Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting, South Africa, 2009-2012.
Identifieur interne : 000240 ( PubMed/Checkpoint ); précédent : 000239; suivant : 000241Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting, South Africa, 2009-2012.
Auteurs : Cheryl Cohen [Afrique du Sud] ; Sibongile Walaza ; Jocelyn Moyes ; Michelle Groome ; Stefano Tempia ; Marthi Pretorius ; Orienka Hellferscee ; Halima Dawood ; Meera Chhagan ; Fathima Naby ; Summaya Haffejee ; Ebrahim Variava ; Kathleen Kahn ; Susan Nzenze ; Akhona Tshangela ; Anne Von Gottberg ; Nicole Wolter ; Adam L. Cohen ; Babatyi Kgokong ; Marietjie Venter ; Shabir A. MadhiSource :
- The Pediatric infectious disease journal [ 1532-0987 ] ; 2015.
Descripteurs français
- KwdFr :
- Analyse de survie, Bronchopneumonie (mortalité), Bronchopneumonie (virologie), Bronchopneumonie (épidémiologie), Co-infection (microbiologie), Co-infection (mortalité), Co-infection (virologie), Co-infection (épidémiologie), Enfant d'âge préscolaire, Femelle, Hospitalisation, Humains, Incidence, Mâle, Nourrisson, Nouveau-né, Partie nasale du pharynx (virologie), Pneumonie à pneumocoques (microbiologie), Pneumonie à pneumocoques (épidémiologie), Pneumopathie virale (mortalité), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Prévalence, Réaction de polymérisation en chaîne, République d'Afrique du Sud (épidémiologie), Virus (), Virus (isolement et purification), Études prospectives.
- MESH :
- isolement et purification : Virus.
- microbiologie : Co-infection, Pneumonie à pneumocoques.
- mortalité : Bronchopneumonie, Co-infection, Pneumopathie virale.
- virologie : Bronchopneumonie, Co-infection, Partie nasale du pharynx, Pneumopathie virale.
- épidémiologie : Bronchopneumonie, Co-infection, Pneumonie à pneumocoques, Pneumopathie virale, République d'Afrique du Sud.
- Analyse de survie, Enfant d'âge préscolaire, Femelle, Hospitalisation, Humains, Incidence, Mâle, Nourrisson, Nouveau-né, Prévalence, Réaction de polymérisation en chaîne, Virus, Études prospectives.
- Wicri :
- geographic : Afrique du Sud.
English descriptors
- KwdEn :
- Bronchopneumonia (epidemiology), Bronchopneumonia (mortality), Bronchopneumonia (virology), Child, Preschool, Coinfection (epidemiology), Coinfection (microbiology), Coinfection (mortality), Coinfection (virology), Female, Hospitalization, Humans, Incidence, Infant, Infant, Newborn, Male, Nasopharynx (virology), Pneumonia, Pneumococcal (epidemiology), Pneumonia, Pneumococcal (microbiology), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), Polymerase Chain Reaction, Prevalence, Prospective Studies, South Africa (epidemiology), Survival Analysis, Viruses (classification), Viruses (isolation & purification).
- MESH :
- geographic , epidemiology : South Africa.
- classification : Viruses.
- epidemiology : Bronchopneumonia, Coinfection, Pneumonia, Pneumococcal, Pneumonia, Viral.
- isolation & purification : Viruses.
- microbiology : Coinfection, Pneumonia, Pneumococcal.
- mortality : Bronchopneumonia, Coinfection, Pneumonia, Viral.
- virology : Bronchopneumonia, Coinfection, Nasopharynx, Pneumonia, Viral.
- Child, Preschool, Female, Hospitalization, Humans, Incidence, Infant, Infant, Newborn, Male, Polymerase Chain Reaction, Prevalence, Prospective Studies, Survival Analysis.
Abstract
Data on the epidemiology of viral-associated acute lower respiratory tract infection (LRTI) from high HIV prevalence settings are limited. We aimed to describe LRTI hospitalizations among South African children aged <5 years.
