Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural south africa: the HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study.
Identifieur interne : 000067 ( PubMed/Checkpoint ); précédent : 000066; suivant : 000068Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural south africa: the HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study.
Auteurs : Thomas A. Gaziano [États-Unis] ; Shafika Abrahams-Gessel [États-Unis] ; F Xavier Gomez-Olive [États-Unis] ; Alisha Wade [Afrique du Sud] ; Nigel J. Crowther [Afrique du Sud] ; Sartaj Alam [États-Unis] ; Jennifer Manne-Goehler [États-Unis] ; Chodziwadziwa W. Kabudula [Afrique du Sud] ; Ryan Wagner [Afrique du Sud] ; Julia Rohr [États-Unis] ; Livia Montana [États-Unis] ; Kathleen Kahn [Afrique du Sud] ; Till W. B Rnighausen [États-Unis] ; Lisa F. Berkman [États-Unis] ; Stephen Tollman [Afrique du Sud]Source :
- BMC public health [ 1471-2458 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antirétroviraux (usage thérapeutique), Comorbidité, Diabète (mortalité), Diabète (épidémiologie), Entretiens comme sujet, Espérance de vie, Facteurs de risque, Facteurs socioéconomiques, Femelle, Glycémie, Humains, Hémoglobine A glycosylée, Infections à VIH (mortalité), Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Lipides (sang), Maladies cardiovasculaires (mortalité), Maladies cardiovasculaires (épidémiologie), Mâle, Poids et mesures du corps, Population rurale (), Pression sanguine, Protéine C-réactive, Prévalence, Rapport taille-hanches, République d'Afrique du Sud (épidémiologie), Sujet âgé, Systèmes automatisés lit malade, Vieillissement, Études longitudinales.
- MESH :
- mortalité : Diabète, Infections à VIH, Maladies cardiovasculaires.
- sang : Lipides.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- épidémiologie : Diabète, Infections à VIH, Maladies cardiovasculaires, République d'Afrique du Sud.
- Adulte, Adulte d'âge moyen, Comorbidité, Entretiens comme sujet, Espérance de vie, Facteurs de risque, Facteurs socioéconomiques, Femelle, Glycémie, Humains, Hémoglobine A glycosylée, Mâle, Poids et mesures du corps, Population rurale, Pression sanguine, Protéine C-réactive, Prévalence, Rapport taille-hanches, Sujet âgé, Systèmes automatisés lit malade, Vieillissement, Études longitudinales.
English descriptors
- KwdEn :
- Adult, Aged, Aging, Anti-Retroviral Agents (therapeutic use), Blood Glucose, Blood Pressure, Body Weights and Measures, C-Reactive Protein, Cardiovascular Diseases (epidemiology), Cardiovascular Diseases (mortality), Comorbidity, Diabetes Mellitus (epidemiology), Diabetes Mellitus (mortality), Female, HIV Infections (drug therapy), HIV Infections (epidemiology), HIV Infections (mortality), Hemoglobin A, Glycosylated, Humans, Interviews as Topic, Life Expectancy, Lipids (blood), Longitudinal Studies, Male, Middle Aged, Point-of-Care Systems, Prevalence, Risk Factors, Rural Population (statistics & numerical data), Socioeconomic Factors, South Africa (epidemiology), Waist-Hip Ratio.
- MESH :
- chemical , blood : Lipids.
- chemical , therapeutic use : Anti-Retroviral Agents.
- drug therapy : HIV Infections.
- epidemiology : Cardiovascular Diseases, Diabetes Mellitus, HIV Infections, South Africa.
- mortality : Cardiovascular Diseases, Diabetes Mellitus, HIV Infections.
- statistics & numerical data : Rural Population.
- Adult, Aged, Aging, Blood Glucose, Blood Pressure, Body Weights and Measures, C-Reactive Protein, Comorbidity, Female, Hemoglobin A, Glycosylated, Humans, Interviews as Topic, Life Expectancy, Longitudinal Studies, Male, Middle Aged, Point-of-Care Systems, Prevalence, Risk Factors, Socioeconomic Factors, Waist-Hip Ratio.
Abstract
A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults.
