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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>
–albumin adduct levels in HIV-positive Ghanaians: preliminary observations</title>
<author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E." last="Jolly">P. E. Jolly</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M." last="Shuaib">F. M. Shuaib</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name>
<affiliation><nlm:aff id="A2">AIDS ALLY and St. Markus Hospital, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name>
<affiliation><nlm:aff id="A2">AIDS ALLY and St. Markus Hospital, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name>
<affiliation><nlm:aff id="A3">Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name>
<affiliation><nlm:aff id="A4">Department of Environmental Health Science, University of Georgia, Athens, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name>
<affiliation><nlm:aff id="A5">Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name>
<affiliation><nlm:aff id="A6">College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21749228</idno>
<idno type="pmc">3381352</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381352</idno>
<idno type="RBID">PMC:3381352</idno>
<idno type="doi">10.1080/19440049.2011.581698</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000363</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000363</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>
–albumin adduct levels in HIV-positive Ghanaians: preliminary observations</title>
<author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E." last="Jolly">P. E. Jolly</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M." last="Shuaib">F. M. Shuaib</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name>
<affiliation><nlm:aff id="A2">AIDS ALLY and St. Markus Hospital, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name>
<affiliation><nlm:aff id="A2">AIDS ALLY and St. Markus Hospital, Kumasi, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name>
<affiliation><nlm:aff id="A3">Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name>
<affiliation><nlm:aff id="A4">Department of Environmental Health Science, University of Georgia, Athens, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name>
<affiliation><nlm:aff id="A5">Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name>
<affiliation><nlm:aff id="A6">College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment</title>
<idno type="ISSN">1944-0049</idno>
<idno type="eISSN">1944-0057</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>
–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>−1</sup>
albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101485040</journal-id>
<journal-id journal-id-type="pubmed-jr-id">35483</journal-id>
<journal-id journal-id-type="nlm-ta">Food Addit Contam Part A Chem Anal Control Expo Risk Assess</journal-id>
<journal-id journal-id-type="iso-abbrev">Food Addit Contam Part A Chem Anal Control Expo Risk Assess</journal-id>
<journal-title-group><journal-title>Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment</journal-title>
</journal-title-group>
<issn pub-type="ppub">1944-0049</issn>
<issn pub-type="epub">1944-0057</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21749228</article-id>
<article-id pub-id-type="pmc">3381352</article-id>
<article-id pub-id-type="doi">10.1080/19440049.2011.581698</article-id>
<article-id pub-id-type="manuscript">NIHMS378183</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>
–albumin adduct levels in HIV-positive Ghanaians: preliminary observations</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jolly</surname>
<given-names>P.E.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shuaib</surname>
<given-names>F.M.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jiang</surname>
<given-names>Y.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Preko</surname>
<given-names>P.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baidoo</surname>
<given-names>J.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stiles</surname>
<given-names>J.K.</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>J.-S.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Phillips</surname>
<given-names>T.D.</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Williams</surname>
<given-names>J.H.</given-names>
</name>
<xref ref-type="aff" rid="A6">f</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</aff>
<aff id="A2"><label>b</label>
AIDS ALLY and St. Markus Hospital, Kumasi, Ghana</aff>
<aff id="A3"><label>c</label>
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA</aff>
<aff id="A4"><label>d</label>
Department of Environmental Health Science, University of Georgia, Athens, GA, USA</aff>
<aff id="A5"><label>e</label>
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA</aff>
<aff id="A6"><label>f</label>
College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author. <email>jollyp@uab.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>31</day>
<month>5</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>7</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>25</day>
<month>6</month>
<year>2012</year>
</pub-date>
<volume>28</volume>
<issue>9</issue>
<fpage>1224</fpage>
<lpage>1234</lpage>
<permissions><copyright-statement>© 2011 Taylor & Francis</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>
–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>−1</sup>
albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</p>
</abstract>
<kwd-group><kwd>aflatoxins</kwd>
<kwd>HIV</kwd>
<kwd>liver function</kwd>
<kwd>Ghana</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Center on Minority Health and Health Disparities : NIMHD</funding-source>
<award-id>G12 MD007602 || MD</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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