Le SIDA au Ghana (serveur d'exploration)

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Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005-2015, Ghana.

Identifieur interne : 000056 ( PubMed/Checkpoint ); précédent : 000055; suivant : 000057

Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005-2015, Ghana.

Auteurs : Maru Aregawi [Suisse] ; Keziah L. Malm [Ghana] ; Mohammed Wahjib [Ghana] ; Osae Kofi [Ghana] ; Naa-Korkor Allotey [Ghana] ; Peprah Nana Yaw [Ghana] ; Wilmot Abba-Baffoe [Ghana] ; Sylvester Segbaya [Ghana] ; Felicia Owusu-Antwi [Ghana] ; Abderahmane T. Kharchi [Burkina Faso] ; Ryan O. Williams [Suisse] ; Mark Saalfeld [Suisse] ; Nibretie Workneh [Suisse] ; Estifanos Biru Shargie [Suisse] ; Abdisalan M. Noor [Suisse] ; Constance Bart-Plange [Ghana]

Source :

RBID : pubmed:28446198

Abstract

Since 2005, the Government of Ghana and its partners, in concerted efforts to control malaria, scaled up the use of artemisinin-based combination therapy (ACT) and insecticide-treated nets (ITNs). Beginning in 2011, a mass campaign of long-lasting insecticidal nets (LLINs) was implemented, targeting all the population. The impact of these interventions on malaria cases, admissions and deaths was assessed using data from district hospitals.

DOI: 10.1186/s12936-017-1828-6
PubMed: 28446198


Affiliations:


