SidaGhanaV1, Pmc, Corpus, bibRecord, 000338

Low Level of Transmitted HIV Drug Resistance at Two HIV Care Centres in Ghana: A Threshold Survey

Identifieur interne : 000338 ( Pmc/Corpus ); précédent : 000337; suivant : 000339

Low Level of Transmitted HIV Drug Resistance at Two HIV Care Centres in Ghana: A Threshold Survey

Auteurs : E Y Bonney ; N A Addo ; N A A. Ntim ; F. Addo-Yobo ; P. Bondzie ; K-E Aryee ; J. Barnor ; J. Brandful ; V. Bekoe ; S-A Ohene ; W. Ampofo

Source :

Ghana Medical Journal [ 0016-9560 ] ; 2013.

RBID : PMC:3743108

Abstract

SummaryBackground

As access to antiretroviral therapy (ART) increases, the emergence and transmission of HIV drug resistant strains becomes a major problem. The World Health Organization (WHO) therefore recommends an initial minimum-resource method to signal when transmitted HIV drug resistance (HIVDR) requires action.

Objective

This survey sought to generate information on the presence of HIV drug-resistant strains in the locality where Ghana's ART for HIV was first introduced.

Methods

The Ghana HIVDR threshold survey (TS) was conducted and analyzed according to WHO strategy for surveillance of HIVDR in the Eastern Region of Ghana. Sixty (60) plasma specimens were collected from 2007 to 2009 by an unlinked anonymous method from HIV seropositive pregnant women, aged between 15 to24 years, who were with their first pregnancy and ART naive. Genotyping was done as follows; Ribonucleic acid (RNA) was extracted from the samples and the protease (PR) and reverse transcriptase (RT) genes amplified and sequenced. The sequences were then analyzed for HIV drug resistance mutations using Stanford University HIV Drug Resistance Database.

Results

Only two individuals were found with major HIVDR mutations: one each in the PR and RT genes. Thus the level of HIVDR in the study population in 2009 was classified as low (< 5%).

Conclusion

As at February 2009, transmitted drug resistance was not a serious problem in the Eastern Region of Ghana. However, it is important to continue monitoring tHIVDR in order to understand the dynamics of the evolution of HIV drug resistance in the country.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743108