DOI: 10.1097/INF.0000000000000478
PubMed: 25093972
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting, South Africa, 2009-2012.</title><author><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name><affiliation wicri:level="1"><nlm:affiliation>From the *Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service; †School of Public Health, Faculty of Health Sciences, University of the Witwatersrand; ‡Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand; §Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa; ¶Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; ‖Influenza Programme, Centers for Disease Control and Prevention-South Africa, Pretoria; **Department of Medicine, Pietermaritzburg Metropolitan Hospital; ††Department of Medicine, University of KwaZulu Natal; ‡‡Department of Paediatrics, Pietermaritzburg Metropolitan Hospital §§School of Pathology, University of KwaZulu Natal, Pietermaritzburg; ¶¶Department of Medicine, Klerksdorp Tshepong Hospital, Klerksdorp; ‖‖Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand; ***MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †††Centre for Global Health Research, Umeå University, Umeå, Sweden; ‡‡‡INDEPTH Network, Accra, Ghana; and §§§Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Gauteng, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>From the *Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service; †School of Public Health, Faculty of Health Sciences, University of the Witwatersrand; ‡Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand; §Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa; ¶Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; ‖Influenza Programme, Centers for Disease Control and Prevention-South Africa, Pretoria; **Department of Medicine, Pietermaritzburg Metropolitan Hospital; ††Department of Medicine, University of KwaZulu Natal; ‡‡Department of Paediatrics, Pietermaritzburg Metropolitan Hospital §§School of Pathology, University of KwaZulu Natal, Pietermaritzburg; ¶¶Department of Medicine, Klerksdorp Tshepong Hospital, Klerksdorp; ‖‖Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand; ***MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †††Centre for Global Health Research, Umeå University, Umeå, Sweden; ‡‡‡INDEPTH Network, Accra, Ghana; and §§§Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Gauteng</wicri:regionArea><wicri:noRegion>Gauteng</wicri:noRegion></affiliation></author><author><name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name></author><author><name sortKey="Moyes, Jocelyn" sort="Moyes, Jocelyn" uniqKey="Moyes J" first="Jocelyn" last="Moyes">Jocelyn Moyes</name></author><author><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name></author><author><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name></author><author><name sortKey="Pretorius, Marthi" sort="Pretorius, Marthi" uniqKey="Pretorius M" first="Marthi" last="Pretorius">Marthi Pretorius</name></author><author><name sortKey="Hellferscee, Orienka" sort="Hellferscee, Orienka" uniqKey="Hellferscee O" first="Orienka" last="Hellferscee">Orienka Hellferscee</name></author><author><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name></author><author><name sortKey="Chhagan, Meera" sort="Chhagan, Meera" uniqKey="Chhagan M" first="Meera" last="Chhagan">Meera Chhagan</name></author><author><name sortKey="Naby, Fathima" sort="Naby, Fathima" uniqKey="Naby F" first="Fathima" last="Naby">Fathima Naby</name></author><author><name sortKey="Haffejee, Summaya" sort="Haffejee, Summaya" uniqKey="Haffejee S" first="Summaya" last="Haffejee">Summaya Haffejee</name></author><author><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name></author><author><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name></author><author><name sortKey="Nzenze, Susan" sort="Nzenze, Susan" uniqKey="Nzenze S" first="Susan" last="Nzenze">Susan Nzenze</name></author><author><name sortKey="Tshangela, Akhona" sort="Tshangela, Akhona" uniqKey="Tshangela A" first="Akhona" last="Tshangela">Akhona Tshangela</name></author><author><name sortKey="Von Gottberg, Anne" sort="Von Gottberg, Anne" uniqKey="Von Gottberg A" first="Anne" last="Von Gottberg">Anne Von Gottberg</name></author><author><name sortKey="Wolter, Nicole" sort="Wolter, Nicole" uniqKey="Wolter N" first="Nicole" last="Wolter">Nicole Wolter</name></author><author><name sortKey="Cohen, Adam L" sort="Cohen, Adam L" uniqKey="Cohen A" first="Adam L" last="Cohen">Adam L. Cohen</name></author><author><name sortKey="Kgokong, Babatyi" sort="Kgokong, Babatyi" uniqKey="Kgokong B" first="Babatyi" last="Kgokong">Babatyi Kgokong</name></author><author><name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name></author><author><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A" last="Madhi">Shabir A. Madhi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25093972</idno><idno type="pmid">25093972</idno><idno type="doi">10.1097/INF.0000000000000478</idno><idno type="wicri:Area/PubMed/Corpus">000625</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000625</idno><idno type="wicri:Area/PubMed/Curation">000625</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000625</idno><idno type="wicri:Area/PubMed/Checkpoint">000625</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000625</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting, South Africa, 2009-2012.