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Le document en format XML

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<name sortKey="Owusu Antwi, Felicia" sort="Owusu Antwi, Felicia" uniqKey="Owusu Antwi F" first="Felicia" last="Owusu-Antwi">Felicia Owusu-Antwi</name>
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<name sortKey="Abba Baffoe, Wilmot" sort="Abba Baffoe, Wilmot" uniqKey="Abba Baffoe W" first="Wilmot" last="Abba-Baffoe">Wilmot Abba-Baffoe</name>
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<nlm:affiliation>National Malaria Control Programme, Ministry of Health, Accra, Ghana.</nlm:affiliation>
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<name sortKey="Segbaya, Sylvester" sort="Segbaya, Sylvester" uniqKey="Segbaya S" first="Sylvester" last="Segbaya">Sylvester Segbaya</name>
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<nlm:affiliation>AngloGold Ashanti Malaria Control Programme, Obuasi, Ashanti, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
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<name sortKey="Owusu Antwi, Felicia" sort="Owusu Antwi, Felicia" uniqKey="Owusu Antwi F" first="Felicia" last="Owusu-Antwi">Felicia Owusu-Antwi</name>
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<nlm:affiliation>World Health Organization, WHO Country Office, Accra, Ghana.</nlm:affiliation>
<country xml:lang="fr">Ghana</country>
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<name sortKey="Kharchi, Abderahmane T" sort="Kharchi, Abderahmane T" uniqKey="Kharchi A" first="Abderahmane T" last="Kharchi">Abderahmane T. Kharchi</name>
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<name sortKey="Williams, Ryan O" sort="Williams, Ryan O" uniqKey="Williams R" first="Ryan O" last="Williams">Ryan O. Williams</name>
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<nlm:affiliation>World Health Organization, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
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<wicri:noRegion>Geneva</wicri:noRegion>
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<name sortKey="Saalfeld, Mark" sort="Saalfeld, Mark" uniqKey="Saalfeld M" first="Mark" last="Saalfeld">Mark Saalfeld</name>
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<nlm:affiliation>The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
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<wicri:noRegion>Geneva</wicri:noRegion>
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<name sortKey="Workneh, Nibretie" sort="Workneh, Nibretie" uniqKey="Workneh N" first="Nibretie" last="Workneh">Nibretie Workneh</name>
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<nlm:affiliation>The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
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<wicri:noRegion>Geneva</wicri:noRegion>
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<name sortKey="Shargie, Estifanos Biru" sort="Shargie, Estifanos Biru" uniqKey="Shargie E" first="Estifanos Biru" last="Shargie">Estifanos Biru Shargie</name>
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<nlm:affiliation>The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.</nlm:affiliation>
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<name sortKey="Noor, Abdisalan M" sort="Noor, Abdisalan M" uniqKey="Noor A" first="Abdisalan M" last="Noor">Abdisalan M. Noor</name>
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<nlm:affiliation>World Health Organization, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
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<wicri:noRegion>Geneva</wicri:noRegion>
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<name sortKey="Bart Plange, Constance" sort="Bart Plange, Constance" uniqKey="Bart Plange C" first="Constance" last="Bart-Plange">Constance Bart-Plange</name>
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<nlm:affiliation>National Malaria Control Programme, Ministry of Health, Accra, Ghana.</nlm:affiliation>
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<settlement type="city">Accra</settlement>
<region nuts="2">Région du Grand Accra</region>
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<title level="j">Malaria journal</title>
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<div type="abstract" xml:lang="en">Since 2005, the Government of Ghana and its partners, in concerted efforts to control malaria, scaled up the use of artemisinin-based combination therapy (ACT) and insecticide-treated nets (ITNs). Beginning in 2011, a mass campaign of long-lasting insecticidal nets (LLINs) was implemented, targeting all the population. The impact of these interventions on malaria cases, admissions and deaths was assessed using data from district hospitals.</div>
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<DateCreated>
<Year>2017</Year>
<Month>04</Month>
<Day>27</Day>
</DateCreated>
<DateRevised>
<Year>2017</Year>
<Month>05</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Electronic">
<Journal>
<ISSN IssnType="Electronic">1475-2875</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>16</Volume>
<Issue>1</Issue>
<PubDate>
<Year>2017</Year>
<Month>Apr</Month>
<Day>26</Day>
</PubDate>
</JournalIssue>
<Title>Malaria journal</Title>
<ISOAbbreviation>Malar. J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005-2015, Ghana.</ArticleTitle>
<Pagination>
<MedlinePgn>177</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12936-017-1828-6</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Since 2005, the Government of Ghana and its partners, in concerted efforts to control malaria, scaled up the use of artemisinin-based combination therapy (ACT) and insecticide-treated nets (ITNs). Beginning in 2011, a mass campaign of long-lasting insecticidal nets (LLINs) was implemented, targeting all the population. The impact of these interventions on malaria cases, admissions and deaths was assessed using data from district hospitals.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Records of malaria cases and deaths and availability of ACT in 88 hospitals, as well as at district level, ITN distribution, and indoor residual spraying were reviewed. Annual proportion of the population potentially protected by ITNs was estimated with the assumption that each LLIN covered 1.8 persons for 3 years. Changes in trends of cases and deaths in 2015 were estimated by segmented log-linear regression, comparing trends in post-scale-up (2011-2015) with that of pre-scale-up (2005-2010) period. Trends of mortality in children under 5 years old from population-based household surveys were also compared with the trends observed in hospitals for the same time period.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Among all ages, the number of outpatient malaria cases (confirmed and presumed) declined by 57% (95% confidence interval [CI], 47-66%) by first half of 2015 (during the post-scale-up) compared to the pre-scale-up (2005-2010) period. The number of microscopically confirmed cases decreased by 53% (28-69%) while microscopic testing was stable. Test positivity rate (TPR) decreased by 41% (19-57%). The change in malaria admissions was insignificant while malaria deaths fell significantly by 65% (52-75%). In children under 5 years old, total malaria outpatient cases, admissions and deaths decreased by 50% (32-63%), 46% (19-75%) and 70% (49-82%), respectively. The proportion of outpatient malaria cases, admissions and deaths of all-cause conditions in both all ages and children under five also fell significantly by >30%. Similar decreases in the main malaria indicators were observed in the three epidemiological strata (coastal, forest, savannah). All-cause admissions increased significantly in patients covered by the National Health Insurance Scheme (NHIS) compared to the non-insured. The non-malaria cases and non-malaria deaths increased or remained unchanged during the same period. All-cause mortality for children under 5 years old in household surveys, similar to those observed in the hospitals, declined by 43% between 2008 and 2014.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The data provide compelling evidence of impact following LLIN mass campaigns targeting all ages since 2011, while maintaining other anti-malarial interventions. Malaria cases and deaths decreased by over 50 and 65%, respectively. The declines were stronger in children under five. Test positivity rate in all ages decreased by >40%. The decrease in malaria deaths was against a backdrop of increased admissions owing to free access to hospitalization through the NHIS. The study demonstrated that retrospective health facility-based data minimize reporting biases to assess effect of interventions. Malaria control in Ghana is dependent on sustained coverage of effective interventions and strengthened surveillance is vital to monitor progress of these investments.</AbstractText>
</Abstract>
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<ForeName>Maru</ForeName>
<Initials>M</Initials>
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<Affiliation>World Health Organization, Geneva, Switzerland. aregawim@who.int.</Affiliation>
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<ForeName>Keziah L</ForeName>
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<Affiliation>National Malaria Control Programme, Ministry of Health, Accra, Ghana.</Affiliation>
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<ForeName>Felicia</ForeName>
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<Language>eng</Language>
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<Keyword MajorTopicYN="N">Ghana</Keyword>
<Keyword MajorTopicYN="N">Impact</Keyword>
<Keyword MajorTopicYN="N">Indoor residual spraying</Keyword>
<Keyword MajorTopicYN="N">LLIN mass campaign</Keyword>
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