SidaGhanaV1, PascalFrancis, Corpus, bibRecord, 000012

Diagnosis of treponemal co-infection in HIV-infected West Africans

Identifieur interne : 000012 ( PascalFrancis/Corpus ); précédent : 000011; suivant : 000013

Diagnosis of treponemal co-infection in HIV-infected West Africans

Auteurs : Yaasir Mamoojee ; Grace Tan ; Sandra Gittins ; Stephen Sarfo ; Lisa Stephenson ; David Carrington ; George Bedu-Addo ; Richard Phillips ; Lambert T. Appiah ; David Chadwick

Source :

TM & IH. Tropical medicine & international health [ 1360-2276 ] ; 2012.

RBID : Pascal:13-0002896

Descripteurs français

Pascal (Inist)
- Tréponématose, Infection mixte, SIDA, Diagnostic, Syphilis, Pian, Virus immunodéficience humaine, Afrique, Evaluation performance, Médecine tropicale.

English descriptors

KwdEn :
- AIDS, Africa, Diagnosis, Human immunodeficiency virus, Mixed infection, Performance evaluation, Syphilis, Treponematosis, Tropical medicine, Yaws.

Abstract

OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 1360-2276`
A03		`1`		`@0 TM IH, Trop. med. int. health`
A05				`@2 17`
A06				`@2 12`
A08	`01`	`1`	`ENG`	`@1 Diagnosis of treponemal co-infection in HIV-infected West Africans`
A11	`01`	`1`		`@1 MAMOOJEE (Yaasir)`
A11	`02`	`1`		`@1 TAN (Grace)`
A11	`03`	`1`		`@1 GITTINS (Sandra)`
A11	`04`	`1`		`@1 SARFO (Stephen)`
A11	`05`	`1`		`@1 STEPHENSON (Lisa)`
A11	`06`	`1`		`@1 CARRINGTON (David)`
A11	`07`	`1`		`@1 BEDU-ADDO (George)`
A11	`08`	`1`		`@1 PHILLIPS (Richard)`
A11	`09`	`1`		`@1 APPIAH (Lambert T.)`
A11	`10`	`1`		`@1 CHADWICK (David)`
A14	`01`			`@1 The James Cook University Hospital @2 Middlesbrough @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 10 aut.`
A14	`02`			`@1 Komfo Anokye Teaching Hospital @2 Kumasi @3 GHA @Z 4 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut.`
A14	`03`			`@1 Health Protection Agency South West Regional Laboratory @2 Bristol @3 GBR @Z 5 aut. @Z 6 aut.`
A20				`@1 1521-1526`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 26295 @5 354000509007790120`
A44				`@0 0000 @1 © 2013 INIST-CNRS. All rights reserved.`
A45				`@0 1 p.1/4`
A47	`01`	`1`		`@0 13-0002896`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 TM & IH. Tropical medicine & international health`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.
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Format Inist (serveur)

NO :	PASCAL 13-0002896 INIST
ET :	Diagnosis of treponemal co-infection in HIV-infected West Africans
AU :	MAMOOJEE (Yaasir); TAN (Grace); GITTINS (Sandra); SARFO (Stephen); STEPHENSON (Lisa); CARRINGTON (David); BEDU-ADDO (George); PHILLIPS (Richard); APPIAH (Lambert T.); CHADWICK (David)
AF :	The James Cook University Hospital/Middlesbrough/Royaume-Uni (1 aut., 2 aut., 3 aut., 10 aut.); Komfo Anokye Teaching Hospital/Kumasi/Ghana (4 aut., 7 aut., 8 aut., 9 aut.); Health Protection Agency South West Regional Laboratory/Bristol/Royaume-Uni (5 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	TM & IH. Tropical medicine & international health; ISSN 1360-2276; Royaume-Uni; Da. 2012; Vol. 17; No. 12; Pp. 1521-1526; Bibl. 1 p.1/4
LA :	Anglais
EA :	OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.
CC :	002B01; 002B05B02P; 002B05C02D
FD :	Tréponématose; Infection mixte; SIDA; Diagnostic; Syphilis; Pian; Virus immunodéficience humaine; Afrique; Evaluation performance; Médecine tropicale
FG :	Spirochétose; Bactériose; Infection; Virose; Lentivirus; Retroviridae; Virus; Immunodéficit; Immunopathologie; Maladie sexuellement transmissible; Pathologie de la peau
ED :	Treponematosis; Mixed infection; AIDS; Diagnosis; Syphilis; Yaws; Human immunodeficiency virus; Africa; Performance evaluation; Tropical medicine
EG :	Spirochaetosis; Bacteriosis; Infection; Viral disease; Lentivirus; Retroviridae; Virus; Immune deficiency; Immunopathology; Sexually transmitted disease; Skin disease
SD :	Treponematosis; Infección mixta; SIDA; Diagnóstico; Sífilis; Pián; Human immunodeficiency virus; Africa; Evaluación prestación; Medicina tropical
LO :	INIST-26295.354000509007790120
ID :	13-0002896

