Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Identifieur interne : 000187 ( PubMed/Checkpoint ); précédent : 000186; suivant : 000188Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.
Auteurs : Michael Nambozi ; Modest Mulenga ; Tinto Halidou ; Harry Tagbor ; Victor Mwapasa ; Linda Kalilani Phiri ; Gertrude Kalanda ; Innocent Valea ; Maminata Traore ; David Mwakazanga ; Yves Claeys ; Céline Schurmans ; Maaike De Crop ; Joris Menten ; Raffaella Ravinetto ; Kamala Thriemer ; Jean-Pierre Van Geertruyden ; Theonest Mutabingwa ; Umberto D'Alessandro [Belgique]Source :
- Reproductive health [ 1742-4755 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Amodiaquine (effets indésirables), Amodiaquine (usage thérapeutique), Antipaludiques (effets indésirables), Antipaludiques (usage thérapeutique), Artémisinines (effets indésirables), Artémisinines (usage thérapeutique), Association médicamenteuse, Burkina, Complications parasitaires de la grossesse (traitement médicamenteux), Développement foetal (), Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Fluorènes (effets indésirables), Fluorènes (usage thérapeutique), Ghana, Grossesse, Humains, Malawi, Méfloquine (effets indésirables), Méfloquine (usage thérapeutique), Nouveau-né, Paludisme (traitement médicamenteux), Placentation (), Poids de naissance (), Quinoléines (effets indésirables), Quinoléines (usage thérapeutique), Zambie, Éthanolamines (effets indésirables), Éthanolamines (usage thérapeutique), Études de suivi.
- MESH :
- effets indésirables : Amodiaquine, Antipaludiques, Artémisinines, Fluorènes, Méfloquine, Quinoléines, Éthanolamines.
- traitement médicamenteux : Complications parasitaires de la grossesse, Paludisme.
- usage thérapeutique : Amodiaquine, Antipaludiques, Artémisinines, Fluorènes, Méfloquine, Quinoléines, Éthanolamines.
- Adulte, Association médicamenteuse, Burkina, Développement foetal, Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Ghana, Grossesse, Humains, Malawi, Nouveau-né, Placentation, Poids de naissance, Zambie, Études de suivi.
- Wicri :
- geographic : Burkina Faso, Ghana, Malawi, Zambie.
English descriptors
- KwdEn :
- Adult, Amodiaquine (adverse effects), Amodiaquine (therapeutic use), Antimalarials (adverse effects), Antimalarials (therapeutic use), Artemisinins (adverse effects), Artemisinins (therapeutic use), Birth Weight (drug effects), Burkina Faso, Drug Combinations, Ethanolamines (adverse effects), Ethanolamines (therapeutic use), Female, Fetal Development (drug effects), Fluorenes (adverse effects), Fluorenes (therapeutic use), Follow-Up Studies, Ghana, Humans, Infant, Newborn, Malaria (drug therapy), Malawi, Mefloquine (adverse effects), Mefloquine (therapeutic use), Placentation (drug effects), Pregnancy, Pregnancy Complications, Parasitic (drug therapy), Prenatal Exposure Delayed Effects, Quinolines (adverse effects), Quinolines (therapeutic use), Zambia.
- MESH :
- chemical , adverse effects : Amodiaquine, Antimalarials, Artemisinins, Ethanolamines, Fluorenes, Mefloquine, Quinolines.
- chemical , therapeutic use : Amodiaquine, Antimalarials, Artemisinins, Ethanolamines, Fluorenes, Mefloquine, Quinolines.
- geographic : Burkina Faso, Drug Combinations, Ghana, Malawi, Zambia.
- drug effects : Birth Weight, Fetal Development, Placentation.
- drug therapy : Malaria, Pregnancy Complications, Parasitic.
- Adult, Female, Follow-Up Studies, Humans, Infant, Newborn, Pregnancy, Prenatal Exposure Delayed Effects.
Abstract
Asymptomatic and symptomatic malaria during pregnancy has consequences for both mother and her offspring. Unfortunately, there is insufficient information on the safety and efficacy of most antimalarials in pregnancy. Indeed, clinical trials assessing antimalarial treatments systematically exclude pregnancy for fear of teratogenicity and embryotoxicity. The little available information originates from South East Asia while in sub-Saharan Africa such information is still limited and needs to be provided.