</title><author><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name><affiliation wicri:level="1"><nlm:affiliation>From the *Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service; †School of Public Health, Faculty of Health Sciences, University of the Witwatersrand; ‡Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand; §Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa; ¶Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; ‖Influenza Programme, Centers for Disease Control and Prevention-South Africa, Pretoria; **Department of Medicine, Pietermaritzburg Metropolitan Hospital; ††Department of Medicine, University of KwaZulu Natal; ‡‡Department of Paediatrics, Pietermaritzburg Metropolitan Hospital §§School of Pathology, University of KwaZulu Natal, Pietermaritzburg; ¶¶Department of Medicine, Klerksdorp Tshepong Hospital, Klerksdorp; ‖‖Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand; ***MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †††Centre for Global Health Research, Umeå University, Umeå, Sweden; ‡‡‡INDEPTH Network, Accra, Ghana; and §§§Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Gauteng, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>From the *Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service; †School of Public Health, Faculty of Health Sciences, University of the Witwatersrand; ‡Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand; §Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa; ¶Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; ‖Influenza Programme, Centers for Disease Control and Prevention-South Africa, Pretoria; **Department of Medicine, Pietermaritzburg Metropolitan Hospital; ††Department of Medicine, University of KwaZulu Natal; ‡‡Department of Paediatrics, Pietermaritzburg Metropolitan Hospital §§School of Pathology, University of KwaZulu Natal, Pietermaritzburg; ¶¶Department of Medicine, Klerksdorp Tshepong Hospital, Klerksdorp; ‖‖Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand; ***MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †††Centre for Global Health Research, Umeå University, Umeå, Sweden; ‡‡‡INDEPTH Network, Accra, Ghana; and §§§Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Gauteng</wicri:regionArea><wicri:noRegion>Gauteng</wicri:noRegion></affiliation></author><author><name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name></author><author><name sortKey="Moyes, Jocelyn" sort="Moyes, Jocelyn" uniqKey="Moyes J" first="Jocelyn" last="Moyes">Jocelyn Moyes</name></author><author><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name></author><author><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name></author><author><name sortKey="Pretorius, Marthi" sort="Pretorius, Marthi" uniqKey="Pretorius M" first="Marthi" last="Pretorius">Marthi Pretorius</name></author><author><name sortKey="Hellferscee, Orienka" sort="Hellferscee, Orienka" uniqKey="Hellferscee O" first="Orienka" last="Hellferscee">Orienka Hellferscee</name></author><author><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name></author><author><name sortKey="Chhagan, Meera" sort="Chhagan, Meera" uniqKey="Chhagan M" first="Meera" last="Chhagan">Meera Chhagan</name></author><author><name sortKey="Naby, Fathima" sort="Naby, Fathima" uniqKey="Naby F" first="Fathima" last="Naby">Fathima Naby</name></author><author><name sortKey="Haffejee, Summaya" sort="Haffejee, Summaya" uniqKey="Haffejee S" first="Summaya" last="Haffejee">Summaya Haffejee</name></author><author><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name></author><author><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name></author><author><name sortKey="Nzenze, Susan" sort="Nzenze, Susan" uniqKey="Nzenze S" first="Susan" last="Nzenze">Susan Nzenze</name></author><author><name sortKey="Tshangela, Akhona" sort="Tshangela, Akhona" uniqKey="Tshangela A" first="Akhona" last="Tshangela">Akhona Tshangela</name></author><author><name sortKey="Von Gottberg, Anne" sort="Von Gottberg, Anne" uniqKey="Von Gottberg A" first="Anne" last="Von Gottberg">Anne Von Gottberg</name></author><author><name sortKey="Wolter, Nicole" sort="Wolter, Nicole" uniqKey="Wolter N" first="Nicole" last="Wolter">Nicole Wolter</name></author><author><name sortKey="Cohen, Adam L" sort="Cohen, Adam L" uniqKey="Cohen A" first="Adam L" last="Cohen">Adam L. Cohen</name></author><author><name sortKey="Kgokong, Babatyi" sort="Kgokong, Babatyi" uniqKey="Kgokong B" first="Babatyi" last="Kgokong">Babatyi Kgokong</name></author><author><name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name></author><author><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A" last="Madhi">Shabir A. Madhi</name></author></analytic><series><title level="j">The Pediatric infectious disease journal</title><idno type="eISSN">1532-0987</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bronchopneumonia (epidemiology)</term><term>Bronchopneumonia (mortality)</term><term>Bronchopneumonia (virology)</term><term>Child, Preschool</term><term>Coinfection (epidemiology)</term><term>Coinfection (microbiology)</term><term>Coinfection (mortality)</term><term>Coinfection (virology)</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Nasopharynx (virology)</term><term>Pneumonia, Pneumococcal (epidemiology)</term><term>Pneumonia, Pneumococcal (microbiology)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (virology)</term><term>Polymerase Chain Reaction</term><term>Prevalence</term><term>Prospective Studies</term><term>South Africa (epidemiology)</term><term>Survival Analysis</term><term>Viruses (classification)</term><term>Viruses (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de survie</term><term>Bronchopneumonie (mortalité)</term><term>Bronchopneumonie (virologie)</term><term>Bronchopneumonie (épidémiologie)</term><term>Co-infection (microbiologie)</term><term>Co-infection (mortalité)</term><term>Co-infection (virologie)</term><term>Co-infection (épidémiologie)</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Partie nasale du pharynx (virologie)</term><term>Pneumonie à pneumocoques (microbiologie)</term><term>Pneumonie à pneumocoques (épidémiologie)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (virologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Prévalence</term><term>Réaction de polymérisation en chaîne</term><term>République d'Afrique du Sud (épidémiologie)</term><term>Virus ()</term><term>Virus (isolement et purification)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bronchopneumonia</term><term>Coinfection</term><term>Pneumonia, Pneumococcal</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Co-infection</term><term>Pneumonie à pneumocoques</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Coinfection</term><term>Pneumonia, Pneumococcal</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Bronchopneumonia</term><term>Coinfection</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Bronchopneumonie</term><term>Co-infection</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Bronchopneumonie</term><term>Co-infection</term><term>Partie nasale du pharynx</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchopneumonia</term><term>Coinfection</term><term>Nasopharynx</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Bronchopneumonie</term><term>Co-infection</term><term>Pneumonie à pneumocoques</term><term>Pneumopathie virale</term><term>République d'Afrique du Sud</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Incidence</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Polymerase Chain Reaction</term><term>Prevalence</term><term>Prospective Studies</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Prévalence</term><term>Réaction de polymérisation en chaîne</term><term>Virus</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Data on the epidemiology of viral-associated acute lower respiratory tract infection (LRTI) from high HIV prevalence settings are limited. We aimed to describe LRTI hospitalizations among South African children aged <5 years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25093972</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>06</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1532-0987</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Pediatric infectious disease journal</Title><ISOAbbreviation>Pediatr. Infect. Dis. J.</ISOAbbreviation></Journal><ArticleTitle>Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting, South Africa, 2009-2012.</ArticleTitle><Pagination><MedlinePgn>66-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/INF.0000000000000478</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Data on the epidemiology of viral-associated acute lower respiratory tract infection (LRTI) from high HIV prevalence settings are limited. We aimed to describe LRTI hospitalizations among South African children aged <5 years.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We prospectively enrolled hospitalized children with physician-diagnosed LRTI from 5 sites in 4 provinces from 2009 to 2012. Using polymerase chain reaction (PCR), nasopharyngeal aspirates were tested for 10 viruses and blood for pneumococcal DNA. Incidence was estimated at 1 site with available population denominators.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We enrolled 8723 children aged <5 years with LRTI, including 64% <12 months. The case-fatality ratio was 2% (150/8512). HIV prevalence among tested children was 12% (705/5964). The overall prevalence of respiratory viruses identified was 78% (6517/8393), including 37% rhinovirus, 26% respiratory syncytial virus (RSV), 7% influenza and 5% human metapneumovirus. Four percent (253/6612) tested positive for pneumococcus. The annual incidence of LRTI hospitalization ranged from 2530 to 3173/100,000 population and was highest in infants (8446-10532/100,000). LRTI incidence was 1.1 to 3.0-fold greater in HIV-infected than HIV-uninfected children. In multivariable analysis, compared to HIV-uninfected children, HIV-infected children were more likely to require supplemental-oxygen [odds ratio (OR): 1.3, 95% confidence interval (CI): 1.1-1.7)], be hospitalized >7 days (OR: 3.8, 95% CI: 2.8-5.0) and had a higher case-fatality ratio (OR: 4.2, 95% CI: 2.6-6.8). In multivariable analysis, HIV-infection (OR: 3.7, 95% CI: 2.2-6.1), pneumococcal coinfection (OR: 2.4, 95% CI: 1.1-5.6), mechanical ventilation (OR: 6.9, 95% CI: 2.7-17.6) and receipt of supplemental-oxygen (OR: 27.3, 95% CI: 13.2-55.9) were associated with death.