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The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

Identifieur interne : 000315 ( Pmc/Curation ); précédent : 000314; suivant : 000316

The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

Auteurs : Kwabena Obeng Duedu [Ghana, Royaume-Uni] ; Kwamena William Coleman Sagoe [Ghana] ; Patrick Ferdinand Ayeh-Kumi [Ghana] ; Raymond Bedu Affrim [Ghana] ; Theophilus Adiku [Ghana]

Source :

Asian Pacific Journal of Tropical Biomedicine [ 2221-1691 ] ; 2013.

RBID : PMC:3627173

Abstract

Objective

To determin the extent to which parvovirus B19 (B19V) and co-infection of B19V and malaria contribute to risk of anaemia in children.

Methods

B19V DNA and malaria parasites were screened for 234 children at the PML Children's Hospital in Accra. The role of B19V and co-infection with B19V and malaria in anaemia was evaluated by analysing full blood cell counts, malaria and B19V DNA results from these children.

Results

The prevalence of B19V, malaria and co-infection with B19V and malaria was 4.7%, 41.9% and 2.6%, respectively. Malaria posed a greater risk in the development of mild anaemia compared to severe anaemia (OR=5.28 vrs 3.15) whereas B19V posed a higher risk in the development of severe anaemia compared to mild anaemia (OR=4.07 vrs 1.00) from a non-anaemic child. Persons with co-infection with B19V and malaria had 2.23 times the risk (95% CI=0.40-12.54) of developing severe anaemia should they already have a mild anaemia. The degree of anaemia was about three times affected by co-infection (Pillai's trace=0.551, P=0.001) as was affected by malaria alone (Pillai's trace=0.185, P=0.001). B19V alone did not significantly affect the development of anaemia in a non-anaemic child. Microcytic anaemia was associated with B19V and co-infection with B19V and malaria more than normocytic normochromic anaemia.

Conclusions

B19V was associated with malaria in cases of severe anaemia. The association posed a significant risk for exacerbation of anaemia in mild anaemic children. B19V and co-infection with B19V and malaria may be associated with microcytic anaemia rather than normocytic normochromic anaemia as seen in cases of B19V infection among persons with red cell abnormalities.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627173

