Association of high viral load and abnormal liver function with high aflatoxin B1-albumin adduct levels in HIV-positive Ghanaians: preliminary observations
Identifieur interne : 000103 ( PascalFrancis/Curation ); précédent : 000102; suivant : 000104Association of high viral load and abnormal liver function with high aflatoxin B1-albumin adduct levels in HIV-positive Ghanaians: preliminary observations
Auteurs : P. E. Jolly [États-Unis] ; F. M. Shuaib [États-Unis] ; Y. Jiang [États-Unis] ; P. Preko [Ghana] ; J. Baidoo [Ghana] ; J. K. Stiles [États-Unis] ; J.-S. Wang [États-Unis] ; T. D. Phillips [États-Unis] ; J. H. Williams [États-Unis]Source :
- Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Ghana.
- topic : Association.
English descriptors
- KwdEn :
- Adduct, Aflatoxin B1, Albumin, Association, Ghana, Liver, Virus.
Abstract
We examined the association between certain clinical factors and aflatoxin B1-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg-1 albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17-7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>-albumin adduct levels in HIV-positive Ghanaians: preliminary observations</title><author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E" last="Jolly">P. E. Jolly</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M" last="Shuaib">F. M. Shuaib</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country></affiliation></author><author><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country></affiliation></author><author><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Environmental Health Science, University of Georgia</s1><s2>Athens, GA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Veterinary Integrative Biosciences, Texas A&M University</s1><s2>College Station, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>College of Agricultural and Environmental Sciences, University of Georgia</s1><s2>Griffin, GA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0451417</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0451417 INIST</idno><idno type="RBID">Pascal:11-0451417</idno><idno type="wicri:Area/PascalFrancis/Corpus">000029</idno><idno type="wicri:Area/PascalFrancis/Curation">000103</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>-albumin adduct levels in HIV-positive Ghanaians: preliminary observations</title><author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E" last="Jolly">P. E. Jolly</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Shuaib, F M" sort="Shuaib, F M" uniqKey="Shuaib F" first="F. M" last="Shuaib">F. M. Shuaib</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Preko, P" sort="Preko, P" uniqKey="Preko P" first="P." last="Preko">P. Preko</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country></affiliation></author><author><name sortKey="Baidoo, J" sort="Baidoo, J" uniqKey="Baidoo J" first="J." last="Baidoo">J. Baidoo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country></affiliation></author><author><name sortKey="Stiles, J K" sort="Stiles, J K" uniqKey="Stiles J" first="J. K." last="Stiles">J. K. Stiles</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Wang, J S" sort="Wang, J S" uniqKey="Wang J" first="J.-S." last="Wang">J.-S. Wang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Environmental Health Science, University of Georgia</s1><s2>Athens, GA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Veterinary Integrative Biosciences, Texas A&M University</s1><s2>College Station, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author><author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>College of Agricultural and Environmental Sciences, University of Georgia</s1><s2>Griffin, GA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment</title></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adduct</term><term>Aflatoxin B1</term><term>Albumin</term><term>Association</term><term>Ghana</term><term>Liver</term><term>Virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association</term><term>Foie</term><term>Aflatoxine B1</term><term>Virus</term><term>Albumine</term><term>Composé addition</term><term>Ghana</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4<sub>+</sub> T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>-1</sup> albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17-7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</div></front></TEI><inist><standard h6="B"><pA><fA05><s2>28</s2></fA05><fA06><s2>9</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Association of high viral load and abnormal liver function with high aflatoxin B<sub>1</sub>-albumin adduct levels in HIV-positive Ghanaians: preliminary observations</s1></fA08><fA11 i1="01" i2="1"><s1>JOLLY (P. E)</s1></fA11><fA11 i1="02" i2="1"><s1>SHUAIB (F. M)</s1></fA11><fA11 i1="03" i2="1"><s1>JIANG (Y.)</s1></fA11><fA11 i1="04" i2="1"><s1>PREKO (P.)</s1></fA11><fA11 i1="05" i2="1"><s1>BAIDOO (J.)</s1></fA11><fA11 i1="06" i2="1"><s1>STILES (J. K.)</s1></fA11><fA11 i1="07" i2="1"><s1>WANG (J.-S.)</s1></fA11><fA11 i1="08" i2="1"><s1>PHILLIPS (T. D.)</s1></fA11><fA11 i1="09" i2="1"><s1>WILLIAMS (J. H.)</s1></fA11><fA14 i1="01"><s1>Department of Epidemiology, University of Alabama at Birmingham</s1><s2>Birmingham, AL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>AIDS ALLY and St. Markus Hospital</s1><s2>Kumasi</s2><s3>GHA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Environmental Health Science, University of Georgia</s1><s2>Athens, GA</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Veterinary Integrative Biosciences, Texas A&M University</s1><s2>College Station, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="06"><s1>College of Agricultural and Environmental Sciences, University of Georgia</s1><s2>Griffin, GA</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA20><s1>1224-1234</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20834A</s2><s5>354000191265650100</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>11-0451417</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="2"><s0>Food additives & contaminants : part A chemistry, analysis, control, exposure & risk assessment</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>We examined the association between certain clinical factors and aflatoxin B<sub>1</sub>-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4<sub>+</sub> T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg<sup>-1</sup> albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR=2.84; 95% CI=1.17-7.78) and higher direct bilirubin levels (OR=5.47; 95% CI=1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.</s0></fC01><fC02 i1="01" i2="X"><s0>002A35E</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Association</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Association</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Asociación</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Foie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Liver</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Hígado</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Aflatoxine B1</s0><s2>NK</s2><s2>FX</s2><s5>10</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Aflatoxin B1</s0><s2>NK</s2><s2>FX</s2><s5>10</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Aflatoxina B1</s0><s2>NK</s2><s2>FX</s2><s5>10</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2><s5>13</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2><s5>13</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2><s5>13</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Albumine</s0><s5>19</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Albumin</s0><s5>19</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Albúmina</s0><s5>19</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Composé addition</s0><s5>20</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Adduct</s0><s5>20</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Compuesto adición</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Ghana</s0><s2>NG</s2><s5>24</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Ghana</s0><s2>NG</s2><s5>24</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Ghana</s0><s2>NG</s2><s5>24</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Mycotoxine</s0><s5>08</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Mycotoxin</s0><s5>08</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Micotoxina</s0><s5>08</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Toxine</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Toxin</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Toxina</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Afrique</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Africa</s0><s2>NG</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Africa</s0><s2>NG</s2></fC07><fN21><s1>311</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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