Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
Identifieur interne : 000220 ( PubMed/Checkpoint ); précédent : 000219; suivant : 000221Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.
Auteurs : Kirsten Alexandra Eberhardt [Allemagne] ; Fred Stephen Sarfo [Ghana] ; Albert Dompreh [Ghana] ; Edmund Osei Kuffour ; Christof Geldmacher [Allemagne] ; Mareike Soltau [Allemagne] ; Marei Schachscheider [Allemagne] ; Jan Felix Drexler ; Anna Maria Eis-Hübinger ; Dieter H Ussinger ; George Bedu-Addo [Ghana] ; Richard Odame Phillips [Ghana] ; Betty Norman [Ghana] ; Gerd Dieter Burchard [Allemagne] ; Torsten FeldtSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Co-infection (anatomopathologie), Femelle, Ghana, Humains, Infections à Helicobacter (), Infections à Helicobacter (anatomopathologie), Infections à VIH (), Infections à VIH (anatomopathologie), Jeune adulte, Lymphocytes T CD4+ (), Lymphocytes T CD4+ (immunologie), Marqueurs biologiques, Mâle, Sous-populations de lymphocytes T (), Sous-populations de lymphocytes T (immunologie), Études transversales.
- MESH :
- anatomopathologie : Co-infection, Infections à Helicobacter, Infections à VIH.
- immunologie : Lymphocytes T CD4+, Sous-populations de lymphocytes T.
- Adulte, Adulte d'âge moyen, Femelle, Ghana, Humains, Infections à Helicobacter, Infections à VIH, Jeune adulte, Lymphocytes T CD4+, Marqueurs biologiques, Mâle, Sous-populations de lymphocytes T, Études transversales.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Biomarkers, CD4-Positive T-Lymphocytes (chemistry), CD4-Positive T-Lymphocytes (immunology), Coinfection (pathology), Cross-Sectional Studies, Female, Ghana, HIV Infections (complications), HIV Infections (pathology), Helicobacter Infections (complications), Helicobacter Infections (pathology), Humans, Male, Middle Aged, T-Lymphocyte Subsets (chemistry), T-Lymphocyte Subsets (immunology), Young Adult.
- MESH :
- chemical : Biomarkers.
- geographic : Ghana.
- chemistry : CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets.
- complications : HIV Infections, Helicobacter Infections.
- immunology : CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets.
- pathology : Coinfection, HIV Infections, Helicobacter Infections.
- Adult, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Helicobacter pylori coinfection in human immunodeficiency virus (HIV) patients has been associated with higher CD4+ cell counts and lower HIV-1 viral loads, with the underlying mechanisms being unknown. The objective of this study was to investigate the impact of H. pylori infection on markers of T-cell activation in HIV-positive and HIV-negative individuals.
DOI: 10.1093/cid/civ577
PubMed: 26195015
Affiliations:
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Stephen Sarfo</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name><affiliation wicri:level="1"><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Kuffour, Edmund Osei" sort="Kuffour, Edmund Osei" uniqKey="Kuffour E" first="Edmund Osei" last="Kuffour">Edmund Osei Kuffour</name><affiliation><nlm:affiliation>Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</nlm:affiliation><wicri:noCountry code="subField">Heinrich Heine University Düsseldorf</wicri:noCountry></affiliation></author><author><name sortKey="Geldmacher, Christof" sort="Geldmacher, Christof" uniqKey="Geldmacher C" first="Christof" last="Geldmacher">Christof Geldmacher</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (Ludwig Maximilian University [LMU]) German Centre for Infection Research (partner site), Munich.</nlm:affiliation><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of 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Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation><wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry></affiliation></author><author><name sortKey="Eis Hubinger, Anna Maria" sort="Eis Hubinger, Anna Maria" uniqKey="Eis Hubinger A" first="Anna Maria" last="Eis-Hübinger">Anna Maria Eis-Hübinger</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation><wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry></affiliation></author><author><name sortKey="H Ussinger, Dieter" sort="H Ussinger, Dieter" uniqKey="H Ussinger D" first="Dieter" last="H Ussinger">Dieter H Ussinger</name><affiliation><nlm:affiliation>Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</nlm:affiliation><wicri:noCountry code="subField">Heinrich Heine University Düsseldorf</wicri:noCountry></affiliation></author><author><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah 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type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000061</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.</title><author><name sortKey="Eberhardt, Kirsten Alexandra" sort="Eberhardt, Kirsten Alexandra" uniqKey="Eberhardt K" first="Kirsten Alexandra" last="Eberhardt">Kirsten Alexandra Eberhardt</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name><affiliation wicri:level="1"><nlm:affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Kuffour, Edmund Osei" sort="Kuffour, Edmund Osei" uniqKey="Kuffour E" first="Edmund Osei" last="Kuffour">Edmund Osei Kuffour</name><affiliation><nlm:affiliation>Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</nlm:affiliation><wicri:noCountry code="subField">Heinrich Heine University Düsseldorf</wicri:noCountry></affiliation></author><author><name sortKey="Geldmacher, Christof" sort="Geldmacher, Christof" uniqKey="Geldmacher C" first="Christof" last="Geldmacher">Christof Geldmacher</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (Ludwig Maximilian University [LMU]) German Centre for Infection Research (partner site), Munich.