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Pascal:13-0002896

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Diagnosis of treponemal co-infection in HIV-infected West Africans</title>
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<author><name sortKey="Carrington, David" sort="Carrington, David" uniqKey="Carrington D" first="David" last="Carrington">David Carrington</name>
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<author><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name>
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<author><name sortKey="Phillips, Richard" sort="Phillips, Richard" uniqKey="Phillips R" first="Richard" last="Phillips">Richard Phillips</name>
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<author><name sortKey="Appiah, Lambert T" sort="Appiah, Lambert T" uniqKey="Appiah L" first="Lambert T." last="Appiah">Lambert T. Appiah</name>
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<author><name sortKey="Chadwick, David" sort="Chadwick, David" uniqKey="Chadwick D" first="David" last="Chadwick">David Chadwick</name>
<affiliation><inist:fA14 i1="01"><s1>The James Cook University Hospital</s1>
<s2>Middlesbrough</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
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<series><title level="j" type="main">TM & IH. Tropical medicine & international health</title>
<title level="j" type="abbreviated">TM IH, Trop. med. int. health</title>
<idno type="ISSN">1360-2276</idno>
<imprint><date when="2012">2012</date>
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<seriesStmt><title level="j" type="main">TM & IH. Tropical medicine & international health</title>
<title level="j" type="abbreviated">TM IH, Trop. med. int. health</title>
<idno type="ISSN">1360-2276</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Africa</term>
<term>Diagnosis</term>
<term>Human immunodeficiency virus</term>
<term>Mixed infection</term>
<term>Performance evaluation</term>
<term>Syphilis</term>
<term>Treponematosis</term>
<term>Tropical medicine</term>
<term>Yaws</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tréponématose</term>
<term>Infection mixte</term>
<term>SIDA</term>
<term>Diagnostic</term>
<term>Syphilis</term>
<term>Pian</term>
<term>Virus immunodéficience humaine</term>
<term>Afrique</term>
<term>Evaluation performance</term>
<term>Médecine tropicale</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Diagnosis of treponemal co-infection in HIV-infected West Africans</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MAMOOJEE (Yaasir)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>TAN (Grace)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GITTINS (Sandra)</s1>
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<fA11 i1="04" i2="1"><s1>SARFO (Stephen)</s1>
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<fA11 i1="05" i2="1"><s1>STEPHENSON (Lisa)</s1>
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<fA11 i1="06" i2="1"><s1>CARRINGTON (David)</s1>
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<fA11 i1="07" i2="1"><s1>BEDU-ADDO (George)</s1>
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<fA11 i1="08" i2="1"><s1>PHILLIPS (Richard)</s1>
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<fA11 i1="09" i2="1"><s1>APPIAH (Lambert T.)</s1>
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<fA11 i1="10" i2="1"><s1>CHADWICK (David)</s1>
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<fA14 i1="01"><s1>The James Cook University Hospital</s1>
<s2>Middlesbrough</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="02"><s1>Komfo Anokye Teaching Hospital</s1>
<s2>Kumasi</s2>
<s3>GHA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Health Protection Agency South West Regional Laboratory</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>1521-1526</s1>
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<fC01 i1="01" l="ENG"><s0>OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.</s0>
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<s5>08</s5>
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<s5>08</s5>
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<s5>09</s5>
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<s5>10</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Human immunodeficiency virus</s0>
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<s5>10</s5>
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<s5>13</s5>
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<s5>13</s5>
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<server><NO>PASCAL 13-0002896 INIST</NO>
<ET>Diagnosis of treponemal co-infection in HIV-infected West Africans</ET>
<AU>MAMOOJEE (Yaasir); TAN (Grace); GITTINS (Sandra); SARFO (Stephen); STEPHENSON (Lisa); CARRINGTON (David); BEDU-ADDO (George); PHILLIPS (Richard); APPIAH (Lambert T.); CHADWICK (David)</AU>
<AF>The James Cook University Hospital/Middlesbrough/Royaume-Uni (1 aut., 2 aut., 3 aut., 10 aut.); Komfo Anokye Teaching Hospital/Kumasi/Ghana (4 aut., 7 aut., 8 aut., 9 aut.); Health Protection Agency South West Regional Laboratory/Bristol/Royaume-Uni (5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>TM & IH. Tropical medicine & international health; ISSN 1360-2276; Royaume-Uni; Da. 2012; Vol. 17; No. 12; Pp. 1521-1526; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.</EA>
<CC>002B01; 002B05B02P; 002B05C02D</CC>
<FD>Tréponématose; Infection mixte; SIDA; Diagnostic; Syphilis; Pian; Virus immunodéficience humaine; Afrique; Evaluation performance; Médecine tropicale</FD>
<FG>Spirochétose; Bactériose; Infection; Virose; Lentivirus; Retroviridae; Virus; Immunodéficit; Immunopathologie; Maladie sexuellement transmissible; Pathologie de la peau</FG>
<ED>Treponematosis; Mixed infection; AIDS; Diagnosis; Syphilis; Yaws; Human immunodeficiency virus; Africa; Performance evaluation; Tropical medicine</ED>
<EG>Spirochaetosis; Bacteriosis; Infection; Viral disease; Lentivirus; Retroviridae; Virus; Immune deficiency; Immunopathology; Sexually transmitted disease; Skin disease</EG>
<SD>Treponematosis; Infección mixta; SIDA; Diagnóstico; Sífilis; Pián; Human immunodeficiency virus; Africa; Evaluación prestación; Medicina tropical</SD>
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Diagnosis of treponemal co-infection in HIV-infected West Africans

Diagnosis of treponemal co-infection in HIV-infected West Africans

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