Changes in Sexual Risk Behavior Among Participants in a PrEP HIV Prevention Trial
Identifieur interne : 000077 ( PascalFrancis/Curation ); précédent : 000076; suivant : 000078Changes in Sexual Risk Behavior Among Participants in a PrEP HIV Prevention Trial
Auteurs : Greg Guest [États-Unis] ; Dominick Shattuck [États-Unis] ; Laura Johnson [États-Unis] ; Betty Akumatey [Ghana] ; Edith Essie Kekawo Clarke [Ghana] ; Pai-Lien Chen [États-Unis] ; Kathleen M. Macqueen [États-Unis]Source :
- Sexually transmitted diseases [ 0148-5717 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Maladie sexuellement transmissible.
English descriptors
Abstract
Background: One of the concerns raised regarding the introduction of any new HIV-prevention measure, such as PrEP, is the potential for risk disinhibition or sexual risk compensation. The oral tenofovir HIV prevention trial has been the subject of international discussion in this regard. Methods: This article maps the changes in sexual risk behavior among women participating in the oral tenofovir HIV prevention trial in Ghana. Content-driven, thematic analysis was carried out on qualitative data obtained from in-depth interviews with study participants. Growth curve analysis was the primary method used to document trends over time in self-reported sexual behavior collected monthly. Results: Overall, the study found that sexual risk behavior did not increase during the trial. Number of sexual partners and rate of unprotected sex acts decreased across the 12-month period of study enrollment. Certain subgroups of women, however, exhibited different growth curves. Data indicate that the HIV prevention counseling associated with the trial was effective. Conclusions: Counseling during the trial was effective. Different types of counseling and messaging may be needed for different subgroups within a population. These findings also have implications for required sample sizes for future HIV prevention trials where seroconversion is the main outcome.
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Macqueen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Behavioral and Biomedical Research, Family Health International</s1><s2>North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country></affiliation></author></analytic><series><title level="j" type="main">Sexually transmitted diseases</title><title level="j" type="abbreviated">Sex. transm. dis.</title><idno type="ISSN">0148-5717</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Sexually transmitted diseases</title><title level="j" type="abbreviated">Sex. transm. dis.</title><idno type="ISSN">0148-5717</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Clinical trial</term><term>Prevention</term><term>Sexual behavior</term><term>Sexually transmitted disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term><term>Maladie sexuellement transmissible</term><term>Comportement sexuel</term><term>Prévention</term><term>Essai clinique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie sexuellement transmissible</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: One of the concerns raised regarding the introduction of any new HIV-prevention measure, such as PrEP, is the potential for risk disinhibition or sexual risk compensation. The oral tenofovir HIV prevention trial has been the subject of international discussion in this regard. Methods: This article maps the changes in sexual risk behavior among women participating in the oral tenofovir HIV prevention trial in Ghana. Content-driven, thematic analysis was carried out on qualitative data obtained from in-depth interviews with study participants. Growth curve analysis was the primary method used to document trends over time in self-reported sexual behavior collected monthly. Results: Overall, the study found that sexual risk behavior did not increase during the trial. Number of sexual partners and rate of unprotected sex acts decreased across the 12-month period of study enrollment. Certain subgroups of women, however, exhibited different growth curves. Data indicate that the HIV prevention counseling associated with the trial was effective. Conclusions: Counseling during the trial was effective. Different types of counseling and messaging may be needed for different subgroups within a population. These findings also have implications for required sample sizes for future HIV prevention trials where seroconversion is the main outcome.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0148-5717</s0></fA01><fA02 i1="01"><s0>STRDDM</s0></fA02><fA03 i2="1"><s0>Sex. transm. dis.</s0></fA03><fA05><s2>35</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Changes in Sexual Risk Behavior Among Participants in a PrEP HIV Prevention Trial</s1></fA08><fA11 i1="01" i2="1"><s1>GUEST (Greg)</s1></fA11><fA11 i1="02" i2="1"><s1>SHATTUCK (Dominick)</s1></fA11><fA11 i1="03" i2="1"><s1>JOHNSON (Laura)</s1></fA11><fA11 i1="04" i2="1"><s1>AKUMATEY (Betty)</s1></fA11><fA11 i1="05" i2="1"><s1>KEKAWO CLARKE (Edith Essie)</s1></fA11><fA11 i1="06" i2="1"><s1>CHEN (Pai-Lien)</s1></fA11><fA11 i1="07" i2="1"><s1>MACQUEEN (Kathleen M.)</s1></fA11><fA14 i1="01"><s1>Division of Behavioral and Biomedical Research, Family Health International</s1><s2>North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Sociology, University of Ghana</s1><s2>Legon</s2><s3>GHA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Ghana Health Service, Ministry of Health</s1><s3>GHA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="04"><s1>Division of Biostatistics, Family Health International</s1><s2>North Carolina</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA20><s1>1002-1008</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18921</s2><s5>354000185008690090</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. 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Results: Overall, the study found that sexual risk behavior did not increase during the trial. Number of sexual partners and rate of unprotected sex acts decreased across the 12-month period of study enrollment. Certain subgroups of women, however, exhibited different growth curves. Data indicate that the HIV prevention counseling associated with the trial was effective. Conclusions: Counseling during the trial was effective. Different types of counseling and messaging may be needed for different subgroups within a population. 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