faso, Danemark, Espagne, Gambie, Ghana, Mali, Royaume-Uni, États-Unis
Angleterre, Caroline du Nord, Catalogne, Grand Londres, Hovedstaden
Barcelone, Copenhague, Londres
Université de Barcelone

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Le document en format XML

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<author><name sortKey="Williams, John" sort="Williams, John" uniqKey="Williams J" first="John" last="Williams">John Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Navrongo Health Research Centre, Navrongo, Ghana.</nlm:affiliation>
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<author><name sortKey="Abubakar, Ismaela" sort="Abubakar, Ismaela" uniqKey="Abubakar I" first="Ismaela" last="Abubakar">Ismaela Abubakar</name>
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<country xml:lang="fr">Gambie</country>
<wicri:regionArea>Medical Research Council Unit, Fajara</wicri:regionArea>
<wicri:noRegion>Fajara</wicri:noRegion>
</affiliation>
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<author><name sortKey="Akor, Francis" sort="Akor, Francis" uniqKey="Akor F" first="Francis" last="Akor">Francis Akor</name>
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<country xml:lang="fr">Gambie</country>
<wicri:regionArea>Medical Research Council Unit, Fajara</wicri:regionArea>
<wicri:noRegion>Fajara</wicri:noRegion>
</affiliation>
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<author><name sortKey="Mohammed, Khalifa" sort="Mohammed, Khalifa" uniqKey="Mohammed K" first="Khalifa" last="Mohammed">Khalifa Mohammed</name>
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<country xml:lang="fr">Gambie</country>
<wicri:regionArea>Medical Research Council Unit, Fajara</wicri:regionArea>
<wicri:noRegion>Fajara</wicri:noRegion>
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<author><name sortKey="Bationo, Richard" sort="Bationo, Richard" uniqKey="Bationo R" first="Richard" last="Bationo">Richard Bationo</name>
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<country xml:lang="fr">Burkina Faso</country>
<wicri:regionArea>Faculty of Health Sciences, University of Ouagadougou, Ouagadougou</wicri:regionArea>
<wicri:noRegion>Ouagadougou</wicri:noRegion>
</affiliation>
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<author><name sortKey="Dabira, Edgar" sort="Dabira, Edgar" uniqKey="Dabira E" first="Edgar" last="Dabira">Edgar Dabira</name>
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<wicri:regionArea>Faculty of Health Sciences, University of Ouagadougou, Ouagadougou</wicri:regionArea>
<wicri:noRegion>Ouagadougou</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Soulama, Alamissa" sort="Soulama, Alamissa" uniqKey="Soulama A" first="Alamissa" last="Soulama">Alamissa Soulama</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, University of Ouagadougou, Ouagadougou, Burkina Faso.</nlm:affiliation>
<country xml:lang="fr">Burkina Faso</country>
<wicri:regionArea>Faculty of Health Sciences, University of Ouagadougou, Ouagadougou</wicri:regionArea>
<wicri:noRegion>Ouagadougou</wicri:noRegion>
</affiliation>
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<author><name sortKey="Djimde, Moussa" sort="Djimde, Moussa" uniqKey="Djimde M" first="Moussa" last="Djimdé">Moussa Djimdé</name>
<affiliation wicri:level="1"><nlm:affiliation>Malaria Research and Training Centre, Faculty of Medicine and Odonto-stomatology, University of Sciences, Technics and Technologies, Bamako, Mali.</nlm:affiliation>
<country xml:lang="fr">Mali</country>
<wicri:regionArea>Malaria Research and Training Centre, Faculty of Medicine and Odonto-stomatology, University of Sciences, Technics and Technologies, Bamako</wicri:regionArea>
<wicri:noRegion>Bamako</wicri:noRegion>
</affiliation>
</author>
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<affiliation wicri:level="1"><nlm:affiliation>Malaria Research and Training Centre, Faculty of Medicine and Odonto-stomatology, University of Sciences, Technics and Technologies, Bamako, Mali.</nlm:affiliation>
<country xml:lang="fr">Mali</country>
<wicri:regionArea>Malaria Research and Training Centre, Faculty of Medicine and Odonto-stomatology, University of Sciences, Technics and Technologies, Bamako</wicri:regionArea>
<wicri:noRegion>Bamako</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Awine, Timothy" sort="Awine, Timothy" uniqKey="Awine T" first="Timothy" last="Awine">Timothy Awine</name>
<affiliation wicri:level="1"><nlm:affiliation>Navrongo Health Research Centre, Navrongo, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Navrongo Health Research Centre, Navrongo</wicri:regionArea>
<wicri:noRegion>Navrongo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quaye, Stephen" sort="Quaye, Stephen" uniqKey="Quaye S" first="Stephen" last="Quaye">Stephen Quaye</name>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Navrongo Health Research Centre, Navrongo</wicri:regionArea>
<wicri:noRegion>Navrongo</wicri:noRegion>