DOI: 10.1016/S2221-1691(13)60037-4
PubMed: 23593592
PubMed Central: 3627173

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PMC:3627173

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 on type and degree of anaemia in Ghanaian children</title>
<author><name sortKey="Duedu, Kwabena Obeng" sort="Duedu, Kwabena Obeng" uniqKey="Duedu K" first="Kwabena Obeng" last="Duedu">Kwabena Obeng Duedu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana</addr-line>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Scotland, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Scotland</wicri:regionArea>
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<author><name sortKey="Sagoe, Kwamena William Coleman" sort="Sagoe, Kwamena William Coleman" uniqKey="Sagoe K" first="Kwamena William Coleman" last="Sagoe">Kwamena William Coleman Sagoe</name>
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<author><name sortKey="Ayeh Kumi, Patrick Ferdinand" sort="Ayeh Kumi, Patrick Ferdinand" uniqKey="Ayeh Kumi P" first="Patrick Ferdinand" last="Ayeh-Kumi">Patrick Ferdinand Ayeh-Kumi</name>
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<author><name sortKey="Affrim, Raymond Bedu" sort="Affrim, Raymond Bedu" uniqKey="Affrim R" first="Raymond Bedu" last="Affrim">Raymond Bedu Affrim</name>
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<author><name sortKey="Adiku, Theophilus" sort="Adiku, Theophilus" uniqKey="Adiku T" first="Theophilus" last="Adiku">Theophilus Adiku</name>
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 on type and degree of anaemia in Ghanaian children</title>
<author><name sortKey="Duedu, Kwabena Obeng" sort="Duedu, Kwabena Obeng" uniqKey="Duedu K" first="Kwabena Obeng" last="Duedu">Kwabena Obeng Duedu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Scotland, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Scotland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sagoe, Kwamena William Coleman" sort="Sagoe, Kwamena William Coleman" uniqKey="Sagoe K" first="Kwamena William Coleman" last="Sagoe">Kwamena William Coleman Sagoe</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ayeh Kumi, Patrick Ferdinand" sort="Ayeh Kumi, Patrick Ferdinand" uniqKey="Ayeh Kumi P" first="Patrick Ferdinand" last="Ayeh-Kumi">Patrick Ferdinand Ayeh-Kumi</name>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Medical Laboratory Sciences, University of Ghana School of Allied Health Sciences, Korle-Bu, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Department of Medical Laboratory Sciences, University of Ghana School of Allied Health Sciences, Korle-Bu, Accra</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Affrim, Raymond Bedu" sort="Affrim, Raymond Bedu" uniqKey="Affrim R" first="Raymond Bedu" last="Affrim">Raymond Bedu Affrim</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Laboratory Department, Princess Marie Louis Children's Hospital, Derby Avenue, Accra, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Laboratory Department, Princess Marie Louis Children's Hospital, Derby Avenue, Accra</wicri:regionArea>
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<author><name sortKey="Adiku, Theophilus" sort="Adiku, Theophilus" uniqKey="Adiku T" first="Theophilus" last="Adiku">Theophilus Adiku</name>
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<wicri:regionArea>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra</wicri:regionArea>
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<series><title level="j">Asian Pacific Journal of Tropical Biomedicine</title>
<idno type="ISSN">2221-1691</idno>
<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>To determin the extent to which parvovirus B19 (B19V) and co-infection of B19V and malaria contribute to risk of anaemia in children.</p>
</sec>
<sec><title>Methods</title>
<p>B19V DNA and malaria parasites were screened for 234 children at the PML Children's Hospital in Accra. The role of B19V and co-infection with B19V and malaria in anaemia was evaluated by analysing full blood cell counts, malaria and B19V DNA results from these children.</p>
</sec>
<sec><title>Results</title>
<p>The prevalence of B19V, malaria and co-infection with B19V and malaria was 4.7%, 41.9% and 2.6%, respectively. Malaria posed a greater risk in the development of mild anaemia compared to severe anaemia (<italic>OR</italic>
=5.28 vrs 3.15) whereas B19V posed a higher risk in the development of severe anaemia compared to mild anaemia (<italic>OR</italic>
=4.07 vrs 1.00) from a non-anaemic child. Persons with co-infection with B19V and malaria had 2.23 times the risk (95% <italic>CI</italic>
=0.40-12.54) of developing severe anaemia should they already have a mild anaemia. The degree of anaemia was about three times affected by co-infection (Pillai's trace=0.551, <italic>P</italic>
=0.001) as was affected by malaria alone (Pillai's trace=0.185, <italic>P</italic>
=0.001). B19V alone did not significantly affect the development of anaemia in a non-anaemic child. Microcytic anaemia was associated with B19V and co-infection with B19V and malaria more than normocytic normochromic anaemia.</p>
</sec>
<sec><title>Conclusions</title>
<p>B19V was associated with malaria in cases of severe anaemia. The association posed a significant risk for exacerbation of anaemia in mild anaemic children. B19V and co-infection with B19V and malaria may be associated with microcytic anaemia rather than normocytic normochromic anaemia as seen in cases of B19V infection among persons with red cell abnormalities.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Asian Pac J Trop Biomed</journal-id>