DOI: 10.1186/1742-4755-12-5
PubMed: 25592254
Affiliations:
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pubmed:25592254Le document en format XML
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Mwapasa</name></author><author><name sortKey="Phiri, Linda Kalilani" sort="Phiri, Linda Kalilani" uniqKey="Phiri L" first="Linda Kalilani" last="Phiri">Linda Kalilani Phiri</name></author><author><name sortKey="Kalanda, Gertrude" sort="Kalanda, Gertrude" uniqKey="Kalanda G" first="Gertrude" last="Kalanda">Gertrude Kalanda</name></author><author><name sortKey="Valea, Innocent" sort="Valea, Innocent" uniqKey="Valea I" first="Innocent" last="Valea">Innocent Valea</name></author><author><name sortKey="Traore, Maminata" sort="Traore, Maminata" uniqKey="Traore M" first="Maminata" last="Traore">Maminata Traore</name></author><author><name sortKey="Mwakazanga, David" sort="Mwakazanga, David" uniqKey="Mwakazanga D" first="David" last="Mwakazanga">David Mwakazanga</name></author><author><name sortKey="Claeys, Yves" sort="Claeys, Yves" uniqKey="Claeys Y" first="Yves" last="Claeys">Yves Claeys</name></author><author><name sortKey="Schurmans, Celine" sort="Schurmans, Celine" uniqKey="Schurmans C" 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Mutabingwa</name></author><author><name sortKey="D Alessandro, Umberto" sort="D Alessandro, Umberto" uniqKey="D Alessandro U" first="Umberto" last="D'Alessandro">Umberto D'Alessandro</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Tropical Medicine, Antwerp, Belgium. udalessandro@mrc.gm.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></analytic><series><title level="j">Reproductive health</title><idno type="eISSN">1742-4755</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amodiaquine (adverse effects)</term><term>Amodiaquine (therapeutic use)</term><term>Antimalarials (adverse effects)</term><term>Antimalarials (therapeutic use)</term><term>Artemisinins (adverse effects)</term><term>Artemisinins (therapeutic use)</term><term>Birth Weight (drug effects)</term><term>Burkina Faso</term><term>Drug Combinations</term><term>Ethanolamines (adverse effects)</term><term>Ethanolamines (therapeutic use)</term><term>Female</term><term>Fetal Development (drug effects)</term><term>Fluorenes (adverse effects)</term><term>Fluorenes (therapeutic use)</term><term>Follow-Up Studies</term><term>Ghana</term><term>Humans</term><term>Infant, Newborn</term><term>Malaria (drug therapy)</term><term>Malawi</term><term>Mefloquine (adverse effects)</term><term>Mefloquine (therapeutic use)</term><term>Placentation (drug effects)</term><term>Pregnancy</term><term>Pregnancy Complications, Parasitic (drug therapy)</term><term>Prenatal Exposure Delayed Effects</term><term>Quinolines (adverse effects)</term><term>Quinolines (therapeutic use)</term><term>Zambia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Amodiaquine (effets indésirables)</term><term>Amodiaquine (usage thérapeutique)</term><term>Antipaludiques (effets indésirables)</term><term>Antipaludiques (usage thérapeutique)</term><term>Artémisinines (effets indésirables)</term><term>Artémisinines (usage thérapeutique)</term><term>Association médicamenteuse</term><term>Burkina</term><term>Complications parasitaires de la grossesse (traitement médicamenteux)</term><term>Développement foetal ()</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Fluorènes (effets indésirables)</term><term>Fluorènes (usage thérapeutique)</term><term>Ghana</term><term>Grossesse</term><term>Humains</term><term>Malawi</term><term>Méfloquine (effets indésirables)</term><term>Méfloquine (usage thérapeutique)</term><term>Nouveau-né</term><term>Paludisme (traitement médicamenteux)</term><term>Placentation ()</term><term>Poids de naissance ()</term><term>Quinoléines (effets indésirables)</term><term>Quinoléines (usage thérapeutique)</term><term>Zambie</term><term>Éthanolamines (effets indésirables)</term><term>Éthanolamines (usage thérapeutique)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Amodiaquine</term><term>Antimalarials</term><term>Artemisinins</term><term>Ethanolamines</term><term>Fluorenes</term><term>Mefloquine</term><term>Quinolines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amodiaquine</term><term>Antimalarials</term><term>Artemisinins</term><term>Ethanolamines</term><term>Fluorenes</term><term>Mefloquine</term><term>Quinolines</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Burkina Faso</term><term>Drug Combinations</term><term>Ghana</term><term>Malawi</term><term>Zambia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Birth Weight</term><term>Fetal Development</term><term>Placentation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term><term>Pregnancy Complications, Parasitic</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Amodiaquine</term><term>Antipaludiques</term><term>Artémisinines</term><term>Fluorènes</term><term>Méfloquine</term><term>Quinoléines</term><term>Éthanolamines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications parasitaires de la grossesse</term><term>Paludisme</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Amodiaquine</term><term>Antipaludiques</term><term>Artémisinines</term><term>Fluorènes</term><term>Méfloquine</term><term>Quinoléines</term><term>Éthanolamines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant, Newborn</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Association médicamenteuse</term><term>Burkina</term><term>Développement foetal</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Ghana</term><term>Grossesse</term><term>Humains</term><term>Malawi</term><term>Nouveau-né</term><term>Placentation</term><term>Poids de naissance</term><term>Zambie</term><term>Études de suivi</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Burkina Faso</term><term>Ghana</term><term>Malawi</term><term>Zambie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Asymptomatic and symptomatic malaria during pregnancy has consequences for both mother and her offspring. Unfortunately, there is insufficient information on the safety and efficacy of most antimalarials in pregnancy. Indeed, clinical trials assessing antimalarial treatments systematically exclude pregnancy for fear of teratogenicity and embryotoxicity. The little available information originates from South East Asia while in sub-Saharan Africa such information is still limited and needs to be provided.