Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana.
Identifieur interne : 000038 ( PubMed/Checkpoint ); précédent : 000037; suivant : 000039Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana.
Auteurs : Paul Frimpong [Ghana] ; Emmanuel Kofi Amponsah [Ghana] ; Jacob Abebrese [Ghana] ; Soung Min Kim [Corée du Sud]Source :
- Journal of the Korean Association of Oral and Maxillofacial Surgeons [ 2234-7550 ] ; 2017.
Abstract
Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). People with AIDS are much more vulnerable to infections, including opportunistic infections and tumors, than people with a healthy immune system. The objective of this study was to correlate oral lesions associated with HIV/AIDS and immunosuppression levels by measuring clusters of differentiation 4 (CD4) cell counts among patients living in the middle western regions of Ghana.
DOI: 10.5125/jkaoms.2017.43.1.29
PubMed: 28280707
Affiliations:
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Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28280707</idno><idno type="pmid">28280707</idno><idno type="doi">10.5125/jkaoms.2017.43.1.29</idno><idno type="wicri:Area/PubMed/Corpus">000019</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000019</idno><idno type="wicri:Area/PubMed/Curation">000019</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000019</idno><idno type="wicri:Area/PubMed/Checkpoint">000019</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000019</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana.</title><author><name sortKey="Frimpong, Paul" sort="Frimpong, Paul" uniqKey="Frimpong P" first="Paul" last="Frimpong">Paul Frimpong</name><affiliation wicri:level="1"><nlm:affiliation>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani</wicri:regionArea><wicri:noRegion>Sunyani</wicri:noRegion></affiliation></author><author><name sortKey="Amponsah, Emmanuel Kofi" sort="Amponsah, Emmanuel Kofi" uniqKey="Amponsah E" first="Emmanuel Kofi" last="Amponsah">Emmanuel Kofi Amponsah</name><affiliation wicri:level="1"><nlm:affiliation>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani</wicri:regionArea><wicri:noRegion>Sunyani</wicri:noRegion></affiliation></author><author><name sortKey="Abebrese, Jacob" sort="Abebrese, Jacob" uniqKey="Abebrese J" first="Jacob" last="Abebrese">Jacob Abebrese</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ear, Nose and Throat, Brong Ahafo Regional Hospital, Sunyani, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Ear, Nose and Throat, Brong Ahafo Regional Hospital, Sunyani</wicri:regionArea><wicri:noRegion>Sunyani</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Soung Min" sort="Kim, Soung Min" uniqKey="Kim S" first="Soung Min" last="Kim">Soung Min Kim</name><affiliation wicri:level="4"><nlm:affiliation>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author></analytic><series><title level="j">Journal of the Korean Association of Oral and Maxillofacial Surgeons</title><idno type="ISSN">2234-7550</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). People with AIDS are much more vulnerable to infections, including opportunistic infections and tumors, than people with a healthy immune system. The objective of this study was to correlate oral lesions associated with HIV/AIDS and immunosuppression levels by measuring clusters of differentiation 4 (CD4) cell counts among patients living in the middle western regions of Ghana.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28280707</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>10</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2234-7550</ISSN><JournalIssue CitedMedium="Print"><Volume>43</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of the Korean Association of Oral and Maxillofacial Surgeons</Title><ISOAbbreviation>J Korean Assoc Oral Maxillofac Surg</ISOAbbreviation></Journal><ArticleTitle>Oral manifestations and their correlation to baseline CD4 count of HIV/AIDS patients in Ghana.</ArticleTitle><Pagination><MedlinePgn>29-36</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5125/jkaoms.2017.43.1.29</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). People with AIDS are much more vulnerable to infections, including opportunistic infections and tumors, than people with a healthy immune system. The objective of this study was to correlate oral lesions associated with HIV/AIDS and immunosuppression levels by measuring clusters of differentiation 4 (CD4) cell counts among patients living in the middle western regions of Ghana.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">A total of 120 patients who visited the HIV clinic at the Komfo Anokye Teaching Hospital and the Regional Hospital Sunyani of Ghana were consecutively enrolled in this prospective and cross-sectional study. Referred patients' baseline CD4 counts were obtained from medical records and each patient received an initial physician assessment. Intraoral diagnoses were based on the classification and diagnostic criteria of the EEC Clearinghouse, 1993. After the initial assessment, extra- and intraoral tissues from each enrolled patient were examined. Data analyses were carried out using simple proportions, frequencies and chi-square tests of significance.