</affiliation>
</author>
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<country xml:lang="fr">Gambie</country>
<wicri:regionArea>Medical Research Council Unit, Fajara</wicri:regionArea>
<wicri:noRegion>Fajara</wicri:noRegion>
</affiliation>
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<author><name sortKey="Ordi, Jaume" sort="Ordi, Jaume" uniqKey="Ordi J" first="Jaume" last="Ordi">Jaume Ordi</name>
<affiliation wicri:level="4"><nlm:affiliation>Barcelona Centre for International Health Research (CRESIB), Department of Pathology, Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Barcelona Centre for International Health Research (CRESIB), Department of Pathology, Hospital Clinic-Universitat de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
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<country xml:lang="fr">Mali</country>
<wicri:regionArea>Malaria Research and Training Centre, Faculty of Medicine and Odonto-stomatology, University of Sciences, Technics and Technologies, Bamako</wicri:regionArea>
<wicri:noRegion>Bamako</wicri:noRegion>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Navrongo Health Research Centre, Navrongo</wicri:regionArea>
<wicri:noRegion>Navrongo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oduro, Abraham" sort="Oduro, Abraham" uniqKey="Oduro A" first="Abraham" last="Oduro">Abraham Oduro</name>
<affiliation wicri:level="1"><nlm:affiliation>Navrongo Health Research Centre, Navrongo, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Navrongo Health Research Centre, Navrongo</wicri:regionArea>
<wicri:noRegion>Navrongo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meshnick, Steven" sort="Meshnick, Steven" uniqKey="Meshnick S" first="Steven" last="Meshnick">Steven Meshnick</name>
<affiliation wicri:level="2"><nlm:affiliation>Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Steve" sort="Taylor, Steve" uniqKey="Taylor S" first="Steve" last="Taylor">Steve Taylor</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University Medical Center, Durham, NC, United States of America.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Duke University Medical Center, Durham, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Magnussen, Pascal" sort="Magnussen, Pascal" uniqKey="Magnussen P" first="Pascal" last="Magnussen">Pascal Magnussen</name>
<affiliation wicri:level="3"><nlm:affiliation>(Institute of International Health, Immunology and Microbiology and Institute of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>(Institute of International Health, Immunology and Microbiology and Institute of Veterinary Disease Biology, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
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<author><name sortKey="Ter Kuile, Feiko" sort="Ter Kuile, Feiko" uniqKey="Ter Kuile F" first="Feiko" last="Ter Kuile">Feiko Ter Kuile</name>
<affiliation wicri:level="1"><nlm:affiliation>Liverpool School of Tropical Medicine, Liverpool, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool</wicri:regionArea>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Woukeu, Arouna" sort="Woukeu, Arouna" uniqKey="Woukeu A" first="Arouna" last="Woukeu">Arouna Woukeu</name>
<affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milligan, Paul" sort="Milligan, Paul" uniqKey="Milligan P" first="Paul" last="Milligan">Paul Milligan</name>
<affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chandramohan, Daniel" sort="Chandramohan, Daniel" uniqKey="Chandramohan D" first="Daniel" last="Chandramohan">Daniel Chandramohan</name>
<affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Greenwood, Brian" sort="Greenwood, Brian" uniqKey="Greenwood B" first="Brian" last="Greenwood">Brian Greenwood</name>
<affiliation wicri:level="3"><nlm:affiliation>London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Adult</term>
<term>Africa</term>
<term>Antimalarials (therapeutic use)</term>
<term>Birth Weight</term>
<term>Burkina Faso</term>
<term>Drug Combinations</term>
<term>Female</term>
<term>Gambia</term>
<term>Ghana</term>
<term>Hemoglobins (analysis)</term>
<term>Humans</term>
<term>Malaria (drug therapy)</term>
<term>Mali</term>
<term>Mass Screening</term>
<term>Placenta (parasitology)</term>
<term>Pregnancy</term>
<term>Pregnancy Complications, Parasitic (diagnosis)</term>
<term>Pregnancy Complications, Parasitic (drug therapy)</term>
<term>Pregnancy Outcome</term>
<term>Pyrimethamine (therapeutic use)</term>
<term>Sulfadoxine (therapeutic use)</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
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<term>Adulte</term>
<term>Afrique</term>
<term>Antipaludiques (usage thérapeutique)</term>
<term>Association médicamenteuse</term>
<term>Burkina</term>
<term>Complications parasitaires de la grossesse (diagnostic)</term>
<term>Complications parasitaires de la grossesse (traitement médicamenteux)</term>
<term>Dépistage systématique</term>