<journal-id journal-id-type="iso-abbrev">Asian Pac J Trop Biomed</journal-id>
<journal-id journal-id-type="publisher-id">APJTB</journal-id>
<journal-title-group><journal-title>Asian Pacific Journal of Tropical Biomedicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">2221-1691</issn>
<publisher><publisher-name>Asian Pacific Tropical Medicine Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23593592</article-id>
<article-id pub-id-type="pmc">3627173</article-id>
<article-id pub-id-type="publisher-id">apjtb-03-02-129</article-id>
<article-id pub-id-type="doi">10.1016/S2221-1691(13)60037-4</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Researches</subject>
</subj-group>
</article-categories>
<title-group><article-title>The effects of co-infection with human parvovirus B19 and <italic>Plasmodium falciparum</italic>
 on type and degree of anaemia in Ghanaian children</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Duedu</surname>
<given-names>Kwabena Obeng</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sagoe</surname>
<given-names>Kwamena William Coleman</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ayeh-Kumi</surname>
<given-names>Patrick Ferdinand</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Affrim</surname>
<given-names>Raymond Bedu</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adiku</surname>
<given-names>Theophilus</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Department of Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Scotland, UK</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Department of Medical Laboratory Sciences, University of Ghana School of Allied Health Sciences, Korle-Bu, Accra, Ghana</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>Laboratory Department, Princess Marie Louis Children's Hospital, Derby Avenue, Accra, Ghana</addr-line>
</aff>
<contrib-group><contrib contrib-type="reviewer"><name><surname>Huat</surname>
<given-names>Lim Boon</given-names>
<suffix>(PhD)</suffix>
</name>
</contrib>
</contrib-group>
<aff id="aff5"><addr-line>Biomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.</addr-line>
 Tel:<phone>+6 09767 7619</phone>
 Fax:<fax>+6 09767 7515</fax>
 E-mail:<email>limbh@kb.usm.my</email>
</aff>
<author-notes><corresp id="cor1">*Corresponding author: Kwabena Obeng Duedu, Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, UK. Tel: <phone>+44 7577 152176</phone>
 E-mail: <email>koduedu@gmail.com</email>
; <email>kwabena.duedu@ed.ac.uk</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>2</month>
<year>2013</year>
</pub-date>
<volume>3</volume>
<issue>2</issue>
<fpage>129</fpage>
<lpage>139</lpage>
<history><date date-type="received"><day>2</day>
<month>11</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>12</day>
<month>12</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© 2013 by the Asian Pacific Journal of Tropical Biomedicine. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><sec><title>Objective</title>
<p>To determin the extent to which parvovirus B19 (B19V) and co-infection of B19V and malaria contribute to risk of anaemia in children.</p>
</sec>
<sec><title>Methods</title>
<p>B19V DNA and malaria parasites were screened for 234 children at the PML Children's Hospital in Accra. The role of B19V and co-infection with B19V and malaria in anaemia was evaluated by analysing full blood cell counts, malaria and B19V DNA results from these children.</p>
</sec>
<sec><title>Results</title>
<p>The prevalence of B19V, malaria and co-infection with B19V and malaria was 4.7%, 41.9% and 2.6%, respectively. Malaria posed a greater risk in the development of mild anaemia compared to severe anaemia (<italic>OR</italic>
=5.28 vrs 3.15) whereas B19V posed a higher risk in the development of severe anaemia compared to mild anaemia (<italic>OR</italic>
=4.07 vrs 1.00) from a non-anaemic child. Persons with co-infection with B19V and malaria had 2.23 times the risk (95% <italic>CI</italic>
=0.40-12.54) of developing severe anaemia should they already have a mild anaemia. The degree of anaemia was about three times affected by co-infection (Pillai's trace=0.551, <italic>P</italic>
=0.001) as was affected by malaria alone (Pillai's trace=0.185, <italic>P</italic>
=0.001). B19V alone did not significantly affect the development of anaemia in a non-anaemic child. Microcytic anaemia was associated with B19V and co-infection with B19V and malaria more than normocytic normochromic anaemia.</p>
</sec>
<sec><title>Conclusions</title>
<p>B19V was associated with malaria in cases of severe anaemia. The association posed a significant risk for exacerbation of anaemia in mild anaemic children. B19V and co-infection with B19V and malaria may be associated with microcytic anaemia rather than normocytic normochromic anaemia as seen in cases of B19V infection among persons with red cell abnormalities.</p>
</sec>
</abstract>
<kwd-group><kwd>Malaria</kwd>
<kwd>Human parvovirus B19</kwd>
<kwd>Anaemia</kwd>
<kwd>Ghana</kwd>
<kwd>Children</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

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Abstract

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