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Our study included 120 patients, and was comprised of 42 (35.0%) males and 78 (65.0%) females, ranging in age from 21 to 67 years with sex-specific mean ages of 39.31 years (males) and 39.28 years (females). Patient CD4 count values ranged from 3 to 985 cells/mL with a mean baseline CD4 count of 291.29 cells/mL for males and 325.92 cells/mL for females. The mean baseline CD4 count for the entire sample was 313.80 cells/mL. Of the 120 patients we examined, 99 (82.5%) were observed to have at least one HIV-associated intraoral lesion while 21 (17.5%) had no intraoral lesions. Oral candidiasis, periodontitis, melanotic hyperpigmentation, gingivitis and xerostomia were the most common oral lesions.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">From a total of nine oral lesions, six lesions that included oral candidiasis, periodontitis, melanotic hyperpigmentation, gingivitis, xerostomia and oral hairy leukoplakia were significantly correlated with declining CD4 counts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Frimpong</LastName><ForeName>Paul</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0002-1647-2155</Identifier><AffiliationInfo><Affiliation>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amponsah</LastName><ForeName>Emmanuel Kofi</ForeName><Initials>EK</Initials><Identifier Source="ORCID">0000-0002-0720-3025</Identifier><AffiliationInfo><Affiliation>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abebrese</LastName><ForeName>Jacob</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-1125-5482</Identifier><AffiliationInfo><Affiliation>Department of Ear, Nose and Throat, Brong Ahafo Regional Hospital, Sunyani, Ghana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Soung Min</ForeName><Initials>SM</Initials><Identifier Source="ORCID">0000-0002-6916-0489</Identifier><AffiliationInfo><Affiliation>Oral and Maxillofacial Microvascular Reconstruction LAB, Brong Ahafo Regional Hospital, Sunyani, Ghana.; Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>J Korean Assoc Oral Maxillofac Surg</MedlineTA><NlmUniqueID>101580242</NlmUniqueID><ISSNLinking>1225-1585</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int J Dent. 2011;2011:964278</RefSource><PMID Version="1">22046186</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Oral Dis. 2004 Nov;10(6):319-26</RefSource><PMID Version="1">15533205</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ethiop Med J. 2008 Oct;46(4):349-57</RefSource><PMID Version="1">19271399</PMID></CommentsCorrections><CommentsCorrections 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Version="1">11991309</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Oral Dis. 1997 May;3 Suppl 1:S13-7</RefSource><PMID Version="1">9456650</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Oral Dis. 2000 May;6(3):133-5</RefSource><PMID Version="1">10822355</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>East Afr Med J. 2001 Aug;78(8):398-401</RefSource><PMID Version="1">11921559</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Singapore Med J. 1990 Oct;31(5):477-9</RefSource><PMID Version="1">2259948</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acquired immune deficiency syndrome</Keyword><Keyword MajorTopicYN="N">Cluster of differentiation 4 (CD4) cells</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">Oral manifestations</Keyword></KeywordList><CoiStatement>Conflict of Interest: No potential conflict of interest relevant to this article was reported.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28280707</ArticleId><ArticleId IdType="doi">10.5125/jkaoms.2017.43.1.29</ArticleId><ArticleId IdType="pmc">PMC5342969</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>Ghana</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement><orgName><li>Université nationale de Séoul</li></orgName></list><tree><country name="Ghana"><noRegion><name sortKey="Frimpong, Paul" sort="Frimpong, Paul" uniqKey="Frimpong P" first="Paul" last="Frimpong">Paul Frimpong</name></noRegion><name sortKey="Abebrese, Jacob" sort="Abebrese, Jacob" uniqKey="Abebrese J" first="Jacob" last="Abebrese">Jacob Abebrese</name><name sortKey="Amponsah, Emmanuel Kofi" sort="Amponsah, Emmanuel Kofi" uniqKey="Amponsah E" first="Emmanuel Kofi" last="Amponsah">Emmanuel Kofi Amponsah</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Soung Min" sort="Kim, Soung Min" uniqKey="Kim S" first="Soung Min" last="Kim">Soung Min 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