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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Haemophagocytic Lymphohistiocytosis in a Ghanaian Child</title><author><name sortKey="Segbefia, C I" sort="Segbefia, C I" uniqKey="Segbefia C" first="C I" last="Segbefia">C I Segbefia</name><affiliation><nlm:aff id="A1"> University of Ghana Medical School, Accra, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Osei Wusu, A" sort="Osei Wusu, A" uniqKey="Osei Wusu A" first="A" last="Osei-Wusu">A. Osei-Wusu</name><affiliation><nlm:aff id="A2"> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Obeng, W" sort="Obeng, W" uniqKey="Obeng W" first="W" last="Obeng">W. Obeng</name><affiliation><nlm:aff id="A2"> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Dei Adomakoh, Y" sort="Dei Adomakoh, Y" uniqKey="Dei Adomakoh Y" first="Y" last="Dei-Adomakoh">Y. Dei-Adomakoh</name><affiliation><nlm:aff id="A3"> Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23661845</idno><idno type="pmc">3645170</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645170</idno><idno type="RBID">PMC:3645170</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000219</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000219</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Haemophagocytic Lymphohistiocytosis in a Ghanaian Child</title><author><name sortKey="Segbefia, C I" sort="Segbefia, C I" uniqKey="Segbefia C" first="C I" last="Segbefia">C I Segbefia</name><affiliation><nlm:aff id="A1"> University of Ghana Medical School, Accra, Ghana</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Osei Wusu, A" sort="Osei Wusu, A" uniqKey="Osei Wusu A" first="A" last="Osei-Wusu">A. Osei-Wusu</name><affiliation><nlm:aff id="A2"> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Obeng, W" sort="Obeng, W" uniqKey="Obeng W" first="W" last="Obeng">W. Obeng</name><affiliation><nlm:aff id="A2"> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author><author><name sortKey="Dei Adomakoh, Y" sort="Dei Adomakoh, Y" uniqKey="Dei Adomakoh Y" first="Y" last="Dei-Adomakoh">Y. Dei-Adomakoh</name><affiliation><nlm:aff id="A3"> Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana</nlm:aff></affiliation></author></analytic><series><title level="j">Ghana Medical Journal</title><idno type="ISSN">0016-9560</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>We report a case of a previously well nine-month-old infant who presented with prolonged fever, hepatosplenomegaly and pancytopenia. A diagnosis of haemophagocytic lymphohistiocytosis (HLH) was made during the course of hospital admission. There was good initial response to dexamethasone but the patient died less than two months after diagnosis. This is the first report of HLH from Ghana. The disease has a significant mortality rate if untreated and a high index of suspicion is required in all severely ill children.</p></div></front></TEI><pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ghana Med J</journal-id><journal-title-group><journal-title>Ghana Medical Journal</journal-title></journal-title-group><issn pub-type="ppub">0016-9560</issn><publisher><publisher-name>Ghana Medical Association</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23661845</article-id><article-id pub-id-type="pmc">3645170</article-id><article-id pub-id-type="publisher-id">jGMJ.v46.i4.pg254</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Reports</subject></subj-group></article-categories><title-group><article-title>Haemophagocytic Lymphohistiocytosis in a Ghanaian Child</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Segbefia</surname><given-names>C I</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Osei-Wusu</surname><given-names>A</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Obeng</surname><given-names>W</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dei-Adomakoh</surname><given-names>Y</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label> University of Ghana Medical School, Accra, Ghana</aff><aff id="A2"><label>2</label> Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana</aff><aff id="A3"><label>3</label> Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana</aff><author-notes><corresp><bold>Corresponding Author:</bold> Dr Catherine Segbefia <bold>Email:</bold><email>csegbefia@gmail.com</email></corresp><fn fn-type="conflict"><p><bold>Conflict of interest:</bold> None declared</p></fn></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><volume>46</volume><issue>4</issue><fpage>254</fpage><lpage>257</lpage><permissions><copyright-statement>Copyright © Ghana Medical Association 2012</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract abstract-type="executive-summary"><title>Summary</title><p>We report a case of a previously well nine-month-old infant who presented with prolonged fever, hepatosplenomegaly and pancytopenia. A diagnosis of haemophagocytic lymphohistiocytosis (HLH) was made during the course of hospital admission. There was good initial response to dexamethasone but the patient died less than two months after diagnosis. This is the first report of HLH from Ghana. The disease has a significant mortality rate if untreated and a high index of suspicion is required in all severely ill children.</p></abstract><kwd-group><kwd>Haemophagocytic lymphohistiocytosis</kwd><kwd>children</kwd><kwd>hyperinflammation</kwd><kwd>pancytopenia</kwd><kwd>dexamethasone</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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