</nlm:affiliation><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (Ludwig Maximilian University [LMU]) German Centre for Infection Research (partner site)</wicri:orgArea></affiliation></author><author><name sortKey="Soltau, Mareike" sort="Soltau, Mareike" uniqKey="Soltau M" first="Mareike" last="Soltau">Mareike Soltau</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Schachscheider, Marei" sort="Schachscheider, Marei" uniqKey="Schachscheider M" first="Marei" last="Schachscheider">Marei Schachscheider</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation><wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry></affiliation></author><author><name sortKey="Eis Hubinger, Anna Maria" sort="Eis Hubinger, Anna Maria" uniqKey="Eis Hubinger A" first="Anna Maria" last="Eis-Hübinger">Anna Maria Eis-Hübinger</name><affiliation><nlm:affiliation>Institute of Virology, University of Bonn Medical Centre.</nlm:affiliation><wicri:noCountry code="subField">University of Bonn Medical Centre</wicri:noCountry></affiliation></author><author><name sortKey="H Ussinger, Dieter" sort="H Ussinger, Dieter" uniqKey="H Ussinger D" first="Dieter" last="H Ussinger">Dieter H Ussinger</name><affiliation><nlm:affiliation>Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</nlm:affiliation><wicri:noCountry code="subField">Heinrich Heine University Düsseldorf</wicri:noCountry></affiliation></author><author><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name><affiliation wicri:level="1"><nlm:affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Burchard, Gerd Dieter" sort="Burchard, Gerd Dieter" uniqKey="Burchard G" first="Gerd Dieter" last="Burchard">Gerd Dieter Burchard</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany Institute for Interdisciplinary Medicine, Asklepios Klinik St Georg, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany Institute for Interdisciplinary Medicine, Asklepios Klinik St Georg, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name><affiliation><nlm:affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</nlm:affiliation><wicri:noCountry code="subField">Heinrich Heine University Düsseldorf</wicri:noCountry></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biomarkers</term><term>CD4-Positive T-Lymphocytes (chemistry)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Coinfection (pathology)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Ghana</term><term>HIV Infections (complications)</term><term>HIV Infections (pathology)</term><term>Helicobacter Infections (complications)</term><term>Helicobacter Infections (pathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>T-Lymphocyte Subsets (chemistry)</term><term>T-Lymphocyte Subsets (immunology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Co-infection (anatomopathologie)</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Infections à Helicobacter ()</term><term>Infections à Helicobacter (anatomopathologie)</term><term>Infections à VIH ()</term><term>Infections à VIH (anatomopathologie)</term><term>Jeune adulte</term><term>Lymphocytes T CD4+ ()</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Sous-populations de lymphocytes T ()</term><term>Sous-populations de lymphocytes T (immunologie)</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Co-infection</term><term>Infections à Helicobacter</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>T-Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term><term>Helicobacter Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T CD4+</term><term>Sous-populations de lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>T-Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coinfection</term><term>HIV Infections</term><term>Helicobacter Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Infections à Helicobacter</term><term>Infections à VIH</term><term>Jeune adulte</term><term>Lymphocytes T CD4+</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Sous-populations de lymphocytes T</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Helicobacter pylori coinfection in human immunodeficiency virus (HIV) patients has been associated with higher CD4+ cell counts and lower HIV-1 viral loads, with the underlying mechanisms being unknown. The objective of this study was to investigate the impact of H. pylori infection on markers of T-cell activation in HIV-positive and HIV-negative individuals.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26195015</PMID><DateCreated><Year>2015</Year><Month>10</Month><Day>23</Day></DateCreated><DateCompleted><Year>2016</Year><Month>07</Month><Day>27</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><Volume>61</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana.</ArticleTitle><Pagination><MedlinePgn>1615-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/civ577</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Helicobacter pylori coinfection in human immunodeficiency virus (HIV) patients has been associated with higher CD4+ cell counts and lower HIV-1 viral loads, with the underlying mechanisms being unknown. The objective of this study was to investigate the impact of H. pylori infection on markers of T-cell activation in HIV-positive and HIV-negative individuals.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In a cross-sectional, observational study, HIV patients (n = 457) and HIV-negative blood donors (n = 79) presenting to an HIV clinic in Ghana were enrolled. Data on clinical and sociodemographic parameters, CD4+/CD8+ T-cell counts, and HIV-1 viral load were recorded. Helicobacter pylori status was tested using a stool antigen test. Cell surface and intracellular markers related to T-cell immune activation and turnover were quantified by flow cytometry and compared according to HIV and H. pylori status.