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<front><div type="abstract" xml:lang="en">The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive women (ISTp) is an alternative approach.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26258474</PMID>
<DateCreated><Year>2015</Year>
<Month>08</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>05</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>8</Issue>
<PubDate><Year>2015</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy.</ArticleTitle>
<Pagination><MedlinePgn>e0132247</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0132247</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive women (ISTp) is an alternative approach.</AbstractText>
<AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">An open, individually randomized, non-inferiority trial of IPTp-SP versus ISTp was conducted in 5,354 primi- or secundigravidae in four West African countries with a low prevalence of resistance to SP (The Gambia, Mali, Burkina Faso and Ghana). Women in the IPTp-SP group received SP on two or three occasions whilst women in the ISTp group were screened two or three times with a RDT and treated if positive for malaria with artemether-lumefantrine (AL). ISTp-AL was non-inferior to IPTp-SP in preventing low birth weight (LBW), anemia and placental malaria, the primary trial endpoints. The prevalence of LBW was 15.1% and 15.6% in the IPTp-SP and ISTp-AL groups respectively (OR = 1.03 [95% CI: 0.88, 1.22]). The mean hemoglobin concentration at the last clinic attendance before delivery was 10.97g/dL and 10.94g/dL in the IPTp-SP and ISTp-AL groups respectively (mean difference: -0.03 g/dL [95% CI: -0.13, +0.06]). Active malaria infection of the placenta was found in 24.5% and in 24.2% of women in the IPTp-SP and ISTp-AL groups respectively (OR = 0.95 [95% CI 0.81, 1.12]). More women in the ISTp-AL than in the IPTp-SP group presented with malaria parasitemia between routine antenatal clinics (310 vs 182 episodes, rate difference: 49.4 per 1,000 pregnancies [95% CI 30.5, 68.3], but the number of hospital admissions for malaria was similar in the two groups.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite low levels of resistance to SP in the study areas, ISTp-AL performed as well as IPTp-SP. In the absence of an effective alternative medication to SP for IPTp, ISTp-AL is a potential alternative to IPTp in areas where SP resistance is high. It may also have a role in areas where malaria transmission is low and for the prevention of malaria in HIV positive women receiving cotrimoxazole prophylaxis in whom SP is contraindicated.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov NCT01084213 Pan African Clinical trials Registry PACT201202000272122.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tagbor</LastName>
<ForeName>Harry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, London, United Kingdom; School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cairns</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bojang</LastName>
<ForeName>Kalifa</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Medical Research Council Unit, Fajara, The Gambia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coulibaly</LastName>
<ForeName>Sheick Oumar</ForeName>
<Initials>SO</Initials>
<AffiliationInfo><Affiliation>Faculty of Health Sciences, University of Ouagadougou, Ouagadougou, Burkina Faso.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kayentao</LastName>
<ForeName>Kassoum</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Malaria Research and Training Centre, Faculty of Medicine and Odonto-stomatology, University of Sciences, Technics and Technologies, Bamako, Mali.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williams</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Navrongo Health Research Centre, Navrongo, Ghana.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abubakar</LastName>
<ForeName>Ismaela</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Medical Research Council Unit, Fajara, The Gambia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Akor</LastName>
<ForeName>Francis</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Medical Research Council Unit, Fajara, The Gambia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mohammed</LastName>
<ForeName>Khalifa</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Medical Research Council Unit, Fajara, The Gambia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bationo</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Faculty of Health Sciences, University of Ouagadougou, Ouagadougou, Burkina Faso.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dabira</LastName>
<ForeName>Edgar</ForeName>
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	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy.

A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy.

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