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25592254</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>20</Day></DateCreated><DateCompleted><Year>2015</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>15</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1742-4755</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><PubDate><Year>2015</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Reproductive health</Title><ISOAbbreviation>Reprod Health</ISOAbbreviation></Journal><ArticleTitle>Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.</ArticleTitle><Pagination><MedlinePgn>5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1742-4755-12-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Asymptomatic and symptomatic malaria during pregnancy has consequences for both mother and her offspring. Unfortunately, there is insufficient information on the safety and efficacy of most antimalarials in pregnancy. Indeed, clinical trials assessing antimalarial treatments systematically exclude pregnancy for fear of teratogenicity and embryotoxicity. The little available information originates from South East Asia while in sub-Saharan Africa such information is still limited and needs to be provided.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">A Phase 3, non-inferiority, multicentre, randomized, open-label clinical trial on safety and efficacy of 4 ACT when administered during pregnancy was carried out in 4 African countries: Burkina Faso, Ghana, Malawi and Zambia. This is a four arm trial using a balanced incomplete block design. Pregnant women diagnosed with malaria are randomised to receive either amodiaquine-artesunate (AQ-AS), dihydroartemisinin-piperaquine (DHA-PQ), artemether-lumefantrine (AL), or mefloquine-artesunate (MQAS). They are actively followed up until day 63 post-treatment and then monthly until 4-6 weeks post-delivery. The offspring is visited at the time of the first birthday. The primary endpoint is treatment failure (PCR adjusted) at day 63 and safety profiles. Secondary endpoints included PCR unadjusted treatment failure up to day 63, gametocyte carriage, Hb changes, placenta malaria, mean birth weight and low birth weight. The primary statistical analysis will use the combined data from all 4 centres, with adjustment for any centre effects, using an additive model for the response rates. This will allow the assessment of all 6 possible pair-wise treatment comparisons using all available data.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">The strength of this trial is the involvement of several African countries, increasing the generalisability of the results. In addition, it assesses most ACTs currently available, determining their relative '-value-' compared to others. The balanced incomplete block design was chosen because using all 4-arms in each site would have increased complexity in terms of implementation. Excluding HIV-positive pregnant women on antiretroviral drugs may be seen as a limitation because of the possible interactions between antiretroviral and antimalarial treatments. Nevertheless, the results of this trial will provide the evidence base for the formulation of malaria treatment policy for pregnant women in sub-Saharan Africa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nambozi</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mulenga</LastName><ForeName>Modest</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Halidou</LastName><ForeName>Tinto</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tagbor</LastName><ForeName>Harry</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Mwapasa</LastName><ForeName>Victor</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Phiri</LastName><ForeName>Linda Kalilani</ForeName><Initials>LK</Initials></Author><Author ValidYN="Y"><LastName>Kalanda</LastName><ForeName>Gertrude</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Valea</LastName><ForeName>Innocent</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Traore</LastName><ForeName>Maminata</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mwakazanga</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Claeys</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Schurmans</LastName><ForeName>Céline</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>De Crop</LastName><ForeName>Maaike</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Menten</LastName><ForeName>Joris</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ravinetto</LastName><ForeName>Raffaella</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Thriemer</LastName><ForeName>Kamala</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Van Geertruyden</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Mutabingwa</LastName><ForeName>Theonest</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>D'Alessandro</LastName><ForeName>Umberto</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Tropical Medicine, Antwerp, Belgium. udalessandro@mrc.gm.