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HIV-infection was associated with an increased risk of LRTI hospitalization and death. A viral pathogen, commonly RSV, was identified in a high proportion of LRTI cases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Cheryl</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From the *Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service; †School of Public Health, Faculty of Health Sciences, University of the Witwatersrand; ‡Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand; §Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa; ¶Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; ‖Influenza Programme, Centers for Disease Control and Prevention-South Africa, Pretoria; **Department of Medicine, Pietermaritzburg Metropolitan Hospital; ††Department of Medicine, University of KwaZulu Natal; ‡‡Department of Paediatrics, Pietermaritzburg Metropolitan Hospital §§School of Pathology, University of KwaZulu Natal, Pietermaritzburg; ¶¶Department of Medicine, Klerksdorp Tshepong Hospital, Klerksdorp; ‖‖Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand; ***MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †††Centre for Global Health Research, Umeå University, Umeå, Sweden; ‡‡‡INDEPTH Network, Accra, Ghana; and §§§Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Gauteng, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walaza</LastName><ForeName>Sibongile</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Moyes</LastName><ForeName>Jocelyn</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Groome</LastName><ForeName>Michelle</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tempia</LastName><ForeName>Stefano</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Pretorius</LastName><ForeName>Marthi</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hellferscee</LastName><ForeName>Orienka</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Dawood</LastName><ForeName>Halima</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Chhagan</LastName><ForeName>Meera</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Naby</LastName><ForeName>Fathima</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Haffejee</LastName><ForeName>Summaya</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Variava</LastName><ForeName>Ebrahim</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kahn</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Nzenze</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tshangela</LastName><ForeName>Akhona</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>von Gottberg</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Wolter</LastName><ForeName>Nicole</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Adam L</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Kgokong</LastName><ForeName>Babatyi</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Venter</LastName><ForeName>Marietjie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Madhi</LastName><ForeName>Shabir A</ForeName><Initials>SA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U51 IP000155</GrantID><Acronym>IP</Acronym><Agency>NCIRD CDC HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U51/IP000155-04</GrantID><Acronym>IP</Acronym><Agency>NCIRD CDC HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Infect Dis J</MedlineTA><NlmUniqueID>8701858</NlmUniqueID><ISSNLinking>0891-3668</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011018" MajorTopicYN="N">Pneumonia, Pneumococcal</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013019" MajorTopicYN="N" Type="Geographic">South Africa</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4276570</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25093972</ArticleId><ArticleId IdType="doi">10.1097/INF.0000000000000478</ArticleId><ArticleId IdType="pmc">PMC4276570</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><noCountry><name sortKey="Chhagan, Meera" sort="Chhagan, Meera" uniqKey="Chhagan M" first="Meera" last="Chhagan">Meera Chhagan</name><name sortKey="Cohen, Adam L" sort="Cohen, Adam L" uniqKey="Cohen A" first="Adam L" last="Cohen">Adam L. Cohen</name><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name><name sortKey="Haffejee, Summaya" sort="Haffejee, Summaya" uniqKey="Haffejee S" first="Summaya" last="Haffejee">Summaya Haffejee</name><name sortKey="Hellferscee, Orienka" sort="Hellferscee, Orienka" uniqKey="Hellferscee O" first="Orienka" last="Hellferscee">Orienka Hellferscee</name><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name><name sortKey="Kgokong, Babatyi" sort="Kgokong, Babatyi" uniqKey="Kgokong B" first="Babatyi" last="Kgokong">Babatyi Kgokong</name><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A" last="Madhi">Shabir A. Madhi</name><name sortKey="Moyes, Jocelyn" sort="Moyes, Jocelyn" uniqKey="Moyes J" first="Jocelyn" last="Moyes">Jocelyn Moyes</name><name sortKey="Naby, Fathima" sort="Naby, Fathima" uniqKey="Naby F" first="Fathima" last="Naby">Fathima Naby</name><name sortKey="Nzenze, Susan" sort="Nzenze, Susan" uniqKey="Nzenze S" first="Susan" last="Nzenze">Susan Nzenze</name><name sortKey="Pretorius, Marthi" sort="Pretorius, Marthi" uniqKey="Pretorius M" first="Marthi" last="Pretorius">Marthi Pretorius</name><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name><name sortKey="Tshangela, Akhona" sort="Tshangela, Akhona" uniqKey="Tshangela A" first="Akhona" last="Tshangela">Akhona Tshangela</name><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name><name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name><name sortKey="Von Gottberg, Anne" sort="Von Gottberg, Anne" uniqKey="Von Gottberg A" first="Anne" last="Von Gottberg">Anne Von Gottberg</name><name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name><name sortKey="Wolter, Nicole" sort="Wolter, Nicole" uniqKey="Wolter N" first="Nicole" last="Wolter">Nicole Wolter</name></noCountry><country name="Afrique du Sud"><noRegion><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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