PubMed: 23966745
PubMed Central: 3743108

Links to Exploration step

PMC:3743108

Le document en format XML

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<author><name sortKey="Bonney, E Y" sort="Bonney, E Y" uniqKey="Bonney E" first="E Y" last="Bonney">E Y Bonney</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
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<author><name sortKey="Addo, N A" sort="Addo, N A" uniqKey="Addo N" first="N A" last="Addo">N A Addo</name>
<affiliation><nlm:aff id="A2">National AIDS/STI Control Program, Ghana Health Service, Accra</nlm:aff>
</affiliation>
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<author><name sortKey="Ntim, N A A" sort="Ntim, N A A" uniqKey="Ntim N" first="N A A" last="Ntim">N A A. Ntim</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
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<author><name sortKey="Addo Yobo, F" sort="Addo Yobo, F" uniqKey="Addo Yobo F" first="F" last="Addo-Yobo">F. Addo-Yobo</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
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<author><name sortKey="Bondzie, P" sort="Bondzie, P" uniqKey="Bondzie P" first="P" last="Bondzie">P. Bondzie</name>
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<author><name sortKey="Aryee, K E" sort="Aryee, K E" uniqKey="Aryee K" first="K-E" last="Aryee">K-E Aryee</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
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<author><name sortKey="Barnor, J" sort="Barnor, J" uniqKey="Barnor J" first="J" last="Barnor">J. Barnor</name>
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<author><name sortKey="Brandful, J" sort="Brandful, J" uniqKey="Brandful J" first="J" last="Brandful">J. Brandful</name>
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<author><name sortKey="Bekoe, V" sort="Bekoe, V" uniqKey="Bekoe V" first="V" last="Bekoe">V. Bekoe</name>
<affiliation><nlm:aff id="A2">National AIDS/STI Control Program, Ghana Health Service, Accra</nlm:aff>
</affiliation>
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<author><name sortKey="Ohene, S A" sort="Ohene, S A" uniqKey="Ohene S" first="S-A" last="Ohene">S-A Ohene</name>
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<author><name sortKey="Ampofo, W" sort="Ampofo, W" uniqKey="Ampofo W" first="W" last="Ampofo">W. Ampofo</name>
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<author><name sortKey="Bonney, E Y" sort="Bonney, E Y" uniqKey="Bonney E" first="E Y" last="Bonney">E Y Bonney</name>
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<author><name sortKey="Addo, N A" sort="Addo, N A" uniqKey="Addo N" first="N A" last="Addo">N A Addo</name>
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<author><name sortKey="Ntim, N A A" sort="Ntim, N A A" uniqKey="Ntim N" first="N A A" last="Ntim">N A A. Ntim</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
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<author><name sortKey="Addo Yobo, F" sort="Addo Yobo, F" uniqKey="Addo Yobo F" first="F" last="Addo-Yobo">F. Addo-Yobo</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
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<author><name sortKey="Bondzie, P" sort="Bondzie, P" uniqKey="Bondzie P" first="P" last="Bondzie">P. Bondzie</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
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<author><name sortKey="Aryee, K E" sort="Aryee, K E" uniqKey="Aryee K" first="K-E" last="Aryee">K-E Aryee</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Barnor, J" sort="Barnor, J" uniqKey="Barnor J" first="J" last="Barnor">J. Barnor</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brandful, J" sort="Brandful, J" uniqKey="Brandful J" first="J" last="Brandful">J. Brandful</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bekoe, V" sort="Bekoe, V" uniqKey="Bekoe V" first="V" last="Bekoe">V. Bekoe</name>
<affiliation><nlm:aff id="A2">National AIDS/STI Control Program, Ghana Health Service, Accra</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ohene, S A" sort="Ohene, S A" uniqKey="Ohene S" first="S-A" last="Ohene">S-A Ohene</name>
<affiliation><nlm:aff id="A3">World Health Organization, Ghana Office, Accra, Ghana</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ampofo, W" sort="Ampofo, W" uniqKey="Ampofo W" first="W" last="Ampofo">W. Ampofo</name>
<affiliation><nlm:aff id="A1">Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</nlm:aff>
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<series><title level="j">Ghana Medical Journal</title>
<idno type="ISSN">0016-9560</idno>
<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec><title>Background</title>
<p>As access to antiretroviral therapy (ART) increases, the emergence and transmission of HIV drug resistant strains becomes a major problem. The World Health Organization (WHO) therefore recommends an initial minimum-resource method to signal when transmitted HIV drug resistance (HIVDR) requires action.</p>
</sec>
<sec><title>Objective</title>
<p>This survey sought to generate information on the presence of HIV drug-resistant strains in the locality where Ghana's ART for HIV was first introduced.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>The Ghana HIVDR threshold survey (TS) was conducted and analyzed according to WHO strategy for surveillance of HIVDR in the Eastern Region of Ghana. Sixty (60) plasma specimens were collected from 2007 to 2009 by an unlinked anonymous method from HIV seropositive pregnant women, aged between 15 to24 years, who were with their first pregnancy and ART naive. Genotyping was done as follows; Ribonucleic acid (RNA) was extracted from the samples and the protease (PR) and reverse transcriptase (RT) genes amplified and sequenced. The sequences were then analyzed for HIV drug resistance mutations using Stanford University HIV Drug Resistance Database.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>Only two individuals were found with major HIVDR mutations: one each in the PR and RT genes. Thus the level of HIVDR in the study population in 2009 was classified as low (< 5%).</p>
</sec>
<sec sec-type="conclusions"><title>Conclusion</title>
<p>As at February 2009, transmitted drug resistance was not a serious problem in the Eastern Region of Ghana. However, it is important to continue monitoring tHIVDR in order to understand the dynamics of the evolution of HIV drug resistance in the country.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Ghana Med J</journal-id>
<journal-title-group><journal-title>Ghana Medical Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">0016-9560</issn>
<publisher><publisher-name>Ghana Medical Association</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23966745</article-id>
<article-id pub-id-type="pmc">3743108</article-id>
<article-id pub-id-type="publisher-id">jGMJ.v47.i2.pg82</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Low Level of Transmitted HIV Drug Resistance at Two HIV Care Centres in Ghana: A Threshold Survey</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bonney</surname>
<given-names>E Y</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Addo</surname>
<given-names>N A</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ntim</surname>
<given-names>N A A</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Addo-Yobo</surname>
<given-names>F</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bondzie</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aryee</surname>
<given-names>K-E</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barnor</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brandful</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bekoe</surname>
<given-names>V</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ohene</surname>
<given-names>S-A</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ampofo</surname>
<given-names>W</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Virology Dept, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon Accra</aff>
<aff id="A2"><label>2</label>
National AIDS/STI Control Program, Ghana Health Service, Accra</aff>
<aff id="A3"><label>3</label>
World Health Organization, Ghana Office, Accra, Ghana</aff>
<author-notes><corresp><bold>Corresponding author:</bold>
 Professor William K. Ampofo <bold>Email:</bold>
<email>wampofo@noguchi.ug.edu.gh</email>
</corresp>
<fn fn-type="conflict"><p><bold>Conflict of interest:</bold>
 None declared</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2013</year>
</pub-date>
<volume>47</volume>
<issue>2</issue>
<fpage>82</fpage>
<lpage>86</lpage>
<permissions><copyright-statement>Copyright © Ghana Medical Association 2013</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract abstract-type="executive-summary"><title>Summary</title>
<sec><title>Background</title>
<p>As access to antiretroviral therapy (ART) increases, the emergence and transmission of HIV drug resistant strains becomes a major problem. The World Health Organization (WHO) therefore recommends an initial minimum-resource method to signal when transmitted HIV drug resistance (HIVDR) requires action.</p>
</sec>
<sec><title>Objective</title>
<p>This survey sought to generate information on the presence of HIV drug-resistant strains in the locality where Ghana's ART for HIV was first introduced.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>The Ghana HIVDR threshold survey (TS) was conducted and analyzed according to WHO strategy for surveillance of HIVDR in the Eastern Region of Ghana. Sixty (60) plasma specimens were collected from 2007 to 2009 by an unlinked anonymous method from HIV seropositive pregnant women, aged between 15 to24 years, who were with their first pregnancy and ART naive. Genotyping was done as follows; Ribonucleic acid (RNA) was extracted from the samples and the protease (PR) and reverse transcriptase (RT) genes amplified and sequenced. The sequences were then analyzed for HIV drug resistance mutations using Stanford University HIV Drug Resistance Database.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>Only two individuals were found with major HIVDR mutations: one each in the PR and RT genes. Thus the level of HIVDR in the study population in 2009 was classified as low (< 5%).</p>
</sec>
<sec sec-type="conclusions"><title>Conclusion</title>
<p>As at February 2009, transmitted drug resistance was not a serious problem in the Eastern Region of Ghana. However, it is important to continue monitoring tHIVDR in order to understand the dynamics of the evolution of HIV drug resistance in the country.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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Low Level of Transmitted HIV Drug Resistance at Two HIV Care Centres in Ghana: A Threshold Survey

Low Level of Transmitted HIV Drug Resistance at Two HIV Care Centres in Ghana: A Threshold Survey

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Abstract

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