DOI: 10.1186/s12889-017-4117-y
PubMed: 28212629
Affiliations:
- Afrique du Sud, États-Unis
- Gauteng, Massachusetts
- Cambridge (Massachusetts), Johannesbourg
- Université Harvard, Université du Witwatersrand
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pubmed:28212629Le document en format XML
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B Rnighausen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Berkman, Lisa F" sort="Berkman, Lisa F" uniqKey="Berkman L" first="Lisa F" last="Berkman">Lisa F. 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Gaziano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Brigham & Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. tgaziano@partners.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiovascular Medicine, Brigham & Women's Hospital, 75 Francis Street, Boston, MA, 02115</wicri:regionArea><wicri:noRegion>02115</wicri:noRegion></affiliation></author><author><name sortKey="Abrahams Gessel, Shafika" sort="Abrahams Gessel, Shafika" uniqKey="Abrahams Gessel S" first="Shafika" last="Abrahams-Gessel">Shafika Abrahams-Gessel</name><affiliation wicri:level="1"><nlm:affiliation>Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Ave., Boston, MA, 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Ave., Boston, MA, 02115</wicri:regionArea><wicri:noRegion>02115</wicri:noRegion></affiliation></author><author><name sortKey="Gomez Olive, F Xavier" sort="Gomez Olive, F Xavier" uniqKey="Gomez Olive F" first="F Xavier" last="Gomez-Olive">F Xavier Gomez-Olive</name><affiliation wicri:level="4"><nlm:affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wade, Alisha" sort="Wade, Alisha" uniqKey="Wade A" first="Alisha" last="Wade">Alisha Wade</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Crowther, Nigel J" sort="Crowther, Nigel J" uniqKey="Crowther N" first="Nigel J" last="Crowther">Nigel J. Crowther</name><affiliation wicri:level="4"><nlm:affiliation>National Health Laboratory Service and Department of Chemical Pathology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd., Johannesburg, Parktown, 2193, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Health Laboratory Service and Department of Chemical Pathology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd., Johannesburg, Parktown, 2193</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Alam, Sartaj" sort="Alam, Sartaj" uniqKey="Alam S" first="Sartaj" last="Alam">Sartaj Alam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA, 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA, 02115</wicri:regionArea><wicri:noRegion>02115</wicri:noRegion></affiliation></author><author><name sortKey="Manne Goehler, Jennifer" sort="Manne Goehler, Jennifer" uniqKey="Manne Goehler J" first="Jennifer" last="Manne-Goehler">Jennifer Manne-Goehler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215</wicri:regionArea><wicri:noRegion>02215</wicri:noRegion></affiliation></author><author><name sortKey="Kabudula, Chodziwadziwa W" sort="Kabudula, Chodziwadziwa W" uniqKey="Kabudula C" first="Chodziwadziwa W" last="Kabudula">Chodziwadziwa W. Kabudula</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Wagner, Ryan" sort="Wagner, Ryan" uniqKey="Wagner R" first="Ryan" last="Wagner">Ryan Wagner</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Rohr, Julia" sort="Rohr, Julia" uniqKey="Rohr J" first="Julia" last="Rohr">Julia Rohr</name><affiliation wicri:level="4"><nlm:affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Montana, Livia" sort="Montana, Livia" uniqKey="Montana L" first="Livia" last="Montana">Livia Montana</name><affiliation wicri:level="4"><nlm:affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="B Rnighausen, Till W" sort="B Rnighausen, Till W" uniqKey="B Rnighausen T" first="Till W" last="B Rnighausen">Till W. B Rnighausen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Berkman, Lisa F" sort="Berkman, Lisa F" uniqKey="Berkman L" first="Lisa F" last="Berkman">Lisa F. Berkman</name><affiliation wicri:level="4"><nlm:affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138</wicri:regionArea><orgName type="university">Université Harvard</orgName><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Tollman, Stephen" sort="Tollman, Stephen" uniqKey="Tollman S" first="Stephen" last="Tollman">Stephen Tollman</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author></analytic><series><title level="j">BMC public health</title><idno type="eISSN">1471-2458</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aging</term><term>Anti-Retroviral Agents (therapeutic use)</term><term>Blood Glucose</term><term>Blood Pressure</term><term>Body Weights and Measures</term><term>C-Reactive Protein</term><term>Cardiovascular Diseases (epidemiology)</term><term>Cardiovascular Diseases (mortality)</term><term>Comorbidity</term><term>Diabetes Mellitus (epidemiology)</term><term>Diabetes Mellitus (mortality)</term><term>Female</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (mortality)</term><term>Hemoglobin A, Glycosylated</term><term>Humans</term><term>Interviews as Topic</term><term>Life Expectancy</term><term>Lipids (blood)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Point-of-Care Systems</term><term>Prevalence</term><term>Risk Factors</term><term>Rural Population (statistics & numerical data)</term><term>Socioeconomic Factors</term><term>South Africa (epidemiology)</term><term>Waist-Hip Ratio</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antirétroviraux (usage thérapeutique)</term><term>Comorbidité</term><term>Diabète (mortalité)</term><term>Diabète (épidémiologie)</term><term>Entretiens comme sujet</term><term>Espérance de vie</term><term>Facteurs de risque</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Glycémie</term><term>Humains</term><term>Hémoglobine A glycosylée</term><term>Infections à VIH (mortalité)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (épidémiologie)</term><term>Lipides (sang)</term><term>Maladies cardiovasculaires (mortalité)</term><term>Maladies cardiovasculaires (épidémiologie)</term><term>Mâle</term><term>Poids et mesures du corps</term><term>Population rurale ()</term><term>Pression sanguine</term><term>Protéine C-réactive</term><term>Prévalence</term><term>Rapport taille-hanches</term><term>République d'Afrique du Sud (épidémiologie)</term><term>Sujet âgé</term><term>Systèmes automatisés lit malade</term><term>Vieillissement</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cardiovascular Diseases</term><term>Diabetes Mellitus</term><term>HIV Infections</term><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cardiovascular Diseases</term><term>Diabetes Mellitus</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Diabète</term><term>Infections à VIH</term><term>Maladies cardiovasculaires</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lipides</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Rural Population</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Diabète</term><term>Infections à VIH</term><term>Maladies cardiovasculaires</term><term>République d'Afrique du Sud</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aging</term><term>Blood Glucose</term><term>Blood Pressure</term><term>Body Weights and Measures</term><term>C-Reactive Protein</term><term>Comorbidity</term><term>Female</term><term>Hemoglobin A, Glycosylated</term><term>Humans</term><term>Interviews as Topic</term><term>Life Expectancy</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Point-of-Care Systems</term><term>Prevalence</term><term>Risk Factors</term><term>Socioeconomic Factors</term><term>Waist-Hip Ratio</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Entretiens comme sujet</term><term>Espérance de vie</term><term>Facteurs de risque</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Glycémie</term><term>Humains</term><term>Hémoglobine A glycosylée</term><term>Mâle</term><term>Poids et mesures du corps</term><term>Population rurale</term><term>Pression sanguine</term><term>Protéine C-réactive</term><term>Prévalence</term><term>Rapport taille-hanches</term><term>Sujet âgé</term><term>Systèmes automatisés lit malade</term><term>Vieillissement</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28212629</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>18</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2458</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Feb</Month><Day>17</Day></PubDate></JournalIssue><Title>BMC public health</Title><ISOAbbreviation>BMC Public Health</ISOAbbreviation></Journal><ArticleTitle>Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural south africa: the HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study.</ArticleTitle><Pagination><MedlinePgn>206</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12889-017-4117-y</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We recruited randomly selected adults aged 40 or older residing in the rural Agincourt sub-district in Mpumalanga Province. In-person interviews were conducted to collect baseline household and socioeconomic data, self-reported health, anthropometric measures, blood pressure, high-sensitivity C-reactive protein (hsCRP), HbA1c, HIV-status, and point-of-care glucose and lipid levels.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Five thousand fifty nine persons (46.4% male) were enrolled with a mean age of 61.7 ± 13.06 years. Waist-to-hip ratio was high for men and women (0.92 ± 0.08 vs. 0.89 ± 0.08), with 70% of women and 44% of men being overweight or obese. Blood pressure was similar for men and women with a combined hypertension prevalence of 58.4% and statistically significant increases were observed with increasing age. High total cholesterol prevalence in women was twice that observed for men (8.5 vs. 4.1%). The prevalence of self-reported CMD conditions was higher among women, except for myocardial infarction, and women had a statistically significantly higher prevalence of angina (10.82 vs. 6.97%) using Rose Criteria. The HIV(-) persons were significantly more likely to have hypertension, diabetes, or be overweight or obese than HIV(+) persons. Approximately 56% of the cohort had at least 2 measured or self-reported clinical co-morbidities, with HIV(+) persons having a consistently lower prevalence of co-morbidities compared to those without HIV. Absolute 10-year risk cardiovascular risk scores ranged from 7.7-9.7% for women and from 12.5-15.3% for men, depending on the risk score equations used.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This cohort has high CMD risk based on both traditional risk factors and novel markers like hsCRP. Longitudinal follow-up of the cohort will allow us to determine the long-term impact of increased lifespan in a population with both high HIV infection and CMD risk.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gaziano</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Brigham & Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. tgaziano@partners.org.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Ave., Boston, MA, 02115, USA. tgaziano@partners.