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Pregact Group</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00852423</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Reprod Health</MedlineTA><NlmUniqueID>101224380</NlmUniqueID><ISSNLinking>1742-4755</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D037621">Artemisinins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004983">Ethanolamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005449">Fluorenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011804">Quinolines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515299">amodiaquine, artesunate drug combination</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C515298">artemether-lumefantrine combination</NameOfSubstance></Chemical><Chemical><RegistryNumber>220236ED28</RegistryNumber><NameOfSubstance UI="D000655">Amodiaquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>60W3249T9M</RegistryNumber><NameOfSubstance UI="C039726">artesunate</NameOfSubstance></Chemical><Chemical><RegistryNumber>6A9O50735X</RegistryNumber><NameOfSubstance UI="C039060">dihydroartemisinin</NameOfSubstance></Chemical><Chemical><RegistryNumber>A0HV2Q956Y</RegistryNumber><NameOfSubstance UI="C034759">piperaquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>TML814419R</RegistryNumber><NameOfSubstance UI="D015767">Mefloquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Hum Pathol. 2000 Jan;31(1):85-93</RefSource><PMID Version="1">10665918</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Antimicrob Chemother. 2014 Sep;69(9):2499-507</RefSource><PMID Version="1">24891429</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2000 Sep 23;356(9235):1051-6</RefSource><PMID Version="1">11009139</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 2003 Jan-Feb;97(1):30-5</RefSource><PMID Version="1">12886801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Jan 3;363(9402):9-17</RefSource><PMID 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Sep;55(9):4338-42</RefSource><PMID Version="1">21709098</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Pharmacokinet. 2011 Nov 1;50(11):705-23</RefSource><PMID Version="1">21973268</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antimicrob Agents Chemother. 2011 Dec;55(12):5500-6</RefSource><PMID Version="1">21947392</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2011 Nov;8(11):e1001119</RefSource><PMID Version="1">22087077</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Clin Pharmacol. 2012 Mar;73(3):467-77</RefSource><PMID Version="1">21950338</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Malar J. 2012;11:141</RefSource><PMID Version="1">22548983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014;9(1):e84976</RefSource><PMID Version="1">24465458</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000655" MajorTopicYN="N">Amodiaquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D037621" MajorTopicYN="N">Artemisinins</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001724" MajorTopicYN="N">Birth Weight</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002050" MajorTopicYN="N" Type="Geographic">Burkina Faso</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004983" MajorTopicYN="N">Ethanolamines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047109" MajorTopicYN="N">Fetal Development</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005449" MajorTopicYN="N">Fluorenes</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005869" MajorTopicYN="N" Type="Geographic">Ghana</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008295" MajorTopicYN="N" Type="Geographic">Malawi</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015767" MajorTopicYN="N">Mefloquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010929" MajorTopicYN="N">Placentation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015597" MajorTopicYN="N">Pregnancy Complications, Parasitic</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011297" MajorTopicYN="N">Prenatal Exposure Delayed Effects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011804" MajorTopicYN="N">Quinolines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015024" MajorTopicYN="N" Type="Geographic">Zambia</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4326323</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25592254</ArticleId><ArticleId IdType="pii">1742-4755-12-5</ArticleId><ArticleId IdType="doi">10.1186/1742-4755-12-5</ArticleId><ArticleId 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last="Mutabingwa">Theonest Mutabingwa</name><name sortKey="Mwakazanga, David" sort="Mwakazanga, David" uniqKey="Mwakazanga D" first="David" last="Mwakazanga">David Mwakazanga</name><name sortKey="Mwapasa, Victor" sort="Mwapasa, Victor" uniqKey="Mwapasa V" first="Victor" last="Mwapasa">Victor Mwapasa</name><name sortKey="Nambozi, Michael" sort="Nambozi, Michael" uniqKey="Nambozi M" first="Michael" last="Nambozi">Michael Nambozi</name><name sortKey="Phiri, Linda Kalilani" sort="Phiri, Linda Kalilani" uniqKey="Phiri L" first="Linda Kalilani" last="Phiri">Linda Kalilani Phiri</name><name sortKey="Ravinetto, Raffaella" sort="Ravinetto, Raffaella" uniqKey="Ravinetto R" first="Raffaella" last="Ravinetto">Raffaella Ravinetto</name><name sortKey="Schurmans, Celine" sort="Schurmans, Celine" uniqKey="Schurmans C" first="Céline" last="Schurmans">Céline Schurmans</name><name sortKey="Tagbor, Harry" sort="Tagbor, Harry" uniqKey="Tagbor H" first="Harry" last="Tagbor">Harry Tagbor</name><name 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