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Helicobacter pylori infection was associated with decreased markers of CD4+ T-cell activation (HLA-DR+CD38+CD4+; 22.55% vs 32.70%; P = .002), cell proliferation (Ki67; 15.10% vs 26.80%; P = .016), and immune exhaustion (PD-1; 32.45% vs 40.00%; P = .005) in 243 antiretroviral therapy (ART)-naive patients, but not in 214 patients on ART. In HIV-negative individuals, H. pylori infection was associated with decreased frequencies of activated CD4+ and CD8+ T cells (6.31% vs 10.40%; P = .014 and 18.70% vs 34.85%, P = .006, respectively).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings suggest that H. pylori coinfection effectuates a systemic immune modulatory effect with decreased T-cell activation in HIV-positive, ART-naive patients but also in HIV-negative individuals. This finding might, in part, explain the observed association of H. pylori infection with favorable parameters of HIV disease progression.</AbstractText><AbstractText Label="CLINICAL TRIALS REGISTRATION" NlmCategory="BACKGROUND">Clinicaltrials.gov NCT01897909.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eberhardt</LastName><ForeName>Kirsten Alexandra</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarfo</LastName><ForeName>Fred Stephen</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dompreh</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuffour</LastName><ForeName>Edmund Osei</ForeName><Initials>EO</Initials><AffiliationInfo><Affiliation>Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geldmacher</LastName><ForeName>Christof</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (Ludwig Maximilian University [LMU]) German Centre for Infection Research (partner site), Munich.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soltau</LastName><ForeName>Mareike</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schachscheider</LastName><ForeName>Marei</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drexler</LastName><ForeName>Jan Felix</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eis-Hübinger</LastName><ForeName>Anna Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Bonn Medical Centre.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Häussinger</LastName><ForeName>Dieter</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bedu-Addo</LastName><ForeName>George</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Richard Odame</ForeName><Initials>RO</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norman</LastName><ForeName>Betty</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital, Kumasi, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burchard</LastName><ForeName>Gerd Dieter</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany Institute for Interdisciplinary Medicine, Asklepios Klinik St Georg, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feldt</LastName><ForeName>Torsten</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01897909</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016481" MajorTopicYN="N">Helicobacter Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016176" MajorTopicYN="N">T-Lymphocyte Subsets</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">HIV/AIDS</Keyword><Keyword MajorTopicYN="N">Helicobacter pylori</Keyword><Keyword MajorTopicYN="N">immune activation</Keyword><Keyword MajorTopicYN="N">sub-Saharan Africa</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>02</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26195015</ArticleId><ArticleId IdType="pii">civ577</ArticleId><ArticleId IdType="doi">10.1093/cid/civ577</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Ghana</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Hambourg</li></region><settlement><li>Hambourg</li><li>Munich</li></settlement></list><tree><noCountry><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><name sortKey="Eis Hubinger, Anna Maria" sort="Eis Hubinger, Anna Maria" uniqKey="Eis Hubinger A" first="Anna Maria" last="Eis-Hübinger">Anna Maria Eis-Hübinger</name><name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name><name sortKey="H Ussinger, Dieter" sort="H Ussinger, Dieter" uniqKey="H Ussinger D" first="Dieter" last="H Ussinger">Dieter H Ussinger</name><name sortKey="Kuffour, Edmund Osei" sort="Kuffour, Edmund Osei" uniqKey="Kuffour E" first="Edmund Osei" last="Kuffour">Edmund Osei Kuffour</name></noCountry><country name="Allemagne"><region name="Hambourg"><name sortKey="Eberhardt, Kirsten Alexandra" sort="Eberhardt, Kirsten Alexandra" uniqKey="Eberhardt K" first="Kirsten Alexandra" last="Eberhardt">Kirsten Alexandra Eberhardt</name></region><name sortKey="Burchard, Gerd Dieter" sort="Burchard, Gerd Dieter" uniqKey="Burchard G" first="Gerd Dieter" last="Burchard">Gerd Dieter Burchard</name><name sortKey="Geldmacher, Christof" sort="Geldmacher, Christof" uniqKey="Geldmacher C" first="Christof" last="Geldmacher">Christof Geldmacher</name><name sortKey="Schachscheider, Marei" sort="Schachscheider, Marei" uniqKey="Schachscheider M" first="Marei" last="Schachscheider">Marei Schachscheider</name><name sortKey="Soltau, Mareike" sort="Soltau, Mareike" uniqKey="Soltau M" first="Mareike" last="Soltau">Mareike Soltau</name></country><country name="Ghana"><noRegion><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name></noRegion><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name><name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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