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abrahams-Gessel</LastName><ForeName>Shafika</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for Health Decision Science, Harvard T.H. Chan School of Public Health, 718 Huntington Ave., Boston, MA, 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gomez-Olive</LastName><ForeName>F Xavier</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wade</LastName><ForeName>Alisha</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crowther</LastName><ForeName>Nigel J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>National Health Laboratory Service and Department of Chemical Pathology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd., Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alam</LastName><ForeName>Sartaj</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA, 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manne-Goehler</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kabudula</LastName><ForeName>Chodziwadziwa W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rohr</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montana</LastName><ForeName>Livia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kahn</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bärnighausen</LastName><ForeName>Till W</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>Department of Global Health & Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Health Research Institute (AHRI), Mtubatuba, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Public Health, Faculty of Medicine, University of Heidelberg, INF 130.3, Heidelberg, Baden-Württemberg, 69120, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berkman</LastName><ForeName>Lisa F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Harvard Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA, 02138, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tollman</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Medical Research Council/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St. Andrew's Road, Johannesburg, Parktown, 2193, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INDEPTH Network, Accra, Ghana.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Africa Wits-INDEPTH Genomic Studies of Cardiovascular Disease, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Public Health</MedlineTA><NlmUniqueID>100968562</NlmUniqueID><ISSNLinking>1471-2458</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006442">Hemoglobin A, Glycosylated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Clin Epidemiol. 1992 Oct;45(10):1101-9</RefSource><PMID Version="1">1474406</PMID></CommentsCorrections><CommentsCorrections 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Version="1">18179616</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044966" MajorTopicYN="N">Anti-Retroviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001837" MajorTopicYN="N">Body Weights and Measures</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003920" MajorTopicYN="N">Diabetes Mellitus</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006442" MajorTopicYN="N">Hemoglobin A, Glycosylated</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007407" MajorTopicYN="N">Interviews as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008017" MajorTopicYN="N">Life Expectancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019095" MajorTopicYN="N">Point-of-Care Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012424" MajorTopicYN="N">Rural Population</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013019" MajorTopicYN="N">South Africa</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049629" MajorTopicYN="N">Waist-Hip Ratio</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aging</Keyword><Keyword MajorTopicYN="N">Antiretrovirals</Keyword><Keyword MajorTopicYN="N">Cardiometabolic</Keyword><Keyword MajorTopicYN="N">Cardiovascular</Keyword><Keyword MajorTopicYN="N">Diabetes</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">Hypertension</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28212629</ArticleId><ArticleId IdType="doi">10.1186/s12889-017-4117-y</ArticleId><ArticleId IdType="pii">10.1186/s12889-017-4117-y</ArticleId><ArticleId IdType="pmc">PMC5314614</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li><li>États-Unis</li></country><region><li>Gauteng</li><li>Massachusetts</li></region><settlement><li>Cambridge (Massachusetts)</li><li>Johannesbourg</li></settlement><orgName><li>Université Harvard</li><li>Université du Witwatersrand</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Gaziano, Thomas A" sort="Gaziano, Thomas A" uniqKey="Gaziano T" first="Thomas A" last="Gaziano">Thomas A. Gaziano</name></noRegion><name sortKey="Abrahams Gessel, Shafika" sort="Abrahams Gessel, Shafika" uniqKey="Abrahams Gessel S" first="Shafika" last="Abrahams-Gessel">Shafika Abrahams-Gessel</name><name sortKey="Alam, Sartaj" sort="Alam, Sartaj" uniqKey="Alam S" first="Sartaj" last="Alam">Sartaj Alam</name><name sortKey="B Rnighausen, Till W" sort="B Rnighausen, Till W" uniqKey="B Rnighausen T" first="Till W" last="B Rnighausen">Till W. B Rnighausen</name><name sortKey="Berkman, Lisa F" sort="Berkman, Lisa F" uniqKey="Berkman L" first="Lisa F" last="Berkman">Lisa F. Berkman</name><name sortKey="Gomez Olive, F Xavier" sort="Gomez Olive, F Xavier" uniqKey="Gomez Olive F" first="F Xavier" last="Gomez-Olive">F Xavier Gomez-Olive</name><name sortKey="Manne Goehler, Jennifer" sort="Manne Goehler, Jennifer" uniqKey="Manne Goehler J" first="Jennifer" last="Manne-Goehler">Jennifer Manne-Goehler</name><name sortKey="Montana, Livia" sort="Montana, Livia" uniqKey="Montana L" first="Livia" last="Montana">Livia Montana</name><name sortKey="Rohr, Julia" sort="Rohr, Julia" uniqKey="Rohr J" first="Julia" last="Rohr">Julia Rohr</name></country><country name="Afrique du Sud"><region name="Gauteng"><name sortKey="Wade, Alisha" sort="Wade, Alisha" uniqKey="Wade A" first="Alisha" last="Wade">Alisha Wade</name></region><name sortKey="Crowther, Nigel J" sort="Crowther, Nigel J" uniqKey="Crowther N" first="Nigel J" last="Crowther">Nigel J. Crowther</name><name sortKey="Kabudula, Chodziwadziwa W" sort="Kabudula, Chodziwadziwa W" uniqKey="Kabudula C" first="Chodziwadziwa W" last="Kabudula">Chodziwadziwa W. Kabudula</name><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name><name sortKey="Tollman, Stephen" sort="Tollman, Stephen" uniqKey="Tollman S" first="Stephen" last="Tollman">Stephen Tollman</name><name sortKey="Wagner, Ryan" sort="Wagner, Ryan" uniqKey="Wagner R" first="Ryan" last="Wagner">Ryan Wagner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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