Ocular complications in HIV positive patients on antiretroviral therapy in Ghana
Identifieur interne : 000104 ( Pmc/Curation ); précédent : 000103; suivant : 000105Ocular complications in HIV positive patients on antiretroviral therapy in Ghana
Auteurs : Alexander Martin-Odoom [Ghana] ; Evelyn Yayra Bonney [Ghana] ; Derek Kofi Opoku [Ghana]Source :
- BMC Ophthalmology [ 1471-2415 ] ; 2016.
Abstract
Patients infected with human immunodeficiency virus (HIV) usually develop some form of ocular complication in the different segments of the eye due to immune deficiency. In Ghana, data regarding ocular complications among HIV/AIDS patients is scarce. This study investigated the occurrence of ocular complications in HIV infected patients undergoing antiretroviral therapy at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana.
Blood samples were taken from 100 confirmed HIV infected patients. The CD4 + T cell count and WHO clinical staging were determined. The patients were taken through thorough ophthalmic assessments to determine any ocular complications.
Forty-eight patients (48 %) had at least one HIV-related ocular complication. These complications occurred more frequently among those with CD4 counts below 200 cells/μL. Of the participants with HIV-related ocular complications, 11 (23 %) had retinal microvasculopathy, 10 (21 %) showed allergic conjunctivitis, 7 (15 %) had HIV retinopathy and 7 (15 %) had conjunctival carcinoma. All the participants in the study were on first-line antiretroviral therapy; 68 % were females and 72 % were in the Stage 3 of the WHO Clinical Staging of HIV infection.
The prevalence of ocular complications in HIV positive persons under treatment in Ghana is high. Lower CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications.
Url:
DOI: 10.1186/s12886-016-0310-5
PubMed: 27487853
PubMed Central: 4973055
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<author><name sortKey="Martin Odoom, Alexander" sort="Martin Odoom, Alexander" uniqKey="Martin Odoom A" first="Alexander" last="Martin-Odoom">Alexander Martin-Odoom</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana</nlm:aff>
<country xml:lang="fr">Ghana</country>
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<author><name sortKey="Bonney, Evelyn Yayra" sort="Bonney, Evelyn Yayra" uniqKey="Bonney E" first="Evelyn Yayra" last="Bonney">Evelyn Yayra Bonney</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Patients infected with human immunodeficiency virus (HIV) usually develop some form of ocular complication in the different segments of the eye due to immune deficiency. In Ghana, data regarding ocular complications among HIV/AIDS patients is scarce. This study investigated the occurrence of ocular complications in HIV infected patients undergoing antiretroviral therapy at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana.</p>
</sec>
<sec><title>Methods</title>
<p>Blood samples were taken from 100 confirmed HIV infected patients. The CD4 + T cell count and WHO clinical staging were determined. The patients were taken through thorough ophthalmic assessments to determine any ocular complications.</p>
</sec>
<sec><title>Results</title>
<p>Forty-eight patients (48 %) had at least one HIV-related ocular complication. These complications occurred more frequently among those with CD4 counts below 200 cells/μL. Of the participants with HIV-related ocular complications, 11 (23 %) had retinal microvasculopathy, 10 (21 %) showed allergic conjunctivitis, 7 (15 %) had HIV retinopathy and 7 (15 %) had conjunctival carcinoma. All the participants in the study were on first-line antiretroviral therapy; 68 % were females and 72 % were in the Stage 3 of the WHO Clinical Staging of HIV infection.</p>
</sec>
<sec><title>Conclusion</title>
<p>The prevalence of ocular complications in HIV positive persons under treatment in Ghana is high. Lower CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Ophthalmol</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Ophthalmol</journal-id>
<journal-title-group><journal-title>BMC Ophthalmology</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2415</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
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<article-meta><article-id pub-id-type="pmid">27487853</article-id>
<article-id pub-id-type="pmc">4973055</article-id>
<article-id pub-id-type="publisher-id">310</article-id>
<article-id pub-id-type="doi">10.1186/s12886-016-0310-5</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Ocular complications in HIV positive patients on antiretroviral therapy in Ghana</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-4737-5718</contrib-id>
<name><surname>Martin-Odoom</surname>
<given-names>Alexander</given-names>
</name>
<address><email>siel.miel@yahoo.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonney</surname>
<given-names>Evelyn Yayra</given-names>
</name>
<address><email>ebonney@noguchi.ug.edu.gh</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Opoku</surname>
<given-names>Derek Kofi</given-names>
</name>
<address><email>opkderick1189@yahoo.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana</aff>
<aff id="Aff2"><label>2</label>
Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana</aff>
</contrib-group>
<pub-date pub-type="epub"><day>3</day>
<month>8</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>8</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>16</volume>
<elocation-id>134</elocation-id>
<history><date date-type="received"><day>31</day>
<month>12</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>28</day>
<month>7</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© Martin-Odoom et al. 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Patients infected with human immunodeficiency virus (HIV) usually develop some form of ocular complication in the different segments of the eye due to immune deficiency. In Ghana, data regarding ocular complications among HIV/AIDS patients is scarce. This study investigated the occurrence of ocular complications in HIV infected patients undergoing antiretroviral therapy at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana.</p>
</sec>
<sec><title>Methods</title>
<p>Blood samples were taken from 100 confirmed HIV infected patients. The CD4 + T cell count and WHO clinical staging were determined. The patients were taken through thorough ophthalmic assessments to determine any ocular complications.</p>
</sec>
<sec><title>Results</title>
<p>Forty-eight patients (48 %) had at least one HIV-related ocular complication. These complications occurred more frequently among those with CD4 counts below 200 cells/μL. Of the participants with HIV-related ocular complications, 11 (23 %) had retinal microvasculopathy, 10 (21 %) showed allergic conjunctivitis, 7 (15 %) had HIV retinopathy and 7 (15 %) had conjunctival carcinoma. All the participants in the study were on first-line antiretroviral therapy; 68 % were females and 72 % were in the Stage 3 of the WHO Clinical Staging of HIV infection.</p>
</sec>
<sec><title>Conclusion</title>
<p>The prevalence of ocular complications in HIV positive persons under treatment in Ghana is high. Lower CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Human immunodeficiency virus</kwd>
<kwd>Anterior segment</kwd>
<kwd>Visual impairment</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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