Association of high viral load and abnormal liver function with high aflatoxin B1–albumin adduct levels in HIV-positive Ghanaians: preliminary observations
Identifieur interne : 000394 ( Pmc/Checkpoint ); précédent : 000393; suivant : 000395Association of high viral load and abnormal liver function with high aflatoxin B1–albumin adduct levels in HIV-positive Ghanaians: preliminary observations
Auteurs : P. E. Jolly [États-Unis] ; F. M. Shuaib [États-Unis] ; Y. Jiang [États-Unis] ; P. Preko [Ghana] ; J. Baidoo [Ghana] ; J. K. Stiles [États-Unis] ; J.-S. Wang [États-Unis] ; T. D. Phillips [États-Unis] ; J. H. Williams [États-Unis]Source :
- Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [ 1944-0049 ] ; 2011.
Abstract
We examined the association between certain clinical factors and aflatoxin B1–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg−1 albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.
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DOI: 10.1080/19440049.2011.581698
PubMed: 21749228
PubMed Central: 3381352
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E." last="Jolly">P. E. Jolly</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M." last="Shuaib">F. M. Shuaib</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. 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Stiles</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Environmental Health Science, University of Georgia, Athens, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Science, University of Georgia, Athens, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name><affiliation wicri:level="2"><nlm:aff id="A6">College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment</title><idno type="ISSN">1944-0049</idno><idno type="eISSN">1944-0057</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>−1</sup> albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101485040</journal-id><journal-id journal-id-type="pubmed-jr-id">35483</journal-id><journal-id journal-id-type="nlm-ta">Food Addit Contam Part A Chem Anal Control Expo Risk Assess</journal-id><journal-id journal-id-type="iso-abbrev">Food Addit Contam Part A Chem Anal Control Expo Risk Assess</journal-id><journal-title-group><journal-title>Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment</journal-title></journal-title-group><issn pub-type="ppub">1944-0049</issn><issn pub-type="epub">1944-0057</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21749228</article-id><article-id pub-id-type="pmc">3381352</article-id><article-id pub-id-type="doi">10.1080/19440049.2011.581698</article-id><article-id pub-id-type="manuscript">NIHMS378183</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>–albumin adduct levels in HIV-positive Ghanaians: preliminary observations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jolly</surname><given-names>P.E.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Shuaib</surname><given-names>F.M.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Preko</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Baidoo</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Stiles</surname><given-names>J.K.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>J.-S.</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>T.D.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>J.H.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA</aff><aff id="A2"><label>b</label>AIDS ALLY and St. Markus Hospital, Kumasi, Ghana</aff><aff id="A3"><label>c</label>Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA</aff><aff id="A4"><label>d</label>Department of Environmental Health Science, University of Georgia, Athens, GA, USA</aff><aff id="A5"><label>e</label>Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA</aff><aff id="A6"><label>f</label>College of Agricultural and Environmental Sciences, University of Georgia, Griffin, GA, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. <email>jollyp@uab.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>5</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>12</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>6</month><year>2012</year></pub-date><volume>28</volume><issue>9</issue><fpage>1224</fpage><lpage>1234</lpage><permissions><copyright-statement>© 2011 Taylor & Francis</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>–albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>−1</sup> albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17–7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03–22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</p></abstract><kwd-group><kwd>aflatoxins</kwd><kwd>HIV</kwd><kwd>liver function</kwd><kwd>Ghana</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Center on Minority Health and Health Disparities : NIMHD</funding-source><award-id>G12 MD007602 || MD</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Ghana</li><li>États-Unis</li></country><region><li>Alabama</li><li>Géorgie (États-Unis)</li><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Alabama"><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E." last="Jolly">P. E. Jolly</name></region><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M." last="Shuaib">F. M. Shuaib</name><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name></country><country name="Ghana"><noRegion><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name></noRegion><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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